Toward a biological network for atherosclerosis

Journal of Lipid Research

Volumn 45, Issue 10, 2004, Pages 1793-1805

  Ghazalpour, Anatole ^a   Doss, Sudheer ^a   Yang, Xia ^a   Aten, Jason ^b   Toomey, Edward M ^a   Van Nas, Atila ^a   Wang, Susanna ^a   Drake, Thomas A ^a   Lusis, Aidons J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bayesian networks; Correlation coefficients; Genetics; Genomics; Principal components; Proteomics; Quantitative trait locus mapping; Systems biology; Transgenic mice

Indexed keywords

ALLELE; ATHEROGENESIS; ATHEROSCLEROSIS; DISEASE MODEL; GENE EXPRESSION; GENE INTERACTION; GENE SEQUENCE; GENETIC RECOMBINATION; HEREDITY; HUMAN; KNOCKOUT MOUSE; MATHEMATICAL MODEL; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTEOMICS; QUANTITATIVE TRAIT LOCUS MAPPING; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TECHNOLOGY; TRANSCRIPTOMICS; TRANSGENIC MOUSE; ANIMAL; ARTERIOSCLEROSIS; GENOMICS; METHODOLOGY; SYSTEMS BIOLOGY;

ANIMALS; ARTERIOSCLEROSIS; GENE EXPRESSION; GENOMICS; HUMANS; PROTEOMICS; SYSTEMS BIOLOGY;

EID: 22244454728     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.R400006-JLR200     Document Type: Review

References (76)

1. Lusis, A. J., R. Mar, and P. Pajukanta. 2004. Genetics of atherosclerosis. Annu. Rev. Genet. In press.
2. Lusis, A. J., A. M. Fogelman, and G. Fonarow. 2004. Genetic basis of atherosclerosis: new genes and pathways. Circulation. In press.
3. Horikawa, Y., N. Oda, N. J. Cox, X. Li, M. Orho-Melander, M. Hara, Y. Hinokio, T. H. Lindner, H. Mashima, P. E. Schwarz, L. del Bosque-Plata, Y. Oda, I. Yoshiuchi, S. Colilla, K. S. Polonsky, S. Wei, P. Concannon, N. Iwasaki, J. Schulze, L. J. Baier, C. Bogardus, L. Groop, E. Boerwinkle, C. L. Hanis, and G. I. Bell. 2000. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26: 163-175.
4. Botstein, D., and N. Risch. 2003. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 33 (Suppl): 228-237.
5. Ozaki, K., Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, M. Hori, Y. Nakamura, and T. Tanaka. 2002. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat. Genet. 32: 650-654.
6. Williams, S. M., J. L. Haines, and J. H. Moore. 2004. The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings? Bioessays. 26: 170-179.
7. Qin, M., Z. Zeng, J. Zheng, P. K. Shah, S. M. Schwartz, L. D. Adams, and B. G. Sharifi. 2003. Suppression subtractive hybridization identifies distinctive expression markers for coronary and internal mammary arteries. Arierioscler. Thromb. Vasc. Biol. 23: 425-433.
8. Johnson, C. D., Y. Balagurunathan, K. P. Lu, M. Tadesse, M. H. Falahatpisheh, R. J. Carroll, E. R. Dougherty, C. A. Afshari, and K. S. Ramos. 2003. Genomic profiles and predictive biological networks in oxidant-induced atherogenesis. Physiol. Genomics. 13: 263-275.
9. Shi, W., X. Wang, K. Tangchitpiyanond, J. Wong, Y. Shi, and A. J. Lusis. 2002. Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrow. Arterioscler. Thromb. Vasc. Biol. 22: 650-655.
10. Stryke, D., M. Kawamoto, C. C. Huang, S.J. Johns, L. A. King, C. A. Harper, E. C. Meng, R. E. Lee, A. Yee, L. L'Italien, P. T. Chuang, S. G. Young, W. C. Skarnes, P. C. Babbitt, and T. E. Ferrin. 2003. Baygenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 31: 278-281.
11. Peterfy, M., J. Phan, P. Xu, and K. Reue. 2001. Lipodystrophy in the fid mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27: 121-124.
12. Kile, B. T., T. E. Hentges, A. T. Clark, H. Nakamura, A. P. Salinger, B. Liu, N. Box, D. W. Stockton, R. L. Johnson, R. R. Behringer, A. Bradley, and M. J. Justice. 2003. Functional genetic analysis of mouse chromosome 11. Nature. 425: 81-86.
13. Geary, R. L., J. M. Wong, A. Rossini, S. M. Schwartz, and L. D. Adams. 2002. Expression profiling identifies 147 genes contributing to a unique primate neointimal smooth muscle cell phenotype. Arterioscler. Thromb. Vasc. Biol. 22: 2010-2016.
14. Stoehr, J. P., J. E. Byers, S. M. Clee, H. Lan, I. V. Boronenkov, K. L. Schueler, B. S. Yandell, and A. D. Attie. 2004. Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes. 53: 245-249.
15. Stoll, M., A. W. Cowley, Jr., P. J. Tonellato, A. S. Greene, M. L. Kaldunski, R. J. Roman, P. Dumas, N. J. Schork, Z. Wang, and H. J. Jacob. 2001. A genomic-systems biology map for cardiovascular function. Science. 294: 1723-1726.
16. Allayee, H., A. Ghazalpour, and A. J. Lusis. 2003. Using mice to dissect genetic factors in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23:1501-1509.
17. Abiola, O., J. M. Angel, P. Avner, A. A. Bachmanov, J. K. Belknap, B. Bennett, E. P. Blankenhorn, D. A. Blizard, V. Bolivar, G. A. Brockmann, K. J. Buck, J. F. Bureau, W. L. Casley, E. J. Chesler, J. M. Cheverud, G. A. Churchill, M. Cook, J. C. Crabbe, W. E. Crusio, A. Darvasi, G. de Haan, P. Dermant, R. W. Doerge, R. W. Elliot, C. R. Farber, L. Flaherty, J. Flint, H. Gershenfeld, J. P. Gibson, J. Gu, W. Gu, H. Himmelbauer, R. Hitzemann, H. C. Hsu, K. Hunter, F. F. Iraqi, R. C. Jansen, T. E. Johnson, B. C. Jones, G. Kempermann, F. Lammert, L. Lu, K. F. Manly, D. B. Matthews, J. F. Medrano, M. Mehrabian, G. Mittlemann, B. A. Mock, J. S. Mogil, X. Montagutelli, G. Morahan, J. D. Mountz, H. Nagase, R. S. Nowakowski, B. F. O'Hara, A. V. Osadchuk, B. Paigen, A. A. Palmer, J. L. Peirce, D. Pomp, M. Rosemann, G. D. Rosen, L. C. Schalkwyk, Z. Seltzer, S. Settle, K. Shimomura, S. Shou, J. M. Sikela, L. D. Siracusa, J. L. Spearow, C. Teuscher, D. W. Threadgill, L. A. Toth, A. A. Toye, C. Vadasz, G. Van Zant, E. Wakeland, R. W. Williams, H. G. Zhang, and F. Zou. 2003. The nature and identification of quantitative trait loci: a community's view. Nat. Rev. Genet. 4: 911-916.
18. Bodnar, J. S., A. Chatterjee, L. W. Castellani, D. A. Ross, J. Ohmen, J. Cavalcoli, C. Wu, K, M. Dains, J. Catanese, M. Chu, S. S. Sheth, K. Charugundla, P. Demant, D. B. West, P. de Jong, and A. J. Lusis. 2002. Positional cloning of the combined hyperlipidemia gene Hyplipl. Nat. Genet. 30:110-116.
19. Iakoubova, O. A., C. L. Olsson, K. M. Dains, D. A. Ross, A. Andalibi, K. Lau, J. Choi, I. Kalcheva, M. Cunanan, J. Louie, V. Nimon, M. Machrus, L. G. Bentley, C. Beauheim, S. Silvey, J. Cavalcoli, A. J. Lusis, and D. B. West. 2001. Genome-tagged mice (GTM): two sets of genome-wide congenic strains. Genomics. 74: 89-104.
20. Demant, P. 2003. Cancer susceptibility in the mouse: genetics, biology and implications for human cancer. Nat. Rev. Genet. 4: 721-734.
21. Singer, J. B., A. E. Hill, L. C. Burrage, K. R. Olszens, J. Song, M. Justice, W. E. O'Brien, D. V. Conti, J. S. Witte, E. S. Lander, and J. H. Nadeau. 2004. Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 304: 445-448.
22. Grupe, A., S. Germer, J. Usuka, D. Aud, J. K. Belknap, R. F. Klein, M. K. Ahluwalia, R. Higuchi, and G. Peltz. 2001. In silico mapping of complex disease-related traits in mice. Science. 292: 1915-1918.
23. Chesler, E. J., S. L. Rodriguez-Zas, and J. S. Mogil. 2001. In silico mapping of mouse quantitative trait loci. Science. 294: 2423.
24. Darvasi, A. 2001. In silico mapping of mouse quantitative trait loci. Science. 294: 2423.
25. Park, Y. G., R. Clifford, K. H. Buetow, and K. W. Hunter. 2003. Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes. Genome Res. 13: 118-121.
26. Threadgill, D. W., K. W. Hunter, and R. W. Williams. 2002. Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm. Genome. 13: 175-178.
27. Pravenec, M., C. Wallace, T. J. Aitman, and T. W. Kurtz. 2003. Gene expression profiling in hypertension research: a critical perspective. Hypertension. 41: 3-8.
28. Rinn, J. L., J. S. Rozowsky, I. J. Laurenzi, P. H. Petersen, K. Zou, W. Zhong, M. Gerstein, and M. Snyder. 2004. Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev. Cell. 6: 791-800.
29. Aitman, T. J., A. M. Glazier, C. A. Wallace, L. D. Cooper, P. J. Norsworthy, F. N. Wahid, K. M. Al-Majali, P. M. Trembling, C. J. Mann, C. C. Shoulders, D. Graf, E. St. Lezin, T. W. Kurtz, V. Kren, M. Pravenec, A. Ibrahimi, N. A. Abumrad, L. W. Stanton, and J. Scott. 1999. Identification of CD36 (fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat. Genet. 21: 76-83.
30. Karp, C. L., A. Grupe, E. Schadt, S. L. Ewart, M. Keane-Moore, P. J. Cuomo, J. Kohl, L. Wahl, D. Kuperman, S. Germer, D. Aud, G. Peltz, and M. Wills-Karp. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat. Immunol. 1: 221-226.
31. Klein, R. F., J. Allard, Z. Avnur, T. Nikolcheva, D. Rotstein, A. S. Carlos, M. Shea, R. V. Waters, J. K. Belknap, G. Peltz, and E. S. Orwoll. 2004. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science. 303: 229-232.
32. Mootha, V. K., C. M. Lindgren, K. F. Eriksson, A. Subramanian, S. Sihag, J. Lehar, P. Puigserver, E. Carlsson, M. Ridderstrale, E. Laurila, N. Houstis, M. J. Daly, N. Patterson, J. P. Mesirov, T. R. Golub, P. Tamayo, B. Spiegelman, E. S. Lander, J. N. Hirschhorn, D. Altshuler, and L. C. Groop. 2003. Pgc-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34: 267-273.
33. Alban, A., S. O. David, L. Bjorkesten, C. Andersson, E. Sloge, S. Lewis, and I. Currie. 2003. A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics. 3: 36-44.
34. Swatton, J. E., S. Prabakaran, N. A. Karp, K. S. Lilley, and S. Bahn. 2004. Protein profiling of human postmortem brain using two-dimensional fluorescence difference gel electrophoresis (2-D DIGE). Mol. Psychiatry. 9: 128-143.
35. Gavin, A. C., M. Bosche, R. Krause, P. Grandi, M. Marzioch, A. Bauer, J. Schultz, J. M. Rick, A. M. Michon, C. M. Crucial, M. Remor, C. Hofert, M. Schelder, M. Brajenovic, H. Ruffner, A. Merino, K. Klein, M. Hudak, D. Dickson, T. Rudi, V. Gnau, A. Bauch, S. Bastuck, B. Huhse, C. Leutwein, M. A. Heurtier, R. R. Copley, A. Edelmann, E. Querfurth, V. Rybin, G. Drewes, M. Raida, T. Bouwmeester, P. Bork, B. Seraphin, B. Kuster, G. Neubauer, and G. Superti-Furga. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 415: 141-147.
36. Phizicky, E., P. I. Bastiaens, H. Zhu, M. Snyder, and S. Fields. 2003. Protein analysis on a proteomic scale. Nature. 422: 208-215.
37. Watkins, S. M., P. R. Reifsnyder, H. J. Pan, J. B. German, and E. H. Leiter. 2002. Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J. Lipid Res. 43: 1809-1817.
38. Jansen, R. C., and J. P. Nap. 2001. Genetical genomics: the added value from segregation. Trends Genet. 17: 388-391.
39. Jansen, R. C. 2003. Studying complex biological systems using multifactorial perturbation. Nat. Rev. Genet. 4: 145-151.
40. Machleder, D., B. Ivandic, C. Welch, L. Castellani, K. Reue, and A.J. Lusis. 1997. Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism. J. Clin. Invest. 99: 1406-1419.
41. Brem, R. B., G. Yvert, R. Clinton, and L. Kruglyak. 2002. Genetic dissection of transcriptional regulation in budding yeast. Science. 296: 752-755.
42. Lan, H., J. P. Stoehr, S. T. Nadler, K. L. Schueler, B. S. Yandell, and A. D. Attie. 2003. Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics. 164: 1607-1614.
43. Schadt, E. E., S. A. Monks, T. A. Drake, A. J. Lusis, N. Che, V. Colinayo, T. G. Ruff, S. B. Milligan, J. R. Lamb, G. Cavet, P. S. Linsley, M. Mao, R. B. Stoughton, and S. H. Friend. 2003. Genetics of gene expression surveyed in maize, mouse and man. Nature. 422: 297-302.
44. Colinayo, V. V., J. H. Qiao, X. Wang, K. L. Krass, E. Schadt, A. J. Lusis, and T. A. Drake. 2003. Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice. Mamm. Genome. 14: 464-471.
45. Sabatti, C., S. Service, and N. Freimer. 2003. False discovery rate in linkage and association genome screens for complex disorders. Genetics. 164: 829-833.
46. Raychaudhuri, S., J. M. Stuart, and R. B. Altman. 2000. Principal components analysis to summarize microarray experiments: application to sporulation time series. Pac. Symp. Biocomput. 455-466.
47. Xia, X., and Z. Xie. 2001. AMADA: Analysis of microarray data. Bioinformatics. 17: 569-570.
48. Chase, K., D. R. Carrier, F. R. Adler, T. Jarvik, E. A. Ostrander, T. D. Lorentzen, and K. G. Lark. 2002. Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton. Proc. Natl. Acad. Sci. USA. 99: 9930-9935.
49. Costello, T. J., M. D. Swartz, M. Sabripour, X. Gu, R. Sharma, and C. J. Etzel. 2003. Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits (Abstract). BMC Genet. 4 (Suppl. 1): 66.
50. Pociot, F., A. E. Karlsen, C. B. Pedersen, M. Aalund, and J. Nerup. 2004. Novel analytical methods applied to type 1 diabetes genome-scan data. Am. J. Hum. Genet. 74: 647-660.
51. Lucek, P., J. Hanke, J. Reich, S. A. Solla, and J. Ott. 1998. Multilocus nonparametric linkage analysis of complex trait loci with neural networks. Hum. Hered. 48: 275-284.
52. Yoon, Y., J. Song, S. H. Hong, and J. Q. Kim. 2003. Analysis of multiple single nucleotide polymorphisms of candidate genes related to coronary heart disease susceptibility by using support vector machines. Clin. Chem. Lab. Med. 41: 529-534.
53. Zhang, H., C. P. Tsai, C. Y. Yu, and G. Bonney. 2001. Tree-based linkage and association analyses of asthma. Genet. Epidemiol. 21 (Suppl. 1): 317-322.
54. Atkinson, E. J., and M. de Andrade. 2003. Screening the genome to detect an association with hypertension. BMC Genet. 4 (Suppl. 1): 63.
55. Bureau, A., J. Dupuis, B. Hayward, K. Falls, and P. Van Eerdewegh. 2003. Mapping complex traits using random forests. BMC Genet. 4 (Suppl. 1): 64.
56. Chen, C. H., C. J. Chang, W. S. Yang, C. L. Chen, and C. S. Fann. 2003. A genome-wide scan using tree-based association analysis for candidate loci related to fasting plasma glucose levels. BMC Genet. 4 (Suppl. 1): 65.
57. Guo, Z., X. Li, S. Rao, K. L. Moser, T. Zhang, B. Gong, G. Shen, L. Li, R. Cannata, E. Zirzow, E. J. Topol, and Q. Wang. 2003. Multi-variate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches. BMC Genet. 4 (Suppl. 1): 68.
58. Oh, C., K. Q. Ye, Q. He, and N. R. Mendell. 2003. Locating disease genes using Bayesian variable selection with the Haseman-Elston method. BMC Genet. 4 (Suppl. 1): 69.
59. Tahri-Daizadeh, N., D. A. Tregouet, V. Nicaud, N. Manuel, F. Cambien, and L. Tiret. 2003. Automated detection of informative combined effects in genetic association studies of complex traits. Genome Res. 13: 1952-1960.
60. Beaumont, M. A., and B. Rannala. 2004. The Bayesian revolution in genetics. Nat. Rev. Genet. 5: 251-261.
61. Sachs, K., D. Gifford, T. Jaakkola, P. Sorger, and D. A. Lauffenburger. 2002. Bayesian network approach to cell signaling pathway modeling. Sci. STKE. 2002: PE38.
62. Bockhorst, J., M. Craven, D. Page, J. Shavlik, and J. Glasner. 2003. A Bayesian network approach to operon prediction. Bioinformatics. 19: 1227-1235.
63. Savoie, C. J., S. Aburatani, S. Watanabe, Y. Eguchi, S. Muta, S. Imoto, S. Miyano, S. Kuhara, and K. Tashiro. 2003. Use of gene networks from full genome microarray libraries to identify functionally relevant drug-affected genes and gene regulation cascades. DNA Res. 10: 19-25.
64. Green, M. L., and P. D. Karp. 2004. A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases. BMC Bioinformatics. 5: 76.
65. Jensen, F. V. 2001. Bayesian Networks and Decision Graphs. Springer-Verlag, New York.
66. Pearl, J. 1988. Probabilistic Reasoning in Intelligent Systems. Morgan Kaufmann, San Mateo, CA.
67. Pearl, J. 2000. Causality: Models, Reasoning, and Inference. Cambridge University Press, Cambridge, UK.
68. Greenspan, R. J. 2001. The flexible genome. Nat. Rev. Genet. 2: 383-387.
69. Barabasi, A. L., and Z. N. Oltvai. 2004. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5: 101-113.
70. Jeong, H., S. P. Mason, A. L. Barabasi, and Z. N. Oltvai. 2001. Lethality and centrality in protein networks. Nature. 411: 41-42.
71. Ideker, T., V. Thorsson, J. A. Ranish, R. Christmas, J. Buhler, J. K. Eng, R. Bumgarner, D. R. Goodlett, R. Aebersold, and L. Hood. 2001. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science. 292: 929-934.
72. Herrgard, M. J., M. W. Covert, and B. O. Palsson. 2004. Reconstruction of microbial transcriptional regulatory networks. Curr. Opin. Biotechnol. 15: 70-77.
73. Tong, A. H., G. Lesage, G. D. Bader, H. Ding, H. Xu, X. Xin, J. Young, G. F. Berriz, R. L. Brost, M. Chang, Y. Chen, X. Cheng, G. Chua, H. Friesen, D. S. Goldberg, J. Haynes, C. Humphries, G. He, S. Hussein, L. Ke, N. Krogan, Z. Li, J. N. Levinson, H. Lu, P. Menard, C. Munyana, A. B. Parsons, O. Ryan, R. Tonikian, T. Roberts, A. M. Sdicu, J. Shapiro, B. Sheikh, B. Suter, S. L. Wong, L. V. Zhang, H. Zhu, C. G. Burd, S. Munro, C. Sander, J. Rine, J. Greenblatt, M. Peter, A. Bretscher, G. Bell, F. P. Roth, G. W. Brown, B. Andrews, H. Bussey, and C. Boone. 2004. Global mapping of the yeast genetic interaction network. Science. 303: 808-813.
74. Li, S., C. M. Armstrong, N. Bertin, H. Ge, S. Milstein, M. Boxem, P. O. Vidalain, J. D. Han, A. Chesneau, T. Hao, D. S. Goldberg, N. Li, M. Martinez, J. F. Rual, P. Lamesch, L. Xu, M. Tewari, S. L. Wong, L. V. Zhang, G. F. Berriz, L. Jacotot, P. Vaglio, J. Reboul, T. Hirozane-Kishikawa, Q. Li, H. W. Gabel, A. Elewa, B. Baumgartner, D. J. Rose, H. Yu, S. Bosak, R. Sequerra, A. Fraser, S. E. Mango, W. M. Saxton, S. Strome, S. Van Den Heuvel, F. Piano, J. Vandenhaute, C. Sardet, M. Gerstein, L. Doucette-Stamm, K. C. Gunsalus, J. W. Harper, M. E. Cusick, F. P. Roth, D. E. Hill, and M. Vidal. 2004. A map of the interactome network of the metazoan C. elegans. Science. 303: 540-543.
75. Giot, L., J. S. Bader, C. Brouwer, A. Chaudhuri, B. Kuang, Y. Li, Y. L. Hao, C. E. Ooi, B. Godwin, E. Vitols, G. Vijayadamodar, P. Pochart, H. Machineni, M. Welsh, Y. Kong, B. Zerhusen, R. Malcolm, Z. Varrone, A. Collis, M. Minto, S. Burgess, L. McDaniel, E. Stimpson, F. Spriggs, L. Williams, K. Neurath, N. Ioime, M. Agee, E. Voss, K. Furtak, R. Renzulli, N. Aanensen, S. Carrolla, E. Bickelhaupt, Y. Lazovatsky, A. DaSilva, J. Zhong, C. A. Stanyon, R. L. Finley, Jr., K. P. White, M. Braverman, T. Jarvie, S. Gold, M. Leach, J. Knight, R. A. Shimkets, M. P. McKenna, J. Chant, and J. M. Rothberg. 2003. A protein interaction map of Drosophila melanogaster. Science. 302: 1727-1736.
76. Nadeau, J. H., L. C. Burrage, J. Restivo, Y. H. Pao, G. Churchill, and B. D. Hoit. 2003. Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations. Genome Res. 13: 2082-2091.