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Volumn 19, Issue 11, 2005, Pages 1263-1268

BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BORTEZOMIB; PROTEIN BAK; PROTEIN BCL XL; PROTEIN MCL 1;

EID: 22344456263     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1326205     Document Type: Review
Times cited : (102)

References (49)
  • 1
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • Adams, J.M. 2003. Ways of dying: Multiple pathways to apoptosis. Genes & Dev. 17: 2481-2495.
    • (2003) Genes & Dev. , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 3
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B
    • Campbell, K.J., Rocha, S., and Perkins, N.D. 2004. Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B. Mol. Cell 13: 853-865.
    • (2004) Mol. Cell , vol.13 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 7
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory, S., Huang, D.C., and Adams, J.M. 2003. The Bcl-2 family: Roles in cell survival and oncogenesis. Oncogene 22: 8590-8607.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 8
    • 0036791781 scopus 로고    scopus 로고
    • Viral homologues of Bcl-2: Role of apoptosis in the regulation of virus infection
    • Cuconati, A. and White, E. 2002. Viral homologues of Bcl-2: Role of apoptosis in the regulation of virus infection. Genes & Dev. 16: 2465-2478.
    • (2002) Genes & Dev. , vol.16 , pp. 2465-2478
    • Cuconati, A.1    White, E.2
  • 9
    • 0348014686 scopus 로고    scopus 로고
    • DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    • Cuconati, A., Mukherjee, C., Perez, D., and White, E. 2003. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes & Dev. 17: 2922-2932.
    • (2003) Genes & Dev. , vol.17 , pp. 2922-2932
    • Cuconati, A.1    Mukherjee, C.2    Perez, D.3    White, E.4
  • 10
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial, N.N. and Korsmeyer, S.J. 2004. Cell death: Critical control points. Cell 116: 205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 11
    • 14244265108 scopus 로고    scopus 로고
    • Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands
    • Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C.S., and Hind, M.G. 2005. Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J. Biol. Chem. 280: 4738-4744.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4738-4744
    • Day, C.L.1    Chen, L.2    Richardson, S.J.3    Harrison, P.J.4    Huang, D.C.S.5    Hind, M.G.6
  • 12
    • 0036729911 scopus 로고    scopus 로고
    • Bax and Bak mediate p53-independent suppression of tumorigenesis
    • Degenhardt, K., Chen, G., Lindsten, T., and White, E. 2002a. Bax and Bak mediate p53-independent suppression of tumorigenesis. Cancer Cell 2: 193-203.
    • (2002) Cancer Cell , vol.2 , pp. 193-203
    • Degenhardt, K.1    Chen, G.2    Lindsten, T.3    White, E.4
  • 13
  • 14
    • 1942437456 scopus 로고    scopus 로고
    • Bim is a suppressor of Myc-induced mouse B cell leukemia
    • Egle, A., Harris, A.L., Bouillet, P., and Cory, S. 2004. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc. Natl. Acad. Sci. 101: 6164-6169.
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 6164-6169
    • Egle, A.1    Harris, A.L.2    Bouillet, P.3    Cory, S.4
  • 16
    • 0242298578 scopus 로고    scopus 로고
    • CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response
    • Kato Jr., T., Delhase, M., Hoffmann, A., and Karin, M. 2003. CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response. Mol. Cell 12: 829-839.
    • (2003) Mol. Cell , vol.12 , pp. 829-839
    • Kato Jr., T.1    Delhase, M.2    Hoffmann, A.3    Karin, M.4
  • 17
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin, M., Cao, Y., Greten, F.R., and Li, Z.W. 2002. NF-κB in cancer: From innocent bystander to major culprit. Nat. Rev. Cancer 2: 301-310.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 18
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-κB is the answer-Role of Rel/NF-κB in the regulation of apoptosis
    • Kucharczak, J., Simmons, M.J., Fan, Y., and Gelinas, C. 2003. To be, or not to be: NF-κB is the answer-Role of Rel/NF-κB in the regulation of apoptosis. Oncogene 22: 8961-8982.
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 19
    • 22344436226 scopus 로고    scopus 로고
    • Constitutive proteasome-mediated turnover of Bfl-1/ A1 and its processing in response to TNF receptor activation in FL5-12 pro-B cells convert it into a pro-death factor
    • in press
    • Kucharczak, J.F., Simmons, M.J., Duckett, C.S., and Gelinas, C. 2005. Constitutive proteasome-mediated turnover of Bfl-1/ A1 and its processing in response to TNF receptor activation in FL5-12 pro-B cells convert it into a pro-death factor. Cell. Death Differ. (in press).
    • (2005) Cell. Death Differ.
    • Kucharczak, J.F.1    Simmons, M.J.2    Duckett, C.S.3    Gelinas, C.4
  • 20
    • 13944277343 scopus 로고    scopus 로고
    • BH3 domains of BH3-only proteins differentially regulate baxmediated mitochondrial membrane permeabilization both directly and indirectly
    • Kuwana, T., Bouchier-Hayes, L., Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R., and Newmeyer, D.D. 2005. BH3 domains of BH3-only proteins differentially regulate baxmediated mitochondrial membrane permeabilization both directly and indirectly. Mol. Cell 17: 525-535.
    • (2005) Mol. Cell , vol.17 , pp. 525-535
    • Kuwana, T.1    Bouchier-Hayes, L.2    Chipuk, J.E.3    Bonzon, C.4    Sullivan, B.A.5    Green, D.R.6    Newmeyer, D.D.7
  • 21
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai, A., Bassik, M.C., Walensky, L.D., Sorcinelli, M.D., Weiler, S., and Korsmeyer, S.J. 2002. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 22
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu, J.I., Dumont, P., Hafey, M., Murphy, M.E., and George, D.L. 2004. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 6: 443-450.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 23
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    • Ley, R., Balmanno, K., Hadfield, K., Weston, C., and Cook, S.J. 2003. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278: 18811-18816.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 24
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of the proapoptotic Bcl-2 family members, Bak and Bax, are essential for the normal development of multiple tissues
    • Lindsten, T., Ross, A.J., King, A., Zong, W.-X., Rathmell, J.C., Shiels, H.A., Ulrich, E., Waymire, K.G., Mahar, P., Frauwirth, K., et al. 2000. The combined functions of the proapoptotic Bcl-2 family members, Bak and Bax, are essential for the normal development of multiple tissues. Mol. Cell 6: 1389-1399.
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1    Ross, A.J.2    King, A.3    Zong, W.-X.4    Rathmell, J.C.5    Shiels, H.A.6    Ulrich, E.7    Waymire, K.G.8    Mahar, P.9    Frauwirth, K.10
  • 25
    • 0242521470 scopus 로고    scopus 로고
    • Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
    • Luciano, F., Jacquel, A., Colosetti, P., Herrant, M., Cagnol, S., Pages, G., and Auberger, P. 2003. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 22: 6785-6793.
    • (2003) Oncogene , vol.22 , pp. 6785-6793
    • Luciano, F.1    Jacquel, A.2    Colosetti, P.3    Herrant, M.4    Cagnol, S.5    Pages, G.6    Auberger, P.7
  • 26
    • 0035284812 scopus 로고    scopus 로고
    • Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells
    • Marshansky, V., Wang, X., Bertrand, R., Luo, H., Duguid, W., Chinnadurai, G., Kanaan, N., Vu, M.D., and Wu, J. 2001. Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. J. Immunol. 166: 3130-3142.
    • (2001) J. Immunol. , vol.166 , pp. 3130-3142
    • Marshansky, V.1    Wang, X.2    Bertrand, R.3    Luo, H.4    Duguid, W.5    Chinnadurai, G.6    Kanaan, N.7    Vu, M.D.8    Wu, J.9
  • 29
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • Nijhawan, D., Fang, M., Traer, E., Zhong, Q., Gao, W., Du, F., and Wang, X. 2003. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes & Dev. 17: 1475-1496.
    • (2003) Genes & Dev. , vol.17 , pp. 1475-1496
    • Nijhawan, D.1    Fang, M.2    Traer, E.3    Zhong, Q.4    Gao, W.5    Du, F.6    Wang, X.7
  • 30
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic Mcl-1
    • Opferman, J.T., Letai, A., Beard, C., Sorcinelli, M.D., Ong, C.C., and Korsmeyer, S. 2003. Development and maintenance of B and T lymphocytes requires antiapoptotic Mcl-1. Nature 426: 671-676.
    • (2003) Nature , vol.426 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3    Sorcinelli, M.D.4    Ong, C.C.5    Korsmeyer, S.6
  • 31
    • 13844319184 scopus 로고    scopus 로고
    • Obligate role of antiapoptotic MCL-1 in the survival of hematopoietic stem cells
    • Opferman, J.T., Iwasaki, H., Ong, C.C., Suh, H., Mizuno, S.-I., Akashi, K., and Korsmeyer, S. 2005. Obligate role of antiapoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307: 1101-1104.
    • (2005) Science , vol.307 , pp. 1101-1104
    • Opferman, J.T.1    Iwasaki, H.2    Ong, C.C.3    Suh, H.4    Mizuno, S.-I.5    Akashi, K.6    Korsmeyer, S.7
  • 32
    • 0033634781 scopus 로고    scopus 로고
    • TNF-α signals apoptosis through a Bid-dependent conformational change in Bax that is inhibited by E1B 19K
    • Perez, D. and White, E. 2000. TNF-α signals apoptosis through a Bid-dependent conformational change in Bax that is inhibited by E1B 19K. Mol. Cell 6: 53-63.
    • (2000) Mol. Cell , vol.6 , pp. 53-63
    • Perez, D.1    White, E.2
  • 33
    • 10644239087 scopus 로고    scopus 로고
    • Regulation of NF-κB by atypical activators and tumour suppressors
    • Perkins, N.D. 2004. Regulation of NF-κB by atypical activators and tumour suppressors. Biochem. Soc. Trans. 32: 936-939.
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 936-939
    • Perkins, N.D.1
  • 34
    • 0036097786 scopus 로고    scopus 로고
    • Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    • Puthalakath, H. and Strasser, A. 2002. Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9: 505-512.
    • (2002) Cell Death Differ. , vol.9 , pp. 505-512
    • Puthalakath, H.1    Strasser, A.2
  • 39
    • 0035976902 scopus 로고    scopus 로고
    • Tumor Necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
    • Sundararajan, R., Cuconati, A., Nelson, D., and White, E. 2001. Tumor Necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K. J. Biol. Chem. 276: 45120-45127.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45120-45127
    • Sundararajan, R.1    Cuconati, A.2    Nelson, D.3    White, E.4
  • 40
    • 0033713002 scopus 로고    scopus 로고
    • Structure of Bax: Coregulation of dimer formation and intracellular localization
    • Suzuki, M., Youle, R.J., and Tjandra, N. 2000. Structure of Bax: Coregulation of dimer formation and intracellular localization. Cell 103: 645-654.
    • (2000) Cell , vol.103 , pp. 645-654
    • Suzuki, M.1    Youle, R.J.2    Tjandra, N.3
  • 44
    • 0037151030 scopus 로고    scopus 로고
    • Bcl-2 family member Bfl-1/AI sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax
    • Werner, A.B., de Vries, E., Tait, S.W., Bontjer, I., and Borst, J. 2002. Bcl-2 family member Bfl-1/AI sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax. J. Biol. Chem. 277: 22781-22788.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22781-22788
    • Werner, A.B.1    De Vries, E.2    Tait, S.W.3    Bontjer, I.4    Borst, J.5
  • 46
    • 0035877981 scopus 로고    scopus 로고
    • MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes
    • Zhou, P., Levy, N.B., Xie, H., Qian, L., and Lee, C.Y. 2001. MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes. Blood 97: 3902-3909.
    • (2001) Blood , vol.97 , pp. 3902-3909
    • Zhou, P.1    Levy, N.B.2    Xie, H.3    Qian, L.4    Lee, C.Y.5
  • 47
    • 22344442683 scopus 로고    scopus 로고
    • Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors
    • in press
    • Zhu, H., Zhang, L., Dong, F., Guo, W., Wu, S., Teraishi, F., Davis, J.J., Chiao, P.J., and Fang, B. 2005. Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. Oncogene (in press).
    • (2005) Oncogene
    • Zhu, H.1    Zhang, L.2    Dong, F.3    Guo, W.4    Wu, S.5    Teraishi, F.6    Davis, J.J.7    Chiao, P.J.8    Fang, B.9
  • 49
    • 0035876483 scopus 로고    scopus 로고
    • BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
    • Zong, W.-X., Lindsten, T., Ross, A.J., MacGregor, G.R., and Thompson, C.B. 2001. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes & Dev. 15: 1481-1486.
    • (2001) Genes & Dev. , vol.15 , pp. 1481-1486
    • Zong, W.-X.1    Lindsten, T.2    Ross, A.J.3    MacGregor, G.R.4    Thompson, C.B.5


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