Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: A longitudinal randomised trial

Lancet

Volumn 360, Issue 9350, 2002, Pages 2031-2038

  Dorsey, Grant ^a,c   Njama, Denise ^b   Kamya, Moses R ^b   Cattamanchi, Adithya ^a   Kyabayinze, Daniel ^b   Staedke, Sarah G ^a   Gasasira, Anne ^b   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^c SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ARTESUNATE; FANSIDAR; MEROZOITE SURFACE PROTEIN 1; PLACEBO; PYRIMETHAMINE; SULFADOXINE;

ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; FEMALE; FOLLOW UP; HUMAN; INFANT; LONG TERM CARE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA; MALE; NONHUMAN; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TREATMENT FAILURE; TREATMENT OUTCOME; UGANDA;

EID: 0037153723     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)12021-6     Document Type: Article

References (29)

1. Breman J.G. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg. 64:(Suppl):2001;1-11.
2. Remme J.H.F., Binka F., Nabarro D. Toward a framework and indicators for monitoring roll back malaria. Am J Trop Med Hyg. 64:(Suppl):2001;76-84.
3. Trape J.F. The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg. 64:(Suppl):2001;12-17.
4. White N.J., Nosten F., Looareesuwan S., et al. Averting a malaria disaster. Lancet. 353:1999;1965-1967.
5. Mberu E.K., Mosobo M.K., Nzila A.M., Kokwaro G.O., Sibley C.H., Watkins W.M. The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. Am J Trop Med Hyg. 62:2000;396-401.
6. Olliaro P., Nevill C., LeBras J., et al. Systematic review of amodiaquine treatment in uncomplicated malaria. Lancet. 348:1996;1196-1201.
7. White N.J. Can amodiaquine be resurrected? Lancet. 348:1996;1184-1185.
8. White N. Antimalarial drug resistance and combination chemotherapy. Philos Trans R Soc Lond B Biol Sci. 354:1999;739-749.
9. de Vries P.J., Dien T.K. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs. 52:1996;818-836.
10. Staedke S.G., Kamya M.R., Dorsey G., et al. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Lancet. 358:2001;368-374.
11. von Seidlein L., Milligan P., Pinder M., et al. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 355:2000;352-357.
12. Rogier C., Tall A., Diagne N., Fontenille D., Spiegel A., Trape J.F. Plasmodium falciparum clinical malaria: lessons from longitudinal studies in Senegal. Parasitologia. 41:1999;255-259.
13. Marsh K., Snow R.W. Malaria transmission and morbidity. Parasitologia. 41:1999;241-246.
14. Basco L.K., Ringwald P. Molecular epidemiology of malaria in Yaounde, Cameroon. VII. Analysis of recrudescence and reinfection in patients with uncomplicated falciparum malaria. Am J Trop Med Hyg. 63:2000;215-221.
15. WHO. Assessment of Therapeutic Efficacy of Antimalarial Drugs for Uncomplicated Falciparum Malaria in Areas with Intense Transmission. Geneva: World Health Organization, 1996.
16. Dorsey G., Kamya M.R., Ndeezi G., et al. Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 62:2000;686-692.
17. Kamya M.R., Dorsey G., Gasasira A., et al. The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Trans R Soc Trop Med Hyg. 95:2001;50-55.
18. Warrell D.A., Molyneux M.E., Beales P.F. Severe and complicated malaria. Trans R Soc Trop Med Hyg. 84:(Suppl):1990;1-65.
19. WHO. Antimalarial Drug Policies: Data Requirements, Treatment of Uncomplicated Malaria and Management of Malaria in Pregnancy. Geneva: World Health Organization, 1994.
20. Zwetyenga J., Rogier C., Tall A., et al. No influence of age on infection complexity and allelic distribution in Plasmodium falciparum infections in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Am J Trop Med Hyg. 59:1998;726-735.
21. Fenton B., Clark J.T., Khan C.M., et al. Structural and antigenic polymorphism of the 35- to 48-kilodalton merozoite surface antigen (MSA-2) of the malaria parasite Plasmodium falciparum. Mol Cell Biol. 11:1991;963-974.
22. Liang K.Y., Zeger S.L. Longitudinal data analysis using generalized linear models. Biometrika. 73:1986;13-22.
23. Nosten F., Luxemburger C., ter Kuile F., et al. Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combinations. J Infect Dis. 170:1994;971-977.
24. Nosten F., van Vugt M., Price R., et al. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet. 356:2000;297-302.
25. Bloland P.B., Ettling M., Meek S. Combination therapy for malaria in Africa: hype or hope? Bull World Health Organ. 78:2000;1378-1388.
26. Watkins W.M., Mberu E.K., Winstanley P., Plowe C.V. The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses. Parasitology Today. 13:1997;459-464.
27. Adjuik M., Agnamey P., Babiker A., et al. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet. 359:2002;1365-1372.
28. Winstanley P. Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Trop Med Int Health. 6:2001;952-954.
29. Wendo C. African scientists discuss drug-resistant malaria. Lancet. 359:2002;770.