Glycation, ageing and carnosine: Are carnivorous diets beneficial?

Mechanisms of Ageing and Development

Volumn 126, Issue 10, 2005, Pages 1034-1039

  Hipkiss, Alan R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Ageing; Aldehydes; Carbonyls; Carnosine; Diabetes; Diet; Glycation

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALDEHYDE; AMINOGUANIDINE; ANTIOXIDANT; CARBONYL DERIVATIVE; CARNOSINE; HERBACEOUS AGENT; LACTOYLGLUTATHIONE LYASE; MALONALDEHYDE; METHYLGLYOXAL; PENICILLAMINE; POLYAMINE; PYRIDOXAMINE; SCAVENGER;

AGING; ALZHEIMER DISEASE; CARNIVORE; CELL SURVIVAL; CEREBROSPINAL FLUID LEVEL; CROSS LINKING; DIABETES MELLITUS; DIET; DRUG EFFECT; ENZYME BLOOD LEVEL; ERYTHROCYTE; GLYCATION; HEMOLYSIS; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; REJUVENATION; REVIEW; SENESCENCE; TELOMERE;

EID: 24344436796     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2005.05.002     Document Type: Article

References (97)

1. N. Ahmed Advanced glycation endproducts - role in pathology of diabetic complications Diab. Res. Clin. Pract. 67 2005 3 21
2. N. Ahmed, U. Ahmed, P.J. Thornalley, K. Hager, G. Fleischer, and G. Munch Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment J. Neurochem. 92 2005 255 263
3. G. Aldini, M. Carini, G. Beretta, S. Bradamante, and R.B. Facino Carnosine is a quencher of 4-hydroxy-nonenal: though what is the mechanism of reaction? Biochem. Biophys. Res. Commun. 298 2002 699 706
4. V. Amarnath, K. Amarnath, K. Amarnath, S. Davies, and L.J. Roberts 2nd Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls Chem. Res. Toxicol. 17 2004 410 415
5. F.M. Antonini, E. Petruzzi, P. Pinzani, C. Orlando, M. Poggesi, M. Serio, M. Pazzagli, and G. Masotti The meat in the diet of aged subjects and the antioxidant effects of carnosine Arch. Gerontol. Geriatr. Suppl. 8 2002 7 14
6. M. Argirova, and O. Argirov Inhibition of ascorbic acid-induced modification in lens proteins by peptides J. Pept. Sci. 9 2003 170 176
7. M.A. Barbizhayev Rejuvenation of visual function in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops Rejuven. Res. 7 2004 186 198
8. M.A. Barbizhayev, A.I. Deyev, V.N. Yermakova, I.V. Brikman, and J. Bours Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and canine eyes Drugs 5 2004 125 139
9. M.A. Barbizhayev, A.I. Deyev, V.N. Yermakova, Y.A. Semiletov, N.G. Davydova, N.I. Kurysheva, A.V. Zhukotskii, and I.M. Goldman N-acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in the treatment of human cataracts Peptides 22 2001 979 994
10. E.J. Baran Metal complexes of carnosine Biochem. 65 2000 789 797 (Moscow)
11. S. Battah, N. Ahmed, and P.J. Thornally Novel anti-glycation therapeutic agents: glyoxylase-1-mimetics Int. Congr. Ser. 1245 2002 107 111
12. J.W. Baynes Pyridoxamine, a versatile inhibitor of advanced glycation and lipoxidation reactions Int. Congr. Ser. 1245 2002 3135
13. A. Boldyrev, E. Bulygina, T. Leinsoo, I. Petrushanko, S. Tsebone, and H. Abe Protection of neuronal cells against reactive oxygen species by carnosine and related compounds Comp. Biochem. Physiol. Part B 137 2003 81 88
14. A. Boldyrev, T. Fedorova, S. Stvolinsky, C. Borras, J. Sastre, and J. Vina Chemical intervention in senescence-accelerated mice metabolism for modelling neurodegenerative diseases: an overview Int. Congr. Ser. 1260 2004 109 115
15. A. Boldyrev, R. Song, D. Lawrence, and D.O. Carpenter Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species Neuroscience 94 1999 571 577
16. A. Boldyrev, S.L. Stvolinsky, O.V. Tyulina, V.B. Koshelev, N. Hori, and O. Carpenter Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals Cell. Mol. Neurobiol. 17 1997 259 271
17. L. Bonfanti, P. Peretto, S. de Marchis, and A. Fasolo Carnosine-related dipeptides in the mammalian brain Prog. Neurobiol. 59 1999 333 353
18. M. Brownlee Biochemistry and molecular biology of diabetic complications Nature 414 2001 813 820
19. C. Brownson, and A.R. Hipkiss Carnosine reacts with a glycated protein Free Rad. Biol. Med. 28 2000 1564 1570
20. P.C. Burcham, L.M. Kaminskas, F.R. Fontaine, D.R. Peterson, and S.M. Pyke Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products Toxicology 181/182 2002 229 236
21. M. Carini, G. Aldini, G. Beretta, E. Arlandini, and R.M. Facino Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry J. Mass Spectrom. 38 2003 996 1006
22. F. Chen, M.A. Wollmer, F. Hoerndli, G. Munch, B. Kuhla, E. Rogaev, M. Tsolaki, A. Papassotiropoulos, and J. Gotz Role of glyoxalase 1 in Alzheimer's disease Proc. Natl. Acad. Sci. USA 101 2004 7687 7692
23. M.G. Chez, C.P. Buchanan, and M.C. Aimonovitch Double-blind, placebo-controlled study of l-carnosine supplementation in children with autistic spectrum disorders J. Child Neurol. 17 2002 833 837
24. I. Dalle-Donne, D. Giustarini, R. Clombo, R. Rossi, and A. Milzani Protein carbonylation in human diseases Trends Mol. Med. 9 2003 169 176
25. V.V. Davydov, N.M. Dobaeva, and A.I. Bozhkov Possible role of alteration of aldehyde's scavenger enzymes during aging Exp. Gerontol. 39 2004 11 16
26. M. Fontana, F. Pinnen, G. Lucente, and L. Pecci Prevention of peroxynitrate-dependent damage by carnosine and related sulphonamide pseudopeptides Cell Mol. Life Sci. 59 2002 546 551
27. E. Gayova, I. Kron, K. Suchozova, V. Pavlisak, M. Fedurco, and I. Novakova Carnosine in patients with type 1 diabetes mellitus Bratisl. Lek. Listy 100 1999 500 502
28. H.A. Ghanbari, K. Ghanbari, P.L.R. Harris, P.K. Jones, Z. Kubat, R.J. Castellani, B.L. Wolozin, M.A. Smith, and G. Perry Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients Aging Cell 3 2004 41 44
29. M.P. Gianelli, M. Flores, and F. Toldra Interactions of soluble peptides and proteins from skeletal muscle on the release of volatile compounds J. Agric. Food Chem. 51 2003 6828 6834
30. A. Gugliucci A practical method to study functional impairment of proteins by glycation and effects of inhibitors using current coagulation/fibrinolysis reagent kits Clin. Biochem. 36 2003 155 158
31. A. Gugliucci, and T. Menini The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules? Life Sci. 9314 2003 1 14
32. A. Gugliucci, M.E. Smith, and T. Menini Carnosine in physiological concentrations inhibits advanced glycation of histones by reactive trioses methylglyoxal and glyceraldehyde Diabetes 51 2002 2111
33. S. Gulewitsch, and S. Amiradzibi Ueber das carnosin, eine neue organische base des fleischextracts Ber. Dtsch. Chem. Ges. 33 1900 344 379
34. H.-P. Hammes, X. Du, D. Edelstein, T. Taguchi, T. Matsumura, Q. Ju, J. Lin, A. Bierhaus, P. Nawroth, D. Hannak, M. Neumaier, R. Bergfeld, I. Giadino, and M. Brownlee Benfotiamine blocks three major pathways of hyperglycaemic damage and prevents experimental diabetic retinopathy Nat. Med. 9 2003 294 299
35. A.R. Hipkiss Is carnosine a naturally occurring suppressor of olfactory damage in olfactory neurones? Rejuven. Res. 7 2004 253 255
36. A.R. Hipkiss Could carnosine be a naturally-occurring scavenger of acrolein and other reactive aldehydes in the brain? Neurobiol. Aging 23 2002 645 646
37. A.R. Hipkiss Carnosine, a protective anti-ageing peptide? Int. J. Biochem. Cell Biol. 30 1998 863 868
38. A.R. Hipkiss, and C. Brownson A possible new role for the anti-ageing peptide carnosine Cell. Mol. Life Sci. 57 2000 747 753
39. A.R. Hipkiss, C. Brownson, and M.J. Carrier Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups Mech. Ageing Dev. 122 2001 1431 1445
40. A.R. Hipkiss, and H. Chana Carnosine protects against methylglyoxal-mediated modifications Biochem. Biophys. Res. Commun. 248 1998 28 32
41. A.R. Hipkiss, J. Michaelis, and P. Syrris Non-enzymic glycosylation of the dipeptide l-carnosine, a potential anti-protein-cross-linking agent FEBS Lett. 371 1995 81 85
42. A.R. Hipkiss, J.E. Preston, D.T.M. Himsworth, V.C. Worthington, and N.J. Abbott Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells Neurosci. Lett. 238 1997 135 138
43. A.R. Hipkiss, J.E. Preston, D.T.M. Himsworth, V.C. Worthington, M. Keown, J. Michaelis, J. Lawrence, A. Mateen, L. Allende, P.A.M. Eagles, and N.J. Abbott Pluripotent protective effects of carnosine, a naturally-occurring dipeptide Ann. NY Acad. Sci. 854 1998 37 53
44. A.R. Hipkiss, V.C. Worthington, D.T.J. Himsworth, and W. Herwig Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite Biochim. Biophys. Acta 1380 1998 46 54
45. L.J. Hobart, I. Seibel, G.S. Yeargans, and N.W. Seidler Anti-crosslinking properties of carnosine: significance of histidine Life Sci. 75 2004 1379 1389
46. M.S. Horning, L.J. Blakemore, and P.Q. Trombley Endogenous mechanisms of neuroprotection: role of zinc, copper and carnosine Brain Res. 852 2000 56 61
47. Y. Huang, J. Duan, H. Chen, M. Chen, and G. Chen Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection Electrophoresis 26 2005 593 599
48. P. Johnson, and J.L. Hammer Histidine dipeptide levels in aging and hypertensive rat skeletal and cardiac muscles Comp. Biochem. Physiol. Part B Biochem. Mol. Biol. 103 1992 981 984
49. S.S. Kantha, S. Wada, H. Tanaka, M. Takeuchi, S. Watabe, and H. Ochi Carnosine sustains the retention of morphology in continuous fibroblast culture subjected nutritional insult Biochem. Biophys. Res. Commun. 223 1996 278 282
50. S. Kikuchi, K. Shinpo, M. Takeuchi, S. Yamagishi, Z. Makita, N. Sasaki, and K. Tashiro Glycation - a sweet tempter for neuronal death Brain Res. Rev. 41 2003 306 323
51. H.Y. Kim, B.H. Moon, H.J. Lee, and D.H. Choi Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory potential J. Ethnopharmacol. 93 2004 227 230
52. K.S. Kim, S.Y. Choi, H.Y. Kwon, M.H. Won, T.-C. Kang, and J.H. Kang The ceruloplasmin and hydrogen peroxide system induces α-synuclein aggregation in vitro Biochimie 84 2002 625 631
53. R. Kohen, Y. Yamamoto, K.C. Cundy, and B.N. Ames Antioxidant activity of carnosine, homocarnosine and anserine present in muscle and brain Proc. Natl. Acad. Sci. USA 95 1988 2175 2179
54. V.N. Korobov, R.B. Maurisio, I.O. Mulalov, and S.L. Stvolinskii Carnosine stabilization of the normal erythrocyte membrane in experimental diabetes Patol. Fiziol. Eksp. Ter. 13 2000 5
55. T. Koschinsky, C.J. He, T. Mitsuhashi, R. Bucala, C. Liu, C. Buenting, K. Heitmann, and H. Vlassara Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy Proc. Natl. Acad. Sci. USA 94 1997 6474 6479
56. M. Krajcovicova-Kudlackova, K. Sebekova, R. Schinzel, and J. Klvanova Advanced glycation end products and nutrition Physiol. Res. 51 2002 313 316
57. Y. Lee, C. Hsu, M. Lin, K. Liu, and M. Yin Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation Eur. J. Pharmacol. 512 2005 145 150
58. R.L. Levine Carbonyl modified proteins in cellular regulation, aging and disease Free Rad. Biol. Med. 32 2002 790 796
59. Y. Liu, G. Xu, and L.M. Sayre Carnosine inhibits (E)-4-hydroxy-2-nonenal- induced protein cross-linking: structural characterization of the carnosine-HNE adducts Chem. Res. Toxicol. 16 2003 1589 1597
60. S. de Marchis, C. Modena, P. Peretto, A. Migheli, F.L. Margolis, and A. Fasalo Carnosine-related dipeptides in neurons and glia Biochem. 65 2000 824 833 (Moscow)
61. L.M. Maynard, G.A. Boissonneault, C.K. Chow, and G.G. Bruckner High levels of dietary carnosine are associated with increased concentrations of carnosine and histidine in rat soleus muscle J. Nutr. 131 2001 287 290
62. M.F. McCarty The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production Med. Hypotheses 64 2005 394 398
63. G.A. McFarland, and R. Holliday Retardation of senescence in cultured human diploid fibroblasts by carnosine Exp. Cell Res. 212 1994 167 175
64. G.A. McFarland, and R. Holliday Further evidence for the rejuvenating effects of the dipeptide l-carnosine on cultured diploid fibroblasts Exp. Gerontol. 34 1999 35 45
65. W.R. McGinnis Oxidative stress in autism Altern. Ther. Health Med. 10 2004 22 36
66. A.G. Miller, S.J. Meade, and J.A. Gerrard New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics Bioorg. Med. Chem. 11 2003 843 852
67. V.M. Monnier Intervention against the Maillard reaction in vivo Arch. Biochem. Biophys. 419 2003 1 15
68. T. Miyata, and C. van Ypersele van Strihou Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors: implications of radical scavenging and transition metal chelation in inhibition of advanced glycosylation end product formation Arch. Biochem. Biophys. 419 2003 50 54
69. G. Munch, S. Mayer, J. Michaelis, A.R. Hipkiss, P. Riederer, R. Muller, A. Neumann, R. Schinzel, and A.M. Cunningham Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide Biochim. Biophys. Acta 1360 1997 17 29
70. K. Nagai, A. Niijima, T. Yamano, H. Otani, N. Okumra, N. Tsuruoka, M. Nakai, and Y. Kiso Possible role of l-carnosine in the regulation of blood glucose through controlling autonomic nerves Exp. Biol. Med. 228 2003 1138 1145 (Maywood)
71. T. Nagasawa, T. Yonekura, N. Nishizawa, and D.D. Kitts In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine Mol. Cell. Biochem. 225 2001 29 34
72. M.J. Picklo Sr., T.J. Montine, V. Amarnath, and M.D. Neely Carbonyl toxicology and Alzheimer's disease Toxicol. Appl. Pharmacol. 184 2002 187 197
73. J.E. Preston, A.R. Hipkiss, D.J.T. Himsworth, I.A. Romero, and J.N. Abbott Toxic effects of β-amyloid (25-35) on immortalised rat brain endothelial cells: protection by carnosine, homocarnosine and β-alanine Neurosci. Lett. 242 1998 105 108
74. P.J. Quinn, A.A. Boldyrev, and V.E. Formazuyk Carnosine: its properties, functions and potential therapeutic applications Mol. Aspects Med. 13 1992 379 444
75. S. Rahbar, and J.L. Figarola Novel inhibitors of advanced glycation endproducts Arch. Biochem. Biophys. 419 2003 63 79
76. V.P. Reddy, M.E. Obrenovich, C.S. Atwood, G. Perry, and M.A. Smith Involvement of Maillard reactions in Alzheimer's disease Neurotox. Res. 4 2002 191 209
77. M.M. Sassoe-Pognetto, D. Cantino, P. Panzanelli, L.V. di Cantagno, M. Giustetto, F. Margolis, L. de Biasi, and A. Fasolo Presynaptic colocalization of carnosine and glutamate in olfactory neurones Neuroreport 5 1993 7 10
78. 1H NMR spectra J. Mag. Reson. 171 2004 213 224
79. N.W. Seidler Carnosine prevents glycation-induced changes in electrophoretic mobility of aspartate aminotransferase J. Biochem. Mol. Toxicol. 14 2000 215 220
80. N.W. Seidler, G.S. Yeargans, and T.G. Morgan Carnosine disaggregates glycated α-crystallin: an in vitro study Arch. Biochem. Biophys. 427 2004 110 115
81. L. Shao, Q.-H. Li, and Z. Tan l-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts Biochem. Biophys. Res. Commun. 324 2004 931 936
82. V.V. Shuvaev, I. Laffont, M. Serot, J. Fujii, N. Taniguchi, and G. Siest Increased protein glycation in cerebrospinal fluid of Alzheimer's disease Neurobiol. Aging 22 2001 397 402
83. H.J. Stuerenburg The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases Biochem. 65 2000 862 865 (Moscow)
84. H.J. Stuerenburg, and K. Kunze Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle and rat muscles Arch. Gerontol. Geriat. 29 1999 107 113
85. G. Suji, and S. Sivakami Glucose, glycation and aging Biogerontology 5 2004 365 373
86. T.A. Swearengin, C. Fitzgerald, and N.W. Seidler Carnosine prevents glyceraldehydes 3-phosphate-mediated inhibition of aspartate aminotransferase Arch. Toxicol. 73 1999 307 309
87. S.Y. Tang, M. Whiteman, Z.F. Peng, A. Jenner, E.L. Yong, and B. Halliwell Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional Chinese medicines Free Rad. Biol. Med. 36 2004 1575 1587
88. P.J. Thornalley Use of aminoguanidine (Pimagedine) to prevent formation of advanced glycation endproducts Arch. Biochem. Biophys. 419 2003 31 40
89. H. Ukeda, Y. Hasegawa, Y. Harada, and M. Sawamura Effect of carnosine and related compounds on the inactivation of human Cu, Zn-superoxide dismutase by modification of fructose and glycolaldehyde Biosci. Biotechnol. Biochem. 66 2002 36 43
90. J.A. Vinson, and T.B. Howard Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients Nutrit. Biochem. 7 1996 659 663
91. P. Wang, Z. Zhang, X. Ma, Y. Huang, X. Liu, P. Tu, and T. Tong HDTIC-1 and HDTIC-3, two compounds extracted from Astragali Radix delay replicative senescence of human diploid fibroblasts Mech. Ageing Dev. 124 2003 1025 1034
92. G.T. Wondrak, D. Cervantes-Laurean, M.J. Roberts, J.G. Qaasem, M. Kim, E.L. Jacobson, and M.K. Jacobson Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress Biochem. Pharm. 63 2002 361 373
93. T. Yamano, A. Niijima, S. Limori, N. Tsuruoka, Y. Kiso, and K. Nagai Effect of l-carnosine on the hyperglycaemia caused by intracranial injection of 2-deoxy-d-glucose Neurosci. Lett. 313 2001 78 82
94. Yan, H., Harding, J.J., in press. Carnosine protects against the inactivation of esterase induced by glycation and a steroid. Biochim. Biophys. Acta.
95. T. Yokozawa, and T. Nakagawa Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage Food Chem. Toxicol. 42 2004 975 981
96. M.O. Yuneva, E.R. Bulygina, S.C. Gallant, G.G. Kramarenko, S.L. Stvolinsky, M.L. Semyonova, and A.A. Boldyrev Effect of carnosine on age-induced changes in senescence-accelerated mice J. Anti-Aging Med. 2 1999 337 342
97. A.O. Yuneva, G.G. Kramarenko, T.V. Vetreshchak, S. Gallant, and A.A. Boldyrev Effect of carnosine on Drosophila melanogaster lifespan Bull. Exp. Biol. Med. 133 2002 559 561