MMP2 activation by collagen I and concanavalin a in cultured human hepatic stellate cells

Hepatology

Volumn 30, Issue 2, 1999, Pages 462-468

  Théret, Nathalie ^a   Lehti, Kaisa ^b   Musso, Orlando ^a   Clément, Bruno ^a,c  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITY OF HELSINKI   (Finland)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 6; CONCANAVALIN A; CYCLOHEXIMIDE; DACTINOMYCIN; GELATINASE A; LAMININ; MATRIX METALLOPROTEINASE INHIBITOR;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LIVER FIBROSIS; PRIORITY JOURNAL; STELLATE CELL; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 0032765483     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300236     Document Type: Article

References (18)

1. rd ed. London: Bailliere Tindall, 1992;822-881.
2. Gressner AM. The cell biology of liver fibrogenesis-an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998;292:447-452.
3. Arthur MJP. Fibrosis and altered matrix degradation. Digestion 1998;59:376-380.
4. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 1995;7:728-735.
5. Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJP. Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci 1995;89:75-81.
6. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994;370:61-65.
7. Corcoran ML, Hewitt R, Kleiner DE Jr, Stetler-Stevenson WG. MMP-2: expression, activation and inhibition. Enzyme Protein 1996;49:7-19.
8. Strongin AY, Collier I, Bannikov G, Marmer L, Grant GA, Goldberg GI. Mechanism of cell surface activation of 72-kDa type IV collagenase. J Biol Chem 1995;270:5331-5338.
9. Butler GS, Butler MS, Atkinson SJ, Will H, Tamura T, Schade von Westrum S, Crabbe T, et al. TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. J Biol Chem 1998;273:871-880.
10. Kinoshita T, Sato H, Okada A, Ohuchi E, Imai K, Okada Y, Seiki M. TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads. J Biol Chem 1998;273:16098-16103.
11. Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med 1993;328:1828-1835.
12. Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72-kA type IV collagenase/gelatinase by cultured human lipocytes: analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992;287:701-707.
13. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP. Expression of tissue inhibitor of metalloproteinase 1 and 2 is increased in fibrotic human liver. Gastroenterology 1996;110:821-831.
14. Théret N, Musso O, L'Helgoualc'h A, Clément B. Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol 1997;150:51-58.
15. Théret N, Musso O, L'Helgoualc'h A, Campion JP, Clément B. Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinase (MMPs) in association with MMP2 activation in injured human livers. Am J Pathol 1998;153:945-954.
16. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992;90:196-203.
17. Overall CM, Sodek J. Concanavalin A produces a matrix-degradative phenotype in human fibroblast. J Biol Chem 1990;265:21141-21151.
18. Loréal O, Levavasseur F, Fromaget C, Gros D, Guillouzo A, Clément B. Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro. Am J Pathol 1993;143:538-544.