Spi-1/PU.1 Transgenic mice develop multistep erythroleukemias

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 2453-2463

  Moreau Gachelin, F ^a   Wendling, F ^b   Molina, T ^c   Denis, N ^a   Titeux, M ^b   Grimber, G ^d   Briand, P ^d   Vainchenker, W ^b   Tavitian, A ^a  

^a INSTITUT CURIE   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c Lab Univ Rech en Histopathologie   (France)

^d INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; ERYTHROCYTE TRANSFUSION; ERYTHROLEUKEMIA; GENE EXPRESSION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; TRANSGENIC MOUSE; VIRUS INDUCTION;

ANIMALIA; FRIEND MURINE LEUKEMIA VIRUS; MUS MUSCULUS;

EID: 0029978734     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2453     Document Type: Article

References (64)

1. Aizawa, S., Y. Suda, Y. Furuta, T. Yagi, N. Takeda, N. Watanabe, M. Nagayoshi, and Y. Ikawa. 1990. Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells EMBO J. 7:2107-2116.
2. Baron, M. H., and T. Maniatis. 1986. Rapid reprogramming of globin gene expression in transient heterokaryons. Cell 46:591-602.
3. Ben-David, Y., and A. Bernstein. 1991. Friend virus-induced erythroleukemia and the multistage nature of cancer. Cell 66:831-834.
4. Ben-David, Y., V. R. Prideaux, V. Chow, S. Benchimol, and A. Bernstein. 1988. Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus. Oncogene 3:179-185.
5. Bishop, J. M. 1991. Molecular themes in oncogenesis. Cell 64:235-248.
6. Bosze, Z., H. J. Thiesen, and P. Charnay. 1986. A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus EMBO J. 5:1615-1623.
7. Carvalho, M., and D. Derse. 1993. The PU 1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter. J. Virol. 67:3885-3890.
8. Chen, H. M., D. Ray-Gallet, P. Zhang, C. J. Hetherington, D. A. Gonzalez, D. E. Zhang, F. Moreau-Gachelin, and D. G. Tenen. 1995. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11:1549-1560.
9. Chomczynski, P., and N. Sacchi. 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
10. Damm, K., C. C. Thompson, and R. M. Evans. 1989. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature (London) 339:593-597.
11. Delgado, D., M. Hallier, P. Meneceur, A. Tavitian, and F. Moreau-Gachelin. 1994. Inhibition of Friend cells proliferation by spi-1 antisense oligodeoxynucleotides. Oncogene 9:1723-1727.
12. Eisenbeis, C. F., H. Singh, and U. Storb. 1993. PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin λ2-4 enhancer. Mol Cell Biol. 13:6452-6461.
13. Eisenbeis, C. F., H. Singh, and U. Storb. 1995. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 9:1377-1387.
14. Feinman, R., W. Q. Qiu, R. N. Pearse, B. S. Nikolajczyk, R. Sen, M. Sheffery, and J. V. Ravetch. 1994. PU.1 and an HLH family member contribute to the myeloid-specific transcription of the FcγRIIIA promoter. EMBO J. 13:3852-3860.
15. Fort, P., L. Marty, M. Piechaczyk, S. E. Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1431-1441.
16. Fuerstenberg, S., I. Leitner, C. Schroeder, H. Schwarz, B. Vennström, and H. Beug. 1992. Transcriptional repression of band 3 and CALL in v-erbA transformed erythroblasts accounts for an important part of the phenotype. EMBO J. 11:3355-3365.
17. Gandrillon, O., P. Jurdic, B. Pain, C. Desbois, J. J. Madjar, M. G. Moscovici, C. Moscovici, and J. Samarut. 1989. Expression of the v-erbA product an altered nuclear hormone receptor, is sufficient to transform erythrocytic cells in vitro. Cell 58:115-121.
18. Gauthier, J. M., B. Bourachot, V. Doucas, M. Yaniv, and F. Moreau-Gachelin. 1993. Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors. EMBO J. 12:5089-5096
19. Goebl, M. G., F. Moreau-Gachelin, D. Ray, P. Tambourin, A. Tavitian, M. J. Klemsz, S. R. McKercher, A. Celada, C. Van Beveren, and R. A. Maki. 1990. The PU.1 transcription factor is the product of the putative oncogene spi-1. Cell 61:1165-1166
20. Henkel, G., and M. A. Brown. 1994. PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci USA 91:7737-7741.
21. Hogan, B. L., F. Costantini, and E. Lacy. 1986 Manipulating the mouse embryo: a laboratory manual Cold Spring Harbor Laboratory Press. Cold Spring Harbor, N.Y.
22. - progenitor cells in long-term cultures and semi-solid assays. Blood 81:2916-2924.
23. Kabat, D. 1989. Molecular biology of Friend viral erythroleukemia Curr. Top. Microbiol. Immunol. 148:1-42.
24. Klemsz, M. J., S. R. McKercher, A. Celada, C. Van Beveren, and R. A. Maki. 1990. The macrophage and B-cell-specific transcription factor PU.1 is related to the as oncogene. Cell 61:113-124
25. Krantz, S. B. 1991. Erythropoietin. Blood 77:419-434.
26. Lacombe, C., S. Chretien, V. Lemarchandel, P. Mayeux, P. H. Romeu, S. Gisselbrecht, and J. P. Cartron. 1991. Spleen focus-forming virus long terminal repeat insertional activation of the murine erythropoietin receptor gene in the T3C1-2 Friend leukemia cell line. J. Biol. Chem. 266:6952-6956.
27. k interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element. EMBO J. 13:5624-5632
28. Li, J.-P., A. D'Andrea, H. F. Lodish, and D. Baltimore. 1990 Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (London) 343:762-764.
29. Linemeyer, D. L., S. K. Ruscetti, E. M. Scolnick, L. H. Evans, and P. H. Duesberg. 1981. Biological activity of the spleen focus-forming virus is encoded by a molecularly cloned subgenomic fragment of spleen focus-forming virus DNA Proc. Natl. Acad. Sci USA 78:1401-1405
30. Mager, D. L., T. W. Mak, and A. Bernstein. 1981. Quantitative colony method for tumorigenic cells transformed by two distinct strains of Friend leukemia virus. Proc Natl. Acad. Sci. USA 78:1703-1707.
31. Mitjavila, M. T., J. P. Le Couedic, N. Casadevall, S. Navarro, J. L. Villeval, A. Dubart, and W. Vainchenker. 1991. Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro J. Clin. Invest. 88:789-797.
32. Moreau-Gachelin, F. 1994. Spi-1/PU.1: an oncogene of the Ets family Biochim Biophys. Acta 1198:149-163.
33. Moreau-Gachelin, F., D. Ray, N. J. de Both, J. M. van der Feltz, P. Tambourin, and A. Tavitian. 1990 Spi-1 oncogene activation in Rauscher and Friend murine virus-induced acute erythroleukemiai. Leukemia 4:20-23
34. Moreau-Gachelin, F., D. Ray, M. G. Mattel, P. Tambourin, and A. Tavitian. 1989. The putative oncogene spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene 4:1449-1456.
35. Moreau-Gachelin, F., A. Tavitian, and P. Tambourin. 1988. Spi-1 is a putative oncogene in virally induced murine erythroleukemia. Nature (London) 331:277-280.
36. Moulton, K. S., K. Semple, H. Wu, and C. K. Glass. 1994. Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif Mol. Cell. Biol. 14:4408-4418.
37. Munroe, D. G., J. W. Peacock, and S. Benchimol. 1990. Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Mol. Cell. Biol. 10:3307-3313
38. Munroe, D. G., B. Rovinski, A. Bernstein, and S. Benchimol. 1988. Loss of a highly conserved domain on p53 as a result of gene deletion during Freind virus-induced erythroleukemia. Oncogene 2:621-624
39. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid-specific immunoglobulin μ heavy chain gene enhancer by ETS-domain proteins. Science 261:82-86.
40. Pahl, H. L., R. J. Scheibe, D. E. Zhang, H. M. Chen, D. Galson, R. A. Maki, and D. G. Tenen. 1993. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J. Biol. Chem. 268:5014-5020
41. Palacios, R., and M. Steinmetz. 1985. IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727-734.
42. Paul, R., S. Schuetze, S. L. Kozak, and D. Kabat. 1989. A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization. J. Virol. 63:4958-4961
43. Perez, C., E. Coeffier, F. Moreau-Gachelin, J. Wietzerbin, and P. O. Benech. 1994. Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fcγ receptor. Mol. Cell. Biol. 14:5023-5031.
44. Peters, L. L., N. C. Andrews, E. M. Eicher, M. B. Davidson, S. H. Orkin, and S. E. Lux. 1993. Mouse microcytic anaemia caused by a defect in the gene encoding the giobin enhancer-binding protein NF-E2 Nature (London) 362:768-770.
45. Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S. F. Tsai, V. D'Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (London) 349:257-260.
46. Pongubala, J. M. R., S. Nagulapalli, M. J. Klemz, S. R. McKercher, R. A. Maki, and M. L. Atchinson. 1992. PU.1 recruits a second nuclear factor to a site important for immunoglobulin κ 3′ enhancer activity. Mol. Cell. Biol. 12:368-378.
47. Pongubala, J. M. R., C. Van Beveren, S. Nagulapalli, M. J. Klemz, S. R. McKercher, R. A. Maki, and M. L. Atchinson. 1993. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259:1622-1625.
48. Ray, D., R. Bosselut, J. Ghysdael, M. G. Mattel, A. Tavitian, and F. Morean-Gachelin. 1992. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol. Cell. Biol. 12:4297-4304.
49. Ray-Gallet, D., C. Mao, A. Tavitian, and F. Moreau-Gachelin. 1995. DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter. Oncogene 11:303-313.
50. Rivera, R. R., M. H. Stuiver, R. Steenbergen, and C. Murre. 1993. EtS proteins new factors that regulate immunoglobulin heavy-chain gene expression. Mol Cell. Biol 13:7163-7169.
51. Romeo, P. H., M. H. Prandini, V. Joulin, V. Mignotte, M. Prenant, W. Vainchenker, G. Marguerie, and G. Uzan. 1990. Megacaryocytic and erythrocytic lineages share specific transcription factors. Nature (London) 344: 447-449.
52. Sawyers, C. L., C. T. Denny, and O. N. Witte. 1991. Leukemia and the disruption of normal hematopoiesis. Cell 64:337-350.
53. Schroeder, C., L. Gibson, M. Zenke, and H. Beug. 1992 Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action. Oncogene 7:217-227.
54. Schuetze, S., R. Paul, B. C. Gliniak, and D. Rabat. 1992. Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells Mol. Cell Biol. 12:2967-2975.
55. Schuetze, S., P. E. Stenberg, and D. Kabal. 1993. The Ets-related transcription factor PU.1 immortalizes erythroblasts. Mol. Cell. Biol. 13:5670-5678.
56. Schwarzenbach, H., J. W. Newell, and P. Matthias. 1995. Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters. J Biol. Chem. 270:898-907.
57. Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573-1577.
58. Shin, M. K., and M. E. Koshland. 1993. Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev. 7:2006-2015.
59. Tambourin, P. E., N. Casadevall, J. Choppin, C. Lacombe, J. M. Heard, S. Fichelson, F. Wendling, and B. Varet. 1983. Production of erythropoietin-like activity by a murine erythroleukemia cell line. Proc Natl. Acad. Sci. USA 80:6269-6273.
60. Tsai, S. F., D. I. K. Martin, L. I. Zon, A. D. D'Andrea, G. W. Gordon, and S. H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells Nature (London) 339:446-451.
61. Villeval, J. L., M. T. Mitjavila, I. Dusanter-Fourt, F. Wendung, P. Mayeux, and W. Vainchenker. 1994. Autocrine stimulation by erythropoietin (EPO) requires EPO secretion. Blood 84:2649-2662.
62. Wendling, F., F. Moreau-Gachelin, and P. Tambourin. 1981. Emergence of tumorigenic cells during the course of Friend virus leukemias. Proc. Natl. Acad. Sci. USA 78:3614-3618.
63. Youssoufian, H., L. Zon, S. H. Orkin, A. D. d'Andrea, and H. F. Lodish. 1990. Structure and transcription of the mouse erythropoietin receptor gene. Mol. Cell Biol 10:3675-3682.
64. Zhang, D., J. Hetherington, H. Chen, and D. G. Tenen. 1994. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell. Biol. 14:373-381.