Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors

Cancer

Volumn 83, Issue 1, 1998, Pages 41-47

  Phillips, Wayne A ^a   St Clair, Fiona ^a   Munday, Adam D ^b   Thomas, Robert J S ^a   Mitchell, Christina A ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Colon carcinoma; Colorectal tumors; P85; Phosphatydylinositol 3 kinase; Ras mutations

Indexed keywords

ALKALINE PHOSPHATASE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCLONAL ANTIBODY;

ARTICLE; COLON MUCOSA; COLORECTAL TUMOR; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE MUTATION; HUMAN; HUMAN TISSUE; ONCOGENE RAS; PRIORITY JOURNAL; TUMOR DIFFERENTIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; COLORECTAL NEOPLASMS; GENES, RAS; HUMANS; MUTATION; PHOSPHORYLATION;

EID: 0032125580     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19980701)83:1<41::AID-CNCR6>3.0.CO;2-H     Document Type: Article

References (19)

1. Fry MJ. Structure, regulation and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1994;1226:237-68.
2. Carpenter CL, Cantley LC. Phosphoinositide 3-kinaseand the regulation of cell growth. Biochim Biophys Acta 1996; 1288:M11-6.
3. Jackson SP, Schoenwaelder SM, Matzaris M, Brown S, Mitchell CA. Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase. EMBO J 1995;14:4490-500.
4. Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC. Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 1990; 265:19704-11.
5. Divecha N, Banfic H, Irvine RF. The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J 1991;10:3207-14.
6. Stephens LR, Hughes KT, Irvine RF. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 1991;351:33-9.
7. Thomas RJS, Liu Y, St. Clair F, Norris PM, Valentine R, Phillips WA. Frequency and clinico-pathological associations of ras in colorectal cancer in the Victorian population. Aust N Z J Surg 1997;67:233-8.
8. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I, et al. PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J 1994;13: 522-33.
9. Carpenter CL, Auger KR, Duckworth BC, Hou WM, Schaffhausen B, Cantley LC. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol Cell Biol 1993;13:1657-65.
10. Yamauchi K, Holt K, Pessin JE. Phosphatidylinositol 3-kinase functions upstream of ras and raf in mediating insulin stimulation of c-fos transcription. J Biol Chem 1993;268: 14597-600.
11. Hu Q, Klippel A, Muslin AJ, Fantl WI, Williams LT. Rasdependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 1995;268: 100-2.
12. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, et al. Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin induced DNA synthesis and c-fos expression. Mol Cell Biol 1994;14:7466-75.
13. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994;370:527-32.
14. Kodaki T, Woscholski R, Hallberg B, Rodriguez-Viaana P, Downward J, Parker PJ. The activation of phosphatidylinositol 3-kinase by Ras. Curr Biol 1994;4:798-806.
15. Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphoinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence ras activity. Mol Cell Biol 1996;16:5905-14.
16. Zhang QX, Davis ID, Baldwin GS. Controlled overexpression of selected domains of the P85 subunit of phosphatidylinositol 3-kinase reverts v-Ha-Ras transformation. Biochim Biophys Acta 1996;1312:207-14.
17. McMichael AJ, Potter JD. Host factors in carcinogenesis: certain bile-acid metabolic profiles that selectively increase the risk of proximal colon cancer. J Natl Cancer Inst 1985; 75:185-91.
18. Singhal RL, Prajda N, Yeh YA, Weber G. 1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme. Cancer Res 1994;54:5574-8.
19. Singhal RL, Yeh YA, Look KY, Sledge GW, Weber G. Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells. Life Sci 1994;55:1487-92.