Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations

Genome Research

Volumn 13, Issue 9, 2003, Pages 2082-2091

  Nadeau, Joseph H ^a,b,c   Burrage, Lindsay C ^a,b,c   Restivo, Joe ^a   Pao, Yoh Han ^b   Churchill, Gary ^d   Hoit, Brian D ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; ANESTHESIA; ARTICLE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE MUTATION; GENETIC TRAIT; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE WALL; HOMEOSTASIS; MOUSE; MOUSE STRAIN; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; SAMPLE SIZE;

ANIMALS; BODY WEIGHT; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; GENETICS, POPULATION; HOMEOSTASIS; MICE; MICE, INBRED A; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MODELS, GENETIC; MULTIFACTORIAL INHERITANCE; QUANTITATIVE TRAIT, HERITABLE; RANDOM ALLOCATION;

EID: 0141742300     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.1186603     Document Type: Article

References (57)

1. Alonso-Blanco, C., Koornneef, M., and Stam, P. 1998. The use of recombinant inbred lines (RILs) for genetic mapping. Methods Mol. Biol. 82: 137-146.
2. Arkin, A., Shen, P., and Ross, J. 1997. A test case for correlation metric construction of a reaction pathway from measurements. Science 277: 1275-1279.
3. Bailey, D.W. 1956. A comparison of genetic and environmental influences on the shape of the axis in mice. Genetics 41: 207-222.
4. Bailey, D.W. 1981. Recombinant inbred strains and bilineal congenic strains. In The mouse in biomedical research, Vol. 1. History, genetics and wild mice (eds. H.L. Foster et al.), pp. 223-239. Academic Press, New York.
5. Brem, R.B., Yvert, G., Clinton, R., and Kruglyak, L. 2002. Genetic dissection of transcriptional regulation in budding yeast. Science 296: 752-755.
6. Butte, A.J., Tamayo, P., Slomin, D., Golub, T.R., and Kohane, I.S. 2000. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc. Natl. Acad. Sci. 97: 12182-12186.
7. Churchill, G.A. and Doerge, R.W. 1994. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-967.
8. Cittadini, A., Mantzoros, C.S., Hampton, T.G., Travers, K.E., Katz, S.E., Morgan, J.P., Flier, J.S., and Douglas, P.S. 1999. Cardiovascular abnormalities in transgenic mice with reduced brown fat: An animal model of human obesity. Circulation 100: 2177-2183.
9. Cureton, E.F. and D'Agostino, R.B. 1983. Factor analysis: An applied approach. Lawrence Erlbaum Associates, Hillsdale, NJ.
10. Darvasi, A. 1998. Experimental strategies for the genetic dissection of complex traits in animal models. Nat. Genet. 18: 19-24.
11. Davidson, E.H., Rast, J.P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C.-H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., et al. 2002. A genomic regulatory network for development. Science 295: 1669-1678.
12. Demant, P. and Hart, A.A. 1986. Recombinant congenic strains-A new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24: 416-422.
13. Desai, K.H., Schauble, W., Luo, W., Kranias, E.G., and Bernstein, D. 1999. Phospholamban deficiency does not compromise exercise capacity. Am. J. Physiol. 276: H1172-H1177.
14. Duda, R.O. and Hart, P.E. 1973. Pattern Classification and Scene Analysis. John Wiley, New York.
15. Eisen, M.B., Spellman, P.T., Brown, P.O., and Botstein, D. 1998. Cluster analysis and display of genome-wide expression data. Proc. Natl. Acad. Sci. 95: 14863-14868.
16. Ernest, S.R., Christiansen, B., Gilfix, B.M., Mamer, O.A., Dunn, P.J., Hosack, A., Rodier, M., Colmenares, C., McGrath, J., Bale, A., et al. 2002. Genetic, molecular and physiological control of folate and homocysteine metabolism in mutant mice. Mamm. Genome 13: 259-268.
17. Festing, M.F.W. 1996. Origins and characteristics of inbred strains of mice. In Genetic variants and strains of the laboratory mouse, 3rd ed. (eds. M.F. Lyon et al.), pp. 1537, 1544-1545. Oxford University Press, Oxford, UK.
18. Fisher, R.A. 1935. The design of experiments. Oliver and Boyd, Edinburgh, U.K.
19. Fortin, A., Diez, E., Rochefort, D., Laroche, L., Malo, D., Rouleau, G.A., Gros, P., and Skamene, E. 2001. Recombinant congenic strains derived from A/J and C57BL/6J: A tool for genetic dissection of complex traits. Genomics 74: 21-35.
20. Gilman, A. and Arkin, A.P. 2002. Genetic 'code': Representation and dynamical models of genetic components and networks. Annu. Rev. Genomics Hum. Genet. 3: 341-369.
21. Guyton, A.C., Coleman, T.G., and Granger, H.J. 1972. Circulation: Overall regulation. Annu. Rev. Physiol. 34: 13-46.
22. Hoit, B.D. and Nadeau, J.H. 2001. Phenotype-driven genetic approaches in mice: High-throughput phenotyping for discovering new models of cardiovascular disease. Trends Cardiovasc. Med. 11: 82-89.
23. Hoit, B.D., Kiatchoosakun, S., Restivo, J., Kirkpatrick, D., Olszens, K., Shao, H., Pao, Y.-H., and Nadeau, J.H. 2002. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics 79: 679-685.
24. Huang, W., Sher, Y.P., Peck, K., and Fung, Y.C. 2002. Matching gene activity with physiological functions. Proc. Natl. Acad. Sci. 99: 2603-2608.
25. Hughes, T.R., Marton, M.J., Jones, A.R., Roberts, C.J., Stoughton, R., Armour, C.D., Bennett, H.A., Coffey, E., Dai, H., He, Y.D., et al. 2000. Functional discovery via a compendium of expression profiles. Cell 102: 109-126.
26. Ideker, T., Galitski, T., and Hood, L. 2001a. A new approach to decoding life: Systems biology. Annu. Rev. Genomics Hum. Genet. 2: 343-372.
27. Ideker, T., Thorsson, V., Ranish, J.A., Christmas, R., Buhler, J., Eng, J.K., Bumgarner, R., Goodlett, D.R., Aebersold, R., and Hood, L. 2001b. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292: 929-934.
28. Jansen, R.C. and Nap, J.P.H. 2001. Genetical genomics: The benefit from segregation. Trends Genet. 17: 388-391.
29. Kiatchoosakun, S., Kirkpatrick, D., and Hoit, B.D. 2001. Effects of tribromoethanol anesthesia on echocardiographic assessment of left ventricular function in mice. Comp. Med. 51: 26-29.
30. Kitano, H. 2001. Systems biology: Towards system-level understanding of biological systems. In Foundations of systems biology (ed. H. Kitano), pp. 1-36. MIT Press, Cambridge, MA.
31. Kitano, H. 2002. Systems biology: A brief overview. Science 295: 1662-1664.
32. Klose, J., Nock, C., Herrmann, M., Stuhler, K., Marcus, K., Bluggel, M., Krause, E., Schalkwyk, L.C., Rastan, S., Brown, S.D.M., et al. 2002. Genetic analysis of the mouse proteome. Nat. Genet. 30: 385-393.
33. Kren, V., Pravenec, M., Bila, V., Krenova, D., Zidek, V., Simakova, M., and Printz, M. 1999. Rat congenic and recombinant inbred strains: A genetic model for the study of quantitative trait loci. Transplant. Proc. 31: 1592-1593.
34. Li, C.C. 1975. Path analysis: A primer. Boxwood Press, Pacific Grove, CA.
35. Lilly, L.S. 1993. Pathophysiology of heart disease. Lippincott, Williams and Wilkins, New York.
36. Nadeau, J.H., Arbuckle, L.D, and Skamene, E. 1995. Genetic dissection of inflammatory responses. J. Inflammation 45: 27-48.
37. Nadeau, J.H., Singer, J.B., Martin, A., and Nadeau, J.H. 2000. Analyzing complex genetic traits with chromosome substitution strains. Nat. Genet. 24: 221-225.
38. Noble, D. 2002. Modeling the heart-From genes to cells to the whole organism. Science 295: 1678-1682.
39. Paigen, K. and Eppig, J.T. 2000. A mouse phenome project. Mamm. Genome. 11: 715-717.
40. Prows, D.R. and Horner, M.L. 2002. Parental genetic contributions in the AXB/BXA recombinant inbred mouse strains. Mamm. Genome 13: 123-133.
41. Ramoni, M.F., Sebastiani, P., and Kohane, I.S. 2002. Cluster analysis of gene expression dynamics. Proc. Natl. Acad. Sci. 99: 9121-9126.
42. Rao, D.C. 2000. The future of path analysis, segregation analysis, and combined models for genetic dissection of complex traits. Hum. Hered. 50: 34-42.
43. Sampson, S.B., Higgins, D.C., Elliot, R.W., Taylor, B.A., Lueders, K.K., Koza, R.A., and Paigen, B. 1998. An edited linkage map of the AXB and BXA recombinant inbred mouse strains. Mamm. Genome 9: 688-694.
44. Schmidt, A.G., Kadambi, V.J., Ball, N., Sato, Y., Walsh, R.A., Kranias, E.G., and Hoit, B.D. 2000. Cardiac-specific overexpression of calsequestrin results in left ventricular hypertrophy, depressed force-frequency relation and pulsus alternans in vivo. J. Mol. Cell. Cardiol. 32: 1735-1744.
45. Segre, D., Vitkup, D., and Church, G.M. 2002. Analysis of optimality in natural and perturbed metabolic networks. Proc. Natl. Acad. Sci. 99: 15112-15117.
46. Steinmetz, L.M., Sinha, H., Richards, D.R., Spiegelman, J.I., Oefner, P.J., McCusker, J.H., and Davis, R.W. 2002. Dissecting the architecture of a quantitative trait locus in yeast. Nature 416: 326-330.
47. Stevens, J. 1986. Applied multivariate statistics for the social science. Lawrence Erlbaum Assoc., Hillsdale, NJ.
48. Stoll, M., Cowley, A.W., Tonellato, P.J., Greene, A.S., Kaldunski, M.L., Roman, R.J., Dumas, P., Schork, N.J., Wang, Z., and Jacob, H.J. 2001. A genomic-systems biology map for cardiovascular function. Science 294: 1723-1726.
49. Taylor, B.A. 1996. Recombinant inbred strains. In Genetic variants and strains of the laboratory mouse (eds. M.F. Lyon et al.), pp. 1597-1659. Oxford University Press, Oxford, UK.
50. Thompson, W.R. 1957. Traits, factors and genes. Eugenics Quart. 4: 8-16.
51. Toh, H., and Horimoto, K. 2002. Inference of a genetic network by a combined approach of cluster analysis and graphical Gaussian modeling. Bioinformatics 18: 287-297.
52. Vatner S.F., Takagi, G., Asai, K., and Shannon R.P. 2002. Cardiovascular physiology in mice: Conscious measurements and effects of anesthesia. In Cardiovascular physiology in the genetically engineered mouse (eds. B.D. Hoit and R.A. Walsh), pp. 257-275. Kluwer Academic Publishing, Boston, MA.
53. von Bertalanffy, L. 1969. General system theory, foundations, development, applications. George Braziller, New York.
54. Wagner, A. 2001. How to construct a large genetic network from n gene perturbations in fewer than n2 easy steps. Bioinformatics 17: 1183-1197.
55. Wakasaki, H., Koya, D., Schoen, F.J., Jirousek, M.R., Ways, D.K., Hoit, B.D., Walsh, R.A., and King, G.L. 1999. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc. Natl. Acad. Sci. 94: 9320-9325.
56. Wright, S. 1921. Correlation and causation. J. Agric. Res. 20: 557-585.
57. Wright, S. 1978. Evolution and the genetics of populations. Variability within and among natural populations. Vol. 4, pp. 382-388. University of Chicago Press, Chicago, IL.