Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species

Neuroscience

Volumn 94, Issue 2, 1999, Pages 571-577

  Boldyrev, A ^a,b,c   Song, R ^b,c   Lawrence, D ^b,c   Carpenter, D O ^b,c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITY AT ALBANY   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

Apoptosis; Cell death; Cerebellar granule cells; Flow cytometry; Kainate; NMDA

Indexed keywords

AMINO ACID RECEPTOR STIMULATING AGENT; CARNOSINE; EXCITOTOXIN; FLUORESCENT DYE; GLUTAMIC ACID; HOMOCARNOSINE; HYDROXYL RADICAL; KAINIC ACID; LIPOCORTIN 5; N ACETYLCARNOSINE; N METHYL DEXTRO ASPARTIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CEREBELLUM; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CARNOSINE; CELLS, CULTURED; KAINIC ACID; KINETICS; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0032833418     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00273-0     Document Type: Article

References (53)

1. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. natn. Acad. Sci. U.S.A. 90:1993;7915-7922.
2. Aruoma O.I., Laughton M.J., Halliwell B. Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? Biochem. J. 264:1989;863-869.
3. Bate-Smith E.C. The buffering of muscle in rigor; protein, phosphate and carnosine. J. Physiol., Lond. 92:1938;336-343.
4. Berkowitcz D.A., Tromley P.Q., Shepherd G.M. Evidence for glutamate as the olfactory receptor cell neurotransmitter. J. Neurophysiol. 71:1994;2557-2561.
5. Boldyrev A., Dupin A., Bunin A., Babizhaev M., Severin S. The anti-oxidative properties of carnosine, a natural histidine-containing dipeptide. Biochem. Int. 15:1987;1105-1113.
6. Boldyrev A. A., Lawrence D. A. and Carpenter D. O. (1998) Effect of carnosine and its natural derivatives on apoptosis of neurons induced by excitotoxic compounds. In Peptide Science B Present and Future (ed. Shimonishi Y.), pp. 424-426. Kluwer Acad., Manchester, U.K.
7. Boldyrev A. A., Carpenter D., Kovalenko Z. S., Kuleva N. V., Lawrence D. and Song R. (1999) Carnosine protects neurons from excitotoxic effects of NMDA and kainate. In Maturation Phenomenon in Cerebral Ischemia (ed. Ito U.), p. 529. Springer-Verlag, Berlin, Heidelberg.
8. Boldyrev A.A., Stvolinsky S.L., Tyulina O.V., Koshelev V.B., Hori N., Carpenter D.O. Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals. Cell. molec. Neurobiol. 17:1997;259-271.
9. Carpenter D., Stoner C.R.T., Lawrence D.A. Flow cytometric measurements on neuronal death triggered by PCBs. NeuroToxicology. 18:1997;507-514.
10. Ciani E., Gronend L., Voltattorni M., Rolseth V., Contestabile A., Paulsen R.E. Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons. Brain Res. 728:1996;1-6.
11. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-694.
12. Darzynkiewicz Z., Juan G., Xun L., Gorczica W., Murakami T., Traganos F. Cytometry in cell neurobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry. 27:1997;1-20.
13. Degunie V., Menasche M., Ferrari P., Fraisse L., Poulinquen Y., Robert L. Free radical depolymerization of hyaluronan by Maillard reaction products. Role in liquefaction of aging vitreous. Int. J. biol. Macromolec. 22:1998;17-22.
14. Evsitgneeva R.P., Zheltukhina G.A., Rozkova E.A., Grigorjev D.N. Interrelation between structure of N-acyl substituting group, conformation and antioxidant properties of carnosine, carcinine and their structural analogs. Proc. Akad. Sci. Russia. 349:1996;129-132.
15. Gunasekar P.G., Kanthasamy A.G., Borowitz J.L., Ison G.E. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death. J. Neurochem. 65:1995;2016-2021.
16. Hartman P.E., Hartman Z., Ault K.T. Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid. Photochem. Photobiol. 51:1990;59-66.
17. Hipkiss A.R. Carnosine, a protective, anti-aging agent? Int. J. Biochem. Cell Biol. 30:1998;863-868.
18. Kantha S.S., Wada S.-I., Tanaka H., Takeuchi M., Watabe S., Ochi H. Carnosine sustains the retention of cell morphology in continuous fibroblast culture subjected to nutritional insult. Biochem. biophys. Res. Commun. 223:1996;278-282.
19. Klebanov G.I., Teselkin Yu. O., Babenkova I.V., Popov I.N., Levin G., Tyulina O.V., Boldyrev A.A., Vladimirov Yu. A. Evidence for a direct interaction of superoxide anion radical with carnosine. Biochem. molec. Biol. Int. 43:1997;99-106.
20. Kohen R., Yamamoto Y., Cundy K.C., Ames B.N. Antioxidant activity of carnosine, homocarnosine and anserine present in muscle and brain. Proc. natn. Acad. Sci. U.S.A. 85:1988;3175-3179.
21. Kuba T., Enokido Y., Yamada M., Oka T., Uchiyama Y., Hatanaka H. Oxygen-induced apopotosis in PC12 cells with special reference to the role of Bcl-2. Brain Res. 733:1996;175-183.
22. Kuleva N.V., Kovalenko Z.S. Changes in the functional properties of actin by its glycation in vitro. Biochemistry, Moscow. 62:1997;1119-1123.
23. LeBel C.P., Bondy S.C. Persistent protein damage reduced oxygen radical formation in the aging rat brain. Int. J. dev. Neurosci. 9:1991;139-146.
24. Li-Y M., Mitsuhashi T., Wojciechowicz D., Shimizu N., Li J., Stitt A., He C., Banerjee D., Vlassara H. Molecular identity and cellular distribution of advanced glycation end product receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins. Proc. natn. Acad. Sci. U.S.A. 93:1996;11,047-11,052.
25. MacLeod N.K., Straughan D.W. Responses of olfactory bulb neurones to the dipeptide carnosine. Expl Brain Res. 34:1979;183-188.
26. Margolis F. L. (1980) Carnosine: an olfactory neuropeptide. In The Role of Peptides in Neuronal Function (eds Barker J. L. and Smith T. G. Jr), pp. 545-572. Marcel Dekker, New York.
27. Margolis F.L. Carnosine in the primary olfactory pathway. Science. 184:1974;909-911.
28. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23:1997;134-147.
29. McFarland G.A., Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Expl Cell Res. 212:1994;167-175.
30. McGowan A.J., Fernandes R.S., Samali A., Cotter T.G. Anti-oxidants and apoptosis. Biochem. Soc. Trans. 24:1996;229-233.
31. Munch G., Mayer S., Michaelis J., Hipkiss A.R., Riederer P., Muller R., Neumann A., Schinzel R., Cunningham A.M. Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide. Biochim. Biophys. Acta. 1369:1997;17-29.
32. Nadi N.S., Hirsch J.D., Margolis F.L. Laminar distribution of putative neurotransmitter amino acids and ligand binding sites in the dog olfactory bulb. J. Neurochem. 34:1980;138-146.
33. 2+ of brain neurons: a technical report. Brain Res. 728:1996;121-124.
34. Patel M., Day B.J., Crapo J.D., Fridovich I., McNamara J.O. Requirement for superoxide in excitotoxic cell death. Neuron. 16:1996;345-355.
35. Qin Z.-H., Wang Y., Chase T.N. Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain. Brain Res. 725:1996;166-176.
36. Reutelingsperger C.P., van Heerde W.L. Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis. Cell. molec. Life Sci. 53:1997;527-532.
37. Reynolds I.J., Hastings T.G. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15:1995;3318-3327.
38. 2+: their relationship to apoptosis and oncogenesis. Fedn Eur. biochem. Socs Lett. 125:1993;104-107.
39. Rothman S.M. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J. Neurosci. 5:1985;1483-1489.
40. Salim-Hanna M., Lissi E., Videla L.A. Free radical scavenging activity of carnosine. Free Rad. Res. Commun. 14:1991;263-270.
41. Sassoe-Pognetto M.S., Catino D., Panzanelli P., Verdun-di-Cantogno L., Giustetto M., Margolis F.L., DeBiasi S., Fasolo A. Presynaptic co-localization of carnosine and glutamate in olfactory neurones. NeuroReport. 5:1993;7-10.
42. Satoh T., Numakawa T., Abiru Y., Yamagata T., Ishikawa Y., Enokido Y., Hatanaka H. Production of reactive oxygen species and release of L-glutamate during superoxide anion-induced cell death of cerebellar granule neurons. J. Neurochem. 70:1998;316-324.
43. Schreiber S.J., Megow D., Raupach A., Victorov I.V., Dirnagl U. Age-related changes in oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence. Brain Res. 703:1995;227-230.
44. Schulz J.B., Henshaw D.R., Siwek D., Jenkins B.G., Ferrante R.J., Cipolloni P.B., Kowall N.W., Rosen B.R., Beal M.F. Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64:1995;2239-2247.
45. Shilton B.H., Walton D.J. Sites of glycation of human and horse liver alcohol dehydrogenase in vivo. J. biol. Chem. 266:1991;5587-5592.
46. Simonian N.A., Getz R.L., Leveque J.C., Konrad C., Coyle J.T. Kainate induces apoptosis in neurons. Neuroscience. 74:1996;675-683.
47. Sobue D., Konishi H., Nakajama T. Isolation and identification of N-acetyl-homocarnosine and N-acetyl-carnosine from brain and muscle. J. Neurochem. 24:1975;1261-1263.
48. Van-Engeland M., Nieland L.J.W., Ramaekers F.C.S., Schutte B., Reutelingsperger C. Annexin-V affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 31:1998;1-9.
49. Vladimirov Yu.A. (1996) Studies of the antioxidant activity by measuring chemiluminescence kinetics. In Proceedings of the International Symposium on Natural Antioxidants. Molecular Mechanisms and Health Effects (eds Parcker L., Traber M. G. and Xin W.), pp. 125-144. AOCS Press, Champaign, Illinois.
50. Wood K.A., Youle R.J. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:1995;5851-5857.
51. Yamashita T., Shimada S., Guo W., Sato K., Kohmura E., Hayakawa T., Takagi T., Tohyma M. Cloning and functional expression of a brain peptide/histidine transporter. J. biol. Chem. 272:1997;10,211-10,295.
52. Yan S.-D., Chen X., Schmidt A.-M., Brett J., Godman G., Zou Y.-S., Scott C.W., Caputo C., Frappier T., Smith M.A., Perry G., Yen S.-H., Stern D. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc. natn. Acad. Sci. U.S.A. 91:1994;7787-7791.
53. Yan S.-D., Schmidt A.-M., Anderson G.M., Brett J., Mora R., Nowygrod R., Stern D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptor/binding proteins. J. biol. Chem. 269:1994;9889-9897.