Pharmacological pleiotropism of the human recombinant α(1A)-adrenoceptor: Implications for α1-adrenoceptor classification

British Journal of Pharmacology

Volumn 121, Issue 6, 1997, Pages 1127-1135

  Ford, Anthony P D W ^a   Daniels, Donald V ^a   Chang, David J ^a   Gever, Joel R ^a   Jasper, Jeffrey R ^a   Lesnick, John D ^a   Clarke, David E ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

1 adrenoceptors; Inositol phosphates; Noradrenaline; Prazosin; Radioligand binding; RS 17053; Second messenger; Tamsulosin

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 CHLORO N [2 (2 CYCLOPROPYLMETHOXYPHENOXY)ETHYL] ALPHA,ALPHA DIMETHYL 1H INDOLE 3 ETHANAMINE; 5 METHYLURAPIDIL; 8 [3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 3 METHYLFLAVONE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; INDORAMIN; INOSITOL PHOSPHATE; NIGULDIPINE; NORADRENALIN; PRAZOSIN; RECEPTOR SUBTYPE; RECOMBINANT PROTEIN; TAMSULOSIN;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL MEMBRANE; CHO CELL; CLASSIFICATION; CONTROLLED STUDY; FEMALE; HOMOGENATE; MEMBRANE BINDING; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SMOOTH MUSCLE CONTRACTION; URETHRA;

ADRENERGIC AGENTS; ANIMALS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; HUMANS; INOSITOL PHOSPHATES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1; RECOMBINANT PROTEINS;

EID: 0030790446     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701207     Document Type: Article

References (29)

1. 1C-adrenoceptor: studies in the isolated perfused kidney of the rat. Br. J. Pharmacol., 115, 283-294.
2. BROWN, E., KENDALL, D.A. & NAHORSKI, S.R. (1984). Inositol phospholipid hydrolysis in rat cerebral cortical slices. I. Receptor characterisation. J. Neurochem., 42, 1379.
3. BYLUND, D.B., EIKENBURG, D.C., HIEBLE, J.P., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P., MOLINOFF, P.B., RUFFOLO, R.R. JR. & TRENDELENBURG, U. (1994). International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol. Rev., 46, 121-136.
4. i) and the concentration of inhibitor which causes 50 percent inhibition of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
5. EGLEN, R.M., REDDY, H., WATSON, N. & CHALLISS, R.A.J. (1994). Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol. Sci., 15, 114-119.
6. 1B-adrenoceptors subtypes in vas deferens, kidney, and aorta of rat. Eur. J. Pharmacol., 224, 125-136.
7. 1-adrenoceptor subtypes present in the human prostate. Life Sci., 54, 1595-1605.
8. FLAVAHAN, N.A. & VANHOUTTE, P.M. (1986). α-Adrenoceptor classification in vascular smooth muscle. Trends Pharmacol. Sci., 7, 347-349.
9. FLEGNER, P.L., GADEK, T.R., HOLM, M., ROMAN, R., CHAN, H.W., WENZ, M., NORTHROP, J.P., RINGOLD, G.M. & DANIELSEN, M. (1987). Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U.S.A., 84, 7413-7417.
10. 1-adrenoceptors in prostate of man: implications for adrenoceptor classification. Mol. Pharmacol., 49, 209-215.
11. 1-adrenoceptors in isolated anococcygeus muscle of rat. Br. J. Pharmacol., 109, 112P.
12. 1-Adrenoceptor classification: sharpening Occam's razor. Trends Pharmacol. Sci., 15, 167-170.
13. 1C-adrenoceptor subtype. Mol. Pharmacol., 45, 703-708.
14. 1-adrenoceptors; Consensus update. Pharmacol. Rev., 47, 267-270.
15. HOLCK, C.M., JONES, C.H.M. & HAEUSLER, G. (1983). Differential interactions of clonidine and methoxamine with postsynaptic α-adrenoceptors of rabbit main pulmonary artery. J. Cardiovasc. Pharmacol., 5, 240-248.
16. JENKINSON, D.H., BARNARD, E.A., HOYER, D., HUMPHREY, P.P.A., LEFF, P. & SHANKLEY, N.P. (1995). International union of pharmacology committee on receptor nomenclature and drug classification. IX. Recommendations on terms and symbols in quantitative pharmacology. Pharmacol. Rev., 47, 255-266.
17. KENAKIN, T. (1993). Competitive antagonism. In Pharmacological Analysis of Drug-Receptor Interaction. pp. 278-321. New York: Raven Press.
18. 1A receptor subtype. J. Pharmacol. Exp. Ther., 274, 97-103.
19. 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Br. J. Pharmacol., 120, 819-826.
20. LEFF, P. & DOUGALL, I.G. (1993). Further concerns over Cheng-Prusoff analysis. Trends Pharmacol. Sci., 15, 141-144.
21. 1-Adrenergic receptor subtypes, inositol phosphates and sources of cell calcium. Pharmacol. Rev., 40, 87-119.
22. 1-adrenergic receptor subtypes. Mol. Pharmacol., 46, 929-936.
23. 1-adrenoceptors: subclassification and functional aspects. In α-Adrenoceptors: Signal Transduction, Ionic Channels, and Effector Organs, ed. Fujiwara, M., Sugimoto, T. & Kogure, K. pp. 193-202, Tokyo: Excerpta Medica, Ltd.
24. 1-adrenoceptors and native tissues. Mol. Pharmacol., 48, 250-258.
25. TAKEBE, Y., SEIKI, M., FUGISAWA, J., HOY, P., YOKOTA, K., ARAI, K., YOSHIDA, M. & ARAI, N. (1988). Srα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukeia virus type 1 long terminal repeat. Mol. Cell. Biol., 8, 466-472.
26. 1-adrenoceptor antagonist. Pharmacol. Commun., 6, 79-86.
27. 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. Br. J. Pharmacol., 115, 1475-1485.
28. 2+ channel antagonist niguldipine. J. Med. Chem., 38, 1579-1581.
29. 1A-AR in Chinese hamster ovary (CHO-K1) cells. Br. J. Pharmacol., 119, 359P.