2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: Synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 1969-1972

  Haubmann, Christian ^a   Hübner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; PYRROLYLMETHYLENEMALONONITRILE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DOPAMINE BRAIN LEVEL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; RECEPTOR AFFINITY; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATTLE; CHO CELLS; CLOZAPINE; CRICETINAE; HUMANS; ISOMERISM; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NITRILES; PIPERAZINES; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033584150     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00302-9     Document Type: Article

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21. Binding data are the means of two to three experiments performed in triplicate at eight concentrations.
22. Ab initio calculations and visualizations have been done using the programs Gaussian 94 Rev. E.2 (Gaussian Inc.) and PC Spartan Plus (Wavefimction, Inc.).