Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP)

Biochemical Journal

Volumn 372, Issue 3, 2003, Pages 799-809

  Worley, Joanna R ^a   Thompkins, Philip B ^b   Lee, Meng H ^a   Hutton, Mike ^a   Soloway, Paul ^c   Edwards, Dylan R ^a   Murphy, Gillian ^a,d   Knäuper, Vera ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c 108 Savage Hall ^*  (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Activation; Murine tissue inhibitor of metalloproteinases 4 (TIMP 4); Site directed mutagenesis; Trimolecular complex

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME INHIBITION; TISSUE;

ANGIOGENESIS;

PROTEINS;

CYSTEINE; GELATINASE A; LEUCINE; MATRIX METALLOPROTEINASE 14; MUTANT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DELETION MUTANT; DRUG PROTEIN BINDING; ENZYME ACTIVATION; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

AMINO ACID MOTIFS; ANIMALS; BASE SEQUENCE; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME PRECURSORS; GELATINASES; GENE DELETION; GENES; HUMANS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

ANIMALIA; MURINAE;

EID: 0038266866     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021573     Document Type: Article

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