Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase

Biochemical Journal

Volumn 387, Issue 2, 2005, Pages 497-506

  Toth, Marta ^a   Osenkowski, Pamela ^b   Hesek, Dusan ^a   Brown, Stephen ^a   Meroueh, Samy ^a   Sakr, Wael ^b   Mobashery, Shahriar ^a   Fridman, Rafael ^b  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ectodomain; Matrix metalloproteinase (MMP); Protease; Proteolysis; Shedding; Tissue inhibitor of metalloproteinase (TIMP)

Indexed keywords

ANTIBODIES; BIOLOGICAL ORGANS; CELL MEMBRANES; MASS SPECTROMETRY; TUMORS;

CELL SURFACES; CYTOSOL; METALLOPROTEINASE; PHYSIOLOGICAL PROCESSES;

ENZYMES;

GALECTIN 3; GELATINASE A; MATRIX METALLOPROTEINASE 14; PROGELATINASE A; PROTEIN PRECURSOR; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME STRUCTURE; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MEMBRANE BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; BREAST; BREAST NEOPLASMS; CATALYSIS; CELL LINE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 17644390235     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041324     Document Type: Article

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