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Volumn 81, Issue 5, 2005, Pages 368-377

Role of transcription factors C/EBPα and PU.1 in normal hematopoiesis and leukemia

Author keywords

C EPB ; Hematopoiesis; Leukemia; PU.1; Transcription factors

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1;

EID: 21544465306     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.05051     Document Type: Review
Times cited : (65)

References (91)
  • 1
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404:193-197.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 2
    • 0024466796 scopus 로고
    • Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
    • Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood. 1989; 74:1563-1570.
    • (1989) Blood , vol.74 , pp. 1563-1570
    • Sutherland, H.J.1    Eaves, C.J.2    Eaves, A.C.3    Dragowska, W.4    Lansdorp, P.M.5
  • 3
    • 0018922995 scopus 로고
    • Competitive repopulation: A new assay for long-term stem cell functional capacity
    • Harrison DE. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood. 1980;55:77-81.
    • (1980) Blood , vol.55 , pp. 77-81
    • Harrison, D.E.1
  • 4
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997; 91:661-672.
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 5
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241: 58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 6
    • 0030925298 scopus 로고    scopus 로고
    • Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
    • Cashman JD, Lapidot T, Wang JC, et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 1997;89:4307-4316.
    • (1997) Blood , vol.89 , pp. 4307-4316
    • Cashman, J.D.1    Lapidot, T.2    Wang, J.C.3
  • 7
    • 17844370871 scopus 로고    scopus 로고
    • The ordered expression of transcription factors directs hierarchical lineage specification of eosinophils, basophils and mast cells
    • Iwasaki H, Arinobu Y, Mizuno S, et al. The ordered expression of transcription factors directs hierarchical lineage specification of eosinophils, basophils and mast cells. Blood. 2004;104:68a.
    • (2004) Blood , vol.104
    • Iwasaki, H.1    Arinobu, Y.2    Mizuno, S.3
  • 8
    • 2542471001 scopus 로고    scopus 로고
    • PU.1 deficiency blocks the production of common myeloid and common lymphoid progenitors in both adult and fetal liver myelopoiesis
    • Duprez E, Iwasaki-Arai J, Geary K, et al. PU.1 deficiency blocks the production of common myeloid and common lymphoid progenitors in both adult and fetal liver myelopoiesis. Blood. 2002;100: 61a.
    • (2002) Blood , vol.100
    • Duprez, E.1    Iwasaki-Arai, J.2    Geary, K.3
  • 9
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H, Ye M, Feng R, Graf T. Stepwise reprogramming of B cells into macrophages. Cell. 2004;117:663-676.
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Ye, M.2    Feng, R.3    Graf, T.4
  • 10
    • 0141455931 scopus 로고    scopus 로고
    • GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages
    • Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/ erythrocyte lineages. Immunity. 2003;19: 451-462.
    • (2003) Immunity , vol.19 , pp. 451-462
    • Iwasaki, H.1    Mizuno, S.2    Wells, R.A.3    Cantor, A.B.4    Watanabe, S.5    Akashi, K.6
  • 11
    • 0042025062 scopus 로고    scopus 로고
    • Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors
    • Heavey B, Charalambous C, Cobaleda C, Busslinger M. Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J. 2003;22:3887-3897.
    • (2003) EMBO J , vol.22 , pp. 3887-3897
    • Heavey, B.1    Charalambous, C.2    Cobaleda, C.3    Busslinger, M.4
  • 12
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 13
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577.
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 14
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15:5647-5658.
    • (1996) EMBO J , vol.15 , pp. 5647-5658
    • McKercher, S.R.1    Torbett, B.E.2    Anderson, K.L.3
  • 15
    • 21544467339 scopus 로고    scopus 로고
    • PU.1 is a critical downstream target of AML1
    • Huang G, Zhang P, Koschmieder S, et al. PU.1 is a critical downstream target of AML1. Blood. 2004;104:105a.
    • (2004) Blood , vol.104
    • Huang, G.1    Zhang, P.2    Koschmieder, S.3
  • 16
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A. 1997;94: 569-574.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 17
    • 0031008479 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing
    • Yamanaka R, Kim GD, Radomska HS, et al. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci U S A. 1997;94:6462-6467.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6462-6467
    • Yamanaka, R.1    Kim, G.D.2    Radomska, H.S.3
  • 18
    • 0033135842 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge
    • Lekstrom-Himes J, Xanthopoulos KG. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge. Blood. 1999;93:3096-3105.
    • (1999) Blood , vol.93 , pp. 3096-3105
    • Lekstrom-Himes, J.1    Xanthopoulos, K.G.2
  • 19
    • 0029121271 scopus 로고
    • Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
    • Robb L, Lyons I, Li R, Hartley L, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-7079.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7075-7079
    • Robb, L.1    Lyons, I.2    Li, R.3    Hartley, L.4
  • 20
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373:432-434.
    • (1995) Nature , vol.373 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 21
    • 0037472895 scopus 로고    scopus 로고
    • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    • Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421: 547-551.
    • (2003) Nature , vol.421 , pp. 547-551
    • Mikkola, H.K.1    Klintman, J.2    Yang, H.3
  • 22
    • 0037417892 scopus 로고    scopus 로고
    • The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
    • Hall MA, Curtis DJ, Metcalf D, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003;100:992-997.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 992-997
    • Hall, M.A.1    Curtis, D.J.2    Metcalf, D.3
  • 23
    • 1942425445 scopus 로고    scopus 로고
    • SCL is required for normal function of short-term repopulating hematopoietic stem cells
    • Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood. 2004;103:3342-3348.
    • (2004) Blood , vol.103 , pp. 3342-3348
    • Curtis, D.J.1    Hall, M.A.2    Van Stekelenburg, L.J.3    Robb, L.4    Jane, S.M.5    Begley, C.G.6
  • 24
    • 2342451948 scopus 로고    scopus 로고
    • AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    • Ichikawa M, Asai T, Saito T, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004;10:299-304.
    • (2004) Nat Med , vol.10 , pp. 299-304
    • Ichikawa, M.1    Asai, T.2    Saito, T.3
  • 25
    • 10344230611 scopus 로고    scopus 로고
    • Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
    • Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004; 21:853-863.
    • (2004) Immunity , vol.21 , pp. 853-863
    • Zhang, P.1    Iwasaki-Arai, J.2    Iwasaki, H.3
  • 26
    • 0029763203 scopus 로고    scopus 로고
    • Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
    • Brass AL, Kehrli E, Eisenbeis CF, Storb U, Singh H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1 Genes Dev. 1996;10:2335-2347.
    • (1996) Genes Dev , vol.10 , pp. 2335-2347
    • Brass, A.L.1    Kehrli, E.2    Eisenbeis, C.F.3    Storb, U.4    Singh, H.5
  • 27
    • 0027494858 scopus 로고
    • PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer
    • Eisenbeis CF, Singh H, Storb U. PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol. 1993;13: 6452-6461.
    • (1993) Mol Cell Biol , vol.13 , pp. 6452-6461
    • Eisenbeis, C.F.1    Singh, H.2    Storb, U.3
  • 29
    • 0029073345 scopus 로고
    • Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
    • Eisenbeis CF, Singh H, Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995;9:1377-1387.
    • (1995) Genes Dev , vol.9 , pp. 1377-1387
    • Eisenbeis, C.F.1    Singh, H.2    Storb, U.3
  • 30
    • 0027159217 scopus 로고
    • The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds
    • Kanno Y, Kozak CA, Schindler C, et al. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol. 1993;13:3951-3963.
    • (1993) Mol Cell Biol , vol.13 , pp. 3951-3963
    • Kanno, Y.1    Kozak, C.A.2    Schindler, C.3
  • 31
    • 0030024112 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    • Zhang DE, Hetherington CJ, Meyers S, et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol. 1996;16:1231-1240.
    • (1996) Mol Cell Biol , vol.16 , pp. 1231-1240
    • Zhang, D.E.1    Hetherington, C.J.2    Meyers, S.3
  • 32
    • 0029121366 scopus 로고
    • PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
    • Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang DE, Tenen DG PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol. 1995;15:5830-5845.
    • (1995) Mol Cell Biol , vol.15 , pp. 5830-5845
    • Hohaus, S.1    Petrovick, M.S.2    Voso, M.T.3    Sun, Z.4    Zhang, D.E.5    Tenen, D.G.6
  • 33
    • 0029793902 scopus 로고    scopus 로고
    • PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
    • Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood. 1996;88:1234-1247.
    • (1996) Blood , vol.88 , pp. 1234-1247
    • Smith, L.T.1    Hohaus, S.2    Gonzalez, D.A.3    Dziennis, S.E.4    Tenen, D.G.5
  • 34
    • 0034234513 scopus 로고    scopus 로고
    • AML1MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon
    • Shimizu K, Kitabayashi I, Kamada N, et al. AML1MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood. 2000;96:288-296.
    • (2000) Blood , vol.96 , pp. 288-296
    • Shimizu, K.1    Kitabayashi, I.2    Kamada, N.3
  • 35
    • 0031472234 scopus 로고    scopus 로고
    • FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    • Tsang AP, Visvader JE, Turner CA, et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997;90: 109-119.
    • (1997) Cell , vol.90 , pp. 109-119
    • Tsang, A.P.1    Visvader, J.E.2    Turner, C.A.3
  • 36
    • 0033083804 scopus 로고    scopus 로고
    • Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex
    • Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell. 1999;3: 219-228.
    • (1999) Mol Cell , vol.3 , pp. 219-228
    • Crispino, J.D.1    Lodish, M.B.2    MacKay, J.P.3    Orkin, S.H.4
  • 37
    • 0033582475 scopus 로고    scopus 로고
    • C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
    • Behre G, Whitmarsh AJ, Coghlan MP, et al. C-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem. 1999;274:4939-4946.
    • (1999) J Biol Chem , vol.274 , pp. 4939-4946
    • Behre, G.1    Whitmarsh, A.J.2    Coghlan, M.P.3
  • 38
    • 0032478276 scopus 로고    scopus 로고
    • CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
    • Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci USA. 1998;95:2061-2066.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2061-2066
    • Blobel, G.A.1    Nakajima, T.2    Eckner, R.3    Montminy, M.4    Orkin, S.H.5
  • 39
    • 0036094806 scopus 로고    scopus 로고
    • Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1
    • Hong W, Kim AY, Ky S, et al. Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1. Mol Cell Biol. 2002;22:3729-3743.
    • (2002) Mol Cell Biol , vol.22 , pp. 3729-3743
    • Hong, W.1    Kim, A.Y.2    Ky, S.3
  • 40
    • 0034667672 scopus 로고    scopus 로고
    • PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
    • Zhang P, Zhang X, Iwama A, et al. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 2000;96:2641-2648.
    • (2000) Blood , vol.96 , pp. 2641-2648
    • Zhang, P.1    Zhang, X.2    Iwama, A.3
  • 41
    • 0033587755 scopus 로고    scopus 로고
    • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
    • Zhang P, Behre G, Pan J, et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci USA. 1999;96:8705-8710.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8705-8710
    • Zhang, P.1    Behre, G.2    Pan, J.3
  • 42
    • 0033151624 scopus 로고    scopus 로고
    • Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
    • Rekhtman N, Radparvar F, Evans T, Skoultchi AI. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 1999;13:1398-1411.
    • (1999) Genes Dev , vol.13 , pp. 1398-1411
    • Rekhtman, N.1    Radparvar, F.2    Evans, T.3    Skoultchi, A.I.4
  • 43
    • 0029978734 scopus 로고    scopus 로고
    • Spi-1/PU.1 transgenic mice develop multistep erythroleukemias
    • Moreau-Gachelin F, Wendling F, Molina T, et al. Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. Mol Cell Biol. 1996;16:2453-2463.
    • (1996) Mol Cell Biol , vol.16 , pp. 2453-2463
    • Moreau-Gachelin, F.1    Wendling, F.2    Molina, T.3
  • 44
    • 0141953999 scopus 로고    scopus 로고
    • Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1
    • Choe KS, Radparvar F, Matushansky I, Rekhtman N, Han X, Skoultchi AI. Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1. Cancer Res. 2003;63: 6363-6369.
    • (2003) Cancer Res , vol.63 , pp. 6363-6369
    • Choe, K.S.1    Radparvar, F.2    Matushansky, I.3    Rekhtman, N.4    Han, X.5    Skoultchi, A.I.6
  • 45
    • 0023839919 scopus 로고
    • Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
    • Moreau-Gachelin F, Tavitian A, Tambourin P. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature. 1988;331:277-280.
    • (1988) Nature , vol.331 , pp. 277-280
    • Moreau-Gachelin, F.1    Tavitian, A.2    Tambourin, P.3
  • 46
    • 0142124320 scopus 로고    scopus 로고
    • Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor
    • Dahl R, Walsh JC, Lancki D, et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol. 2003;4:1029-1036.
    • (2003) Nat Immunol , vol.4 , pp. 1029-1036
    • Dahl, R.1    Walsh, J.C.2    Lancki, D.3
  • 47
    • 0037100304 scopus 로고    scopus 로고
    • Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions
    • Reddy VA, Iwama A, Iotzova G, et al. Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood. 2002;100:483-490.
    • (2002) Blood , vol.100 , pp. 483-490
    • Reddy, V.A.1    Iwama, A.2    Iotzova, G.3
  • 48
    • 2642519463 scopus 로고    scopus 로고
    • Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    • Rosenbauer F, Wagner K, Kutok JL, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004;36:624-630.
    • (2004) Nat Genet , vol.36 , pp. 624-630
    • Rosenbauer, F.1    Wagner, K.2    Kutok, J.L.3
  • 49
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science. 2000; 288:1439-1441.
    • (2000) Science , vol.288 , pp. 1439-1441
    • Dekoter, R.P.1    Singh, H.2
  • 50
    • 0037013889 scopus 로고    scopus 로고
    • Making eosinophils through subtle shifts in transcription factor expression
    • McNagny K, Graf T. Making eosinophils through subtle shifts in transcription factor expression. J Exp Med. 2002;195:F43-F47.
    • (2002) J Exp Med , vol.195
    • McNagny, K.1    Graf, T.2
  • 51
    • 0025029777 scopus 로고
    • Reporter genes: Application to the study of mammalian gene transcription
    • Alam J, Cook JL. Reporter genes: application to the study of mammalian gene transcription. Anal Biochem. 1990;188:245-254.
    • (1990) Anal Biochem , vol.188 , pp. 245-254
    • Alam, J.1    Cook, J.L.2
  • 53
    • 0035892121 scopus 로고    scopus 로고
    • Regulation of the PU.1 gene by distal elements
    • Li Y, Okuno Y, Zhang P, et al. Regulation of the PU.1 gene by distal elements. Blood. 2001;98:2958-2965.
    • (2001) Blood , vol.98 , pp. 2958-2965
    • Li, Y.1    Okuno, Y.2    Zhang, P.3
  • 54
    • 0029943308 scopus 로고    scopus 로고
    • Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter
    • Chen H, Zhang P, Radomska HS, Hetherington CJ, Zhang DE, Tenen DG. Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter. J Biol Chem. 1996;271: 15743-15752.
    • (1996) J Biol Chem , vol.271 , pp. 15743-15752
    • Chen, H.1    Zhang, P.2    Radomska, H.S.3    Hetherington, C.J.4    Zhang, D.E.5    Tenen, D.G.6
  • 55
    • 0028826488 scopus 로고
    • PU.1 (Spi-1) autoregulates its expression in myeloid cells
    • Chen H, Ray-Gallet D, Zhang P, et al. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene. 1995;11:1549-1560.
    • (1995) Oncogene , vol.11 , pp. 1549-1560
    • Chen, H.1    Ray-Gallet, D.2    Zhang, P.3
  • 56
    • 21544483826 scopus 로고    scopus 로고
    • Deletion of a key PU.1 gene regulatory element induces T-cell lymphoma
    • Rosenbauer F, Steidl U, Owens BM, et al. Deletion of a key PU.1 gene regulatory element induces T-cell lymphoma. Blood. 2004; 104:105a.
    • (2004) Blood , vol.104
    • Rosenbauer, F.1    Steidl, U.2    Owens, B.M.3
  • 57
    • 0035135174 scopus 로고    scopus 로고
    • Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells
    • Yokomizo T, Ogawa M, Osato M, et al. Requirement of Runx1/AML1/ PEBP2alphaB for the generation of haematopoietic cells from endothelial cells. Genes Cells. 2001;6:13-23.
    • (2001) Genes Cells , vol.6 , pp. 13-23
    • Yokomizo, T.1    Ogawa, M.2    Osato, M.3
  • 58
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer. 2003;3:89-101.
    • (2003) Nat Rev Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 59
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029-3035.
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 60
    • 0036727413 scopus 로고    scopus 로고
    • Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    • Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 2002;32:148-152.
    • (2002) Nat Genet , vol.32 , pp. 148-152
    • Wechsler, J.1    Greene, M.2    McDevitt, M.A.3
  • 61
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 62
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 63
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004; 350:1617-1628.
    • (2004) N Engl J Med , vol.350 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 64
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27: 263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 65
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C, Sagot C, Boissel N, et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood. 2002;100:2717-2723.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3
  • 66
    • 0345269758 scopus 로고    scopus 로고
    • Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
    • Snaddon J, Smith ML, Neat M, et al. Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. Genes Chromosomes Cancer. 2003;37:72-78.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 72-78
    • Snaddon, J.1    Smith, M.L.2    Neat, M.3
  • 67
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol. 2004;22:624-633.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3
  • 68
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart AF, Hofmann WK, Kawano S, et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood. 2002;99:1332-1340.
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1    Hofmann, W.K.2    Kawano, S.3
  • 69
    • 0037591396 scopus 로고    scopus 로고
    • Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML
    • Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer J, et al. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J. 2003;4:31-40.
    • (2003) Hematol J , vol.4 , pp. 31-40
    • Barjesteh Van Waalwijk Van Doorn-Khosrovani, S.1    Erpelinck, C.2    Meijer, J.3
  • 70
    • 0035047652 scopus 로고    scopus 로고
    • AMLl-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia
    • Pabst T, Mueller BU, Harakawa N, et al. AMLl-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med. 2001;7:444-451.
    • (2001) Nat Med , vol.7 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3
  • 71
    • 0141593492 scopus 로고    scopus 로고
    • Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias
    • Cilloni D, Carturan S, Gottardi E, et al. Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias. Blood. 2003;102:2705-2706.
    • (2003) Blood , vol.102 , pp. 2705-2706
    • Cilloni, D.1    Carturan, S.2    Gottardi, E.3
  • 72
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki M, Schwable J, Steur C, et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood. 2003;101:3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3
  • 73
    • 0036893435 scopus 로고    scopus 로고
    • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    • Zheng R, Friedman AD, Small D. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood. 2002;100: 4154-4161.
    • (2002) Blood , vol.100 , pp. 4154-4161
    • Zheng, R.1    Friedman, A.D.2    Small, D.3
  • 74
    • 1442307974 scopus 로고    scopus 로고
    • Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression
    • Zheng R, Friedman AD, Levis M, Li L, Weir EG, Small D. Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression. Blood. 2004; 103:1883-1890.
    • (2004) Blood , vol.103 , pp. 1883-1890
    • Zheng, R.1    Friedman, A.D.2    Levis, M.3    Li, L.4    Weir, E.G.5    Small, D.6
  • 75
    • 0031283125 scopus 로고    scopus 로고
    • Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
    • Zahnow CA, Younes P, Laucirica R, Rosen JM. Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J Natl Cancer Inst. 1997; 89:1887-1891.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1887-1891
    • Zahnow, C.A.1    Younes, P.2    Laucirica, R.3    Rosen, J.M.4
  • 76
    • 0036682473 scopus 로고    scopus 로고
    • Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    • Mueller BU, Pabst T, Osato M, et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood. 2002;100: 998-1007.
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1    Pabst, T.2    Osato, M.3
  • 77
    • 0037114703 scopus 로고    scopus 로고
    • Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?
    • Lamandin C, Sagot C, Roumier C, et al. Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)? Blood. 2002;100:4680-4681.
    • (2002) Blood , vol.100 , pp. 4680-4681
    • Lamandin, C.1    Sagot, C.2    Roumier, C.3
  • 78
    • 0242662157 scopus 로고    scopus 로고
    • Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: A study of the AML Study Group Ulm (AMLSG ULM)
    • Dohner K, Tobis K, Bischof T, et al. Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: a study of the AML Study Group Ulm (AMLSG ULM). Blood. 2003;102:3850.
    • (2003) Blood , vol.102 , pp. 3850
    • Dohner, K.1    Tobis, K.2    Bischof, T.3
  • 79
    • 0037369257 scopus 로고    scopus 로고
    • Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    • Mueller BU, Pabst T, Osato M, et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood. 2003;101:2074.
    • (2003) Blood , vol.101 , pp. 2074
    • Mueller, B.U.1    Pabst, T.2    Osato, M.3
  • 80
    • 0030611964 scopus 로고    scopus 로고
    • PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
    • Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 1997;6:437-447.
    • (1997) Immunity , vol.6 , pp. 437-447
    • Scott, E.W.1    Fisher, R.C.2    Olson, M.C.3    Kehrli, E.W.4    Simon, M.C.5    Singh, H.6
  • 81
    • 0037222293 scopus 로고    scopus 로고
    • The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
    • Vangala RK, Heiss-Neumann MS, Rangatia JS, et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood. 2003;101:270-277.
    • (2003) Blood , vol.101 , pp. 270-277
    • Vangala, R.K.1    Heiss-Neumann, M.S.2    Rangatia, J.S.3
  • 82
    • 7744220635 scopus 로고    scopus 로고
    • MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    • Shachaf CM, Kopelman AM, Arvanitis C, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature. 2004;431:1112-1117.
    • (2004) Nature , vol.431 , pp. 1112-1117
    • Shachaf, C.M.1    Kopelman, A.M.2    Arvanitis, C.3
  • 83
    • 0037816153 scopus 로고    scopus 로고
    • Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia
    • Steffen B, Serve H, Berdel WE, et al. Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia. Proc Natl Acad Sci USA. 2003;100:8448-8453.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8448-8453
    • Steffen, B.1    Serve, H.2    Berdel, W.E.3
  • 84
    • 0344413639 scopus 로고    scopus 로고
    • In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
    • Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med. 2003;9:1428-1432.
    • (2003) Nat Med , vol.9 , pp. 1428-1432
    • Krosl, J.1    Austin, P.2    Beslu, N.3    Kroon, E.4    Humphries, R.K.5    Sauvageau, G.6
  • 85
    • 3943086381 scopus 로고    scopus 로고
    • Complementation of alpha-thalassaemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus
    • Al-Hasani K, Vadolas J, Voullaire L, Williamson R, Ioannou PA. Complementation of alpha-thalassaemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus. Transgenic Res. 2004;13:235-243.
    • (2004) Transgenic Res , vol.13 , pp. 235-243
    • Al-Hasani, K.1    Vadolas, J.2    Voullaire, L.3    Williamson, R.4    Ioannou, P.A.5
  • 86
    • 0035005526 scopus 로고    scopus 로고
    • C-Myc is a critical target for c/EBPalpha in granulopoiesis
    • Johansen LM, Iwama A, Lodie TA, et al. C-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol. 2001;21: 3789-3806.
    • (2001) Mol Cell Biol , vol.21 , pp. 3789-3806
    • Johansen, L.M.1    Iwama, A.2    Lodie, T.A.3
  • 87
    • 0029926485 scopus 로고    scopus 로고
    • Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
    • Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA. 1996;93:12355-12358.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12355-12358
    • Fujiwara, Y.1    Browne, C.P.2    Cunniff, K.3    Goff, S.C.4    Orkin, S.H.5
  • 88
    • 0030926006 scopus 로고    scopus 로고
    • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
    • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16:3965-3973.
    • (1997) EMBO J , vol.16 , pp. 3965-3973
    • Shivdasani, R.A.1    Fujiwara, Y.2    McDevitt, M.A.3    Orkin, S.H.4
  • 89
    • 0025977563 scopus 로고
    • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
    • Pevny L, Simon MC, Robertson E, et al. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;349:257-260.
    • (1991) Nature , vol.349 , pp. 257-260
    • Pevny, L.1    Simon, M.C.2    Robertson, E.3
  • 91
    • 16044369709 scopus 로고    scopus 로고
    • Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
    • Holtschke T, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996;87:307-317.
    • (1996) Cell , vol.87 , pp. 307-317
    • Holtschke, T.1    Lohler, J.2    Kanno, Y.3


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