Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Pharmazie

Volumn 58, Issue 12, 2003, Pages 854-856

  Wiesner, J ^c   Mitsch, A ^b   Altenkamper M ^b   Ortmann, R ^a   Jomaa, H ^c   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Institut fur Pharmazeutische Chemie   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLOYLAMINOBENZOPHENONE; ANTIMALARIAL AGENT; BENZOPHENONE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; BENZOPHENONES; DRUG DESIGN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INDICATORS AND REAGENTS; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0345735585     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Sachs, J.; Malaney, P.: Nature 415, 680 (2002)
2. Ridley, R. G.: Nature 415, 686 (2002)
3. Schlitzer, M.: Curr. Pharm. Design 8, 1713 (2002)
4. Wiesner, J.; Wißner, P.; Dahse, H.-M.; Jomaa, H.; Schlitzer, M.: Bioorg. Med. Chem. 9, 785 (2001)
5. Wiesner, J.; Mitsch, A.; Wißner, P.; Jomaa, H.; Schlitzer, M.: Bioorg. Med. Chem. Lett. 11, 423 (2001)
6. Wiesner, J.; Kettler, K.; Jomaa, H.; Schlitzer, M.: Bioorg. Med. Chem. Lett. 12, 543 (2002)
7. Wiesner, J.; Mitsch, A.; Wißner, P.; Krämer, O.; Jomaa, H.; Schlitzer, M.: Bioorg. Med. Chem. Lett. 12, 2681 (2002)
8. Wiesner, J.; Kettler, K.; Sakowski, J.; Ortmann, R.; Jomaa, H.; Schlitzer, M.: Bioorg. Med. Chem. Lett. 13, 361 (2003)
9. Shin, S. S.; Noh, M.-S.; Byun, Y. J; Choi, J. K.; Kim, J. Y.; Lim, K. M. ; Ha, J.-Y.; Kim, J. K.; Lee, C. H.; Chung, S.: Bioog. Med. Chem. Lett. 11, 165 (2001)
10. Sakowski, J., Böhm, M.; Sattler, I.; Dahse, H.-M.; Schlitzer, M.: J. Med. Chem. 44, 2886 (2001)
11. Böhm, M.; Mitsch, A.; Wißner, P.; Sattler, I.; Schlitzer, M.: J. Med. Chem. 44, 3117 (2001)
12. Desjardins, R. E.; Canfield, C. J.; Haynes, J. D.; Chulay, J. D.: Antimicrob. Agents Chemother. 16, 710 (1979)
13. Trager, W.; Jensen, J. B.: Science 193, 673 (1976)
14. Ancelin, M. L.; Calas, M., Bompart, J.; Cordina, G.; Martin, D.; Bari, M. B.; Jei, T.; Druilhe, P.; Vial, H. J.: Blood 91, 1 (1998)