Inhibitors of farnesyltransferase: 5-Arylacryloylaminobenzophenones show antimalarial activity

Pharmazie

Volumn 58, Issue 4, 2003, Pages 289-290

  Wiesner, J ^c,d   Ortmann, R ^a   Mitsch, A ^b   Wissner P ^b   Sattler, I ^e   Jomaa, H ^c   Schlitzer, Martin ^a,f  

^a UNIVERSITY OF MUNICH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

^d Jomaa Pharmaka GmbH Gießen   (Germany)

^e HANS KNÖLL INSTITUTE   (Germany)

^f Zentrum fur Pharmaforschung   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPHENONE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; INDOLE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; PLASMODIUM FALCIPARUM;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; BENZOPHENONES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0345352797     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Ridley, R. G.: Nature 415, 686 (2002)
2. Chakrabarti, D.; Azam, T.; DelVecchio, C.; Qiu, L.; Park, Y.; Allen, C. M.: Mol. Biochem. Parasitol. 94, 175 (1998)
3. Ohkanda, J.; Lockman, J. W.; Yokohama, K.; Gelb, M. H.; Croft, S. L.; Kendrick, H.; Harrell, M. I.; Feagin, J. E.; Blaskovich, M. A.; Sebti, S. M.; Hamilton, A. D.: Bioorg. Med. Chem. Lett. 11, 761 (2001)
4. Mitsch, A.; Böhm, M.; Wißner, P.; Sattler, I.; Schlitzer, M.: Bioorg. Med. Chem. 10, 2657 (2002)
5. Desjardins, R. E.; Canfield, C. J.; Haynes, J. D.; Chulay, J. D.: Antimicrob. Agents Chemother. 16, 710 (1979)
6. Trager, W.; Jensen, J. B.: Science 193, 673 (1976)
7. Ancelin, M. L.; Calas, M.; Bompart, J.; Cordina, G.; Martin, D.; Bari, M. B.; Jei, T.; Druilhe, P.; Vial, H. J.: Blood 91, 1 (1998)