The induction of virus-specific CTL as a function of increasing epitope expression: Responses rise steadily until excessively high levels of epitope are attained

Journal of Immunology

Volumn 163, Issue 7, 1999, Pages 3735-3745

  Wherry, E John ^a   Puorro, Kristin A ^a   Porgador, Angel ^b   Eisenlohr, Laurence C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VACCINIA VIRUS; VIRUS INFECTION;

ANIMALS; ANTIGENS, SURFACE; ANTIGENS, VIRAL; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EGG PROTEINS; EPITOPES, T-LYMPHOCYTE; FEMALE; HYBRIDOMAS; INFLUENZA A VIRUS; L CELLS (CELL LINE); LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; NUCLEOPROTEINS; OVALBUMIN; RNA-BINDING PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA VIRUS; VIRAL CORE PROTEINS; VIRAL VACCINES;

EID: 0033214423     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. + T cell memory. Immunol. Rev. 150:23.
2. Zinkernagel, R. M., M. F. Bachmann, T. M. Klindig, S. Oehen, H. Pircher, and H. Hengartner. 1996. On immunological memory. Annu. Rev. Immunol. 14:333.
3. Zarozinski, C. C., and R. M. Welsh. 1997. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185: 1629.
4. Ehl, S., J. Hombach, P. Aichele, H. Hengartner, and R. M. Zinkernagel. 1997. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185:1241.
5. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. D. Sourdive, A. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177.
6. + T cells during an acute virus infection. Immunity 8:167.
7. + T cells in primary and secondary influenza pneumonia. Immunity 8:683.
8. + T-cell memory determined by clonal burst size. Nature 369:652.
9. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J. L. Casanova, and P. R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
10. Sourdive, D. J., K. Murali-Krishna, J. D. Altman, A. J. Zajac, J. K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed, R. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71.
11. + T cell memory in vivo. Eur. J. Immunol. 28:4382.
12. Busch, D. H., I. Pilip, and E. G. Pamer, E.G. 1998. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188:61.
13. Lin, M. Y., and R. M. Welsh. 1998. Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J. Exp. Med. 188:1993.
14. Nanda, N. K., R. Apple, and E. Sercarz. 1991. Limitations in plasticity of the T-cell receptor repertoire. Proc. Natl. Acad. Sci. USA 88:9503.
15. Daly, D., P. Nguyen, D. L. Woodland, and M. A. Blackman. 1995. Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire. J. Virol. 69:7416.
16. + CTL response to an influenza hemagglutinin epitope reflects limited T cell availability. J. Immunol. 157:505.
17. Tough, D. F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947.
18. + T cells in vivo by IL-15. Immunology 8:591.
19. - T cell differentiation. J. Immunol. 159:5956.
20. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
21. Cai, Z., and I. Sprent. 1996. Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro. J. Exp. Med. 183:2247.
22. d-restricted cytotoxic T lymphocytes. J. Exp. Med. 173:849.
23. De Bruijn, M. L., T. N. Schumacher, J. D. Nieland, H. L. Ploegh, W. M. Kast. and C. J. Melief. 1991. Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses. Eur. J. Immunol. 21:2963.
24. Motta, I., Y. C. Lone, and P. Kourilsky. 1998. In vitro induction of naive cylotoxic T lymphocytes with complexes of peptide and recombinant MHC class I molecules coated onto beads: role of TCR/ligand density. Eur. J. Immunol. 28: 3685.
25. + T cell responses induced by recombinant influenza and vaccinia viruses. Cell. Immunol. 173:96.
26. Kundig, T. M., M. F. Bachmann, S. Oehen, U. W. Hoffmann, J. J. Simard, C. P. Kalberer, H. Pircher, P. S. Ohashi, H. Hengartner, and R. M. Zinkernagel. 1996. On the role of antigen in maintaining cytotoxic T-cell memory. Proc. Natl. Acad. Sci. USA 93:9716.
27. Bachmann, M. F., T. M. Kundig, H. Hengartner, and R. M. Zinkernagel. 1997. Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"? Proc. Natl. Acad Sci. USA 94:640.
28. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579.
29. + T cells. J. Exp. Med. 182:1591.
30. Levitsky, V., Q.-J. Zhang, J. Levitskaya, and M. Masucci. 1996. The lifespan of major histocompatibility complex-peptide complexes influenzes the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 183:915.
31. Gallimore, A., T. Dumrese, H. Hengartner, R. M. Zinkernagel, and H.-G. Rammensee. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J. Exp. Med. 187:1647.
32. Chen, W., S. Khilko, J. Fecondo, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 180:1471.
33. van der Burg, S. H., M. J. Visseren, R. M. Brandt, W. M. Kast, and C. J. Melief. 1996. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol. 156:3308.
34. Sijts, A. J. A. M., and E. G. Pamer. 1997. Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. J. Exp. Med. 185:1403.
35. Busch, D. H., I. M. Pilip, S. Vigh, and E. G. Pamer. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 8:353.
36. Antón, L. C., J. W. Yewdell, and J. R. Bennink. 1997. MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158:2535.
37. Porgador, A., J. W. Yewdell, Y. Deng, J. R> Bennink, and R. N. Germain. 1997. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6:715.
38. Restifo, N. P., I. Bacík, K. R. Irvine, J. W. Yewdell, B. J. McFarland, R. W. Anderson, L. C. Eisenlohr, S. A. Rosenberg, and J. R. Bennink 1995. Antigen processing in vivo and the elicitation of primary cytotoxic T lymphocyte responses. J. Immunol. 154:4414.
39. Vijh, S., I. M. Pilip, and E. G. Pamer. 1998. Effect of antigen-processing efficiency on in vivo T cell response magnitudes. J. Immunol. 160:3971.
40. Bullock, T. N. J., and L. C. Eisenlohr. 1996. Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames. J. Exp. Med. 184:1319.
41. Yellen-Shaw, A. J., C. E. Laughlin, R. M. Metrione, and L. C. Eisenlohr. 1997. Murine TAP preferences influence class I-restricted T cell responses. J. Exp. Med. 186:1655.
42. Eisenlohr, L. C., J. M. Yewdell, and J. R. Bennink. 1992. Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes. J. Exp. Med. 175:481.
43. Sanderson, S., and N. Shastri. 1994. LacZ inducible, antigen/MHC-specific T cell hybrids. Int. Immunol. 6:369.
44. Yellen-Shaw, A. J., E. J. Wherry, G. C. Dubois, and L. C. Eisenlohr. 1997. Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein. J. Immunol. 158:3227.
45. Carroll, M. W., and B. Moss. 1997. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology 238:198.
46. Taswell, C. 1981. Limiting dilution assays for the determination of immunocompetent cell frequencies. J. Immunol. 126:1614.
47. + T cells using an ELISPOT assay. J. Immunol. Methods 181:45.
48. Yellen-Shaw, A. J., and L. C. Eisenlohr. 1997. Regulation of class I-restricted epitope processing by local or distal flanking sequence. J. Immunol. 158:1727.
49. Bullock, T. N. J., A. E. Patterson, L. L. Franlin, E. Notidis, and L. C. Eisenlohr. 1997. Initiation codon scanthrough versus termination codon readthrough demonstrates strong potential for MHC class I-restricted cryptic epitope expression. J. Exp. Med. 186:1051.
50. Sigal, L. J., S. Crotty, R. Andino, and K. L. Rock. 1999. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 398:77.
51. + T cells. Science 280:227.
52. Johnson, G. P., S. J. Goebel, and E. Paoletti, E. 1993. An update on the vaccinia virus genome. Virology 196:381.
53. Townsend, A., J. Bastin, K. Gould, G. Brownlee, M. Andrew, B. Coupar, D. Boyle, S. Chan, and G. Smith. 1988. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. J. Exp. Med. 168:1211.
54. Grant, E. P., M. T. Michalek, A. L. Goldberg, and K. L. Rock, K.L. 1995. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation. J. Immunol. 155:3750.
55. Tobery, T. W., and R. F. Siliciano. 1997. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med 185:909.
56. Rodriguez, F., J. Zhang, and J. L. Whitton. 1997. DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J. Virol. 71:8497.
57. Sweetser, M. T., L. Morrison, V. L. Braciale, and T. J. Braciale. 1989. Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells. Nature 342:180.
58. Rodriguez, F., L. L. An, S. Harkins, J. Zhang, M. Yokoyama, G. Widera, J. T. Fuller, C. Kincaid, I. L. Campbell, and J. L. Whitton. 1998. DNA immunization with minigenes: low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination. J. Virol. 72:5174.
59. Buller, R. M. L., and G. J. Palumbo. 1991. Poxvirus pathogenesis. Microbiol. Rev. 55:80.
60. Harty, J. T., L. L. Lenz, and M. J. Bevan. 1996. Primary and secondary immune responses to Listeria monocytogenes. Curr. Opin. Immunol. 8:526.
61. Kimachi, K., M. Croft, and H. M. Grey. 1997. The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells. Eur. J. Immunol. 27:3310.
62. Altman, J. D., P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes (published erratum appears in 1998, Science 280:1821). Science 274:94.
63. Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996. Selective expansion of high-or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93:4102.
64. De Boer, R. J., and A. S. Perelson. 1994. T cell repertoires and competitive exclusion. J. Theor. Biol. 169:375.
65. Bousso, P., A. Casrouge, J. D. Altman, M. Haury, J. Kanellopoulos, J. P. Abastado, and P. Kourilsky. 1998. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires. Immunity 9:169.
66. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel, R.M. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
67. + T cell function during in vivo memory or tolerance induction. Immunity 8:581.
68. Alexander-Miller, M. A., M. A. Derby, A. Sarin, P. A. Henkart, and J. A. Berzofsky. 1998. Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes. J. Exp. Med. 188:1391.