Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward α1- and α2-adrenoceptors

Journal of Medicinal Chemistry

Volumn 44, Issue 13, 2001, Pages 2118-2132

  Barbaro, R ^a   Betti, L ^b   Botta, M ^c   Corelli, F ^c   Giannaccini, G ^b   Maccari, L ^c   Manetti, F ^c   Strappaghetti, G ^a   Corsano, S ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; CARPIPRAMINE; ERGOTAMINE; ETOPERIDONE; PRAZOSIN; PYRIDAZIN 3(2H) ONE DERIVATIVE; PYRIDAZINONE DERIVATIVE; TRAZODONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; PREDICTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CEREBRAL CORTEX; CHEMISTRY, PHYSICAL; DATABASES, FACTUAL; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PRAZOSIN; PYRIDAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035927444     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010821u     Document Type: Article

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