Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load

European Journal of Immunology

Volumn 31, Issue 4, 2001, Pages 1115-11121

  Oxenius, Annette ^a   Günthard, Huldrych F ^b   Hirschel, Bernard ^c   Fidler, Sarah ^d   Weber, Jonathan N ^d   Easterbrook, Philippa J ^e   Bell, John I ^a   Phillips, Rodney E ^a   Price, David A ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d ST MARY S HOSPITAL   (United Kingdom)

^e KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

HIV infection; Tetramer staining

Indexed keywords

ANTIRETROVIRUS AGENT; CD8 ANTIGEN; HLA ANTIGEN CLASS 1; INDINAVIR; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LIPOCORTIN 5; PEPTIDE; T LYMPHOCYTE RECEPTOR; TETRAMER; VIRUS ANTIGEN; ZIDOVUDINE;

ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CASE REPORT; CELL DEATH; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICAL TECHNOLOGY; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SEGREGATION ANALYSIS; STAGING; STAINING; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; VIRUS LOAD;

EID: 0035054379     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200104)31:4<1115::AID-IMMU1115>3.0.CO;2-9     Document Type: Article

References (32)

1. The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
2. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
3. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division
4. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
5. T cell responses are governed by avidity and costimulatory thresholds
6. + cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonist
7. + T cells
8. Differential requirements for survival and proliferation of CD8 naive or memory T cells
9. Agonist-induced T cell receptor down-regulation: Molecular requirements and dissociation from T cell activation
10. T cell receptor alpha-chain tail is required for protein kinase C-mediated down-regulation, but not for signaling
11. Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation
12. + T lymphocytes
13. Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition
14. Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism
15. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice
16. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
17. + T cells during the primary immune response to Epstein-Barr virus in vivo
18. Receptor-stimulated death pathway is opened by antigen in mature T cells
19. Programmed cell death of T lymphocytes during acute viral infection: A mechanism for virus-induced immune deficiency
20. T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions
21. + T cells after antigen challenge in the absence of Fas (CD95)
22. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
23. Induction of apoptosis in mature T cells by tumour necrosis factor
24. Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)
25. Programmed death of T cells in HIV-1 infection
26. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals
27. HIV-specific CD8(+) T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
28. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
29. Detection of low HIV-1 RNA levels in plasma
30. A rapid and simple method for extracting human immunodeficiency virus type 1 RNA from plasma: Enhanced sensitivity
31. Phenotypic analysis of antigen-specific T lymphocytes
32. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent