Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development

Current Topics in Medicinal Chemistry

Volumn 5, Issue 6, 2005, Pages 557-567

  Salter, Michael W ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Glutamate receptors; Microglia; Pain; Spinal dorsal horn; Src; Synaptic plasticity; Tyrosine kinase

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; ANALGESIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CALCIUM CHANNEL BLOCKING AGENT; GLUTAMATE RECEPTOR; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE; PURINE P2X4 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR 4; UNCLASSIFIED DRUG;

ALLODYNIA; CELL FUNCTION; CHRONIC PAIN; COGNITIVE DEFECT; DRUG MECHANISM; DRUG TARGETING; EXCITATORY POSTSYNAPTIC POTENTIAL; GLIA CELL; HALLUCINATION; HUMAN; HYPERALGESIA; MEMORY DISORDER; MICROGLIA; MOLECULAR DYNAMICS; NERVE CELL PLASTICITY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; RESPIRATION DEPRESSION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINAL PAIN; SYNAPTIC TRANSMISSION;

ANALGESICS; DRUG DESIGN; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; MICROGLIA; NEURONAL PLASTICITY; PAIN; POSTERIOR HORN CELLS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 22944483793     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026054367638     Document Type: Review

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