Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors

British Journal of Haematology

Volumn 97, Issue 2, 1997, Pages 429-440

  Xu, Fenghao ^a   Gardner, Agnes ^a   Tu, Yiping ^a   Michl, Patrick ^a   Prager, Diane ^a   Lichtenstein, Alan ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

apoptosis; BCL 2; dexamethasone; insulin like growth factors; multiple myeloma

Indexed keywords

CYCLOHEXIMIDE; DEXAMETHASONE; GYRASE INHIBITOR; INSULIN; MONOCLONAL ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT SOMATOMEDIN B; RECOMBINANT SOMATOMEDIN C;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0030997680     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.592708.x     Document Type: Article

References (51)

1. Barres, B.A., Hart, I.K., Coles, S.R., Burne, J.F., Voyvodiic, J.T., Richardson, W.D. & Raff, M.C. (1992) Cell death and control of cell survival in the oligodendrocyte lineage. Cell, 70, 31-37.
2. Beck, K.D. (1994) Functions of brain-derived neurotropic factor, insulin-like growth factor I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons. Progress in Neurobiology, 44, 497-504.
3. Bozyzko-Coyne, D., Glicksman, M.A., Prantner, J.E., McKenna, B., Connors, T. & Friedman, C. (1993) IGF-I supports the survival and/ or differentiation of multiple types of central nervous system neurons. Annals of the New York Academy of Sciences, 692, 311-316.
4. Canalis, E.T., McCarthy, T. & Centrella, M. (1988) Isolation and characterization of insulin-like growth factor I from cultures of fetal rat calvariae. Endocrinology, 122, 22-29.
5. Cho, C.H., Parker, C., MacEwen, E.G. & Radinsky, R. (1996) Insulin-like growth factor-I prevents adriamycin and 5-FU induced cell death and upregulates BCL-X-L in human colon carcinoma. Proceedings of the American Association of Cancer Research, Abstract 211.
6. Christofori, G., Naik, P. & Hanahan, D. (1994) A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature, 369, 414-420.
7. Clemmons, K.R., Van Wyk, J.J. & Pledger, W.J. (1980) Sequential addition of platelet factor and plasma to BALB/c3T3 fibroblast cultures stimulates somatomedin-C binding early in cell cycle. Proceedings of the National Academy of Sciences of the United States of America, 77, 6644-6650.
8. Czech, M.P. (1989) Signal transmission by the insulin-like growth factors. Cell, 59, 235-240.
9. Dalton, W.S., Durie, B.M.G., Alberts, D.S., Gerlach, J.H. & Cress, A.E. (1986) Characterization of a new drug-resistant myeloma cell line that expresses p-glycoprotein. Cancer Research, 46, 5125-5132.
10. Ernst, M. & Froesch, E.R. (1988) Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochemical and Biophysical Research Communications, 151, 142-148.
11. Freund, G.G., Kulas, D.T. & Mooney, R.A. (1993) Insulin and IGF-I increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. Journal of Immunology, 151, 1811-1819.
12. Freund, G.G., Kulas, D.T., Way, B.A. & Mooney, R.A. (1994) Functional insulin and insulin-like growth factor-I receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines. Cancer Research, 54, 3179-3185.
13. Furlanetto, R.W., DiCarlo, J.N. & Wisehart, C. (1987) The type II insulin-like growth factor receptor does not mediate deoxyribonucleic acid synthesis in human fibroblasts. Journal of Clinical Endocrinolology and Metabolism, 64, 1142-1150.
14. Geier, A., Beery, R., Haimsohn, M. & Karasik, A. (1995) Insulin-like growth factor I inhibits cell death induced by anticancer drugs in the MCF-7 cells: involvement of growth factors in drug resistance. Cancer Investigation, 13, 480-485.
15. Geier, A., Haimsohn, M. & Beery, R. (1992) Insulin-like growth factor-I inhibits cell death induced by cycloheximide in MCF-7 cells: a model system for analyzing control of cell death. In Vitro Cell Development Biology, 28, 725-731.
16. Georgii-Hemming, J., Jernberg, H., Ljunggren, O. & Nilsson, K. (1996) Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines. Blood, 88, 2250-2257.
17. Gibson, L.F., Piktel, D. & Landreth, K.S. (1993) Insulin-like growth factor-I potentiates expansion of interleukin-7 dependent pro-B cells. Blood, 82, 3005-3011.
18. Gluckman, P., Klempt, N., Guan, J., Mallard, C., Sirimanne, E., Dragunow, M., Klempt, M., Singh, K., Williams, C. & Nikolics, K. (1992) A role for IGF-I in the rescue of CNS neurons following hypoxic-ischemic injury. Biochemical and Biophysical Research Communications, 182, 593-599.
19. Hardin, J., MacLeod, S., Grigorieva, I., Chang, R., Barlogie, B., Xiao, H. & Epstein, J. (1994) Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood, 84, 3063-3070.
20. Harrington, E., Bennett, MR., Fanidi, A. & Evan, G.I. (1993) c-Myc induced apoptosis in fibroblasts is inhibited by specific cytokines. The EMBO Journal, 13, 3286-3294.
21. Johnston, B., Mallard, E.C., Williams, C.E. & Gluckman, P.D. (1996) Insulin-like growth factor I is a potent neuronal rescue agent after hypooxic-ischemic injury in fetal lambs. Journal of Clinical Investigation, 97, 300-309.
22. Juge-Morineau, N., Francois, S., Puthier, D., Godard, A., Bataille, R. & Amiot, M. (1995) The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells. British Journal of Haematology, 90, 707-713.
23. Jung, Y.-K., Miura, M. & Yuan, J. (1996) Suppression of interleukin-1B-converting enzyme-mediated cell death by insulin-like growth factor. Journal of Biological Chemistry, 271, 5112-5119.
24. Kawano, M., Mihara, K., Huang, N., Tsujimoto, T. & Kuramoto, A. (1995) Differentiation of early plasma cells on bone marrow stromal cells requires IL-6 for escaping from apoptosis. Blood, 85, 487-494.
25. Kiess, W., Haskell, J.F., Lee, L., Greenstein, L.A., Miller, B.E. & Aarons, A.L. (1987) An Ab that blocks insulin-like growth factor binding to the type II IGF receptor is neither an agonist or an inhibitor of IGF-stimulated biological response in L6 myoblasts. Journal of Biological Chemistry, 262, 12745-1283.
26. Kimata, H. & Yoshida, A. (1994) Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II and insulin on Ig production and growth in human plasma cells. Blood, 83, 1569-1574.
27. Landreth, K.S., Narayanan, R. & Dorshkind, K. (1992) Insulin-like growth factor-I regulates pro-B cell differentiation. Blood, 80, 1207-1213.
28. LeRoith, D., Roberts, C.T., Werner, H., Bondy, C., Raizada, M. & Adamo, M.L. (1993) Insulin-like growth factors in the brain. Neurotrophic Factors, pp. 391-414. Academic Press, San Diego.
29. Lichtenstein, A., Gera, J., Andrews, J., Berenson, J. & Ware, C.F. (1991) Inhibitors of ADP-ribose polymerase decrease the resistance of HER2/neu-expressing cancer cells to the cytotoxic effects of tumor necrosis factor. Journal of Immunology, 146, 2052-20059.
30. Lichtenstein, A., Tu, Y., Fady, C., Vescio, R. & Berenson, J. (1995) Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunology, 162, 248-255.
31. Ludwing, T., LeBorgne, R. & Hoflack, B. (1995) Roles for mannose 6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly. Trends in Cell Biology, 5, 202-210.
32. Macaulay, V.M. (1992) Insulin-like growth factors and cancer. British Journal of Cancer, 65, 311-318.
33. Macdonald, R.G., Pfeffer, S.R., Coussens, L., Tepper, M.A., Brocklebank, C.M. & Mole, J.E. (1988) A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science, 239, 1134-1138.
34. Minshall, C., Arkins, S., Freund, G.G. & Kelley, K.W. (1996) Requirement for phosphatidylinositol-3-kinase to protect hemopoietic progenitors against apoptosis depends upon the extra-cellular survival factor. Journal of Immunology, 156, 939-947.
35. Nissley, P., Kiess, W. & Sklar, M.M. (1991) The insulin-like growth factor II/mannose 6 phosphate receptor. Insulin-like Growth Factors: Molecular and Cellular Aspects (ed. by D. LeRoith), pp. 49-85. CRC Press, Boca Raton.
36. Pettersson, M., Jernberg-Wiklund, H., Larsson, L.G., Sundstrom, C., Givol, L., Tsujimoto, Y. & Nilsson, K. (1992) Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood, 79, 495-502.
37. Prager, D., Li, H-L., Asa, S. & Melmed, S. (1994) Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proceedings of the National Academy of Sciences of the United States of America, 91, 2181-2189.
38. Rampalli, A.M. & Zelenka, P.S. (1995) Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell Growth and Differentiation, 6, 945-952.
39. Resnicoff, M., Abraham, D., Yutanawiboonchi, W., Rotman, H., Katjstura, J., Rubin, R., Zoltick, P. & Baserga, R. (1995a) The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Research, 55, 2463-2470.
40. Resnicoff, M., Burgaud, J-L., Rotman, H., Abraham, D. & Baserga, R. (1995b) Correlation between apoptosis, tumorigenesis and levels of insulin-like growth factor I receptors. Cancer Research, 55, 3739-5745.
41. Rodriguez-Tarduchy, G., Collins, M.K.L., Garcia, I. & Lopez-Rivas, A. (1992) Insulin-like growth factor I inhibits apoptosis in IL-3-dependent hemopoietic cells. Journal of Immunology, 149, 535-543.
42. Rubin, R. & Baserga, R. (1995) Insulin-like growth factor-I receptor. Laboratory Investigation, 73, 311-318.
43. Sara, V.R. & Carllsson-Skwirut, C. (1990) Insulin-like growth factors in the central nervous system: biosynthesis and biological role. Growth Factors: from Genes to Clinical Applications (ed. by V. R. Sara, K. Hall and H. Low), pp. 179-191. Raven Press, New York.
44. Sell, C., Baserga, R. & Rubin, R. (1995) Insulin-like growth factor I and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Research, 55, 303-310.
45. Sell, C., Rubini, M., Rubin, R., Lui, J., Efstradiadis, A. & Baserga, R. (1993) Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type I IGF receptors. Proceedings of the National Academy of Sciences of the United States of America, 90, 11217-11225.
46. Smith, J., Fowkes, G., & Schofield, P.N. (1995) Programmed cell death in dystrophic (mdx) muscle is inhibited by IGF-II. Cell Death and Differentiation, 2, 243-252.
47. Tamm, I. & Kikuchi, T. (1990) Insulin-like growth factor-I, insulin and epidermal growth factor are survival factors for density-inhibited, quiescent Balb/c- 3T3 murine fibroblasts. Journal of Cell Physiology, 143, 494-501.
48. Tu, Y., Xu, F., Liu, J., Vescio, R., Berenson, J., Krajewski, S., Reed, J. & Lichtenstein, A. (1995) Expression of bcl-x in multiple myeloma plasma cells. Blood, 86, 62a (abstract 234).
49. Ullrich, A., Gray, A., Tam, A.W., Tang-Feng, T., Tsubokawa, M. & Collins, C. (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO Journal, 5, 2503-2510.
50. Westendorf, J.J., Lammert, J.M. & Jelinek, D.F. (1992) Expression and function of fas in patient myeloma cells and myeloma cell lines. Blood, 85, 3566-3571.
51. Yao, R. & Cooper, G.M. (1995) Requirement for phosphatidylinositol-3-kinase in the prevention of apoptosis by nerve growth factor. Science, 267, 2003-2011.