The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration

Journal of Immunology

Volumn 172, Issue 10, 2004, Pages 6407-6417

  Betts, Michael R ^a   Price, David A ^a   Brenchley, Jason M ^a   Loré, Karin ^a   Guenaga, F Javier ^a   Smed Sorensen, Anna ^c   Ambrozak, David R ^a   Migueles, Stephen A ^a   Connors, Mark ^a   Roederer, Mario ^b   Douek, Daniel C ^a   Koup, Richard A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b National Institute of AIDS and Infectious Diseases   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; DEGRANULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOREACTIVITY; INFECTION RESISTANCE; LYMPHOCYTOTOXICITY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 2442500442     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.6407     Document Type: Article

References (52)

1. McMichael, A. J., F. M. Gotch, G. R. Noble, and P. A. Beare. 1983. Cytotoxic T-cell immunity to influenza. N. Engl. J. Med. 309:13.
2. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, Y. Wu, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune response with the initial control of viremia in primary HIV-1 syndrome. J. Virol. 68:4650.
3. Guidotti, L. G., T. Ishikawa, M. V. Hobbs, B. Matzke, R. Schreiber, and F. V. Chisari. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25.
4. + T cells in acute infectious mononucleosis. Nat. Med 2:906.
5. Lechner, F., D. K. Wong, P. R. Dunbar, R. Chapam, R. T. Chung, P. Dohranwend, G. Robbins, R. Phillips, P. Klenerman, and B. D. Walker. 2000. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med 191:1499.
6. + T lymphocytes in healthy seropositive donors. J. Virol. 74:8140.
7. Sewell, A. K., D. A. Price, A. Oxenius, A. D. Kelleher, and R. E. Phillips. 2000. Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape. Stem Cells 18:230.
8. + T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol. 18:275.
9. Peters, P. J., J. Borst, V. Oorschot, M. Fukuda, O. Krahenbuhl, J. Tschopp, J. W. Slot, and H. J. Geuze. 1991. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 173:1099.
10. Henkart, P. A. 1985. Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 3:31.
11. Podack, E. R., and A. Kupfer. 1991. T-cell effector functions: mechanisms for delivery of cytotoxicity and help. Annu. Rev. Cell Biol. 7:479.
12. Bossi, G., and G. M. Griffiths. 1999. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells. Nat. Med 5:90.
13. + T-cell responses cannot be predicted by major histocompatibility complex class I haplotype. J. Virol. 74:9144.
14. Schacker, T. W., P. L. Nguyen, G. J. Beilman, S. Wolinsky, M. Larson, C. Reilly, and A. T. Haase. 2002. Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis. J. Clin. Invest. 110:1133.
15. Freeman, A. J., G. Marinos, R. A. Ffrench, and A. R. Lloyd. 2001. Immunopathogenesis of hepatitis C virus infection. Immunol. Cell Biol. 79:515.
16. Champagne, P., G. S. Ogg, A. S. King, C. Knabenhans, K. Ellefsen, M. Nobile, V. Appay, G. P. Rizzardi, S. Fleury, M. Lipp, et al. 2001. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 410:106.
17. + T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192:63.
18. + T cells. Blood 101:2711.
19. + cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J. Acquired Immune. Defic. Syndr. Hum. Retrovirol. 16:83.
20. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917.
21. + T cells specific to a single viral epitope. J. Immunol. 165:6214.
22. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
23. + T cells. Nature 401:76.
24. Isaaz, S., K. Baetz, K. Olsen, E. Podack, and G. M. Griffiths. 1995. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lyric proteins via a non-granule pathway. Eur. J. Immunol. 25:1071.
25. + T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281:65.
26. Rubio, V., T. B. Stuge, N. Singh, M. R. Betts, J. S. Weber, M. Roederer, and P. P. Lee. 2003. Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat. Med. 9:1377.
27. + T cell proliferation is coupled to perfotin expression and is maintained in nonprogression. Nat. Immunol. 3:1061.
28. Douek, D. C., M. R. Betts, J. M. Brenchley, B. J. Hill, D. R. Ambrozak, K. L. Ngai, N. J. Karandikar, J. P. Casazza, and R. A. Koup. 2002. A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J. Immunol. 168:3099.
29. Chenchik, A., Y. Zhu, L. Diatchenko, R. Li, J. Hill, and P. Seibert. 1998. Generation and use of high quality cDNA from small amounts of total RNA by SMART PCR. In RT-PCR Methods for Gene Cloning and Analysis. P. Seibert and J. Larrick, eds. BioTechniques Books, Natick, p. 305.
30. + T lymphocyte activation in response to therapeutic manipulation of virus load. Eur. J. Immunol. 31:1115.
31. Moss, P. A., R. J. Moots, W. M. Rosenberg, S. J. Rowland-Jones, H. C. Bodmer, A. J. McMichael, and J. I. Bell. 1991. Extensive conservation of α and β chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. Natl. Acad. Sci. USA 88: 8987.
32. Burrows, S. R., S. L. Silins, D. J. Moss, R. Khanna, I. S. Misko, and V. P. Argaet. 1995. T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J. Exp. Med. 182:1703.
33. + cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J. Virol. 70:843.
34. Thimme, R., D. Oldach, K. M. Chang, C. Steiger, S. C. Ray, and F. V. Chisari. 2001. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194:1395.
35. + T-cell responsiveness in hepatitis C virus infection. Hepatology 33:267.
36. Guidotti, L. G., R. Rochford, J. Chung, M. Shapiro, R. Purcell, and F. V. Chisari. 1999. Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825.
37. + memory T cell activation requirements at the single clonotype level. J. Immunol. 169:1207.
38. Tsomides, T. J., A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283.
39. Kageyama, S., T. Tsomides, Y. Sykulev, and H. Eisen. 1995. Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J. Immunol. 154:567.
40. Sykulev, Y., M. Joo, I. Vturina, T. J. Tsomides, and H. N. Eisen. 1996. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4:565.
41. Delon, J., C. Gregoire, B. Malissen, S. Darche, F. Lemaitre, P. Kourilsky, J. P. Abastado, and A. Trautmann. 1998. CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. Immunity 9:467.
42. van der Merwe, P. A. 2002. Do T cell receptors do it alone? Nat Immunol. 3:1122.
43. Schott, E., N. Bertho, Q. Ge, M. M. Maurice, and H. L. Ploegh. 2002. Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proc. Natl. Acad. Sci. USA 99:13735.
44. Itoh, Y., B. Hemmer, R. Martin, and R. N. Germain. 1999. Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signalling events. J. Immunol. 162:2073.
45. Wherry, E. J., K. A. Puorro, A. Porgador, and L. C. Eisenlohr. 1999. The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained. J. Immunol. 163:3735.
46. + T cell memory in response to low, high, and excessive levels of epitope. J. Immunol. 168:4455.
47. + T cells. J. Immunol. 170:1822.
48. Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355.
49. Embretson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359.
50. Terrault, N. A., P. J. Dailey, L. Ferrell, M. L. Collins, J. C. Wilber, M. S. Urdea, B. N. Bhandari, and T. L. Wright. 1997. Hepatitis C virus: quantitation and distribution in liver. J. Med. Virol. 51:217.
51. Abel, K., L. La Franco-Scheuch, T. Rourke, Z. M. Ma, V. De Silva, B. Fallert, L. Beckett, T. A. Reinhart, and C. J. Miller. 2004. γ interferon-mediated inflammation is associated with lack of protection from intravaginal simian immunodeficiency virus SIVmac239 challenge in simian-human immunodeficiency virus 89.6-immunized rhesus macaques. J. Virol. 78:841.
52. T) method. Methods 25:402.