Selective α-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2495-2500

  Patane, Michael A ^a   DiPardo, Robert M ^a   Price, RoseAnn P ^a   Chang, Raymond S L ^a   Ransom, Richard W ^a   O'Malley, Stacey S ^a   Di Salvo, Jerry ^a   Bock, Mark G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; IPSAPIRONE;

ANIMAL EXPERIMENT; ANXIETY NEUROSIS; ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; NONHUMAN; PROSTATE HYPERTROPHY; RAT; STEREOCHEMISTRY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTI-ANXIETY AGENTS; DRUG DESIGN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; HUMANS; MALE; MODELS, CHEMICAL; PROSTATIC HYPERPLASIA; PYRIMIDINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032558490     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00451-X     Document Type: Article

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