Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique

Journal of Infectious Diseases

Volumn 183, Issue 9, 2001, Pages 1413-1416

  Mayor, Alfredo G ^a,b   Gómez Olivé, Xavier ^a,b   Aponte, John J ^a,b   Casimiro, Sonia ^a,c   Mabunda, Samuel ^a,c   Dgedge, Martinho ^a,d   Barreto, Avertino ^a,c   Alonso, Pedro L ^a,b  

^a Ministérioda Saúde   (Mozambique)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c Ministerio da Saude   (Mozambique)

^d INSTITUTO NACIONAL DE SAÚDE   (Mozambique)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CHLOROQUINE;

ARTICLE; CHILD; CLINICAL ARTICLE; GENE MUTATION; HUMAN; INFANT; MALARIA FALCIPARUM; MOZAMBIQUE; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ANIMALS; ANTIMALARIALS; CHILD, PRESCHOOL; CHLOROQUINE; CODON; DRUG RESISTANCE; FEMALE; GENOTYPE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MEMBRANE PROTEINS; MOZAMBIQUE; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREVALENCE; PROTOZOAN PROTEINS;

EID: 0035341841     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/319856     Document Type: Article

References (10)

1. Impact of chloroquine resistance on malaria mortality
2. Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein
3. Persistence of drug-resistant malaria parasites
4. Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. Falciparum in Southeast Asia and Africa
5. Mutations in the P. Falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
6. Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania
7. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
8. Rapid and simple method for isolating malaria DNA from fingerprick samples of blood
9. Plasmodium falciparum: A rapid technique for typing the merozoite surface protein 2