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Volumn 31, Issue 1 SUPPL. 1, 2004, Pages 28-39

Farnesyltransferase Inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,9,9A HEXAHYDRO 2 [2 (2 METHOXYPHENYL) 1 OXO 2 PROPENYL] 9 (4 METHYLPHENYL) 4,9 ETHANO 3AH BENZ[F]ISOINDOLE 3A CARBOXYLIC ACID; BMS 184878; BMS 193269; BZA2B; BZA5B; CYTOTOXIC AGENT; FTI 2148; FTI 2153; GERANYLGERANYLTRANSFERASE 1; GERANYLTRANSFERASE; L 745631; LONAFARNIB; MITOGEN ACTIVATED PROTEIN KINASE 1; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE METHYL ESTER; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN P16; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; RHO FACTOR; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 1242273875     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2003.12.012     Document Type: Article
Times cited : (105)

References (81)
  • 2
    • 0030693938 scopus 로고    scopus 로고
    • Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: Prospects for drug development
    • Sebti SM, Hamilton AD: Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: Prospects for drug development. Exp Opin Invest Drugs 6:1711-1714, 1997
    • (1997) Exp Opin Invest Drugs , vol.6 , pp. 1711-1714
    • Sebti, S.M.1    Hamilton, A.D.2
  • 3
    • 0041781837 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase I inhibitors as novel agents for cancer and cardiovascular diseases
    • Sebti M, Hamilton AD (eds). Totowa, NJ, Humana Press
    • Sebti SM, Hamilton AD: Farnesyltransferase and geranylgeranyltransferase I inhibitors as novel agents for cancer and cardiovascular diseases, in Sebti M, Hamilton AD (eds): Farnesyltransferase Inhibitors in Cancer Therapy. Totowa, NJ, Humana Press, 2000, pp 197-220
    • (2000) Farnesyltransferase Inhibitors in Cancer Therapy , pp. 197-220
    • Sebti, S.M.1    Hamilton, A.D.2
  • 4
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox AD, Der CJ: Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras? Biochim Biophys Acta 1333:F51-F71, 1997
    • (1997) Biochim Biophys Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 5
    • 0030962347 scopus 로고    scopus 로고
    • The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
    • Gibbs JB, Oliff A: The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu Rev Pharmacol Toxicol 37:143-166, 1997
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 143-166
    • Gibbs, J.B.1    Oliff, A.2
  • 6
    • 0030749464 scopus 로고    scopus 로고
    • Inhibition of Ras prenylation: A novel approach to cancer chemotherapy
    • Sebti SM, Hamilton AD: Inhibition of Ras prenylation: A novel approach to cancer chemotherapy. Pharmacol Ther 74:103-114, 1997
    • (1997) Pharmacol Ther , vol.74 , pp. 103-114
    • Sebti, S.M.1    Hamilton, A.D.2
  • 7
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey PJ, Seabra MC: Protein prenyltransferases. J Biol Chem 271:5289-5296, 1996
    • (1996) J Biol Chem , vol.271 , pp. 5289-5296
    • Casey, P.J.1    Seabra, M.C.2
  • 8
    • 0026729445 scopus 로고
    • Steady-state kinetic mechanism of Ras farnesyl: Protein transferase
    • Pompliano DL, Rands E, Schaber MD, et al: Steady-state kinetic mechanism of Ras farnesyl: protein transferase. Biochem 31:3800-3807, 1992
    • (1992) Biochem , vol.31 , pp. 3800-3807
    • Pompliano, D.L.1    Rands, E.2    Schaber, M.D.3
  • 9
    • 0030999833 scopus 로고    scopus 로고
    • Substrate binding is required for release of product from mammalian protein farnesyltransferase
    • Tschantz WR, Furfine ES, Casey PJ: Substrate binding is required for release of product from mammalian protein farnesyltransferase. J Biol Chem 272:9989-9993, 1997
    • (1997) J Biol Chem , vol.272 , pp. 9989-9993
    • Tschantz, W.R.1    Furfine, E.S.2    Casey, P.J.3
  • 10
    • 0029007105 scopus 로고
    • Protein farnesyltransferase: Kinetics of farnesyl pyrophosphate binding and product release
    • Furfine ES, Leban JJ, Landavazo A, et al: Protein farnesyltransferase: Kinetics of farnesyl pyrophosphate binding and product release. Biochem 34:6857-6862, 1995
    • (1995) Biochem , vol.34 , pp. 6857-6862
    • Furfine, E.S.1    Leban, J.J.2    Landavazo, A.3
  • 11
    • 1242325925 scopus 로고    scopus 로고
    • Structures of protein farnesyltransferasein
    • Sebti SM, Hamilton AD (eds). Totowa JN, 2000, Humana Press
    • Long SB, Beese LS: Structures of protein farnesyltransferasein, in Sebti SM, Hamilton AD (eds): Structures of Protein Farnesyltransferase. Totowa JN, 2000, Humana Press, 2000, pp 37-48
    • (2000) Structures of Protein Farnesyltransferase , pp. 37-48
    • Long, S.B.1    Beese, L.S.2
  • 12
    • 0033214457 scopus 로고    scopus 로고
    • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine
    • Sun J, Blaskovich MA, Knowles D, et al: Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res 59:4919-4926, 1999
    • (1999) Cancer Res , vol.59 , pp. 4919-4926
    • Sun, J.1    Blaskovich, M.A.2    Knowles, D.3
  • 13
    • 0025194466 scopus 로고
    • Inhibition of purified p21ras farnesyl: Protein transferase by Cys-AAX tetrapeptides
    • Reiss Y, Goldstein JL, Seabra MC, et al: Inhibition of purified p21ras farnesyl: protein transferase by Cys-AAX tetrapeptides. Cell 62:81-88, 1990
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3
  • 14
    • 0028973293 scopus 로고
    • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
    • Lerner EC, Qian Y, Blaskovich MA, et al: Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem 270:26802-26806, 1995
    • (1995) J Biol Chem , vol.270 , pp. 26802-26806
    • Lerner, E.C.1    Qian, Y.2    Blaskovich, M.A.3
  • 15
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • James GL, Goldstein JL, Brown MS: Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J Biol Chem 270:6221-6226, 1995
    • (1995) J Biol Chem , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 16
    • 0030923192 scopus 로고    scopus 로고
    • K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
    • Whyte DB, Kirschmeier P, Hockenberry TN, et al: K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem 272:14459-14464, 1997
    • (1997) J Biol Chem , vol.272 , pp. 14459-14464
    • Whyte, D.B.1    Kirschmeier, P.2    Hockenberry, T.N.3
  • 17
    • 0030968859 scopus 로고    scopus 로고
    • Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo
    • Rowell CA, Kowalczyk JJ, Lewis MD, et al: Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J Biol Chem 272:14093-14097, 1997
    • (1997) J Biol Chem , vol.272 , pp. 14093-14097
    • Rowell, C.A.1    Kowalczyk, J.J.2    Lewis, M.D.3
  • 18
    • 0030952552 scopus 로고    scopus 로고
    • Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
    • Lerner EC, Zhang TT, Knowles DB, et al: Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 15:1283-1288, 1997
    • (1997) Oncogene , vol.15 , pp. 1283-1288
    • Lerner, E.C.1    Zhang, T.T.2    Knowles, D.B.3
  • 19
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • Sun J, Qian Y, Hamilton AD, et al: Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene 16:1467-1473, 1998
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3
  • 20
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion
    • Sun J, Qian Y, Hamilton AD, et al: Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res 55:4243-4247, 1995
    • (1995) Cancer Res , vol.55 , pp. 4243-4247
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3
  • 21
    • 0031834918 scopus 로고    scopus 로고
    • Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth
    • discussion 131-132
    • Bredel M, Pollack IF, Freund JM, et al: Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth. Neurosurgery 43:124-131; discussion 131-132, 1998
    • (1998) Neurosurgery , vol.43 , pp. 124-131
    • Bredel, M.1    Pollack, I.F.2    Freund, J.M.3
  • 22
    • 0032750731 scopus 로고    scopus 로고
    • Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II-Preclinical studies in a nude mouse model
    • Pollack IF, Bredel M, Erff M, et al: Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II-Preclinical studies in a nude mouse model. Neurosurgery 45:1208-1214, 1999
    • (1999) Neurosurgery , vol.45 , pp. 1208-1214
    • Pollack, I.F.1    Bredel, M.2    Erff, M.3
  • 23
    • 0005691302 scopus 로고    scopus 로고
    • Antitumor efficacy of a farnesyltransferase inhibitor in transgenic mice
    • Sebti SM, Hamilton AD (eds). Totowa, NJ, Humana Press
    • Gibbs JB, Graham SL, Hartman GD, et al: Antitumor efficacy of a farnesyltransferase inhibitor in transgenic mice, in Sebti SM, Hamilton AD (eds): Farnesyltransferase Inhibitors in Cancer Therapy. Totowa, NJ, Humana Press, 2000, pp 65-70
    • (2000) Farnesyltransferase Inhibitors in Cancer Therapy , pp. 65-70
    • Gibbs, J.B.1    Graham, S.L.2    Hartman, G.D.3
  • 24
    • 0034658479 scopus 로고    scopus 로고
    • Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl: Protein transferase inhibitor
    • Omer CA, Chen Z, Diehl RE, et al: Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl: protein transferase inhibitor. Cancer Res 60:2680-2688, 2000
    • (2000) Cancer Res , vol.60 , pp. 2680-2688
    • Omer, C.A.1    Chen, Z.2    Diehl, R.E.3
  • 25
    • 0033959438 scopus 로고    scopus 로고
    • Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Lantry LE, Zhang Z, Yao R, et al: Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 21:113-116, 2000
    • (2000) Carcinogenesis , vol.21 , pp. 113-116
    • Lantry, L.E.1    Zhang, Z.2    Yao, R.3
  • 26
    • 0030774573 scopus 로고    scopus 로고
    • The geranylgeranyltransferase I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21WAF1/CIP1/SDII in a-p53 independent manner
    • Vogt A, Qian Y, Hamilton AD, et al: The geranylgeranyltransferase I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21WAF1/CIP1/SDII in a-p53 independent manner. J Biol Chem 272:27224-27229, 1997
    • (1997) J Biol Chem , vol.272 , pp. 27224-27229
    • Vogt, A.1    Qian, Y.2    Hamilton, A.D.3
  • 27
    • 0032493641 scopus 로고    scopus 로고
    • A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells
    • Sepp-Lorenzino L, Rosen N: A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells. J Biol Chem 273:20243-20251, 1998
    • (1998) J Biol Chem , vol.273 , pp. 20243-20251
    • Sepp-Lorenzino, L.1    Rosen, N.2
  • 28
    • 0034730625 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
    • Ashar HR, et al: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem 275:30451-30457, 2000
    • (2000) J Biol Chem , vol.275 , pp. 30451-30457
    • Ashar, H.R.1
  • 29
    • 0036714596 scopus 로고    scopus 로고
    • Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis
    • Hussein D, Taylor SS: Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci 115:3403-3414, 2002
    • (2002) J Cell Sci , vol.115 , pp. 3403-3414
    • Hussein, D.1    Taylor, S.S.2
  • 30
    • 0035844247 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
    • Crespo NC, Ohkanda J, Yen TJ, et al: The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem 276:16161-16167, 2001
    • (2001) J Biol Chem , vol.276 , pp. 16161-16167
    • Crespo, N.C.1    Ohkanda, J.2    Yen, T.J.3
  • 31
    • 0035988368 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status
    • Crespo NC, Delarue F, Ohkanda J, et al: The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death Differ 9:702-709, 2002
    • (2002) Cell Death Differ , vol.9 , pp. 702-709
    • Crespo, N.C.1    Delarue, F.2    Ohkanda, J.3
  • 32
    • 0034031248 scopus 로고    scopus 로고
    • Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes
    • Lee J, Miyano T, Dai Y, et al: Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes. Mol Reprod Dev 56:51-62, 2000
    • (2000) Mol Reprod Dev , vol.56 , pp. 51-62
    • Lee, J.1    Miyano, T.2    Dai, Y.3
  • 33
    • 0031050738 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment
    • Lebowitz PF, Sakamuro D, Prendergast GC: Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer Res 57:708-713, 1997
    • (1997) Cancer Res , vol.57 , pp. 708-713
    • Lebowitz, P.F.1    Sakamuro, D.2    Prendergast, G.C.3
  • 34
    • 0032417689 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
    • Suzuki N, Urano J, Tamanoi F: Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells. Proc Natl Acad Sci U S A 95:15356-15361, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15356-15361
    • Suzuki, N.1    Urano, J.2    Tamanoi, F.3
  • 35
    • 0033986790 scopus 로고    scopus 로고
    • The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis
    • Jiang K, Coppola D, Crespo NC, et al: The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol 20:139-148, 2000
    • (2000) Mol Cell Biol , vol.20 , pp. 139-148
    • Jiang, K.1    Coppola, D.2    Crespo, N.C.3
  • 36
    • 0033198386 scopus 로고    scopus 로고
    • Activation of the PI3′K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors
    • Du W, Liu A, Prendergast GC: Activation of the PI3′K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors. Cancer Res 59:4208-4212, 1999
    • (1999) Cancer Res , vol.59 , pp. 4208-4212
    • Du, W.1    Liu, A.2    Prendergast, G.C.3
  • 37
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang FL, Casey PJ: Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem 65:241-269, 1996
    • (1996) Annu Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 38
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl: Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, et al: A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 55:5302-5309, 1995
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3
  • 39
    • 0033546419 scopus 로고    scopus 로고
    • Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
    • Voice JK, Klemke RL, Le A, et al: Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J Biol Chem 274:17164-17170, 1999
    • (1999) J Biol Chem , vol.274 , pp. 17164-17170
    • Voice, J.K.1    Klemke, R.L.2    Le, A.3
  • 40
    • 0032508517 scopus 로고    scopus 로고
    • Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
    • Yan J, Roy S, Apolloni A, et al: Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem 273:24052-24056, 1998
    • (1998) J Biol Chem , vol.273 , pp. 24052-24056
    • Yan, J.1    Roy, S.2    Apolloni, A.3
  • 41
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
    • Nagasu T, Yoshimatsu K, Rowell C, et al: Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res 55:5310-5314, 1995
    • (1995) Cancer Res , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3
  • 42
    • 0030916369 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
    • Lebowitz PF, Casey PJ, Prendergast GC, et al: Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem 272:15591-15594, 1997
    • (1997) J Biol Chem , vol.272 , pp. 15591-15594
    • Lebowitz, P.F.1    Casey, P.J.2    Prendergast, G.C.3
  • 43
    • 0033231190 scopus 로고    scopus 로고
    • Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors
    • Du W, Prendergast GC: Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res 59:5492-5496, 1999
    • (1999) Cancer Res , vol.59 , pp. 5492-5496
    • Du, W.1    Prendergast, G.C.2
  • 44
    • 0033860183 scopus 로고    scopus 로고
    • RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors
    • Liu A, Du W, Liu JP, et al: RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Mol Cell Biol 20:6105-6113, 2000
    • (2000) Mol Cell Biol , vol.20 , pp. 6105-6113
    • Liu, A.1    Du, W.2    Liu, J.P.3
  • 45
    • 0034674417 scopus 로고    scopus 로고
    • Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
    • Chen Z, Sun J, Pradines A, et al: Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice. J Biol Chem 275:17974-17978, 2000
    • (2000) J Biol Chem , vol.275 , pp. 17974-17978
    • Chen, Z.1    Sun, J.2    Pradines, A.3
  • 46
    • 0032541613 scopus 로고    scopus 로고
    • Rho family proteins and Ras transformation: The RHOad less traveled gets congested
    • Zohn IM, Campbell SL, Khosravi-Far R, et al: Rho family proteins and Ras transformation: The RHOad less traveled gets congested. Oncogene 17:1415-1438, 1998
    • (1998) Oncogene , vol.17 , pp. 1415-1438
    • Zohn, I.M.1    Campbell, S.L.2    Khosravi-Far, R.3
  • 47
    • 0035992372 scopus 로고    scopus 로고
    • Suppression of Rho B expression in invasive carcinoma from head and neck cancer patients
    • Adnane J, Muro-Cacho C, Mathews L, et al: Suppression of Rho B expression in invasive carcinoma from head and neck cancer patients. Clin Cancer Res 8:2225-2232, 2002
    • (2002) Clin Cancer Res , vol.8 , pp. 2225-2232
    • Adnane, J.1    Muro-Cacho, C.2    Mathews, L.3
  • 48
    • 0035993192 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors as anticancer agents
    • Haluska P, Dy GK, Adjei AA: Farnesyltransferase inhibitors as anticancer agents. Eur J Oncol 38:1685-1700, 2002
    • (2002) Eur J Oncol , vol.38 , pp. 1685-1700
    • Haluska, P.1    Dy, G.K.2    Adjei, A.A.3
  • 49
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, et al: Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial. Blood 97:3361-3369, 2001
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 50
    • 0035282735 scopus 로고    scopus 로고
    • Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336
    • Reichert A, Heisterkamp N, Daley GQ, et al: Treatment of Bcr/ Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood 97:1399-1403, 2001
    • (2001) Blood , vol.97 , pp. 1399-1403
    • Reichert, A.1    Heisterkamp, N.2    Daley, G.Q.3
  • 51
    • 0003268466 scopus 로고    scopus 로고
    • Interim results from a phase II study of R115777 (Zarnestra) in patients with relapsed and refractory acute myelogenous leukemia
    • abstr 1056
    • Harousseau J-L, Stone R, Thomas X, et al: Interim results from a phase II study of R115777 (Zarnestra) in patients with relapsed and refractory acute myelogenous leukemia. Proc Am Soc Clin Oncol 21:265a, 2002 (abstr 1056)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Harousseau, J.-L.1    Stone, R.2    Thomas, X.3
  • 52
    • 0036655765 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Current therapies and the potential role of farnesyltransferase inhibitors
    • Keating A: Chronic myeloid leukemia: Current therapies and the potential role of farnesyltransferase inhibitors. Semin Hematol 39:11-17, 2002 (suppl 2)
    • (2002) Semin Hematol , vol.39 , Issue.SUPPL. 2 , pp. 11-17
    • Keating, A.1
  • 53
    • 79960970844 scopus 로고    scopus 로고
    • Phase I study of a farnesyl transferase inhibitor, R115777, in patients with myelodysplastic syndrome
    • abstr 2609
    • Kurzrock R, Sebti SM, Kantarjian HM, et al: Phase I study of a farnesyl transferase inhibitor, R115777, in patients with myelodysplastic syndrome. Blood 98:623a, 2001 (abstr 2609)
    • (2001) Blood , vol.98
    • Kurzrock, R.1    Sebti, S.M.2    Kantarjian, H.M.3
  • 54
    • 79960970803 scopus 로고    scopus 로고
    • Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome
    • abstr 3520
    • Kurzrock R, Cortes J, Ryback ME, et al: Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome. Blood 98:848, 2001 (abstr 3520)
    • (2001) Blood , vol.98 , pp. 848
    • Kurzrock, R.1    Cortes, J.2    Ryback, M.E.3
  • 55
    • 0003230749 scopus 로고    scopus 로고
    • Phase I/II study of farnesyltransferase inhibitor R115777 (Zarnestra) in patients with myeloproliferative disorders (MPDs): Preliminary results
    • abstr 14
    • Gotlib J, Dugan K, Katamneni U, et al: Phase I/II study of farnesyltransferase inhibitor R115777 (Zarnestra) in patients with myeloproliferative disorders (MPDs): Preliminary results. Proc Am Soc Clin Oncol 21:4a, 2002 (abstr 14)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Gotlib, J.1    Dugan, K.2    Katamneni, U.3
  • 56
    • 0013329920 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor FTI-R115777 is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
    • abstr 4960
    • Alsina M, Overton R, Belle N, et al: Farnesyltransferase inhibitor FTI-R115777 is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Proc Am Assoc Cancer Res 43:1000, 2002 (abstr 4960)
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 1000
    • Alsina, M.1    Overton, R.2    Belle, N.3
  • 57
    • 0009944899 scopus 로고    scopus 로고
    • Clinical activity and inhibition of protein farnesylation of FTI-R115777 treated patients with myelodysplastic syndrome (MDS)
    • abstr 4959
    • Kurzrock R, Wilson EF, Sebti SM: Clinical activity and inhibition of protein farnesylation of FTI-R115777 treated patients with myelodysplastic syndrome (MDS). Proc Am Assoc Cancer Res 43:1000, 2002 (abstr 4959)
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 1000
    • Kurzrock, R.1    Wilson, E.F.2    Sebti, S.M.3
  • 58
    • 0001139688 scopus 로고    scopus 로고
    • NCIC CTG IND.128: A phase II study of a farnesyl transferase inhibitor (SCH 66336) in patients with unresectable or metastatic transitional cell carcinoma of the urothelial tract failing prior chemotherapy
    • abstr 785
    • Winquist E, Moore MJ, Chi K, et al: NCIC CTG IND.128: A phase II study of a farnesyl transferase inhibitor (SCH 66336) in patients with unresectable or metastatic transitional cell carcinoma of the urothelial tract failing prior chemotherapy. Proc Am Soc Clin Oncol 20:197a, 2001 (abstr 785)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Winquist, E.1    Moore, M.J.2    Chi, K.3
  • 59
    • 0012802908 scopus 로고    scopus 로고
    • Phase II trial of R115777, an inhibitor of farnesyltransferase, in patients with hormone refractory prostate cancer
    • abstr 721
    • Haas N, Peereboom D, Ranganathan S, et al: Phase II trial of R115777, an inhibitor of farnesyltransferase, in patients with hormone refractory prostate cancer. Proc Am Soc Clin Oncol 21:181a, 2002 (abstr 721)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Haas, N.1    Peereboom, D.2    Ranganathan, S.3
  • 60
    • 0035990832 scopus 로고    scopus 로고
    • A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan
    • Sharma S, Kemeny N, Kelsen DP, et al: A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan. Ann Oncol 13:1067-1071, 2002
    • (2002) Ann Oncol , vol.13 , pp. 1067-1071
    • Sharma, S.1    Kemeny, N.2    Kelsen, D.P.3
  • 61
    • 0001674319 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colorectal cancer
    • abstr 502
    • Cunningham D, de Gramont A, Scheithauer W, et al: Randomized double-blind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colorectal cancer. Proc Am Soc Clin Oncol 21:126a, 2002 (abstr 502)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Cunningham, D.1    De Gramont, A.2    Scheithauer, W.3
  • 62
    • 0001120709 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer. A Southwest Oncology Group (SWOG) study
    • abstr 548
    • Macdonald JS, Chansky K, Whitehead R, et al: A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer. A Southwest Oncology Group (SWOG) study. Proc Am Soc Clin Oncol 21:138a, 2002 (abstr 548)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Macdonald, J.S.1    Chansky, K.2    Whitehead, R.3
  • 63
    • 0038413837 scopus 로고    scopus 로고
    • Phase II and pharmacodynamic trial of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
    • abstr 545
    • Cohen SJ, Ho L, Ranganathan S, et al: Phase II and pharmacodynamic trial of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. Proc Am Soc Clin Oncol 21:137a, 2002 (abstr 545)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Cohen, S.J.1    Ho, L.2    Ranganathan, S.3
  • 64
    • 0000324578 scopus 로고    scopus 로고
    • Phase III trial comparing gemcitabine + R115777 (Zarnestra) versus gemcitabine + placebo in advanced pancreatic cancer (PC)
    • abstr 517
    • Van Cutsem E, Karasek P, Oettle H, et al: Phase III trial comparing gemcitabine + R115777 (Zarnestra) versus gemcitabine + placebo in advanced pancreatic cancer (PC). Proc Am Soc Clin Oncol 21:130a, 2002 (abstr 517)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Van Cutsem, E.1    Karasek, P.2    Oettle, H.3
  • 65
    • 0000990647 scopus 로고    scopus 로고
    • Efficacy and tolerability of two dosing regimens of R115777 (Zarnestra), a farnesyl protein transferase inhibitor, in patients with advanced breast cancer
    • abstr 138
    • Johnston SRD, Hickish T, Houston S, et al: Efficacy and tolerability of two dosing regimens of R115777 (Zarnestra), a farnesyl protein transferase inhibitor, in patients with advanced breast cancer. Proc Am Soc Clin Oncol 21:35a, 2002 (abstr 138)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Johnston, S.R.D.1    Hickish, T.2    Houston, S.3
  • 66
    • 0003258673 scopus 로고    scopus 로고
    • Phase II trial of R115777 (Zarnestra) in patients with recurrent glioma not taking enzyme inducing antiepileptic drugs (EIAED): A North American Brain Tumor Consortium (NABTC) report
    • abstr 317
    • Cloughesy TF, Kuhn J, Wen P, et al: Phase II trial of R115777 (Zarnestra) in patients with recurrent glioma not taking enzyme inducing antiepileptic drugs (EIAED): A North American Brain Tumor Consortium (NABTC) report. Proc Am Soc Clin Oncol 21:80a, 2002 (abstr 317)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Cloughesy, T.F.1    Kuhn, J.2    Wen, P.3
  • 67
    • 0003258673 scopus 로고    scopus 로고
    • Phase I trial of R115777 (Zarnestra) in patients with recurrent malignant glioma taking enzyme inducting antiepileptic drugs (EIAED). A North American Brain Tumor Consortium (NABTC) report
    • abstr 342
    • Kuhn JG, Prados M, Robins HI, et al: Phase I trial of R115777 (Zarnestra) in patients with recurrent malignant glioma taking enzyme inducting antiepileptic drugs (EIAED). A North American Brain Tumor Consortium (NABTC) report. Proc Am Soc Clin Oncol 21:86a, 2002 (abstr 342)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kuhn, J.G.1    Prados, M.2    Robins, H.I.3
  • 68
    • 0036605562 scopus 로고    scopus 로고
    • Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R 115777 in advanced cancer
    • Crul M, de Klerk GJ, Swart M, et al: Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol 20:2726-2735, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 2726-2735
    • Crul, M.1    De Klerk, G.J.2    Swart, M.3
  • 69
    • 0000165438 scopus 로고    scopus 로고
    • A phase I, clinical and pharmacokinetic (PK) trial of the farnesyl transferase inhibitor (FTI) R115777 + docetaxel: A promising combination in patients (PTS) with solid tumors
    • abstr 318
    • Piccart-Gebhart MJ, Branle D, de Valeriola M, et al: A phase I, clinical and pharmacokinetic (PK) trial of the farnesyl transferase inhibitor (FTI) R115777 + docetaxel: A promising combination in patients (PTS) with solid tumors. Proc Am Soc Clin Oncol 20:80a, 2001 (abstr 318)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Piccart-Gebhart, M.J.1    Branle, D.2    De Valeriola, M.3
  • 70
    • 0001229384 scopus 로고    scopus 로고
    • Combination studies with the farnesyltransferase inhibitor R115777 and chemotherapy agents
    • abstr
    • Adjei AA, Bruzek LM, Erlichman C, et al: Combination studies with the farnesyltransferase inhibitor R115777 and chemotherapy agents. Eur J Cancer 37:792, 2001 (suppl 6) (abstr)
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 6 , pp. 792
    • Adjei, A.A.1    Bruzek, L.M.2    Erlichman, C.3
  • 71
    • 0038362742 scopus 로고    scopus 로고
    • A phase II study of the farnesyltransferase inhibitor R115777 in patients with advanced non-small cell lung cancer
    • abstr 1156
    • Adjei AA, Mauer A, Marks R, et al: A phase II study of the farnesyltransferase inhibitor R115777 in patients with advanced non-small cell lung cancer. Proc Am Soc Clin Oncol 21:290a, 2002 (abstr 1156)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Adjei, A.A.1    Mauer, A.2    Marks, R.3
  • 72
    • 0001120711 scopus 로고    scopus 로고
    • Phase II study of the farnesyl transferase inhibitor (FTI) R115777 (Zarnestra) in patients with relapsed small cell lung cancer (SCLC)
    • abstr 1275
    • Heymach JV, De Porte PM, Devore RF, et al: Phase II study of the farnesyl transferase inhibitor (FTI) R115777 (Zarnestra) in patients with relapsed small cell lung cancer (SCLC). Proc Am Soc Clin Oncol 21:319a, 2002 (abstr 1275)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Heymach, J.V.1    De Porte, P.M.2    Devore, R.F.3
  • 73
    • 0034071688 scopus 로고    scopus 로고
    • A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity
    • Adjei AA, Erlichman C, Davis JN, et al: A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity. Cancer Res 60:1871-1877, 2000
    • (2000) Cancer Res , vol.60 , pp. 1871-1877
    • Adjei, A.A.1    Erlichman, C.2    Davis, J.N.3
  • 74
    • 0003054845 scopus 로고    scopus 로고
    • Phase I study of farnesyl transferase inhibitor (FTI) SCH66336 with paclitaxel in solid tumors: Dose finding, pharmacokinetics, efficacy/safety
    • abstr 799
    • Khuri FR, Glisson BS, Meyers ML, et al: Phase I study of farnesyl transferase inhibitor (FTI) SCH66336 with paclitaxel in solid tumors: Dose finding, pharmacokinetics, efficacy/safety. Proc Am Soc Clin Oncol 19:205a, 2000 (abstr 799)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Khuri, F.R.1    Glisson, B.S.2    Meyers, M.L.3
  • 75
    • 0000086473 scopus 로고    scopus 로고
    • A phase I/II study of the farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) with paclitaxel in taxane-refractory/resistant patients with non-small cell lung cancer (NSCLC): Final report
    • abstr 2735
    • Kim ES, Kies MS, Fossella FV, et al: A phase I/II study of the farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) with paclitaxel in taxane-refractory/resistant patients with non-small cell lung cancer (NSCLC): Final report. Proc Am Assoc Cancer Res 43:550, 2002 (abstr 2735)
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 550
    • Kim, E.S.1    Kies, M.S.2    Fossella, F.V.3
  • 76
    • 0035886842 scopus 로고    scopus 로고
    • Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
    • Rose WC, Lee FYF, Fairchild CR, et al: Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res 61:7507-7517, 2001
    • (2001) Cancer Res , vol.61 , pp. 7507-7517
    • Rose, W.C.1    Lee, F.Y.F.2    Fairchild, C.R.3
  • 77
    • 0003236113 scopus 로고    scopus 로고
    • Dose escalation study of oral farnesyl transferase inhibitor (FTI) BMS-214662 in patients with solid tumors
    • abstr 311
    • Camacho LH, Soignet SL, Pezzulli S, et al: Dose escalation study of oral farnesyl transferase inhibitor (FTI) BMS-214662 in patients with solid tumors. Proc Am Soc Clin Oncol 20:79a, 2001 (abstr 311)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Camacho, L.H.1    Soignet, S.L.2    Pezzulli, S.3
  • 78
    • 0000441628 scopus 로고    scopus 로고
    • Phase I clinical trial of the farnesyltransferase (FT) inhibitor BMS-214662 in patients with advanced solid tumors
    • abstr 720
    • Ryan DP, Eder JP, Supko JG, et al: Phase I clinical trial of the farnesyltransferase (FT) inhibitor BMS-214662 in patients with advanced solid tumors. Proc Am Soc Clin Oncol 19:720, 2000 (abstr 720)
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 720
    • Ryan, D.P.1    Eder, J.P.2    Supko, J.G.3
  • 79
    • 0000086474 scopus 로고    scopus 로고
    • A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662 in combination with paclitaxel and carboplatin in patients with advanced cancer
    • abstr 2736
    • Dy GK, Bruzek LM, Croghan GA, et al: A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662 in combination with paclitaxel and carboplatin in patients with advanced cancer. Proc Am Assoc Cancer Res 43:550, 2002 (abstr 2736)
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 550
    • Dy, G.K.1    Bruzek, L.M.2    Croghan, G.A.3
  • 80
    • 0034525706 scopus 로고    scopus 로고
    • Chemopreventive efficacy of promising farnesyltransferase inhibitors
    • Lantry LE, Zhang Z, Crist KA, Wang Y, et al: Chemopreventive efficacy of promising farnesyltransferase inhibitors. Exp Lung Res 26:773-790, 2000
    • (2000) Exp Lung Res , vol.26 , pp. 773-790
    • Lantry, L.E.1    Zhang, Z.2    Crist, K.A.3    Wang, Y.4
  • 81
    • 0036655043 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials of R115777 (Zarnestra)
    • 930-931935-937
    • Wright JJ, Zerivitz K, Gravell AE, et al: Clinical trials referral resource. Current clinical trials of R115777 (Zarnestra). Oncology (Huntingt) 16:930-931935-937, 2002
    • (2002) Oncology (Huntingt) , vol.16
    • Wright, J.J.1    Zerivitz, K.2    Gravell, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.