Gene repression paradigms in animal cells

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 69, Issue , 2004, Pages 131-138

  Lande Diner, L ^a   Zhang, J ^a   Hashimshony, T ^a   Goren, A ^a   Keshet, I ^a   Cedar, H ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; DNA; DNA METHYLTRANSFERASE 1; PROTEIN P53; RNA;

ANIMAL CELL; CELL CYCLE S PHASE; CHROMATIN STRUCTURE; CONFERENCE PAPER; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; DNA REPLICATION TIMING; EMBRYO; FIBROBLAST; GENE; GENE ACTIVATION; GENE ACTIVITY; GENE REPLICATION; GENE REPRESSION; GENE SILENCING; GENE STRUCTURE; HISTONE CODE; HOUSEKEEPING GENE; HUMAN; HYPOTHESIS; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; REPRESSOR GENE; STRUCTURE ANALYSIS; TISSUE SPECIFICITY; TRANSGENIC MOUSE; ARTICLE; CULTURAL ANTHROPOLOGY; EPIGENETIC REPRESSION; GENE EXPRESSION; HISTONE MODIFICATION; TRANSGENE;

ANIMALS; DNA METHYLATION; DNA REPLICATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENE SILENCING; HISTONES; HUMANS; MICE; MODELS, GENETIC;

ANIMALIA; MUS MUSCULUS;

EID: 22944456025     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2004.69.131     Document Type: Conference Paper

References (38)

1. Bergman Y. and Cedar H. 2004. A stepwise epigenetic process controls immunoglobulin allelic exclusion. Nat. Rev. Immunol. 4: 753.
2. Brandeis M., Frank D., Keshet I., Siegfried Z., Mendelsohn M., Nemes A., Temper V., Razin A., and Cedar H. 1994. Sp1 elements protect a CpG island from de novo methylation. Nature 371: 435.
3. Brown D.D. 1984. The role of stable complexes that repress and activate eucaryotic genes. Cell 37: 359.
4. Busslinger M., Hurst J., and Flavell R.A. 1983. DNA methylation and the regulation of the globin gene expression. Cell 34: 197.
5. Cedar H. 1988. DNA methylation and gene activity. Cell 53: 3.
6. Chong J.A., Tapia-Ramirez J., Kim S., Toledo-Aral J.J., Zheng Y., Boutros M.C., Altshuller Y.M., Frohman M.A., Kraner S.D., and Mandel G. 1995. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80: 949.
7. Eden S., Hashimshony T., Keshet I., Thorne A.W., and Cedar H. 1998. DNA methylation models histone acetylation. Nature 394: 842.
8. Epner E., Forrester W.C., and Groudine M. 1988. Asynchronous DNA replication within the human β-globin gene locus. Proc. Natl. Acad. Sci. 85: 8081.
9. Forrester W.C., Thompson C., Elder J.T., and Groudine M. 1986. A developmentally stable chromatin structure in the human beta-globin gene cluster. Proc. Natl. Acad. Sci. 83: 1359.
10. Fu X.H., Liu D.P., and Liang C.C. 2002. Chromatin structure and transcriptional regulation of the beta-globin locus. Exp. Cell Res. 278: 1.
11. Fuks F., Hurd P.J., Deplus R., and Kouzarides T. 2003. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res. 31: 2305.
12. Fuks F., Burgers W.A., Brehm A., Hughes-Davies L., and Kouzarides T. 2000. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24: 88.
13. Gidekel S. and Bergman Y. 2002. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J. Biol. Chem. 277: 34521.
14. Goren A. and Cedar H. 2003. Replicating by the clock. Nat. Rev. Mol. Cell Biol. 4: 25.
15. Gottesfeld J. and Bloomer L.S. 1982. Assembly of transcriptionally active 5S RNA gene chromatin in vitro. Cell 28: 781.
16. Gruenbaum Y., Stein R., Cedar H., and Razin A. 1981. Methylation of CpG sequences in eukaryotic DNA. FEBS Lett. 123: 67.
17. Hashimshony T., Zhang J., Keshet I., Bustin M., and Cedar H. 2003. The role of DNA methylation in setting up chromatin structure during development. Nat. Genet. 34: 187.
18. Huang Y., Myers S.J., and Dingledine R. 1999. Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes. Nat. Neurosci. 2: 867.
19. Jackson-Grusby L., Beard C., Possemato R., Tudor M., Fambrough D., Csankovszki G., Dausman J., Lee P., Wilson C., Lander E., and Jaenisch R. 2001. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat. Genet. 27: 31.
20. Jenuwein T. and Allis C.D. 2001. Translating the histone code. Science 293: 1074.
21. Jones P.L., Veenstra G.J.C., Wade P.A., Vermaak D., Kass S.U., Landsberg N., Strouboulis J., and Wolffe A.P. 1998. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19: 187.
22. Kafri T., Ariel M., Brandeis M., Shemer R., Urven L., McCarrey J., Cedar H., and Razin A. 1992. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline. Genes Dev. 6: 705.
23. Kuhn R., Schwenk F., Aguet M., and Rajewsky K. 1995. Inducible gene targeting in mice. Science 269: 1427.
24. Lallemand Y., Luria V., Haffner-Krausz R., and Lonai P. 1998. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site specific recombinase. Transgenic Res. 7: 105.
25. Li E., Bestor T.H., and Jaenisch R. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915.
26. Lunyak V.V., Burgess R., Prefontaine G.G., Nelson C., Sze S.-H., Chenoweth J., Schwartz P., Pevzner P.A., Glass C., Mandel G., and Rosenfeld M.G. 2002. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298: 1747.
27. Macleod D., Charlton J., Mullins J., and Bird A.P. 1994. Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8: 2282.
28. Nan X., Ng H.-H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., and Bird A. 1998. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386.
29. Okano M., Bell D.W., Haber D.A., and Li E. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247.
30. Razin A. 1998. CpG methylation, chromatin structure and gene silencing - A three-way connection. EMBO J. 17: 4905.
31. Reynaud C., Bruno C., Boullanger P., Grange J., Barbesti S., and Niveleau A. 1992. Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. Cancer Lett. 61: 255.
32. Robertson K.D., Ait-Si-Ali S., Yokochi T., Wade P.A., Jones P.L., and Wolffe A.P. 2000. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2Fresponsive promoters. Nat. Genet. 25: 338.
33. Rountree M.R., Bachman K.E., and Baylin S.B. 2000. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25: 269.
34. Selig S., Okumura K., Ward D.C., and Cedar H. 1992. Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J. 11: 1217.
35. Siegfried Z., Eden S., Mendelsohn M., Feng X., Tzubari B., and Cedar H. 1999. DNA methylation represses transcription in vivo. Nat. Genet. 22: 203.
36. Simon I., Tenzen T., Mostoslavsky R., Fibach E., Lande L., Milot E., Gribnau J., Grosveld F., Fraser P., and Cedar H. 2001. Developmental regulation of DNA replication timing at the human β globin locus. EMBO J. 20: 6150.
37. Vermaak D., Ahmad K., and Henikoff S. 2003. Maintenance of chromatin states: An open-and-shut case. Curr. Opin. Cell Biol. 15: 266.
38. Zhang J., Feng X., Hashimshony T., Keshet I., and Cedar H. 2002. The establishment of transcriptional competence in early and late S-phase. Nature 420: 198.