-
1
-
-
0023849455
-
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
-
M. Kawano T. Hirano T. Matsuda et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas Nature 332 1988 83-85
-
(1988)
Nature
, vol.332
, pp. 83-85
-
-
Kawano, M.1
Hirano, T.2
Matsuda, T.3
-
2
-
-
0024503249
-
Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
-
B. Klein X.G. Zhang M. Jourdan et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6 Blood 73 1989 517-526
-
(1989)
Blood
, vol.73
, pp. 517-526
-
-
Klein, B.1
Zhang, X.G.2
Jourdan, M.3
-
3
-
-
0035863942
-
Autocrine interleukin-6 production and highly malignant multiple myeloma: Relation with resistance to drug-induced apoptosis
-
M.A. Frassanito A. Cusmai G. Iodice & F. Dammacco Autocrine interleukin-6 production and highly malignant multiple myeloma: Relation with resistance to drug-induced apoptosis Blood 97 2001 483-489
-
(2001)
Blood
, vol.97
, pp. 483-489
-
-
Frassanito, M.A.1
Cusmai, A.2
Iodice, G.3
Dammacco, F.4
-
4
-
-
0028936861
-
CD40 ligand triggered interleukin-6 secretion in multiple myeloma
-
M. Urashima D. Chauhan H. Uchiyama et al. CD40 ligand triggered interleukin-6 secretion in multiple myeloma Blood 85 1995 1903-1912
-
(1995)
Blood
, vol.85
, pp. 1903-1912
-
-
Urashima, M.1
Chauhan, D.2
Uchiyama, H.3
-
5
-
-
0027133422
-
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates IL-6 secretion
-
H. Uchiyama B.A. Barut A.F. Mohrbacher et al. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates IL-6 secretion Blood 82 1993 3712-3720
-
(1993)
Blood
, vol.82
, pp. 3712-3720
-
-
Uchiyama, H.1
Barut, B.A.2
Mohrbacher, A.F.3
-
6
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
-
D. Chauhan H. Uchiyama Y. Akbarali et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB Blood 87 1996 1104-1112
-
(1996)
Blood
, vol.87
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
-
7
-
-
0035195019
-
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
-
D. Gupta S.P. Treon Y. Shima et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications Leukemia 15 2001 1561-1950
-
(2001)
Leukemia
, vol.15
, pp. 1561-1950
-
-
Gupta, D.1
Treon, S.P.2
Shima, Y.3
-
8
-
-
0030026437
-
Transforming growth factor b1: Differential effects on multiple myeloma versus normal B cells
-
M. Urashima A. Ogata D. Chauhan et al. Transforming growth factor b1: differential effects on multiple myeloma versus normal B cells Blood 87 1996 1928-1938
-
(1996)
Blood
, vol.87
, pp. 1928-1938
-
-
Urashima, M.1
Ogata, A.2
Chauhan, D.3
-
9
-
-
0035958517
-
Role of TNF-α in the pathophysiology of human multiple myeloma: Therapeutic applications
-
T. Hideshima D. Chauhan R.L. Schlossman et al. Role of TNF-α in the pathophysiology of human multiple myeloma: Therapeutic applications Oncogene 20 2001 4519-4527
-
(2001)
Oncogene
, vol.20
, pp. 4519-4527
-
-
Hideshima, T.1
Chauhan, D.2
Schlossman, R.L.3
-
10
-
-
0034655957
-
Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
-
B. Dankbar T. Padro R. Leo et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma Blood 95 2000 2630-2636
-
(2000)
Blood
, vol.95
, pp. 2630-2636
-
-
Dankbar, B.1
Padro, T.2
Leo, R.3
-
11
-
-
0032428364
-
Interleukin-1 in multiple myeloma: Producer cells and their role in the control of IL-6 production
-
V. Costes M. Portier Z.Y. Lu Interleukin-1 in multiple myeloma: Producer cells and their role in the control of IL-6 production Br J Haematol 103 1998 1152-1160
-
(1998)
Br. J. Haematol.
, vol.103
, pp. 1152-1160
-
-
Costes, V.1
Portier, M.2
Lu, Z.Y.3
-
12
-
-
18544367201
-
NF-κB as a therapeutic target in multiple myeloma
-
T. Hideshima D. Chauhan P. Richardson et al. NF-κB as a therapeutic target in multiple myeloma J Biol Chem 277 2002 16639-16647
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
-
13
-
-
0037438374
-
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu
-
T. Hideshima M. Akiyama T. Hayashi et al. Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu Blood 101 2003 703-705
-
(2003)
Blood
, vol.101
, pp. 703-705
-
-
Hideshima, T.1
Akiyama, M.2
Hayashi, T.3
-
14
-
-
9944242716
-
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
-
Hideshima T, Podar K, Chauhan D, et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 2004; 23: 8766-8776.
-
(2004)
Oncogene
, vol.23
, pp. 8766-8776
-
-
Hideshima, T.1
Podar, K.2
Chauhan, D.3
-
15
-
-
9344245148
-
TGF-β receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
-
Hayashi T, Hideshima T, Nguyen AN, et al. TGF-β receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res 2004; 10: 7540-7546.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7540-7546
-
-
Hayashi, T.1
Hideshima, T.2
Nguyen, A.N.3
-
16
-
-
0037385313
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
N.N. Iwakoshi A.H. Lee P. Vallabhajosyula et al. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 Nat Immunol 4 2003 321-329
-
(2003)
Nat. Immunol.
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
-
17
-
-
0024832002
-
Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias
-
R. Bataille M. Jourdan X.G. Zhang & B. Klein Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias J Clin Invest 84 1989 2008-2011
-
(1989)
J. Clin. Invest.
, vol.84
, pp. 2008-2011
-
-
Bataille, R.1
Jourdan, M.2
Zhang, X.G.3
Klein, B.4
-
18
-
-
0025875857
-
Interleukin-6 is a prognostic factor in multiple myeloma
-
H. Ludwig D.M. Nachbaur E. Fritz et al. Interleukin-6 is a prognostic factor in multiple myeloma Blood 77 1991 2794-2795
-
(1991)
Blood
, vol.77
, pp. 2794-2795
-
-
Ludwig, H.1
Nachbaur, D.M.2
Fritz, E.3
-
19
-
-
0037085809
-
Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6
-
H. Ishikawa N. Tsuyama S. Abroun et al. Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 Blood 15 2002 2172-2178
-
(2002)
Blood
, vol.15
, pp. 2172-2178
-
-
Ishikawa, H.1
Tsuyama, N.2
Abroun, S.3
-
20
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
T. Taga M. Hibi Y. Hirata et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 58 1989 573-581
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
-
21
-
-
0028344845
-
Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130
-
N. Nishimoto A. Ogata Y. Shima et al. Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130 J Exp Med 179 1994 1343-1347
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1343-1347
-
-
Nishimoto, N.1
Ogata, A.2
Shima, Y.3
-
22
-
-
0029052318
-
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association
-
T. Matsuda T. Fukada M. Takahashi-Tezuka et al. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association J Biol Chem 270 1995 11037-11039
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11037-11039
-
-
Matsuda, T.1
Fukada, T.2
Takahashi-Tezuka, M.3
-
23
-
-
0033083941
-
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
-
I. Kurth U. Horsten S. Pflanz et al. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes J Immunol 162 1999 1480-1487
-
(1999)
J. Immunol.
, vol.162
, pp. 1480-1487
-
-
Kurth, I.1
Horsten, U.2
Pflanz, S.3
-
24
-
-
0031225483
-
Interleukin-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade
-
A. Ogata D. Chauhan G. Teoh et al. Interleukin-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade J Immunol 159 1997 2212-2221
-
(1997)
J. Immunol.
, vol.159
, pp. 2212-2221
-
-
Ogata, A.1
Chauhan, D.2
Teoh, G.3
-
25
-
-
0030948787
-
Blockade of mitogen-activated protein kinase cascade signaling in interleukin-6 independent multiple myeloma cells
-
A. Ogata D. Chauhan M. Urashima et al. Blockade of mitogen-activated protein kinase cascade signaling in interleukin-6 independent multiple myeloma cells Clin Cancer Res 3 1997 1017-1022
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1017-1022
-
-
Ogata, A.1
Chauhan, D.2
Urashima, M.3
-
26
-
-
0032984589
-
Constitutive activation of STAT-3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
R. Catlett-Falcone T.H. Landowski M.M. Oshiro et al. Constitutive activation of STAT-3 signaling confers resistance to apoptosis in human U266 myeloma cells Immunity 10 1999 105-115
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
27
-
-
0032711250
-
IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
-
D. Puthier R. Bataille & M. Amiot IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway Eur J Immunol 29 1999 3945-3950
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3945-3950
-
-
Puthier, D.1
Bataille, R.2
Amiot, M.3
-
28
-
-
0035678875
-
Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells
-
M.M. Oshiro T.H. Landowski R. Catlett-Falcone et al. Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells Clin Cancer Res 7 2001 4262-4271
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 4262-4271
-
-
Oshiro, M.M.1
Landowski, T.H.2
Catlett-Falcone, R.3
-
29
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
A. Brunet A. Bonni M.J. Zigmond et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 1999 857-868
-
(1999)
Cell
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
30
-
-
0033961280
-
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
-
L.V. Madrid C.Y. Wang D.C. Guttridge et al. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB Mol Cell Biol 20 2000 1626-1638
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 1626-1638
-
-
Madrid, L.V.1
Wang, C.Y.2
Guttridge, D.C.3
-
31
-
-
0035379555
-
Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38
-
L.V. Madrid M.W. Mayo J.Y. Reuther & A.S. Baldwin Jr Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38 J Biol Chem 276 2001 18934-18940
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18934-18940
-
-
Madrid, L.V.1
Mayo, M.W.2
Reuther, J.Y.3
Baldwin Jr., A.S.4
-
32
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
D.P. Brazil J. Park & B.A. Hemmings PKB binding proteins. Getting in on the Akt Cell 111 2002 293-303
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
33
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
I. Vivanco & C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489-501
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
34
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655-1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
35
-
-
0037207872
-
Nuclear factor-κB p65 mediates tumor necrosis factor α-induced nuclear translocation of telomerase reverse transcriptase protein
-
M. Akiyama T. Hideshima T. Hayashi et al. Nuclear factor-κB p65 mediates tumor necrosis factor α-induced nuclear translocation of telomerase reverse transcriptase protein Cancer Res 63 2003 18-21
-
(2003)
Cancer Res.
, vol.63
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
-
36
-
-
0035921689
-
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
-
T. Hideshima N. Nakamura D. Chauhan & K.C. Anderson Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma Oncogene 20 2001 5991-6000
-
(2001)
Oncogene
, vol.20
, pp. 5991-6000
-
-
Hideshima, T.1
Nakamura, N.2
Chauhan, D.3
Anderson, K.C.4
-
37
-
-
0031029911
-
Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
-
D. Chauhan S. Kharbanda A. Ogata et al. Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells Blood 89 1997 227-234
-
(1997)
Blood
, vol.89
, pp. 227-234
-
-
Chauhan, D.1
Kharbanda, S.2
Ogata, A.3
-
38
-
-
15144349717
-
Cytochrome-c dependent and independent induction of apoptosis in multiple myeloma cells
-
D. Chauhan P. Pandey A. Ogata et al. Cytochrome-c dependent and independent induction of apoptosis in multiple myeloma cells J Biol Chem 272 1997 29995-299957
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29995-299957
-
-
Chauhan, D.1
Pandey, P.2
Ogata, A.3
-
39
-
-
0035855625
-
The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway
-
L.H. Wei M.L. Kuo C.A. Chen et al. The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway Oncogene 20 2001 5799-5809
-
(2001)
Oncogene
, vol.20
, pp. 5799-5809
-
-
Wei, L.H.1
Kuo, M.L.2
Chen, C.A.3
-
40
-
-
0033581897
-
RAFTK/PYK2-dependent and independent apoptosis in multiple myeloma cells
-
D. Chauhan T. Hideshima P. Pandey et al. RAFTK/PYK2-dependent and independent apoptosis in multiple myeloma cells Oncogene 18 1999 6733-6740
-
(1999)
Oncogene
, vol.18
, pp. 6733-6740
-
-
Chauhan, D.1
Hideshima, T.2
Pandey, P.3
-
41
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
P.K. Epling-Burnette J.H. Liu R. Catlett-Falcone et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression J Clin Invest 107 2001 351-362
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 351-362
-
-
Epling-Burnette, P.K.1
Liu, J.H.2
Catlett-Falcone, R.3
-
42
-
-
0034623059
-
SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apopotosis in multiple myeloma cells
-
D. Chauhan P.T.H. Pandey S. Treon et al. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apopotosis in multiple myeloma cells J Biol Chem 275 2000 27845-27850
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27845-27850
-
-
Chauhan, D.1
Pandey, P.T.H.2
Treon, S.3
-
43
-
-
85047699977
-
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays
-
D. Chauhan D. Auclair E.K. Robinson et al. Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays Oncogene 21 2002 1346-1358
-
(2002)
Oncogene
, vol.21
, pp. 1346-1358
-
-
Chauhan, D.1
Auclair, D.2
Robinson, E.K.3
-
44
-
-
0142025122
-
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells
-
D. Chauhan G. Li M. Sattler et al. Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells Oncogene 22 2003 6296-6300
-
(2003)
Oncogene
, vol.22
, pp. 6296-6300
-
-
Chauhan, D.1
Li, G.2
Sattler, M.3
-
45
-
-
18144438312
-
Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells
-
X.Y. Wen A.K. Stewart R.R. Sooknanan et al. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells Int J Oncol 15 1999 173-178
-
(1999)
Int. J. Oncol.
, vol.15
, pp. 173-178
-
-
Wen, X.Y.1
Stewart, A.K.2
Sooknanan, R.R.3
-
46
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
A.M. Reimold N.N. Iwakoshi J. Manis et al. Plasma cell differentiation requires the transcription factor XBP-1 Nature 412 2001 300-307
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
-
47
-
-
0038542892
-
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays
-
D. Chauhan G. Li D. Auclair et al. Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays Blood 101 2003 3606-3614
-
(2003)
Blood
, vol.101
, pp. 3606-3614
-
-
Chauhan, D.1
Li, G.2
Auclair, D.3
-
48
-
-
0030746359
-
The development of a model for the homing of multiple myeloma cells to human bone marrow
-
M. Urashima B.P. Chen S. Chen et al. The development of a model for the homing of multiple myeloma cells to human bone marrow Blood 90 1997 754-765
-
(1997)
Blood
, vol.90
, pp. 754-765
-
-
Urashima, M.1
Chen, B.P.2
Chen, S.3
-
50
-
-
0030057701
-
Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma
-
K. Pulkki T.T. Pelliniemi A. Rajamaki S et al. oluble interleukin-6 receptor as a prognostic factor in multiple myeloma Br J Haematol 92 1996 370-374
-
(1996)
Br. J. Haematol.
, vol.92
, pp. 370-374
-
-
Pulkki, K.1
Pelliniemi, T.T.2
Rajamaki, A.3
-
51
-
-
0030052779
-
Serum interleukin-6 (IL-6) and interleukin-4 (IL-4) in patients with multiple myeloma
-
M.C. Kyrstsonis G. Dedoussis C. Baxevanis et al. Serum interleukin-6 (IL-6) and interleukin-4 (IL-4) in patients with multiple myeloma Br J Haematol 92 1996 420-422
-
(1996)
Br. J. Haematol.
, vol.92
, pp. 420-422
-
-
Kyrstsonis, M.C.1
Dedoussis, G.2
Baxevanis, C.3
-
52
-
-
0032525085
-
The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma
-
R. Stasi M. Brunetti A. Parma et al. The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma Cancer 82 1998 1860-1866
-
(1998)
Cancer
, vol.82
, pp. 1860-1866
-
-
Stasi, R.1
Brunetti, M.2
Parma, A.3
-
53
-
-
0028952405
-
Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma
-
Finnish Leukemia Group
-
T.T. Pelliniemi K. Irjala K. Mattila et al. Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group Blood 85 1995 765-771
-
(1995)
Blood
, vol.85
, pp. 765-771
-
-
Pelliniemi, T.T.1
Irjala, K.2
Mattila, K.3
-
54
-
-
0031035918
-
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations
-
M.J. Calasanz J.C. Cigudosa M.D. Odero et al. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations Genes Chromosomes Cancer 18 1997 84-93
-
(1997)
Genes Chromosomes Cancer
, vol.18
, pp. 84-93
-
-
Calasanz, M.J.1
Cigudosa, J.C.2
Odero, M.D.3
-
55
-
-
0036162098
-
Predicting long-term (≤5 years) event-free survival in multiple myeloma patients following planned tandem autotransplants
-
G. Tricot T. Spencer J. Sawyer et al. Predicting long-term (≤5 years) event-free survival in multiple myeloma patients following planned tandem autotransplants Br J Haematol 116 2002 211-217
-
(2002)
Br. J. Haematol.
, vol.116
, pp. 211-217
-
-
Tricot, G.1
Spencer, T.2
Sawyer, J.3
-
56
-
-
0029069445
-
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
-
E. Cesarman Y. Chang P.S. Moore et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas N Eng J Med 332 1995 1186-1191
-
(1995)
N. Eng. J. Med.
, vol.332
, pp. 1186-1191
-
-
Cesarman, E.1
Chang, Y.2
Moore, P.S.3
-
57
-
-
8944226103
-
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma
-
S.J. Gao L. Kingsley D.R. Hoover et al. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma N Eng J Med 335 1996 233-241
-
(1996)
N. Eng. J. Med.
, vol.335
, pp. 233-241
-
-
Gao, S.J.1
Kingsley, L.2
Hoover, D.R.3
-
58
-
-
0029837991
-
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
-
P.S. Moore C. Boshoff R.A. Weiss & Y. Chang Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV Science 274 1996 1739-1744
-
(1996)
Science
, vol.274
, pp. 1739-1744
-
-
Moore, P.S.1
Boshoff, C.2
Weiss, R.A.3
Chang, Y.4
-
59
-
-
0032521208
-
Human Herpesvirus Type 8 interleukin-6 homologue is functionally active on human myeloma cells
-
R. Burger F. Neipel B. Fleckenstein et al. Human Herpesvirus Type 8 interleukin-6 homologue is functionally active on human myeloma cells Blood 91 1998 1858-1863
-
(1998)
Blood
, vol.91
, pp. 1858-1863
-
-
Burger, R.1
Neipel, F.2
Fleckenstein, B.3
-
60
-
-
0034114779
-
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6
-
T. Hideshima D. Chauhan G. Teoh et al. Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6 Clin Cancer Res 6 2000 1180-1189
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1180-1189
-
-
Hideshima, T.1
Chauhan, D.2
Teoh, G.3
-
61
-
-
0030852894
-
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
-
J. Molden Y. Chang Y. You et al. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit J Biol Chem 272 1997 19625-19631
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19625-19631
-
-
Molden, J.1
Chang, Y.2
You, Y.3
-
62
-
-
10644253485
-
Kaposi's sarcoma-associated herpesvirus encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: Evidence for a unique autocrine signaling mechanism
-
Meads MB, Medveczky PG. Kaposi's sarcoma-associated herpesvirus encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: Evidence for a unique autocrine signaling mechanism. J Biol Chem 2004; 279: 51793-51803.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51793-51803
-
-
Meads, M.B.1
Medveczky, P.G.2
-
63
-
-
0033562773
-
HHV-8 is present in multiple myeloma patients
-
J.R. Berenson & R.A. Vescio HHV-8 is present in multiple myeloma patients Blood 93 1999 3157-3166
-
(1999)
Blood
, vol.93
, pp. 3157-3166
-
-
Berenson, J.R.1
Vescio, R.A.2
-
64
-
-
0033562774
-
Kaposi's sarcoma-associated herpesvirus and multiple myeloma: Lack of criteria for causality
-
K. Tarte Y. Chang & B. Klein Kaposi's sarcoma-associated herpesvirus and multiple myeloma: Lack of criteria for causality Blood 93 1999 3159-3163
-
(1999)
Blood
, vol.93
, pp. 3159-3163
-
-
Tarte, K.1
Chang, Y.2
Klein, B.3
-
65
-
-
0033104851
-
Detection of Kaposi's sarcoma herpesvirus-8 DNA sequences in multiple myeloma bone marrow stromal cells
-
D. Chauhan A. Bharti N. Raje et al. Detection of Kaposi's sarcoma herpesvirus-8 DNA sequences in multiple myeloma bone marrow stromal cells Blood 93 1999 1482-1486
-
(1999)
Blood
, vol.93
, pp. 1482-1486
-
-
Chauhan, D.1
Bharti, A.2
Raje, N.3
-
66
-
-
0034127296
-
Detection of Kaposi's sarcoma associated herpesvirus gene sequences in primary amyloidosis
-
Raje N, Kica G, Chauhan D, et al. Detection of Kaposi's sarcoma associated herpesvirus gene sequences in primary amyloidosis. Amyloid 2000; 7: 126-132.
-
(2000)
Amyloid
, vol.7
, pp. 126-132
-
-
Raje, N.1
Kica, G.2
Chauhan, D.3
-
67
-
-
0030816233
-
Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients
-
[see comments]
-
M.B. Rettig H.J. Ma R.A. Vescio et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients [see comments] Science 276 1997 1851-1854
-
(1997)
Science
, vol.276
, pp. 1851-1854
-
-
Rettig, M.B.1
Ma, H.J.2
Vescio, R.A.3
-
68
-
-
0030709310
-
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma
-
J.W. Said M.R. Rettig K. Heppner L et al. ocalization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma Blood 90 1997 4278-4282
-
(1997)
Blood
, vol.90
, pp. 4278-4282
-
-
Said, J.W.1
Rettig, M.R.2
Heppner, K.3
-
69
-
-
0037100283
-
Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma
-
C. Brander N. Raje P.G. O'Connor et al. Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma Blood 100 2002 698-700
-
(2002)
Blood
, vol.100
, pp. 698-700
-
-
Brander, C.1
Raje, N.2
O'Connor, P.G.3
-
70
-
-
0033585421
-
Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
-
H. Yu M.R. Spitz J. Mistry et al. Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis J Natl Cancer Inst 91 1999 151-156
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 151-156
-
-
Yu, H.1
Spitz, M.R.2
Mistry, J.3
-
71
-
-
0032499440
-
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
-
S.E. Hankinson W.C. Willett G.A. Colditz et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer Lancet 351 1998 1393-1396
-
(1998)
Lancet
, vol.351
, pp. 1393-1396
-
-
Hankinson, S.E.1
Willett, W.C.2
Colditz, G.A.3
-
72
-
-
0032559272
-
Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
-
J.M. Chan M.J. Stampfer E. Giovannucci et al. Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study Science 279 1998 563-566
-
(1998)
Science
, vol.279
, pp. 563-566
-
-
Chan, J.M.1
Stampfer, M.J.2
Giovannucci, E.3
-
73
-
-
0033531765
-
Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
-
J. Ma M.N. Pollak E. Giovannucci et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 J Natl Cancer Inst 91 1999 620-625
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 620-625
-
-
Ma, J.1
Pollak, M.N.2
Giovannucci, E.3
-
74
-
-
0034692430
-
Role of the insulin-like growth factor family in cancer development and progression
-
H. Yu & T. Rohan Role of the insulin-like growth factor family in cancer development and progression J Natl Cancer Inst 92 2000 1472-1489
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1472-1489
-
-
Yu, H.1
Rohan, T.2
-
75
-
-
0036892647
-
Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor
-
T. Standal M. Borset S. Lenhoff et al. Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor Blood 100 2002 3925-3929
-
(2002)
Blood
, vol.100
, pp. 3925-3929
-
-
Standal, T.1
Borset, M.2
Lenhoff, S.3
-
76
-
-
0031181228
-
A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth
-
D.F. Jelinek T.E. Witzig & B.K. Arendt A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth J Immunol 159 1997 487-496
-
(1997)
J. Immunol.
, vol.159
, pp. 487-496
-
-
Jelinek, D.F.1
Witzig, T.E.2
Arendt, B.K.3
-
77
-
-
0033887015
-
Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line
-
M. Ogawa T. Nishiura K. Oritani et al. Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line Cancer Res 60 2000 4262-4269
-
(2000)
Cancer Res.
, vol.60
, pp. 4262-4269
-
-
Ogawa, M.1
Nishiura, T.2
Oritani, K.3
-
78
-
-
0037158513
-
Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
-
C.S. Mitsiades N. Mitsiades V. Poulaki et al. Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/ Akt signaling in human multiple myeloma cells: Therapeutic implications Oncogene 21 2002 5673-5683
-
(2002)
Oncogene
, vol.21
, pp. 5673-5683
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Poulaki, V.3
-
79
-
-
0032939906
-
Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells
-
K. Vanderkerken K. Asosingh F. Braet et al. Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells Blood 93 1999 235-241
-
(1999)
Blood
, vol.93
, pp. 235-241
-
-
Vanderkerken, K.1
Asosingh, K.2
Braet, F.3
-
80
-
-
0034667606
-
Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
-
N.L. Ge & S. Rudikoff Insulin-like growth factor I is a dual effector of multiple myeloma cell growth Blood 96 2000 2856-2861
-
(2000)
Blood
, vol.96
, pp. 2856-2861
-
-
Ge, N.L.1
Rudikoff, S.2
-
81
-
-
12144290914
-
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
-
C.S. Mitsiades N.S. Mitsiades C.J. McMullan et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors Cancer Cell 5 2004 221-230
-
(2004)
Cancer Cell
, vol.5
, pp. 221-230
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
82
-
-
0036625066
-
Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
-
Y.W. Qiang E. Kopantzev & S. Rudikoff Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk Blood 99 2002 4138-4146
-
(2002)
Blood
, vol.99
, pp. 4138-4146
-
-
Qiang, Y.W.1
Kopantzev, E.2
Rudikoff, S.3
-
83
-
-
0141731299
-
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β-1 integrin and phosphatidylinositol 3′-kinase/AKT signaling
-
Y.T. Tai K. Podar L. Catley et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β-1 integrin and phosphatidylinositol 3′-kinase/AKT signaling Cancer Res 63 2003 5850-5858
-
(2003)
Cancer Res.
, vol.63
, pp. 5850-5858
-
-
Tai, Y.T.1
Podar, K.2
Catley, L.3
-
84
-
-
0030997680
-
Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors
-
F. Xu A. Gardner Y. Tu et al. Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors Br J Haematol 97 1997 429-440
-
(1997)
Br. J. Haematol.
, vol.97
, pp. 429-440
-
-
Xu, F.1
Gardner, A.2
Tu, Y.3
-
85
-
-
0034548453
-
The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: Roles in cytokine-dependent survival and proliferative responses
-
Y. Tu A. Gardner & A. Lichtenstein The phosphatidylinositol 3-kinase/ AKT kinase pathway in multiple myeloma plasma cells: Roles in cytokine-dependent survival and proliferative responses Cancer Res 60 2000 6763-6770
-
(2000)
Cancer Res.
, vol.60
, pp. 6763-6770
-
-
Tu, Y.1
Gardner, A.2
Lichtenstein, A.3
-
86
-
-
1542343942
-
Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I that highly express IL-6 receptor α myeloma cells
-
S. Abroun H. Ishikawa N. Tsuyama et al. Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I that highly express IL-6 receptor α myeloma cells Blood 103 2004 2291-2298
-
(2004)
Blood
, vol.103
, pp. 2291-2298
-
-
Abroun, S.1
Ishikawa, H.2
Tsuyama, N.3
-
87
-
-
0036645153
-
Cytokines modulate telomerase activity in a human multiple myeloma cell line
-
M. Akiyama T. Hideshima T. Hayashi et al. Cytokines modulate telomerase activity in a human multiple myeloma cell line Cancer Res 62 2002 3876-3882
-
(2002)
Cancer Res.
, vol.62
, pp. 3876-3882
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
-
88
-
-
0037458621
-
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells
-
K. Podar Y.T. Tai C.E. Cole et al. Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells J Biol Chem 278 2003 5794-5801
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5794-5801
-
-
Podar, K.1
Tai, Y.T.2
Cole, C.E.3
-
89
-
-
85117737561
-
The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications
-
in press
-
Podar K, Anderson KC. The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications. Blood; in press.
-
Blood
-
-
Podar, K.1
Anderson, K.C.2
-
90
-
-
0035880256
-
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
-
K. Podar Y.T. Tai F.E. Davies et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration Blood 98 2001 428-435
-
(2001)
Blood
, vol.98
, pp. 428-435
-
-
Podar, K.1
Tai, Y.T.2
Davies, F.E.3
-
91
-
-
18544377343
-
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with β-1 integrin- and phosphatidylinositol 3-kinase-dependent PKC α activation
-
K. Podar Y.T. Tai B.K. Lin et al. Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with β-1 integrin- and phosphatidylinositol 3-kinase-dependent PKC α activation J Biol Chem 277 2002 7875-7881
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7875-7881
-
-
Podar, K.1
Tai, Y.T.2
Lin, B.K.3
-
92
-
-
0033134764
-
Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
-
A. Vacca D. Ribatti M. Presta et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma Blood 93 1999 3064-3073
-
(1999)
Blood
, vol.93
, pp. 3064-3073
-
-
Vacca, A.1
Ribatti, D.2
Presta, M.3
-
93
-
-
0032903871
-
Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
-
D. Ribatti A. Vacca B. Nico et al. Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma Br J Cancer 79 1999 451-455
-
(1999)
Br. J. Cancer
, vol.79
, pp. 451-455
-
-
Ribatti, D.1
Vacca, A.2
Nico, B.3
-
94
-
-
0033902037
-
Prognostic value of bone marrow angiogenesis in multiple myeloma
-
S.V. Rajkumar T. Leong P.C. Roche et al. Prognostic value of bone marrow angiogenesis in multiple myeloma Clin Cancer Res 6 2000 3111-3116
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3111-3116
-
-
Rajkumar, S.V.1
Leong, T.2
Roche, P.C.3
-
95
-
-
18744385489
-
Bone marrow angiogenesis in multiple myeloma: Effect of therapy
-
S. Kumar R. Fonseca A. Dispenzieri et al. Bone marrow angiogenesis in multiple myeloma: Effect of therapy Br J Haematol 119 2002 665-671
-
(2002)
Br. J. Haematol.
, vol.119
, pp. 665-671
-
-
Kumar, S.1
Fonseca, R.2
Dispenzieri, A.3
-
96
-
-
0037372435
-
Prognostic value of angiogenesis in solitary bone plasmacytoma
-
S. Kumar R. Fonseca A. Dispenzieri et al. Prognostic value of angiogenesis in solitary bone plasmacytoma Blood 101 2003 1715-1717
-
(2003)
Blood
, vol.101
, pp. 1715-1717
-
-
Kumar, S.1
Fonseca, R.2
Dispenzieri, A.3
-
97
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
[published erratum appears in N Engl J Med Feb 3; 342(5):364]
-
S. Singhal J. Mehta R. Desikan et al. Antitumor activity of thalidomide in refractory multiple myeloma N Engl J Med 1999 1565-1571 [published erratum appears in N Engl J Med Feb 3; 342(5):364]
-
(1999)
N. Engl. J. Med.
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
98
-
-
0033043613
-
Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma
-
S.V. Rajkumar R. Fonseca T.E. Witzig et al. Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma Leukemia 13 1999 469-472
-
(1999)
Leukemia
, vol.13
, pp. 469-472
-
-
Rajkumar, S.V.1
Fonseca, R.2
Witzig, T.E.3
-
99
-
-
0037082449
-
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells
-
Y.T. Tai K. Podar D. Gupta et al. CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells Blood 99 2002 1419-1427
-
(2002)
Blood
, vol.99
, pp. 1419-1427
-
-
Tai, Y.T.1
Podar, K.2
Gupta, D.3
-
100
-
-
0036731996
-
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment
-
B. Lin K. Podar D. Gupta et al. The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment Cancer Res 62 2002 5019-5026
-
(2002)
Cancer Res.
, vol.62
, pp. 5019-5026
-
-
Lin, B.1
Podar, K.2
Gupta, D.3
-
101
-
-
11144354204
-
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment
-
K. Podar L.P. Catley Y.T. Tai et al. GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment Blood 103 2004 3474-3479
-
(2004)
Blood
, vol.103
, pp. 3474-3479
-
-
Podar, K.1
Catley, L.P.2
Tai, Y.T.3
-
102
-
-
0036530301
-
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
-
S. Dias S.V. Shmelkov G. Lam & S. Rafii VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition Blood 99 2002 2532-2540
-
(2002)
Blood
, vol.99
, pp. 2532-2540
-
-
Dias, S.1
Shmelkov, S.V.2
Lam, G.3
Rafii, S.4
-
103
-
-
6944253220
-
VEGF induces MCL-1 upregulation and protects multiple myeloma cells against apoptosis
-
Le Gouill S, Podar K, Amiot M. et al. VEGF induces MCL-1 upregulation and protects multiple myeloma cells against apoptosis. Blood 2004;104: 2886-2892.
-
(2004)
Blood
, vol.104
, pp. 2886-2892
-
-
Le Gouill, S.1
Podar, K.2
Amiot, M.3
-
104
-
-
0042738871
-
Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes
-
T. Hayashi T. Hideshima M. Akiyama et al. Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes Blood 102 2003 1435-1442
-
(2003)
Blood
, vol.102
, pp. 1435-1442
-
-
Hayashi, T.1
Hideshima, T.2
Akiyama, M.3
-
105
-
-
4143119930
-
Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells
-
F. Silvestris P. Cafforio N. Calvani & F. Dammacco Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells Br J Haematol 126 2004 475-486
-
(2004)
Br. J. Haematol.
, vol.126
, pp. 475-486
-
-
Silvestris, F.1
Cafforio, P.2
Calvani, N.3
Dammacco, F.4
-
106
-
-
0029874138
-
The NF-κB and I κB proteins: New discoveries and insights
-
A.S. Baldwin Jr The NF-κB and I κB proteins: New discoveries and insights Annu Rev Immunol 14 1996 649-683
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin Jr., A.S.1
-
107
-
-
0027332498
-
The IκB proteins: Multifunctional regulators of Rel NF-κB transcription factors
-
A.A. Beg & A.S. Baldwin Jr The IκB proteins: Multifunctional regulators of Rel NF-κB transcription factors Genes Dev 7 1993 2064-2070
-
(1993)
Genes Dev.
, vol.7
, pp. 2064-2070
-
-
Beg, A.A.1
Baldwin Jr., A.S.2
-
108
-
-
0030613551
-
The IκB kinase complex (IKK) contains two kinase subunits, IKKa and IKKb, necessary for IκB phosphorylation and NF-κB activation
-
E. Zandi D.M. Rothwarf M. Delhase et al. The IκB kinase complex (IKK) contains two kinase subunits, IKKa and IKKb, necessary for IκB phosphorylation and NF-κB activation Cell 91 1997 243-252
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
-
109
-
-
0028972845
-
Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
-
T.S. Finco & A.S. Baldwin Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis Immunity 3 1995 263-272
-
(1995)
Immunity
, vol.3
, pp. 263-272
-
-
Finco, T.S.1
Baldwin, A.S.2
-
110
-
-
0029665080
-
Role of IκBα ubiquitination in signal-induced activation of NFκB in vivo
-
M. Roff J. Thompson M.S. Rodriguez et al. Role of IκBα ubiquitination in signal-induced activation of NFκB in vivo J Biol Chem 271 1996 7844-7850
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7844-7850
-
-
Roff, M.1
Thompson, J.2
Rodriguez, M.S.3
-
111
-
-
0038369758
-
Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells
-
T.H. Landowski N.E. Olashaw D. Agrawal & W.S. Dalton Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells Oncogene 22 2003 2417-2421
-
(2003)
Oncogene
, vol.22
, pp. 2417-2421
-
-
Landowski, T.H.1
Olashaw, N.E.2
Agrawal, D.3
Dalton, W.S.4
-
112
-
-
0034331194
-
Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy
-
T. Hideshima D. Chauhan Y. Shima et al. Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy Blood 96 2000 2943-2950
-
(2000)
Blood
, vol.96
, pp. 2943-2950
-
-
Hideshima, T.1
Chauhan, D.2
Shima, Y.3
-
113
-
-
0032147012
-
The alpha-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion
-
J.F. Wang Z.Y. Liu & J.E. Groopman The alpha-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion Blood 92 1998 756-764
-
(1998)
Blood
, vol.92
, pp. 756-764
-
-
Wang, J.F.1
Liu, Z.Y.2
Groopman, J.E.3
-
114
-
-
0034656351
-
Stromal cell-derived factor-1 α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: Roles of phosphoinositide-3 kinase and protein kinase C
-
J.F. Wang I.W. Park & J.E. Groopman Stromal cell-derived factor-1 α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: Roles of phosphoinositide-3 kinase and protein kinase C Blood 95 2000 2505-2513
-
(2000)
Blood
, vol.95
, pp. 2505-2513
-
-
Wang, J.F.1
Park, I.W.2
Groopman, J.E.3
-
115
-
-
0036561859
-
The biological sequelae of stromal cell-derived factor-1α in multiple myeloma
-
T. Hideshima D. Chauhan T. Hayashi et al. The biological sequelae of stromal cell-derived factor-1α in multiple myeloma Mol Cancer Ther 1 2002 539-544
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 539-544
-
-
Hideshima, T.1
Chauhan, D.2
Hayashi, T.3
-
116
-
-
0037262287
-
Expression and function of chemokine receptors in human multiple myeloma
-
C. Moller T. Stromberg M. Juremalm et al. Expression and function of chemokine receptors in human multiple myeloma Leukemia 17 2003 203-210
-
(2003)
Leukemia
, vol.17
, pp. 203-210
-
-
Moller, C.1
Stromberg, T.2
Juremalm, M.3
-
117
-
-
0348141711
-
Mobilization of myeloma cells involves SDF-1/CXCR4 signaling and downregulation of VLA-4
-
Y. Gazitt & C. Akay Mobilization of myeloma cells involves SDF-1/CXCR4 signaling and downregulation of VLA-4 Stem Cells 22 2004 65-73
-
(2004)
Stem Cells
, vol.22
, pp. 65-73
-
-
Gazitt, Y.1
Akay, C.2
-
118
-
-
0141679073
-
Transforming growth factor-β1 down-regulates expression of chemokine stromal cell-derived factor-1: Functional consequences in cell migration and adhesion
-
N. Wright T.L. de Lera C. Garcia-Moruja et al. Transforming growth factor-β1 down-regulates expression of chemokine stromal cell-derived factor-1: Functional consequences in cell migration and adhesion Blood 102 2003 1978-1984
-
(2003)
Blood
, vol.102
, pp. 1978-1984
-
-
Wright, N.1
de Lera, T.L.2
Garcia-Moruja, C.3
-
119
-
-
0035383788
-
Janus kinase 2 is involved in stromal cell-derived factor-1α-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells
-
X.F. Zhang J.F. Wang E. Matczak et al. Janus kinase 2 is involved in stromal cell-derived factor-1α-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells Blood 97 2001 3342-3348
-
(2001)
Blood
, vol.97
, pp. 3342-3348
-
-
Zhang, X.F.1
Wang, J.F.2
Matczak, E.3
-
121
-
-
11144355390
-
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
-
P.W. Derksen E. Tjin H.P. Meijer et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells Proc Natl Acad Sci USA 101 2004 6122-6127
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6122-6127
-
-
Derksen, P.W.1
Tjin, E.2
Meijer, H.P.3
-
122
-
-
9144240010
-
DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway
-
Niida A, Hiroko T, Kasai M, et al. DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene 2004; 23: 8520-8526.
-
(2004)
Oncogene
, vol.23
, pp. 8520-8526
-
-
Niida, A.1
Hiroko, T.2
Kasai, M.3
-
123
-
-
0346363760
-
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
-
E. Tian F. Zhan R. Walker et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma N Engl J Med 349 2003 2483-2494
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.2
Walker, R.3
-
124
-
-
0028362802
-
Bone marrow angiogenesis and progression in multiple myeloma
-
A. Vacca D. Ribatti L. Roncali et al. Bone marrow angiogenesis and progression in multiple myeloma Br J Haematol 87 1994 503-508
-
(1994)
Br. J. Haematol.
, vol.87
, pp. 503-508
-
-
Vacca, A.1
Ribatti, D.2
Roncali, L.3
-
125
-
-
0033472710
-
Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32.3) and FGFR3 translocation
-
T. Otsuki O. Yamada K. Yata et al. Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32.3) and FGFR3 translocation Int J Oncol 15 1999 1205-1212
-
(1999)
Int. J. Oncol.
, vol.15
, pp. 1205-1212
-
-
Otsuki, T.1
Yamada, O.2
Yata, K.3
-
126
-
-
0038446643
-
Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
-
G. Bisping R. Leo D. Wenning et al. Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma Blood 101 2003 2775-2783
-
(2003)
Blood
, vol.101
, pp. 2775-2783
-
-
Bisping, G.1
Leo, R.2
Wenning, D.3
-
127
-
-
0035254612
-
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
-
M. Chesi L.A. Brents S.A. Ely et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma Blood 97 2001 729-736
-
(2001)
Blood
, vol.97
, pp. 729-736
-
-
Chesi, M.1
Brents, L.A.2
Ely, S.A.3
-
128
-
-
3242777803
-
Advances in biology of multiple myeloma: Clinical applications
-
T. Hideshima P.L. Bergsagel W.M. Kuehl & K.C. Anderson Advances in biology of multiple myeloma: Clinical applications Blood 104 2004 607-618
-
(2004)
Blood
, vol.104
, pp. 607-618
-
-
Hideshima, T.1
Bergsagel, P.L.2
Kuehl, W.M.3
Anderson, K.C.4
-
129
-
-
9344245148
-
TGF-b receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
-
Hayashi T, Hideshima T, Nguyen AN, et al. TGF-b receptor I kinase inhibitor downregulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res 2004; 10: 7540-7546.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7540-7546
-
-
Hayashi, T.1
Hideshima, T.2
Nguyen, A.N.3
-
130
-
-
0028938265
-
Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells
-
Z.Y. Lu X.G. Zhang C. Rodriguez et al. Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells Blood 85 1995 2521-2527
-
(1995)
Blood
, vol.85
, pp. 2521-2527
-
-
Lu, Z.Y.1
Zhang, X.G.2
Rodriguez, C.3
-
131
-
-
10544241191
-
Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop
-
Z.J. Gu V. Costes Z.Y. Lu et al. Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop Blood 88 1996 3972-3986
-
(1996)
Blood
, vol.88
, pp. 3972-3986
-
-
Gu, Z.J.1
Costes, V.2
Lu, Z.Y.3
-
132
-
-
0342322717
-
Macrophage inflammatory protein 1-α is a potential osteoclast stimulatory factor in multiple myeloma
-
S.J. Choi J.C. Cruz F. Craig et al. Macrophage inflammatory protein 1-α is a potential osteoclast stimulatory factor in multiple myeloma Blood 96 2000 671-675
-
(2000)
Blood
, vol.96
, pp. 671-675
-
-
Choi, S.J.1
Cruz, J.C.2
Craig, F.3
-
133
-
-
0037105599
-
Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
-
M. Abe K. Hiura J. Wilde et al. Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma Blood 100 2002 2195-2202
-
(2002)
Blood
, vol.100
, pp. 2195-2202
-
-
Abe, M.1
Hiura, K.2
Wilde, J.3
-
134
-
-
0032865647
-
Interleukin-15 blocks apoptosis and induces proliferation of the human myeloma cell line OH-2 and freshly isolated myeloma cells
-
H. Hjorth-Hansen A. Waage & M. Borset Interleukin-15 blocks apoptosis and induces proliferation of the human myeloma cell line OH-2 and freshly isolated myeloma cells Br J Haematol 106 1999 28-34
-
(1999)
Br. J. Haematol.
, vol.106
, pp. 28-34
-
-
Hjorth-Hansen, H.1
Waage, A.2
Borset, M.3
-
135
-
-
0034651023
-
Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
-
I. Tinhofer I. Marschitz T. Henn et al. Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma Blood 95 2000 610-618
-
(2000)
Blood
, vol.95
, pp. 610-618
-
-
Tinhofer, I.1
Marschitz, I.2
Henn, T.3
-
136
-
-
0037093258
-
Interleukin-21 is a growth and survival factor for human myeloma cells
-
A.T. Brenne T. Baade Ro A. Waage et al. Interleukin-21 is a growth and survival factor for human myeloma cells Blood 99 2002 3756-3762
-
(2002)
Blood
, vol.99
, pp. 3756-3762
-
-
Brenne, A.T.1
Baade Ro, T.2
Waage, A.3
-
137
-
-
0028799055
-
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells
-
D. Chauhan S.M. Kharbanda A. Ogata et al. Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells J Exp Med 182 1995 1801-1806
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1801-1806
-
-
Chauhan, D.1
Kharbanda, S.M.2
Ogata, A.3
-
138
-
-
10744227618
-
Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival
-
R. Burger F. Bakker A. Guenther et al. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival Br J Haematol 123 2003 869-878
-
(2003)
Br. J. Haematol.
, vol.123
, pp. 869-878
-
-
Burger, R.1
Bakker, F.2
Guenther, A.3
-
139
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
T. Hideshima & K.C. Anderson Molecular mechanisms of novel therapeutic approaches for multiple myeloma Nat Rev Cancer 2 2002 927-937
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 927-937
-
-
Hideshima, T.1
Anderson, K.C.2
-
140
-
-
0035300479
-
The proteasome inhibitor PS-341inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
T. Hideshima P. Richardson D. Chauhan et al. The proteasome inhibitor PS-341inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells Cancer Res. 61 2001 3071-3076
-
(2001)
Cancer Res.
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
141
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
N. Mitsiades C.S. Mitsiades V. Poulaki et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells Proc Natl Acad Sci USA 99 2002 14374-14379
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
143
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
T. Hideshima C. Mitsiades M. Akiyama et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341 Blood 101 2003 1530-1534
-
(2003)
Blood
, vol.101
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
-
144
-
-
0346122900
-
Proteasome Inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma
-
T. Hideshima D. Chauhan T. Hayashi et al. Proteasome Inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma Oncogene 22 2003 8386-8393
-
(2003)
Oncogene
, vol.22
, pp. 8386-8393
-
-
Hideshima, T.1
Chauhan, D.2
Hayashi, T.3
|