NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity

Current Opinion in Neurobiology

Volumn 11, Issue 3, 2001, Pages 336-342

  Ali, Declan W ^a   Salter, Michael W ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; FOCAL ADHESION KINASE 2; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC RECEPTOR; PROTEIN G; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; HIPPOCAMPUS; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR POTENTIAL; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035369919     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(00)00216-6     Document Type: Review

References (55)

1. N-methyl-D-aspartic acid receptor structure and function
2. The glutamate receptor ion channels
3. Postsynaptic organization and regulation of excitatory synapses
4. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
5. Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation
6. Regulation of NMDA receptors by tyrosine kinases and phosphatases
7. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
8. Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family
9. A peptide activator of endogenous tyrosine kinase enhances synaptic currents mediated by NMDA receptors
10. The postsynaptic density protein PSD-95 differentially regulates insulin- and Src-mediated current modulation of mouse NMDA receptors expressed in Xenopus oocytes
11. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition
12. NMDA channel regulation by channel-associated protein tyrosine kinase Src
13. Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity
14. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
15. + in the developing chick spinal cord as revealed with anti-hexapeptide antibody
16. NMDA receptor subunits ε1 (NR2A) and ε2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain
17. Phosphorylation dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase
18. Regulation, substrates and functions of src
19. Signaling through scaffold, anchoring, and adaptor proteins
20. Three-dimensional structure of the tyrosine kinase c-Src
21. Potentiation of synaptic NMDA receptor responses in visual cortical neurons by ATP and Fyn-kinase
22. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A
23. The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor δ2 and ε subunits
24. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B
25. Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits
26. Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition
27. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRepsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor
28. Gain control of NMDA-receptor currents by intracellular sodium
29. The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-γ
30. Cellular functions regulated by Src family kinases
31. Protein kinase C modulation of NMDA currents: An important link for LTP induction
32. Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits
33. Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily
34. 2+-induced regulation of ion channel and MAP kinase functions
35. FAK and PYK2/CAKbeta in the nervous system: A link between neuronal activity, plasticity and survival?
36. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
37. CAKβ/Pyk2 kinase is a signalling link for induction of long-term potentiation in CA1 hippocampus
38. Long-term potentiation - A decade of progress?
39. Postsynaptic protein phosphorylation and LTP
40. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
41. Src activation in the induction of long-term potentiation in CA1 hippocampal neurons
42. High-frequency synaptic stimulation induces association of fyn and c-src to distinct phosphorylated components
43. 2+ entry into hippocampal neurons
44. + imaging in spines and fine dendrites of central neurons
45. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
46. Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors
47. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
48. Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo
49. Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation
50. NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex
51. Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: Synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions
52. + channel Kv1.4
53. L-Aspartic acid induces a region of negative slope conductance in the current-voltage relationship of cultured spinal cord neurons
54. 2+ signals in spines of hippocampal neurons
55. Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor