Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism

Journal of Clinical Investigation

Volumn 99, Issue 6, 1997, Pages 1406-1419

  Machleder, Dietrich ^a   Ivandic, Boris ^a   Welch, Carrie ^a   Castellani, Lawrence ^a   Reue, Karen ^b   Lusis, Aldons J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

aortic fatty streak lesions; Ath 1; cholesterol 7 alpha hydroxylase; cholic acid; linkage analysis; quantitative trait loci

Indexed keywords

APOLIPOPROTEIN A2; CHOLESTEROL 7ALPHA MONOOXYGENASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; ATHEROGENIC DIET; BILE ACID METABOLISM; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 1; CHROMOSOME 11; CHROMOSOME 3; CHROMOSOME 5; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; INBRED STRAIN; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

EID: 0030893854     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119300     Document Type: Article

References (58)

1. Paigen, B., D. Mitchell, K. Reue, A. Morrow, A.J. Lusis, and R.C. LeBoeuf. 1987. Ath-l, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc. Natl. Acad. Sci. USA. 84:3763-3767.
2. Paigen, B., B.Y. Ishida, J. Verstuyft, R.B. Winters, and D. Albee. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis. 10:316-323.
3. Stewart-Phillips, J.L., J. Lough, and E. Skamene. 1989. Ath-3, a new gene for atherosclerosis in the mouse. Clin. Invest. Med. 12:121-126.
4. Nishina, P.M., J. Wang, W. Toyofuku, F.A. Kuypers, B.Y. Ishida, and B. Paigen. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids. 28:599-605.
5. Paigen, B. 1995. Genetics of responsiveness to high fat and high cholesterol diets in the mouse. Am. J. Clin. Nutr. 62:258S-462S.
6. LeBoeuf, R.C., M.H. Doolittle, A. Montcalm, D.C. Martin, K. Reue, and A.J. Lusis. 1990. Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis. J. Lipid Res. 31: 91-101.
7. Purcell-Huynh, D.A., A. Weinreb, L.W. Castellani, M. Mehrabian, M.H. Doolittle, and A.J. Lusis. 1995. Genetic factors in lipoprotein metabolism: analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach. J. Clin. Invest. 96:1845-1858.
8. Jelinek, D.F., S. Andersson, C.A. Slaughter, and D.W. Russell. 1990. Cloning and regulation of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265:8190-8197.
9. Wei, J.S., H.M. Huang, W.C. Shyu, and C.S. Wu. 1989. Simple enzymatic determination of total cholesterol in gallstones. Clin. Chem. 35:2247-2249.
10. Warden, C.H., J.S. Fisler, S.M. Shoemaker, P.-Z. Wen, K.L. Svenson, M.J. Pace, and A.J. Lusis. 1995. Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J. Clin. Invest. 95:1545-1552.
11. Dietrich, W., H. Katz, S.E. Lincoln, H.-S. Shin, J. Friedman, N.C. Dracopoli, and E.S. Lander. 1992. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 131:423-147.
12. Ivandic, B., J.-H. Qiao, D. Machleder, F. Liao, T. Drake, and A.J. Lusis. 1996. A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Proc. Natl. Acad. Sci. USA. 93: 5483-5488.
13. Manly, K.F. 1993. A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm. Genome. 4:303-313.
14. Map Manager home page: http://mcbio.med.buffalo.edu/mapmgr.html
15. Lander, E.S., P. Green, J. Abrahamson, A. Barlow, M. Daley, S. Lincoln, and L. Newburg. 1987. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1:174-181.
16. Churchill, G.A., and R.W. Doerge. 1994. Empirical threshold values for quantitative trait mapping. Genetics. 138:963-971.
17. Welch, C.L., Y.-R. Xia, I. Shechter, R. Farese, M. Mehrabian, S. Mehdizadeh, C.H. Warden, and A.J. Lusis. 1996. Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J. Lipid Res. 37: 1406-1421.
18. Mehrabian, M., J.-H. Qiao, R.H. Hyman, D. Ruddle, C. Laughton, and A.J. Lusis. 1993. Influence of the ApoA-II gene locus on HDL levels and fatty streak development in mice. Arterioscler. Thromb. 13:1-10.
19. Ott, J. 1991. Basic genetics and cytogenetics In Analysis of Human Genetic Linkage. Johns Hopkins University Press, Baltimore, MD. 10-17.
20. Lander, E.S., and N.J. Schork. 1994. Genetic dissection of complex trails. Science (Wash. DC). 265:2037-2048.
21. Doolittle, M.H., R.C. LeBoeuf, C.H. Warden, L.M. Bee, and A.J. Lusis. 1990. A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition. J. Biol. Chem. 265: 16380-16388.
22. Warden, C. H., C. C. Hedrick, J.H. Oiao, L.W. Castellani, and A.J. Lusis. 1993. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science (Wash. DC). 261:469-472.
23. 4 isomerase are closely linked on mouse chromosome 3. Genomics. 16:219-223.
24. McBride, M.W., A.J. Russell, K. Vass, V. Foster, S.M. Burridge, N. Morrison, E. Boyd, B.A.J. Ponder, and R.G. Sutcliffe. 1995. New members of the 3β-hydroxysteroid dehydrogenase gene family. Mol. Cell. Probes. 9:121-128.
25. Chiang, J.Y.L., and D. Stroup. 1994. Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter. J. Biol. Chem. 269:17502-17507.
26. Cohen, J.C., J.J. Cali, D.F. Jelinek, M. Mehrabian, R.S. Sparkes, A.J. Lusis, D.W. Russell, and H.H. Hobbs. 1992. Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12. Genomics. 14:153-161.
27. Mouse Genome Database. 1995. Mouse Genome Informatics Project. The Jackson Laboratory, Bar Harbor, ME. http://www.informatics.jax.org.
28. Dueland, S., J. Drisko, L. Graf, D. Machleder, A.J. Lusis, and R.A. Davis. 1993. Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice. J. Lipid Res. 34: 923-931.
29. Lusis, A.J., B.A. Taylor, R.W. Wangenstein, and R.C. LeBoeuf. 1983. Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J. Biol. Chem. 258:5071-5078.
30. Hedrick, C.C., L.W. Castellani, C.H. Warden, D.L. Puppione, and A.J. Lusis. 1993. Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J. Biol. Chem. 268:20676-20682.
31. Liao, F., A. Andalibi, J.H. Qiao, H. Allayee, A.M. Fogelman, and A.J. Lusis. 1994. Genelic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aorlic fatty streak formation in mice. J. Clin. Invest. 94:877-884.
32. Hyman, R.W., S. Frank, C.H. Warden, A. Daluiski, R. Heller, and A.J. Lusis. 1994. Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice. Biochem. Genet. 32:397-407.
33. Shih, D.M., L. Gu, S. Hama, Y. Xia, M. Navab, A.M. Fogelman, and A.J. Lusis. 1996. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. J. Clin. Invest. 97:1630-1639.
34. Hardon, E.M., M. Frain, G. Paonessa, and R. Cortese. 1988. Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO (Eur. Mol. Biol. Org.) J. 7:1711-1719.
35. Meitus-Snyder, M., F.M. Sladek, G.S. Ginsburg, C.F. Kuo, J.A.A. Ladias, J.E. Darnell, Jr., and S.K. Karathanasis. 1992. Antagonism between apolipoprotien AI regulatory protein 1 Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol. Cell. Biol. 12:1708-1718.
36. Chan, J., H. Nakabayashi, and N.C.W. Wong. 1993. HNF-4 increases activity of the rat apo AI gene. Nuc. Acids Res. 21:1205-1211.
37. Zhong, W., J. Mirkovitch, and J.E. Darnell, Jr. 1994. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol. Cell. Biol. 14: 7276-7284.
38. Poorman, J.A., R.A. Buck, S.A. Smith, M.L. Overturf, and D.S. Loose-Mitchell. 1993. Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits. J. Lipid Res. 34:1675-1685.
39. Overturf, M.L., S.A. Smith, A.M. Gotto, Jr., J.D. Morrisett, T. Tewson, J. Poorman, and D.S. Loose-Mitchell. 1990. Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. J. Lipid Res. 31:2019-2027.
40. Loose-Mitchell, D.S., J. A. Poorman, S.A. Smith, M.L. Overturf, J.D. Morrisett, and A.M. Gotto, Jr., M.R. Soma. 1991. Cholesterol metabolism in hypercholesterolemia-resistant rabbits. Atherosclerosis. 87:169-181.
41. Muller, K.R., J.R. Li, D.M. Dinh, and M.T. Subbiah. 1979. The characteristics and metabolism of a genetically hypercholesterolemic strain of rats (RICO). Biochim.Biophys. Acta. 574:334-343.
42. Spady, D.K., J.A. Cuthbert, M.N. Willard, and R.S. Meidell. 1995. Adenovirus-mediated transfer of a gene encoding cholesterol 7 alpha-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J. Clin. Invest. 96:700-709.
43. Paigen, B., A. Morrow, C. Brandon, D. Mitchell, and P. Holmes. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis. 57:65-73.
44. Carrella, M., S. Ericsson, C. Del Piano, B. Angelin, and K. Einarsson. 1991. Effect of cholestyramine treatment on biliary lipid secretion rates in normolipidaemic men. J. Int. Med. 229:241-246.
45. Einarsson, K., S. Ericsson, S. Ewerth, E. Reihner, M. Rudling, D. Stahlberg, and B. Angelin. 1991. Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism. Eur. J. Clin. Pharm. 40:S53-S58.
46. Reihner, E., B. Angelin, M. Rudling, S. Ewerth, I. Bjorkhem, and K. Einarsson. 1990. Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients. J. Lipid Res. 31: 2219-2226.
47. Hueman, D.M., Z.R. Vlahcevic, M.L. Bailey, and P.B. Hylemon. 1988. Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat. Hepatology. 8:892-897.
48. Hwa, J.J., S. Zollman, C.H. Warden, B.A. Taylor, P.A. Edwards, A.M. Fogelman, and A.J. Lusis. 1992. Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression. J. Lipid Res. 33:711-725.
49. Ishibashi, S., M. Schwarz, P.K. Frykman, J. Herz, and D.W. Russell. 1996. Disruption of cholesterol 7 alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. J. Biol. Chem. 271: 18071-18023.
50. Schwarz, M., E.G. Lund, K.D.R. Setchell, H.J. Kayden, J.E. Zerwekh, I. Bjorkhem, J. Herz, and D.W. Russell. 1996. Disruption of cholesterol 7 alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7 alpha-hydroxylase. J. Biol. Chem. 271:18024-18031.
51. Nishina, P.M., J. Verstuyft, and B. Paigen. 1990. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31:859-869.
52. Chijiiwa, K., I. Hirota, and H. Noshiro. 1993. High vesicular cholesterol and protein in bile are associated with formation of cholesterol but not pigment gallstones. Dig. Dis. Sci. 38:161-166.
53. Heaton, K.W., and A.E. Read. 1969. Gallstones in patients with disorders of the terminal ileum and disturbed bile salt metabolism. Br. Med. J. 3:494-496.
54. Nestel, P.J., and A. Poyser. 1976. Changes in cholesterol synthesis and excretion when cholesterol intake is increased. Metabolism. 25:1591-1599.
55. Lindblad, L., K. Lundholm, and T. Schersten. 1977. Influence of cholic and chenodeoxycholic acid on biliary cholesterol secretion in man. Eur. J. Clin. Invest. 7:383-388.
56. Ito, T., S. Kawata, Y. Imai, H. Kakimoto, J.M. Trazaskos, and Y. Matsuzawa. 1996. Hepatic cholesterol metabolism in patients with cholesterol gallstone: enhanced intracellular transport of cholesterol. Gastroenterology. 110: 1619-1627.
57. Vlahcevic, Z.R., C.C. Bell, Jr., I. Buhac, J.T. Farrar, and L. Swell. 1970. Diminished bile acid pool size in patients with gallstones. Gastroenterology. 59: 165-173.
58. Khanuja, B., Y-C. Cheah, M. Hunt, P.M. Nishina, D.Q.-H. Wang, H.W. Chen, J.T. Billheimer, M.C. Carey, and B. Paigen. 1995. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc. Natl. Acad. Sci. USA. 92:7729-7733.