Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway

International Journal of Cancer

Volumn 98, Issue 1, 2002, Pages 36-41

  Nakashio, Ayako ^a,b   Fujita, Naoya ^a   Tsuruo, Takashi ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b Development and Medical Affairs Division   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

Akt; Endothelial cell; Migration; Topotecan

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; CAMPTOTHECIN DERIVATIVE; CISPLATIN; COMPLEMENTARY DNA; DNA TOPOISOMERASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TOPOTECAN; VASCULOTROPIN;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; PRIORITY JOURNAL; TUMOR GROWTH; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; CELL MOVEMENT; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; HUMANS; LYMPHOKINES; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TOPOTECAN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036497905     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10166     Document Type: Article

References (26)

1. Akt takes center stage in angiogenesis signaling
2. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
3. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
4. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
5. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
6. The P13K-PDK1 connection: More than just a road to PKB
7. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
8. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
9. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
10. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
11. Topotecan - A novel topoisomerase I inhibitor: Pharmacology and clinical experience
12. Antiangiogenic potential of camptothecin and topotecan
13. Antiangiogenic effects of camptothecin analogues 9-amino-20-(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model
14. Prevention of phosphatidyl-inositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
15. Modulation of Akt kinase activity by binding to Hsp90
16. A rapid in vitro assay for quantitating the invasive potential of tumor cells
17. Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian carcinoma
18. Stabilization of disease as a useful predictor of survival following second-line chemotherapy in small cell lung cancer and ovarian cancer patients
19. New perspectives in clinical oncology from angiogenesis research
20. Topotecan - A new treatment option in the therapy of brain metastases of lung cancer
21. The role of systemic chemotherapy in the treatment of brain metastases from small-cell lung cancer
22. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidyl-inositol 3 OH-kinase/Akt/nitric oxide pathway and modulates migration of brain microvascular endothelial cells
23. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells
24. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
25. Regulation of tumor cell invasion by extracellular matrix
26. Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association