Dissecting out mechanisms responsible for peripheral neuropathic pain: Implications for diagnosis and therapy

Life Sciences

Volumn 74, Issue 21, 2004, Pages 2605-2610

  Woolf, Clifford J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Central sensitization; Disinhibition; Ectopic excitability; Peripheral neuropathic pain; Phenotypic switch; Primary sensory neurons; Sensory neuron loss

Indexed keywords

ALLODYNIA; CELL LOSS; CONFERENCE PAPER; DYSESTHESIA; HYPERALGESIA; NERVE CELL; NERVE DEGENERATION; NERVE EXCITABILITY; NERVE FIBER; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; PARESTHESIA; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; SENSORY DYSFUNCTION; SYMPTOM;

GENE EXPRESSION REGULATION; HUMANS; NERVE DEGENERATION; NEURONS, AFFERENT; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES;

EID: 1642276200     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.01.003     Document Type: Conference Paper

References (33)

1. Baba H., Ji R.R., Kohno T., Moore K.A., Ataka T., Wakai A., Okamoto M., Woolf C.J. Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol. Cell. Neurosci. 24:2003;818-830.
2. Campbell J.N., Raja S.N., Meyer R.A., McKinnon S.E. Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain. 32:1988;89-94.
3. Costigan M., Befort K., Karchewski L., Griffin R.S., D'Urso D., Allchorne A., Sitarski J., Mannion J.W., Pratt R.E., Woolf C.J. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 3:2002;16.
4. Decosterd I., Allchorne A., Woolf C.J. Progressive tactile hypersensitivity after a peripheral nerve crush: non-noxious mechanical stimulus-induced neuropathic pain. Pain. 100:2002;155-162.
5. Devor M., Seltzer Z. Pathophysiology of damaged nerves in realtion to chronic pain. Wall P.D., Melzack R. Textbook of Pain. 1999;129-164 Churchill Livingstone, Edinburgh.
6. Felsby S., Nielsen J., Arendt-Nielsen L., Jensen T.S. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium cholride. Pain. 64:1996;283-291.
7. Fukuoka T., Kondo E., Dai Y., Hashimoto N., Noguchi K. Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. J. Neurosci. 21:2001;4891-4900.
8. Galer B.S., Jensen M.P. Development and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale. Neurology. 48:1997;332-338.
9. Ji R.R., Befort K., Brenner G.J., Woolf C.J. ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity. J. Neurosci. 22:2002;478-485.
10. Jin S.X., Zhuang Z.Y., Woolf C.J., Ji R.R. p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain. J. Neurosci. 23:2003;4017-4022.
11. Koltzenburg M. Painful neuropathies. Curr. Opin. Neurol. 11:1998;515-521.
12. Koltzenburg M., Wahren L.K., Torebjork H.E. Dynamic changes of mechanical hyperalgesia in neuropathic pain states and healthy subjects depend on the ongoing activity of unmyelinated nociceptive afferents. Pflugers. Arch. 420:1992;R52.
13. Liu C.N., Devor M., Waxman S.G., Kocsis J.D. Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRG. J. Neurophysiol. 87:2002;2009-2017.
14. Luo Z.D., Chaplan S.R., Higuera E.S., Sorkin L.S., Stauderman K.A., Williams M.E., Yaksh T.L. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J. Neurosci. 21:2001;1868-1875.
15. Mannion R.J., Costigan M., Decosterd I., Amaya F., Ma Q.P., Holstege J.C., Ji R.R., Acheson A., Lindsay R.M., Wilkinson G.A., Woolf C.J. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc. Natl. Acad. Sci. U. S. A. 96:1999;9385-9390.
16. Moore K.A., Kohno T., Karchewski L.A., Scholz J., Baba H., Woolf C.J. Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J. Neurosci. 15:2002;6724-6731.
17. Neumann S., Doubell T.P., Leslie T.A., Woolf C.J. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurones. Nature. 384:1996;360-364.
18. Noguchi K., Kawai Y., Fukuoka T., Senba E., Miki K. Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. J. Neurosci. 15:1995;7633-7643.
19. Rowbotham M.C., Fields H.L. The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia. Brain. 119(Pt 2):1996;347-354.
20. Scholz J., Woolf C.J. Can we conquer pain? Nat. Neurosci. 5:2002;1062-1067. (Suppl.).
21. Sindrup S.H., Jensen T.S. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain. 83:1999;389-400.
22. A and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J. Neurophysiol. 72:1994;169-179.
23. Tandrup T., Woolf C.J., Coggeshall R.E. Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J. Comp. Neurol. 422:2000;172-180.
24. Watkins L.R., Milligan E.D., Maier S.F. Glial activation: a driving force for pathological pain. Trends Neurosci. 24:2001;450-455.
25. Waxman S.G., Dib-Hajj S., Cummins T.R., Black J.A. Sodium channels and pain. Proc. Natl. Acad. Sci. U. S. A. 96:1999;7635-7639.
26. Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity. Nature. 306:1983;686-688.
27. Woolf C.J., Bennett G.J., Doherty M., Dubner R., Kidd B., Koltzenburg M., Lipton R., Loeser J.D., Payne R., Torebjork E. Towards a mechanism-based classification of pain? Pain. 77:1998;227-229.
28. Woolf C.J., Decosterd I. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain. 82:1999;1-7.
29. Woolf C.J., Mannion R.J. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 353:1999;1959-1964.
30. Woolf C.J., Max M.B. Mechanism-based pain diagnosis: issues for analgesic drug development. Anesthesiol. 95:2001;241-249.
31. Woolf C.J., Salter M.W. Neuronal plasticity-increasing the gain in pain. Science. 288:2000;1765-1768.
32. Woolf C.J., Wall P.D. The relative effectiveness of C primary afferent fibres of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J. Neurosci. 6:1986;1433-1443.
33. Xiao H.S., Huang Q.H., Zhang F.X., Bao L., Lu Y.J., Guo C., Yang L., Huang W.J., Fu G., Xu S.H., Cheng X.P., Yan Q., Zhu Z.D., Zhang X., Chen Z., Han Z.G., Zhang X. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc. Natl. Acad. Sci. U. S. A. 99:2002;8360-8365.