Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing

Journal of Biological Chemistry

Volumn 280, Issue 28, 2005, Pages 26160-26168

  Osenkowski, Pamela ^a   Meroueh, Samy O ^b   Pavel, Dumitru ^b   Mobashery, Shahriar ^b   Fridman, Rafael ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CATALYSIS; ENZYMES; MATHEMATICAL MODELS; PATHOLOGY; STRUCTURAL ANALYSIS;

HINGE DETECTION; MATRIX METALLOPROTEINASE (MMP); MUTATIONS; PROTEOLYSIS;

PROTEINS;

ARGININE; GLUTAMINE; GLYCINE; MATRIX METALLOPROTEINASE 14; MEMBRANE TYPE 3 MATRIX METALLOPROTEINASE; PROLINE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURFACE; COLLAGEN DEGRADATION; COMPUTER MODEL; DELETION MUTANT; ENZYME STRUCTURE; EXTRACELLULAR SPACE; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; PERICELLULAR SPACE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; BIOTINYLATION; CATALYSIS; CATALYTIC DOMAIN; CELL MEMBRANE; COMPUTER SIMULATION; DNA MUTATIONAL ANALYSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE DELETION; GLYCINE; HAPLORHINI; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; POINT MUTATION; PROLINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; TIME FACTORS; TRANSFECTION; VACCINIA VIRUS;

EID: 22544471867     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414379200     Document Type: Article

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