Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

Science

Volumn 298, Issue 5599, 2002, Pages 1747-1752

  Lunyak, Victoria V ^a   Burgess, Robert ^a,e   Prefontaine, Gratien G ^a   Nelson, Charles ^a   Sze, Sing Hoi ^b   Chenoweth, Josh ^c   Schwartz, Phillip ^d   Pevzner, Pavel A ^b   Glass, Christopher ^a   Mandel, Gail ^c   Rosenfeld, Michael G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d Affinity BioReagents   (United States)

^e Beckman Institute for Biomedical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MOLECULES; TISSUE; ZINC;

REGULATORY BIOLOGY;

NEUROLOGY;

HISTONE DEACETYLASE; PROTEIN COREST; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REST; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

CHROMOSOME; GENE;

ARTICLE; BRAIN FUNCTION; CHROMOSOME ANALYSIS; CPG ISLAND; DEVELOPMENTAL BIOLOGY; GENE EXPRESSION REGULATION; GENE ISOLATION; GENE SILENCING; GENETIC CODE; HUMAN; MOLECULAR MECHANICS; NERVE CELL; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES; CHROMOSOMES, HUMAN; COMPUTATIONAL BIOLOGY; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; METHYL-CPG-BINDING PROTEIN 2; MICE; MODELS, GENETIC; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RATS; REPRESSOR PROTEINS; SODIUM CHANNELS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 18744405062     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1076469     Document Type: Article

References (42)

1. E. J. Richards, S. C. Elgin, Cell 108, 489 (2002).
2. C. J. Schoenherr, D. Anderson, Science 267, 1360 (1995).
3. J. A. Chong et al., Cell 80, 949 (1995).
4. C. J. Schoenherr, A. J. Paquette, D. J. Anderson, Proc. Natl. Acad. Sci. U.S.A. 93, 988 (1996).
5. N. Mori, R. Stein, D. Sigmund, D. J. Anderson, Neuron 4, 583 (1990).
6. N. Ballas et al., Neuron 31, 353 (2001).
7. Y. Naruse, T. Aoki, T. Kojima, N. Mori, Proc. Natl. Acad. Sci. U.S.A. 96, 13691 (1999).
8. K. Jepsen et al., Cell 102, 753 (2000).
9. M. E. Andres et al., Neuron 96, 9873 (1999).
10. A. You, J. K. Tong, C. M. Grozinger, S. L. Schreiber, Proc. Natl. Acad. Sci. U.S.A. 98, 1454 (2001).
11. G. W. Humphrey et al., J. Biol. Chem. 276, 6817 (2001).
12. M. A. Hakimi et al., Proc. Natl. Acad. Sci. U.S.A. 99, 7420 (2002).
13. Materials and methods are available as supporting material at Science Online.
14. V. V. Lunyak et al., unpublished data.
15. A. Razin, M. Szyf, Biochim. Biophys. Acta 782, 331 (1989).
16. S. Tweedie, S. Charlton, V. Clark, A. Bird, Mol. Cell. Biol. 17, 1469 (1997).
17. M. Brandies, M. Ariel, H. Cedar, Bioassays 15, 709 (1993).
18. P. H. Tate, A. Bird, Curr. Opin. Genet. Dev. 3, 226 (1993).
19. Z. Siegfried, S. Eden, M. Mendelsohn, X. Feng, B. Z. Tsuberi, H. Cedar, Nature Genet. 22, 203 (1999).
20. J. D. Lewis et al., Cell 69, 905 (1992).
21. M. C. Lorincz, D. Schubeler, M. Groudine, Mol. Cell. Biol. 21, 7913 (2001).
22. R. E. Amir et al., Nature Genet. 23, 185 (1999).
23. R. X. Chen, S. Akbarian, M. Tudor, R. Jaenisch, Nature Genet. 27, 327 (2001).
24. A. C. Bell, G. Felsenfeld, Nature 405, 482 (2000).
25. K. Kokura et al., J. Biol. Chem. 276, 34115 (2001).
26. R. I. Gregory et al., Mol. Cell. Biol. 21, 5426 (2001).
27. E. Heard et al., Cell 107, 727 (2001).
28. S. Rea et al., Nature 406, 593 (2000).
29. K. Mechtler, C. P. Ponting, C. D. Allis, T. Jenuwein, Nature 406, 593 (2000).
30. J. C. Rice, C. D. Allis, Curr. Opin. Cell Biol. 13, 263 (2001).
31. K. Noma, C. D. Allis, S. I. Grewal, Science 293, 1150 (2001).
32. A. J. Bannister et al., Nature 410, 120 (2001).
33. M. D. Litt, M. Simpson, M. Gaszner, C. D. Allis, G. Felsenfeld, Science 293, 2453 (2001).
34. M. Lachner, D. O'Carroll, S. Rea, K. Mechtler, T. Jenuwein, Nature 410, 116 (2001).
35. J. Nakayama, A. J. Klar, S. I. Grewal, Cell 101, 307 (2000).
36. J. Nakayama, J. C. Rice, B. D. Strahl, C. D. Allis, S. I. Grewal, Science 292, 10 (2001).
37. P. A. Pevzner, S. H. Sze, Intelligent Systems in Molecular Biology (AAAI Press, La Jolla, CA, 2000), pp. 269-278.
38. M. Mieda, T. Haga, D. W. Saffeen, J. Biol. Chem. 272, 5854 (1997).
39. I. C. Wood, A. Roopra, N. J. Buckley, J. Biol. Chem. 271, 14221 (1996).
40. T. Jenuwein, C. D. Allis, Science 293, 1074 (2001).
41. P. Jones, Nature Rev. Genet. 3, 415 (2002).
42. We particularly thank A. Gonzalez (Santa Cruz Biotech Inc.) for helpful advice, K. Ohgi for technical assistance, and P. Myer and M. Fisher for figure and manuscript preparation. M.G.R. is an Investigator and V.L is an Associate with HHMI. G.P. is supported by the Canadian Institute of Health Research. Supported by grants from NIH to G.M. and M.G.R. and a grant from CapCURE to M.G.R.