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Volumn 295, Issue , 2005, Pages 55-79

Antimalarial drug resistance in Africa: Strategies for monitoring and deterrence

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; CARRIER PROTEIN; CHLOROQUINE; CHLORPROGUANIL PLUS DAPSONE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; FANSIDAR; HALOFANTRINE; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN 1; PROGUANIL; PYRIMETHAMINE; QUININE;

EID: 24144480947     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/3-540-29088-5_3     Document Type: Review
Times cited : (61)

References (79)
  • 4
    • 0003989708 scopus 로고    scopus 로고
    • Drug resistance in malaria
    • WHO/CDS/CSR/DRS/2001.4. Geneva, WHO Department of Communicable Disease Surveillance and Response
    • Bloland PB (2001) Drug resistance in malaria. WHO/CDS/CSR/DRS/2001.4. Geneva, WHO Department of Communicable Disease Surveillance and Response
    • (2001)
    • Bloland, P.B.1
  • 5
    • 0032772398 scopus 로고    scopus 로고
    • Making malaria-treatment policy in the face of drug resistance
    • Bloland PB, Ettling M (1999) Making malaria-treatment policy in the face of drug resistance. Ann Trop Med Parasitol 93:5-23
    • (1999) Ann. Trop. Med. Parasitol. , vol.93 , pp. 5-23
    • Bloland, P.B.1    Ettling, M.2
  • 6
    • 0034490296 scopus 로고    scopus 로고
    • Combination therapy for malaria in Africa: Hype or hope?
    • Bloland PB, Ettling M, Meek S (2000) Combination therapy for malaria in Africa: hype or hope? Bull World Health Organ 78:1378-1388
    • (2000) Bull. World Health Organ. , vol.78 , pp. 1378-1388
    • Bloland, P.B.1    Ettling, M.2    Meek, S.3
  • 7
    • 0027401399 scopus 로고
    • Beyond chloroquine: Implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa
    • Bloland PB, Lackritz EM, Kazembe PN, Were JB, Steketee R, Campbell CC (1993) Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. J Infect Dis 167:932-937
    • (1993) J. Infect. Dis. , vol.167 , pp. 932-937
    • Bloland, P.B.1    Lackritz, E.M.2    Kazembe, P.N.3    Were, J.B.4    Steketee, R.5    Campbell, C.C.6
  • 8
    • 0028021624 scopus 로고
    • Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
    • Brooks DR, Wang P, Read M, Watkins WM, Sims PF, Hyde JE (1994) Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem 224:397-405
    • (1994) Eur. J. Biochem. , vol.224 , pp. 397-405
    • Brooks, D.R.1    Wang, P.2    Read, M.3    Watkins, W.M.4    Sims, P.F.5    Hyde, J.E.6
  • 9
    • 0037316269 scopus 로고    scopus 로고
    • Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: Comparison of results based on genotyping of MSP-1, MSP-2, and GLURP
    • Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G (2003) Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: Comparison of results based on genotyping of MSP-1, MSP-2, and GLURP. Am J Trop Med Hyg 68:133-139
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 133-139
    • Cattamanchi, A.1    Kyabayinze, D.2    Hubbard, A.3    Rosenthal, P.J.4    Dorsey, G.5
  • 10
    • 0000854414 scopus 로고
    • Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
    • Cowman AF, Morry MJ, Biggs BA, Cross GA, Foote SJ (1988) Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 85:9109-9113
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9109-9113
    • Cowman, A.F.1    Morry, M.J.2    Biggs, B.A.3    Cross, G.A.4    Foote, S.J.5
  • 12
    • 0035883813 scopus 로고    scopus 로고
    • Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria
    • Djimde A, Doumbo OK, Steketee RW, Plowe CV (2001b) Application of a molecular marker for surveillance of chloroquine- resistant falciparum malaria. Lancet 358:890-891
    • (2001) Lancet , vol.358 , pp. 890-891
    • Djimde, A.1    Doumbo, O.K.2    Steketee, R.W.3    Plowe, C.V.4
  • 14
    • 0035341936 scopus 로고    scopus 로고
    • Polymorphisms in the Plasmodium falciparum PfCRT and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda
    • Dorsey G, Kamya MR, Singh A, Rosenthal PJ (2001) Polymorphisms in the Plasmodium falciparum PfCRT and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis 183:1417-1420
    • (2001) J. Infect. Dis. , vol.183 , pp. 1417-1420
    • Dorsey, G.1    Kamya, M.R.2    Singh, A.3    Rosenthal, P.J.4
  • 15
    • 0037153723 scopus 로고    scopus 로고
    • Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: A longitudinal randomised trial
    • Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ (2002) Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: A longitudinal randomised trial. Lancet 360:2031-2038
    • (2002) Lancet , vol.360 , pp. 2031-2038
    • Dorsey, G.1    Njama, D.2    Kamya, M.R.3    Cattamanchi, A.4    Kyabayinze, D.5    Staedke, S.G.6    Gasasira, A.7    Rosenthal, P.J.8
  • 16
    • 0034732666 scopus 로고    scopus 로고
    • The tyrosine-86 allele of the PfMDR1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
    • Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC (2000) The tyrosine-86 allele of the PfMDR1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 108:13-23
    • (2000) Mol. Biochem. Parasitol. , vol.108 , pp. 13-23
    • Duraisingh, M.T.1    Jones, P.2    Sambou, I.3    von Seidlein, L.4    Pinder, M.5    Warhurst, D.C.6
  • 18
    • 0032407858 scopus 로고    scopus 로고
    • Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase
    • Fidock DA, Nomura T, Wellems TE (1998) Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase. Mol Pharmacol 54:1140-1147
    • (1998) Mol. Pharmacol. , vol.54 , pp. 1140-1147
    • Fidock, D.A.1    Nomura, T.2    Wellems, T.E.3
  • 19
    • 0030885188 scopus 로고    scopus 로고
    • Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil
    • Fidock DA, Wellems, TE (1997) Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci USA 94:10931-10936
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10931-10936
    • Fidock, D.A.1    Wellems, T.E.2
  • 20
    • 0028266982 scopus 로고
    • The mode of action and the mechanism of resistance to antimalarial drugs
    • Foote SJ, Cowman, AF (1994) The mode of action and the mechanism of resistance to antimalarial drugs. Acta Trop 56:157-171
    • (1994) Acta Trop. , vol.56 , pp. 157-171
    • Foote, S.J.1    Cowman, A.F.2
  • 21
    • 0025263958 scopus 로고
    • Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
    • Foote SJ, Galatis D, Cowman AF (1990) Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc Natl Acad Sci USA 87:3014-3017
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3014-3017
    • Foote, S.J.1    Galatis, D.2    Cowman, A.F.3
  • 23
    • 0030771149 scopus 로고    scopus 로고
    • A model for the origins and spread of drug-resistant malaria
    • Hastings IM (1997) A model for the origins and spread of drug-resistant malaria. Parasitology 115:133-141
    • (1997) Parasitology , vol.115 , pp. 133-141
    • Hastings, I.M.1
  • 24
    • 0031731805 scopus 로고    scopus 로고
    • The emergence of drug-resistant malaria
    • Hastings IM Mackinnon MJ (1998) The emergence of drug-resistant malaria. Parasitology 117:411-417
    • (1998) Parasitology , vol.117 , pp. 411-417
    • Hastings, I.M.1    Mackinnon, M.J.2
  • 25
    • 0024375418 scopus 로고
    • Response of Plasmodium falciparum to chloroquine treatment: Relation to whole blood concentrations of chloroquine and desethylchloroquine
    • Hellgren U, Kihamia CM, Mahikwano LF, Bjorkman A, Eriksson O, Rombo L (1989) Response of Plasmodium falciparum to chloroquine treatment: Relation to whole blood concentrations of chloroquine and desethylchloroquine. Bull World Health Organ 67:197-202
    • (1989) Bull. World Health Organ. , vol.67 , pp. 197-202
    • Hellgren, U.1    Kihamia, C.M.2    Mahikwano, L.F.3    Bjorkman, A.4    Eriksson, O.5    Rombo, L.6
  • 28
    • 3042684521 scopus 로고    scopus 로고
    • Epidemiological models for the spread of anti-malarial resistance
    • Koella JC Antia R (2003) Epidemiological models for the spread of anti-malarial resistance. Malar J 2:3
    • (2003) Malar. J. , vol.2 , pp. 3
    • Koella, J.C.1    Antia, R.2
  • 31
    • 0030219812 scopus 로고    scopus 로고
    • Plasmodium falciparum: Amplification and overexpression of PfMDR1 is not necessary for increased mefloquine resistance
    • Lim AS, Galatis D, Cowman AF. (1996). Plasmodium falciparum: amplification and overexpression of PfMDR1 is not necessary for increased mefloquine resistance. Exp Parasitol. 83:295-303
    • (1996) Exp. Parasitol. , vol.83 , pp. 295-303
    • Lim, A.S.1    Galatis, D.2    Cowman, A.F.3
  • 34
    • 0035341841 scopus 로고    scopus 로고
    • Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (PfCRT) gene and its relation to chloroquine resistance in Mozambique
    • Mayor AG, Gomez-Olive X, Aponte JJ, Casimiro S, Mabunda S, Dgedge M, Barreto A, Alonso PL (2001) Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (PfCRT) gene and its relation to chloroquine resistance in Mozambique. J Infect Dis 183:1413-1416
    • (2001) J. Infect. Dis. , vol.183 , pp. 1413-1416
    • Mayor, A.G.1    Gomez-Olive, X.2    Aponte, J.J.3    Casimiro, S.4    Mabunda, S.5    Dgedge, M.6    Barreto, A.7    Alonso, P.L.8
  • 36
    • 0037021405 scopus 로고    scopus 로고
    • Artemisinin: Mechanisms of action, resistance and toxicity
    • Meshnick SR (2002) Artemisinin: Mechanisms of action, resistance and toxicity. Int J Parasitol 32:1655-1660
    • (2002) Int. J. Parasitol. , vol.32 , pp. 1655-1660
    • Meshnick, S.R.1
  • 37
    • 0016990684 scopus 로고
    • A review. Innate resistance in malaria
    • Miller LH, Carter R (1976) A review. Innate resistance in malaria. Exp Parasitol 40:132-146
    • (1976) Exp. Parasitol. , vol.40 , pp. 132-146
    • Miller, L.H.1    Carter, R.2
  • 38
    • 0042808413 scopus 로고    scopus 로고
    • Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi
    • Mita T, Kaneko A, Lum JK, Bwijo B, Takechi N, Zungu IL, Tsukahara T, Tanabe K, Kobayakawa T, Bjorkman A (2003) Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi. Am J Trop Med Hyg 68:413-415
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 413-415
    • Mita, T.1    Kaneko, A.2    Lum, J.K.3    Bwijo, B.4    Takechi, N.5    Zungu, I.L.6    Tsukahara, T.7    Tanabe, K.8    Kobayakawa, T.9    Bjorkman, A.10
  • 41
    • 0035856231 scopus 로고    scopus 로고
    • Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania
    • Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, Watkins W (2001a) Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet 358:1218-1223
    • (2001) Lancet , vol.358 , pp. 1218-1223
    • Mutabingwa, T.1    Nzila, A.2    Mberu, E.3    Nduati, E.4    Winstanley, P.5    Hills, E.6    Watkins, W.7
  • 43
    • 0019164230 scopus 로고
    • Pyrimethamine sensitivity in Plasmodium falciparum: Determination in vitro by a modified 48-hour test
    • Nguyen-Dinh, P Payne D (1980) Pyrimethamine sensitivity in Plasmodium falciparum: Determination in vitro by a modified 48-hour test. Bull World Health Organ 58:909-912
    • (1980) Bull. World Health Organ. , vol.58 , pp. 909-912
    • Nguyen-Dinh, P.1    Payne, D.2
  • 45
    • 0031786694 scopus 로고    scopus 로고
    • Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection
    • Parise ME, Ayisi JG, Nahlen BL, Schultz LJ, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW (1998) Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59:813-822
    • (1998) Am. J. Trop. Med. Hyg. , vol.59 , pp. 813-822
    • Parise, M.E.1    Ayisi, J.G.2    Nahlen, B.L.3    Schultz, L.J.4    Roberts, J.M.5    Misore, A.6    Muga, R.7    Oloo, A.J.8    Steketee, R.W.9
  • 47
    • 0028135205 scopus 로고
    • A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro
    • Peel SA, Bright P, Yount B, Handy J, Baric RS. (1994). A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro. Am J Trop Med Hyg. 51:648-658
    • (1994) Am. J. Trop. Med. Hyg. , vol.51 , pp. 648-658
    • Peel, S.A.1    Bright, P.2    Yount, B.3    Handy, J.4    Baric, R.S.5
  • 48
    • 0025252334 scopus 로고
    • Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria
    • Peterson DS, Milhous WK, Wellems TE (1990) Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 87:3018-3022
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3018-3022
    • Peterson, D.S.1    Milhous, W.K.2    Wellems, T.E.3
  • 49
    • 0000841123 scopus 로고
    • Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
    • Peterson DS, Walliker D, Wellems TE (1988) Evidence that a point mutation in dihydrofolate reductase- thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 85:9114-9118
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9114-9118
    • Peterson, D.S.1    Walliker, D.2    Wellems, T.E.3
  • 52
    • 0242406973 scopus 로고    scopus 로고
    • Monitoring antimalarial drug resistance: Making the most of the tools at hand
    • Plowe CV. (2003). Monitoring antimalarial drug resistance: making the most of the tools at hand. J Exp Biol 206:3745-3752.
    • (2003) J. Exp. Biol. , vol.206 , pp. 3745-3752
    • Plowe, C.V.1
  • 53
    • 1542283603 scopus 로고    scopus 로고
    • Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: Five year prospective study
    • Plowe CV, Kublin JG, Dzinjalamala FK, Kamwendo DS, Mukadam RA, Chimpeni P, Molyneux ME, Taylor TE (2004) Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: Five year prospective study. Br Med J 328:545-548
    • (2004) Br. Med. J. , vol.328 , pp. 545-548
    • Plowe, C.V.1    Kublin, J.G.2    Dzinjalamala, F.K.3    Kamwendo, D.S.4    Mukadam, R.A.5    Chimpeni, P.6    Molyneux, M.E.7    Taylor, T.E.8
  • 56
    • 0034708162 scopus 로고    scopus 로고
    • Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    • Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906-909
    • (2000) Nature , vol.403 , pp. 906-909
    • Reed, M.B.1    Saliba, K.J.2    Caruana, S.R.3    Kirk, K.4    Cowman, A.F.5
  • 57
    • 0030566669 scopus 로고    scopus 로고
    • In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1
    • Ritchie GY, Mungthin M, Green JE, Bray PG, Hawley SR. Ward SA. (1996). In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1. Mol Biochem Parasitol 83:35-46
    • (1996) Mol. Biochem. Parasitol. , vol.83 , pp. 35-46
    • Ritchie, G.Y.1    Mungthin, M.2    Green, J.E.3    Bray, P.G.4    Hawley, S.R.5    Ward, S.A.6
  • 60
    • 0037020024 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by PfCRT mutations
    • Sidhu AB, Verdier-Pinard D, Fidock DA (2002) Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by PfCRT mutations. Science 298:210-213
    • (2002) Science , vol.298 , pp. 210-213
    • Sidhu, A.B.1    Verdier-Pinard, D.2    Fidock, D.A.3
  • 61
    • 0033063070 scopus 로고    scopus 로고
    • A mechanism for the synergistic antimalarial action of atovaquone and proguanil
    • Srivastava IK Vaidya AB (1999) A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother 43:1334-1339
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1334-1339
    • Srivastava, I.K.1    Vaidya, A.B.2
  • 62
    • 0037068963 scopus 로고    scopus 로고
    • Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: A randomised clinical trial
    • Sulo J, Chimpeni P, Hatcher J, Kublin JG, Plowe CV, Molyneux ME, Marsh K, Taylor TE, Watkins WM, Winstanley PA (2002) Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: A randomised clinical trial. Lancet 360:1136-1143
    • (2002) Lancet , vol.360 , pp. 1136-1143
    • Sulo, J.1    Chimpeni, P.2    Hatcher, J.3    Kublin, J.G.4    Plowe, C.V.5    Molyneux, M.E.6    Marsh, K.7    Taylor, T.E.8    Watkins, W.M.9    Winstanley, P.A.10
  • 68
  • 69
    • 0036790841 scopus 로고    scopus 로고
    • The assessment of antimalarial drug efficacy
    • White NJ (2002) The assessment of antimalarial drug efficacy. Trends Parasitol 18:458-464
    • (2002) Trends Parasitol. , vol.18 , pp. 458-464
    • White, N.J.1
  • 71
    • 0004274815 scopus 로고
    • Chemotherapy of malaria and resistance to antimalarials
    • WHO 529. World Health Organization, Geneva. WHO Technical Report Series
    • WHO (1973) Chemotherapy of malaria and resistance to antimalarials. 529. World Health Organization, Geneva. WHO Technical Report Series
    • (1973)
  • 72
    • 0003869815 scopus 로고    scopus 로고
    • Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission
    • WHO Geneva, World Health Organization, Division of Control of Tropical Diseases
    • WHO (1996) Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. Geneva, World Health Organization, Division of Control of Tropical Diseases
    • (1996)
  • 73
    • 0004157786 scopus 로고    scopus 로고
    • Monitoring antimalarial drug resistance
    • WHO Bloland PB, D'Alessandro, Ringwald, and Watkins. WHO/CDS/CSR/EPH/2002.17. Geneva, World Health Organization
    • WHO (2002) Monitoring antimalarial drug resistance. Bloland PB, D'Alessandro, Ringwald, and Watkins. WHO/CDS/CSR/EPH/2002.17. Geneva, World Health Organization
    • (2002)
  • 75
    • 0034175950 scopus 로고    scopus 로고
    • Chemotherapy for falciparum malaria: The armoury, the problems and the prospects
    • Winstanley PA (2000) Chemotherapy for falciparum malaria: The armoury, the problems and the prospects. Parasitol Today 16:146-153
    • (2000) Parasitol. Today , vol.16 , pp. 146-153
    • Winstanley, P.A.1
  • 76
    • 0029560161 scopus 로고
    • Sensitivity of Plasmodium falciparum in vivo to chloroquine and pyrimethamine-sulfadoxine in Rwandan patients in a refugee camp in Zaire
    • Wolday D, Kibreab T, Bukenya D, Hodes R (1995) Sensitivity of Plasmodium falciparum in vivo to chloroquine and pyrimethamine-sulfadoxine in Rwandan patients in a refugee camp in Zaire. Trans R Soc Trop Med Hyg 89:654-656
    • (1995) Trans. R. Soc. Trop. Med. Hyg. , vol.89 , pp. 654-656
    • Wolday, D.1    Kibreab, T.2    Bukenya, D.3    Hodes, R.4
  • 77
    • 0031836529 scopus 로고    scopus 로고
    • Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: Evidence for quinine resistance
    • Zalis MG, Pang L, Silveira MS, Milhous WK, Wirth DF (1998) Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: Evidence for quinine resistance. Am J Trop Med Hyg 58:630-637
    • (1998) Am. J. Trop. Med. Hyg. , vol.58 , pp. 630-637
    • Zalis, M.G.1    Pang, L.2    Silveira, M.S.3    Milhous, W.K.4    Wirth, D.F.5
  • 78
    • 0024460302 scopus 로고
    • Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum
    • Zolg JW, Plitt JR, Chen GX, Palmer S (1989) Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol Biochem Parasitol 36:253-262
    • (1989) Mol. Biochem. Parasitol. , vol.36 , pp. 253-262
    • Zolg, J.W.1    Plitt, J.R.2    Chen, G.X.3    Palmer, S.4


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