Activated CD4+ CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells

Immunology

Volumn 115, Issue 3, 2005, Pages 305-314

  Dieckmann, Detlef ^a   Plöttner, Heidi ^a   Dotterweich, Stefanie ^a   Schuler, Gerold ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Human; T cells; Tolerance suppression

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN SPECIFICITY; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELLS, CULTURED; CLONE CELLS; COCULTURE TECHNIQUES; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EPITOPES; HUMANS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 21244464403     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02144.x     Document Type: Article

References (35)

1. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101:455-8.
2. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10:1969-80.
3. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188:287-96.
4. Levings MK, Sangregorio R, Roncarolo MG. Human cd25 (+) cd4 (+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193:1295-302.
5. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4 (+) CD25 (+) T cells with regulatory properties from human blood. J Exp Med 2001; 193:1303-10.
6. Taylor PA, Noelle RJ, Blazar BR. CD4 (+) CD25 (+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001; 193:1311-8.
7. Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4 (+) CD25 (+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193:1285-94.
8. Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4 (+) CD25 (+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001; 194:629-44.
9. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3:135-42.
10. McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC. CD4 (+) CD25 (+) immunoregulatory T cells, gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16:311-23.
11. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25 (+) CD4 (+) regulatory cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
12. Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. Immunologic self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192:303-10.
13. Fallarino F, Grohmann U, Hwang KW et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003; 4:1206-12.
14. Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4 (+) CD25 (+) T regulatory cells. Nat Immunol 2003; 4:337-42.
15. + regulatory T cells. Nat Immunol 2003; 4:330-6.
16. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61.
17. Gambineri E, Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 2003; 15:430-5.
18. Brunkow ME, Jeffery EW, Hjerrild KA et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurry mouse. Nat Genet 2001; 27:68-73.
19. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12:431-40.
20. Kumanogoh A, Wang X, Lee I et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J Immunol 2001; 166:353-60.
21. Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells, expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 1998; 10:371-8.
22. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25 (+) regulatory T cells convey suppressor activity to conventional CD4 (+) T helper cells. J Exp Med 2002; 196:255-60.
23. Dieckmann D, Bruett CH, Ploettner H, Lutz MB, Schuler G. Human CD4 (+) CD25 (+) regulatory, contact-dependent T cells induce interleukin 1-producing, contact-independent type 10-like [correction of type 1-like] regulatory T cells. J Exp Med 2002; 196:247-53.
24. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182:18-32.
25. Hara M, Kingsley CI, Niimi M et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001; 166:3789-96.
26. + immunoregulatory cells. J Immunol 2001; 167:1137-40.
27. + T cell activation. Eur J Immunol 2003; 33:3473-83.
28. + T cells. Curr Opin Immunol 2003; 15:690-6.
29. Thurner B, Roder C, Dieckmann D et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods 1999; 223:1-15.
30. + T cells. J Clin Invest 1994; 94:797-807.
31. Valmori D, Fonteneau JF, Lizana CM et al. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/ MART-1 immunodominant peptide analogues. J Immunol 1998; 160:1750-8.
32. Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Ilmmunol 2000; 12:676-83.
33. Shevach EM. Certified professionals: CD4 (+) CD25 (+) suppressor T cells. J Exp Med 2001; 193:F41-F46.
34. + T cell responses. J Exp Med 2002; 196:1585-92.
35. + T cell responses. J Exp Med 2003; 198:889-901.