-
1
-
-
0034624828
-
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
-
Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404:193-197.
-
(2000)
Nature
, vol.404
, pp. 193-197
-
-
Akashi, K.1
Traver, D.2
Miyamoto, T.3
Weissman, I.L.4
-
2
-
-
0024466796
-
Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
-
Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood. 1989; 74:1563-1570.
-
(1989)
Blood
, vol.74
, pp. 1563-1570
-
-
Sutherland, H.J.1
Eaves, C.J.2
Eaves, A.C.3
Dragowska, W.4
Lansdorp, P.M.5
-
3
-
-
0018922995
-
Competitive repopulation: A new assay for long-term stem cell functional capacity
-
Harrison DE. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood. 1980;55:77-81.
-
(1980)
Blood
, vol.55
, pp. 77-81
-
-
Harrison, D.E.1
-
4
-
-
0030831130
-
Identification of clonogenic common lymphoid progenitors in mouse bone marrow
-
Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997; 91:661-672.
-
(1997)
Cell
, vol.91
, pp. 661-672
-
-
Kondo, M.1
Weissman, I.L.2
Akashi, K.3
-
5
-
-
0023922373
-
Purification and characterization of mouse hematopoietic stem cells
-
Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241: 58-62.
-
(1988)
Science
, vol.241
, pp. 58-62
-
-
Spangrude, G.J.1
Heimfeld, S.2
Weissman, I.L.3
-
6
-
-
0030925298
-
Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
-
Cashman JD, Lapidot T, Wang JC, et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 1997;89:4307-4316.
-
(1997)
Blood
, vol.89
, pp. 4307-4316
-
-
Cashman, J.D.1
Lapidot, T.2
Wang, J.C.3
-
7
-
-
17844370871
-
The ordered expression of transcription factors directs hierarchical lineage specification of eosinophils, basophils and mast cells
-
Iwasaki H, Arinobu Y, Mizuno S, et al. The ordered expression of transcription factors directs hierarchical lineage specification of eosinophils, basophils and mast cells. Blood. 2004;104:68a.
-
(2004)
Blood
, vol.104
-
-
Iwasaki, H.1
Arinobu, Y.2
Mizuno, S.3
-
8
-
-
2542471001
-
PU.1 deficiency blocks the production of common myeloid and common lymphoid progenitors in both adult and fetal liver myelopoiesis
-
Duprez E, Iwasaki-Arai J, Geary K, et al. PU.1 deficiency blocks the production of common myeloid and common lymphoid progenitors in both adult and fetal liver myelopoiesis. Blood. 2002;100: 61a.
-
(2002)
Blood
, vol.100
-
-
Duprez, E.1
Iwasaki-Arai, J.2
Geary, K.3
-
9
-
-
2542455620
-
Stepwise reprogramming of B cells into macrophages
-
Xie H, Ye M, Feng R, Graf T. Stepwise reprogramming of B cells into macrophages. Cell. 2004;117:663-676.
-
(2004)
Cell
, vol.117
, pp. 663-676
-
-
Xie, H.1
Ye, M.2
Feng, R.3
Graf, T.4
-
10
-
-
0141455931
-
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages
-
Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/ erythrocyte lineages. Immunity. 2003;19: 451-462.
-
(2003)
Immunity
, vol.19
, pp. 451-462
-
-
Iwasaki, H.1
Mizuno, S.2
Wells, R.A.3
Cantor, A.B.4
Watanabe, S.5
Akashi, K.6
-
11
-
-
0042025062
-
Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors
-
Heavey B, Charalambous C, Cobaleda C, Busslinger M. Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J. 2003;22:3887-3897.
-
(2003)
EMBO J
, vol.22
, pp. 3887-3897
-
-
Heavey, B.1
Charalambous, C.2
Cobaleda, C.3
Busslinger, M.4
-
12
-
-
0030061554
-
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
-
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Okuda, T.1
Van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
-
13
-
-
0028136726
-
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577.
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
-
14
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15:5647-5658.
-
(1996)
EMBO J
, vol.15
, pp. 5647-5658
-
-
McKercher, S.R.1
Torbett, B.E.2
Anderson, K.L.3
-
15
-
-
21544467339
-
PU.1 is a critical downstream target of AML1
-
Huang G, Zhang P, Koschmieder S, et al. PU.1 is a critical downstream target of AML1. Blood. 2004;104:105a.
-
(2004)
Blood
, vol.104
-
-
Huang, G.1
Zhang, P.2
Koschmieder, S.3
-
16
-
-
0031029557
-
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
-
Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A. 1997;94: 569-574.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 569-574
-
-
Zhang, D.E.1
Zhang, P.2
Wang, N.D.3
Hetherington, C.J.4
Darlington, G.J.5
Tenen, D.G.6
-
17
-
-
0031008479
-
CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing
-
Yamanaka R, Kim GD, Radomska HS, et al. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci U S A. 1997;94:6462-6467.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6462-6467
-
-
Yamanaka, R.1
Kim, G.D.2
Radomska, H.S.3
-
18
-
-
0033135842
-
CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge
-
Lekstrom-Himes J, Xanthopoulos KG. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge. Blood. 1999;93:3096-3105.
-
(1999)
Blood
, vol.93
, pp. 3096-3105
-
-
Lekstrom-Himes, J.1
Xanthopoulos, K.G.2
-
19
-
-
0029121271
-
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
-
Robb L, Lyons I, Li R, Hartley L, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-7079.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7075-7079
-
-
Robb, L.1
Lyons, I.2
Li, R.3
Hartley, L.4
-
20
-
-
0028858855
-
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
-
Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373:432-434.
-
(1995)
Nature
, vol.373
, pp. 432-434
-
-
Shivdasani, R.A.1
Mayer, E.L.2
Orkin, S.H.3
-
21
-
-
0037472895
-
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
-
Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421: 547-551.
-
(2003)
Nature
, vol.421
, pp. 547-551
-
-
Mikkola, H.K.1
Klintman, J.2
Yang, H.3
-
22
-
-
0037417892
-
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
-
Hall MA, Curtis DJ, Metcalf D, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003;100:992-997.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 992-997
-
-
Hall, M.A.1
Curtis, D.J.2
Metcalf, D.3
-
23
-
-
1942425445
-
SCL is required for normal function of short-term repopulating hematopoietic stem cells
-
Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood. 2004;103:3342-3348.
-
(2004)
Blood
, vol.103
, pp. 3342-3348
-
-
Curtis, D.J.1
Hall, M.A.2
Van Stekelenburg, L.J.3
Robb, L.4
Jane, S.M.5
Begley, C.G.6
-
24
-
-
2342451948
-
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
-
Ichikawa M, Asai T, Saito T, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004;10:299-304.
-
(2004)
Nat Med
, vol.10
, pp. 299-304
-
-
Ichikawa, M.1
Asai, T.2
Saito, T.3
-
25
-
-
10344230611
-
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
-
Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004; 21:853-863.
-
(2004)
Immunity
, vol.21
, pp. 853-863
-
-
Zhang, P.1
Iwasaki-Arai, J.2
Iwasaki, H.3
-
26
-
-
0029763203
-
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
-
Brass AL, Kehrli E, Eisenbeis CF, Storb U, Singh H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1 Genes Dev. 1996;10:2335-2347.
-
(1996)
Genes Dev
, vol.10
, pp. 2335-2347
-
-
Brass, A.L.1
Kehrli, E.2
Eisenbeis, C.F.3
Storb, U.4
Singh, H.5
-
27
-
-
0027494858
-
PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer
-
Eisenbeis CF, Singh H, Storb U. PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol. 1993;13: 6452-6461.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6452-6461
-
-
Eisenbeis, C.F.1
Singh, H.2
Storb, U.3
-
28
-
-
0026584945
-
PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity
-
Pongubala JM, Nagulapalli S, Klemsz MJ, McKercher SR, Maki RA, Atchison ML. PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity. Mol Cell Biol. 1992;12:368-378.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 368-378
-
-
Pongubala, J.M.1
Nagulapalli, S.2
Klemsz, M.J.3
McKercher, S.R.4
Maki, R.A.5
Atchison, M.L.6
-
29
-
-
0029073345
-
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
-
Eisenbeis CF, Singh H, Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995;9:1377-1387.
-
(1995)
Genes Dev
, vol.9
, pp. 1377-1387
-
-
Eisenbeis, C.F.1
Singh, H.2
Storb, U.3
-
30
-
-
0027159217
-
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds
-
Kanno Y, Kozak CA, Schindler C, et al. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol. 1993;13:3951-3963.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3951-3963
-
-
Kanno, Y.1
Kozak, C.A.2
Schindler, C.3
-
31
-
-
0030024112
-
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
-
Zhang DE, Hetherington CJ, Meyers S, et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol. 1996;16:1231-1240.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1231-1240
-
-
Zhang, D.E.1
Hetherington, C.J.2
Meyers, S.3
-
32
-
-
0029121366
-
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
-
Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang DE, Tenen DG PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol. 1995;15:5830-5845.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5830-5845
-
-
Hohaus, S.1
Petrovick, M.S.2
Voso, M.T.3
Sun, Z.4
Zhang, D.E.5
Tenen, D.G.6
-
33
-
-
0029793902
-
PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
-
Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood. 1996;88:1234-1247.
-
(1996)
Blood
, vol.88
, pp. 1234-1247
-
-
Smith, L.T.1
Hohaus, S.2
Gonzalez, D.A.3
Dziennis, S.E.4
Tenen, D.G.5
-
34
-
-
0034234513
-
AML1MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon
-
Shimizu K, Kitabayashi I, Kamada N, et al. AML1MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood. 2000;96:288-296.
-
(2000)
Blood
, vol.96
, pp. 288-296
-
-
Shimizu, K.1
Kitabayashi, I.2
Kamada, N.3
-
35
-
-
0031472234
-
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
-
Tsang AP, Visvader JE, Turner CA, et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997;90: 109-119.
-
(1997)
Cell
, vol.90
, pp. 109-119
-
-
Tsang, A.P.1
Visvader, J.E.2
Turner, C.A.3
-
36
-
-
0033083804
-
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex
-
Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell. 1999;3: 219-228.
-
(1999)
Mol Cell
, vol.3
, pp. 219-228
-
-
Crispino, J.D.1
Lodish, M.B.2
MacKay, J.P.3
Orkin, S.H.4
-
37
-
-
0033582475
-
C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
-
Behre G, Whitmarsh AJ, Coghlan MP, et al. C-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem. 1999;274:4939-4946.
-
(1999)
J Biol Chem
, vol.274
, pp. 4939-4946
-
-
Behre, G.1
Whitmarsh, A.J.2
Coghlan, M.P.3
-
38
-
-
0032478276
-
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
-
Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci USA. 1998;95:2061-2066.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2061-2066
-
-
Blobel, G.A.1
Nakajima, T.2
Eckner, R.3
Montminy, M.4
Orkin, S.H.5
-
39
-
-
0036094806
-
Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1
-
Hong W, Kim AY, Ky S, et al. Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1. Mol Cell Biol. 2002;22:3729-3743.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3729-3743
-
-
Hong, W.1
Kim, A.Y.2
Ky, S.3
-
40
-
-
0034667672
-
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
-
Zhang P, Zhang X, Iwama A, et al. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 2000;96:2641-2648.
-
(2000)
Blood
, vol.96
, pp. 2641-2648
-
-
Zhang, P.1
Zhang, X.2
Iwama, A.3
-
41
-
-
0033587755
-
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
-
Zhang P, Behre G, Pan J, et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci USA. 1999;96:8705-8710.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8705-8710
-
-
Zhang, P.1
Behre, G.2
Pan, J.3
-
42
-
-
0033151624
-
Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
-
Rekhtman N, Radparvar F, Evans T, Skoultchi AI. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 1999;13:1398-1411.
-
(1999)
Genes Dev
, vol.13
, pp. 1398-1411
-
-
Rekhtman, N.1
Radparvar, F.2
Evans, T.3
Skoultchi, A.I.4
-
43
-
-
0029978734
-
Spi-1/PU.1 transgenic mice develop multistep erythroleukemias
-
Moreau-Gachelin F, Wendling F, Molina T, et al. Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. Mol Cell Biol. 1996;16:2453-2463.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2453-2463
-
-
Moreau-Gachelin, F.1
Wendling, F.2
Molina, T.3
-
44
-
-
0141953999
-
Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1
-
Choe KS, Radparvar F, Matushansky I, Rekhtman N, Han X, Skoultchi AI. Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1. Cancer Res. 2003;63: 6363-6369.
-
(2003)
Cancer Res
, vol.63
, pp. 6363-6369
-
-
Choe, K.S.1
Radparvar, F.2
Matushansky, I.3
Rekhtman, N.4
Han, X.5
Skoultchi, A.I.6
-
45
-
-
0023839919
-
Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
-
Moreau-Gachelin F, Tavitian A, Tambourin P. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature. 1988;331:277-280.
-
(1988)
Nature
, vol.331
, pp. 277-280
-
-
Moreau-Gachelin, F.1
Tavitian, A.2
Tambourin, P.3
-
46
-
-
0142124320
-
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor
-
Dahl R, Walsh JC, Lancki D, et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol. 2003;4:1029-1036.
-
(2003)
Nat Immunol
, vol.4
, pp. 1029-1036
-
-
Dahl, R.1
Walsh, J.C.2
Lancki, D.3
-
47
-
-
0037100304
-
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions
-
Reddy VA, Iwama A, Iotzova G, et al. Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood. 2002;100:483-490.
-
(2002)
Blood
, vol.100
, pp. 483-490
-
-
Reddy, V.A.1
Iwama, A.2
Iotzova, G.3
-
48
-
-
2642519463
-
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
-
Rosenbauer F, Wagner K, Kutok JL, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004;36:624-630.
-
(2004)
Nat Genet
, vol.36
, pp. 624-630
-
-
Rosenbauer, F.1
Wagner, K.2
Kutok, J.L.3
-
49
-
-
0034717335
-
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
-
DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science. 2000; 288:1439-1441.
-
(2000)
Science
, vol.288
, pp. 1439-1441
-
-
Dekoter, R.P.1
Singh, H.2
-
50
-
-
0037013889
-
Making eosinophils through subtle shifts in transcription factor expression
-
McNagny K, Graf T. Making eosinophils through subtle shifts in transcription factor expression. J Exp Med. 2002;195:F43-F47.
-
(2002)
J Exp Med
, vol.195
-
-
McNagny, K.1
Graf, T.2
-
51
-
-
0025029777
-
Reporter genes: Application to the study of mammalian gene transcription
-
Alam J, Cook JL. Reporter genes: application to the study of mammalian gene transcription. Anal Biochem. 1990;188:245-254.
-
(1990)
Anal Biochem
, vol.188
, pp. 245-254
-
-
Alam, J.1
Cook, J.L.2
-
53
-
-
0035892121
-
Regulation of the PU.1 gene by distal elements
-
Li Y, Okuno Y, Zhang P, et al. Regulation of the PU.1 gene by distal elements. Blood. 2001;98:2958-2965.
-
(2001)
Blood
, vol.98
, pp. 2958-2965
-
-
Li, Y.1
Okuno, Y.2
Zhang, P.3
-
54
-
-
0029943308
-
Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter
-
Chen H, Zhang P, Radomska HS, Hetherington CJ, Zhang DE, Tenen DG. Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter. J Biol Chem. 1996;271: 15743-15752.
-
(1996)
J Biol Chem
, vol.271
, pp. 15743-15752
-
-
Chen, H.1
Zhang, P.2
Radomska, H.S.3
Hetherington, C.J.4
Zhang, D.E.5
Tenen, D.G.6
-
55
-
-
0028826488
-
PU.1 (Spi-1) autoregulates its expression in myeloid cells
-
Chen H, Ray-Gallet D, Zhang P, et al. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene. 1995;11:1549-1560.
-
(1995)
Oncogene
, vol.11
, pp. 1549-1560
-
-
Chen, H.1
Ray-Gallet, D.2
Zhang, P.3
-
56
-
-
21544483826
-
Deletion of a key PU.1 gene regulatory element induces T-cell lymphoma
-
Rosenbauer F, Steidl U, Owens BM, et al. Deletion of a key PU.1 gene regulatory element induces T-cell lymphoma. Blood. 2004; 104:105a.
-
(2004)
Blood
, vol.104
-
-
Rosenbauer, F.1
Steidl, U.2
Owens, B.M.3
-
57
-
-
0035135174
-
Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells
-
Yokomizo T, Ogawa M, Osato M, et al. Requirement of Runx1/AML1/ PEBP2alphaB for the generation of haematopoietic cells from endothelial cells. Genes Cells. 2001;6:13-23.
-
(2001)
Genes Cells
, vol.6
, pp. 13-23
-
-
Yokomizo, T.1
Ogawa, M.2
Osato, M.3
-
58
-
-
0037315894
-
Disruption of differentiation in human cancer: AML shows the way
-
Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer. 2003;3:89-101.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 89-101
-
-
Tenen, D.G.1
-
59
-
-
0346100567
-
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
-
Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029-3035.
-
(2003)
Genes Dev
, vol.17
, pp. 3029-3035
-
-
Cozzio, A.1
Passegue, E.2
Ayton, P.M.3
Karsunky, H.4
Cleary, M.L.5
Weissman, I.L.6
-
60
-
-
0036727413
-
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
-
Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 2002;32:148-152.
-
(2002)
Nat Genet
, vol.32
, pp. 148-152
-
-
Wechsler, J.1
Greene, M.2
McDevitt, M.A.3
-
61
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100:59-66.
-
(2002)
Blood
, vol.100
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
-
62
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
-
63
-
-
11144358111
-
Prognostically useful gene-expression profiles in acute myeloid leukemia
-
Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004; 350:1617-1628.
-
(2004)
N Engl J Med
, vol.350
, pp. 1617-1628
-
-
Valk, P.J.1
Verhaak, R.G.2
Beijen, M.A.3
-
64
-
-
0035093813
-
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
-
Pabst T, Mueller BU, Zhang P, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27: 263-270.
-
(2001)
Nat Genet
, vol.27
, pp. 263-270
-
-
Pabst, T.1
Mueller, B.U.2
Zhang, P.3
-
65
-
-
0037108111
-
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
-
Preudhomme C, Sagot C, Boissel N, et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood. 2002;100:2717-2723.
-
(2002)
Blood
, vol.100
, pp. 2717-2723
-
-
Preudhomme, C.1
Sagot, C.2
Boissel, N.3
-
66
-
-
0345269758
-
Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
-
Snaddon J, Smith ML, Neat M, et al. Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. Genes Chromosomes Cancer. 2003;37:72-78.
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 72-78
-
-
Snaddon, J.1
Smith, M.L.2
Neat, M.3
-
67
-
-
1442356729
-
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
-
Frohling S, Schlenk RF, Stolze I, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol. 2004;22:624-633.
-
(2004)
J Clin Oncol
, vol.22
, pp. 624-633
-
-
Frohling, S.1
Schlenk, R.F.2
Stolze, I.3
-
68
-
-
0037082508
-
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
-
Gombart AF, Hofmann WK, Kawano S, et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood. 2002;99:1332-1340.
-
(2002)
Blood
, vol.99
, pp. 1332-1340
-
-
Gombart, A.F.1
Hofmann, W.K.2
Kawano, S.3
-
69
-
-
0037591396
-
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML
-
Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer J, et al. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J. 2003;4:31-40.
-
(2003)
Hematol J
, vol.4
, pp. 31-40
-
-
Barjesteh Van Waalwijk Van Doorn-Khosrovani, S.1
Erpelinck, C.2
Meijer, J.3
-
70
-
-
0035047652
-
AMLl-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia
-
Pabst T, Mueller BU, Harakawa N, et al. AMLl-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med. 2001;7:444-451.
-
(2001)
Nat Med
, vol.7
, pp. 444-451
-
-
Pabst, T.1
Mueller, B.U.2
Harakawa, N.3
-
71
-
-
0141593492
-
Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias
-
Cilloni D, Carturan S, Gottardi E, et al. Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias. Blood. 2003;102:2705-2706.
-
(2003)
Blood
, vol.102
, pp. 2705-2706
-
-
Cilloni, D.1
Carturan, S.2
Gottardi, E.3
-
72
-
-
0037944120
-
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
-
Mizuki M, Schwable J, Steur C, et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood. 2003;101:3164-3173.
-
(2003)
Blood
, vol.101
, pp. 3164-3173
-
-
Mizuki, M.1
Schwable, J.2
Steur, C.3
-
73
-
-
0036893435
-
Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
-
Zheng R, Friedman AD, Small D. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood. 2002;100: 4154-4161.
-
(2002)
Blood
, vol.100
, pp. 4154-4161
-
-
Zheng, R.1
Friedman, A.D.2
Small, D.3
-
74
-
-
1442307974
-
Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression
-
Zheng R, Friedman AD, Levis M, Li L, Weir EG, Small D. Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression. Blood. 2004; 103:1883-1890.
-
(2004)
Blood
, vol.103
, pp. 1883-1890
-
-
Zheng, R.1
Friedman, A.D.2
Levis, M.3
Li, L.4
Weir, E.G.5
Small, D.6
-
75
-
-
0031283125
-
Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
-
Zahnow CA, Younes P, Laucirica R, Rosen JM. Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J Natl Cancer Inst. 1997; 89:1887-1891.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 1887-1891
-
-
Zahnow, C.A.1
Younes, P.2
Laucirica, R.3
Rosen, J.M.4
-
76
-
-
0036682473
-
Heterozygous PU.1 mutations are associated with acute myeloid leukemia
-
Mueller BU, Pabst T, Osato M, et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood. 2002;100: 998-1007.
-
(2002)
Blood
, vol.100
, pp. 998-1007
-
-
Mueller, B.U.1
Pabst, T.2
Osato, M.3
-
77
-
-
0037114703
-
Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?
-
Lamandin C, Sagot C, Roumier C, et al. Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)? Blood. 2002;100:4680-4681.
-
(2002)
Blood
, vol.100
, pp. 4680-4681
-
-
Lamandin, C.1
Sagot, C.2
Roumier, C.3
-
78
-
-
0242662157
-
Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: A study of the AML Study Group Ulm (AMLSG ULM)
-
Dohner K, Tobis K, Bischof T, et al. Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: a study of the AML Study Group Ulm (AMLSG ULM). Blood. 2003;102:3850.
-
(2003)
Blood
, vol.102
, pp. 3850
-
-
Dohner, K.1
Tobis, K.2
Bischof, T.3
-
79
-
-
0037369257
-
Heterozygous PU.1 mutations are associated with acute myeloid leukemia
-
Mueller BU, Pabst T, Osato M, et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood. 2003;101:2074.
-
(2003)
Blood
, vol.101
, pp. 2074
-
-
Mueller, B.U.1
Pabst, T.2
Osato, M.3
-
80
-
-
0030611964
-
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
-
Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 1997;6:437-447.
-
(1997)
Immunity
, vol.6
, pp. 437-447
-
-
Scott, E.W.1
Fisher, R.C.2
Olson, M.C.3
Kehrli, E.W.4
Simon, M.C.5
Singh, H.6
-
81
-
-
0037222293
-
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
-
Vangala RK, Heiss-Neumann MS, Rangatia JS, et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood. 2003;101:270-277.
-
(2003)
Blood
, vol.101
, pp. 270-277
-
-
Vangala, R.K.1
Heiss-Neumann, M.S.2
Rangatia, J.S.3
-
82
-
-
7744220635
-
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
-
Shachaf CM, Kopelman AM, Arvanitis C, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature. 2004;431:1112-1117.
-
(2004)
Nature
, vol.431
, pp. 1112-1117
-
-
Shachaf, C.M.1
Kopelman, A.M.2
Arvanitis, C.3
-
83
-
-
0037816153
-
Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia
-
Steffen B, Serve H, Berdel WE, et al. Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia. Proc Natl Acad Sci USA. 2003;100:8448-8453.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8448-8453
-
-
Steffen, B.1
Serve, H.2
Berdel, W.E.3
-
84
-
-
0344413639
-
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
-
Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med. 2003;9:1428-1432.
-
(2003)
Nat Med
, vol.9
, pp. 1428-1432
-
-
Krosl, J.1
Austin, P.2
Beslu, N.3
Kroon, E.4
Humphries, R.K.5
Sauvageau, G.6
-
85
-
-
3943086381
-
Complementation of alpha-thalassaemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus
-
Al-Hasani K, Vadolas J, Voullaire L, Williamson R, Ioannou PA. Complementation of alpha-thalassaemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus. Transgenic Res. 2004;13:235-243.
-
(2004)
Transgenic Res
, vol.13
, pp. 235-243
-
-
Al-Hasani, K.1
Vadolas, J.2
Voullaire, L.3
Williamson, R.4
Ioannou, P.A.5
-
86
-
-
0035005526
-
C-Myc is a critical target for c/EBPalpha in granulopoiesis
-
Johansen LM, Iwama A, Lodie TA, et al. C-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol. 2001;21: 3789-3806.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3789-3806
-
-
Johansen, L.M.1
Iwama, A.2
Lodie, T.A.3
-
87
-
-
0029926485
-
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
-
Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA. 1996;93:12355-12358.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12355-12358
-
-
Fujiwara, Y.1
Browne, C.P.2
Cunniff, K.3
Goff, S.C.4
Orkin, S.H.5
-
88
-
-
0030926006
-
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
-
Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16:3965-3973.
-
(1997)
EMBO J
, vol.16
, pp. 3965-3973
-
-
Shivdasani, R.A.1
Fujiwara, Y.2
McDevitt, M.A.3
Orkin, S.H.4
-
89
-
-
0025977563
-
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
-
Pevny L, Simon MC, Robertson E, et al. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;349:257-260.
-
(1991)
Nature
, vol.349
, pp. 257-260
-
-
Pevny, L.1
Simon, M.C.2
Robertson, E.3
-
90
-
-
1942517003
-
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
-
Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668-673.
-
(2004)
Nature
, vol.428
, pp. 668-673
-
-
Balsam, L.B.1
Wagers, A.J.2
Christensen, J.L.3
Kofidis, T.4
Weissman, I.L.5
Robbins, R.C.6
-
91
-
-
16044369709
-
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
-
Holtschke T, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996;87:307-317.
-
(1996)
Cell
, vol.87
, pp. 307-317
-
-
Holtschke, T.1
Lohler, J.2
Kanno, Y.3
|