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Volumn 65, Issue 12, 2005, Pages 5221-5230

Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VON HIPPEL LINDAU PROTEIN;

EID: 20444485232     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-0169     Document Type: Article
Times cited : (134)

References (48)
  • 1
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin WG. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002;2:673-82.
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin, W.G.1
  • 2
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994;7:85-90.
    • (1994) Nat Genet , vol.7 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 4
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr. Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1995;1:822-6.
    • (1995) Nat Med , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin Jr., W.G.4
  • 5
    • 0035899491 scopus 로고    scopus 로고
    • The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma
    • Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma. Oncogene 2001;20:5067-74.
    • (2001) Oncogene , vol.20 , pp. 5067-5074
    • Clifford, S.C.1    Astuti, D.2    Hooper, L.3    Maxwell, P.H.4    Ratcliffe, P.J.5    Maher, E.R.6
  • 6
    • 0033607291 scopus 로고    scopus 로고
    • Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
    • Iwai K, Yamanaka K, Kamura T, et al. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A 1999;96:12436-41.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12436-12441
    • Iwai, K.1    Yamanaka, K.2    Kamura, T.3
  • 7
    • 0033597443 scopus 로고    scopus 로고
    • Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
    • Kamura T, Koepp DM, Conrad MN, et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 1999;284:657-61.
    • (1999) Science , vol.284 , pp. 657-661
    • Kamura, T.1    Koepp, D.M.2    Conrad, M.N.3
  • 8
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 9
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
    • Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000;2:423-7.
    • (2000) Nat Cell Biol , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3
  • 10
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003;9:677-84.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 11
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 2001;13:167-71.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 167-171
    • Semenza, G.L.1
  • 12
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 14
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-40.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 16
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr. Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 17
    • 0032085240 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
    • Ohh M, Yauch RL, Lonergan KM, et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998;1:959-68.
    • (1998) Mol Cell , vol.1 , pp. 959-968
    • Ohh, M.1    Yauch, R.L.2    Lonergan, K.M.3
  • 18
    • 1842557655 scopus 로고    scopus 로고
    • pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
    • Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG Jr, Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol 2004;24:3251-61.
    • (2004) Mol Cell Biol , vol.24 , pp. 3251-3261
    • Stickle, N.H.1    Chung, J.2    Klco, J.M.3    Hill, R.P.4    Kaelin Jr., W.G.5    Ohh, M.6
  • 20
    • 0038383678 scopus 로고    scopus 로고
    • Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
    • Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 2003;3:75-88.
    • (2003) Cancer Cell , vol.3 , pp. 75-88
    • Mack, F.A.1    Rathmell, W.K.2    Arsham, A.M.3    Gnarra, J.4    Keith, B.5    Simon, M.C.6
  • 21
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia
    • Sowter HM, Raval R, Moore J, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res 2003;63:6130-4.
    • (2003) Cancer Res , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.2    Moore, J.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 22
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-46.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 23
    • 0036527906 scopus 로고    scopus 로고
    • Two HIFs may be better than one
    • Seagroves T, Johnson RS. Two HIFs may be better than one. Cancer Cell 2002;1:211-3.
    • (2002) Cancer Cell , vol.1 , pp. 211-213
    • Seagroves, T.1    Johnson, R.S.2
  • 24
  • 25
    • 0242581718 scopus 로고    scopus 로고
    • Hypoxia inducible factor activates the transforming growth factor-α/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
    • Gunaratnam L, Morley M, Franovic A, et al. Hypoxia inducible factor activates the transforming growth factor-α/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. J Biol Chem 2003;278:44966-74.
    • (2003) J Biol Chem , vol.278 , pp. 44966-44974
    • Gunaratnam, L.1    Morley, M.2    Franovic, A.3
  • 26
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 27
    • 0035852630 scopus 로고    scopus 로고
    • Role of transforming growth factor-α in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
    • de Paulsen N, Brychzy A, Fournier MC, et al. Role of transforming growth factor-α in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci U S A 2001;98:1387-92.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1387-1392
    • De Paulsen, N.1    Brychzy, A.2    Fournier, M.C.3
  • 28
    • 0036314978 scopus 로고    scopus 로고
    • Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
    • Groulx I, Lee S. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol 2002;22:5319-36.
    • (2002) Mol Cell Biol , vol.22 , pp. 5319-5336
    • Groulx, I.1    Lee, S.2
  • 29
    • 0035847050 scopus 로고    scopus 로고
    • Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein
    • Bonicalzi ME, Groulx I, de Paulsen N, Lee S. Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2001;276:1407-16.
    • (2001) J Biol Chem , vol.276 , pp. 1407-1416
    • Bonicalzi, M.E.1    Groulx, I.2    De Paulsen, N.3    Lee, S.4
  • 30
    • 0037446068 scopus 로고    scopus 로고
    • Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells
    • Nagy P, Arndt-Jovin DJ, Jovin TM. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp Cell Res 2003;285:39-49.
    • (2003) Exp Cell Res , vol.285 , pp. 39-49
    • Nagy, P.1    Arndt-Jovin, D.J.2    Jovin, T.M.3
  • 31
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model
    • Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988;240:177-84.
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 32
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
    • Kunz-Schughart LA, Kreutz M, Knuechel R. Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 1998;79:1-23.
    • (1998) Int J Exp Pathol , vol.79 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 33
    • 0032211360 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
    • Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel RS. von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res 1998;58:4957-62.
    • (1998) Cancer Res , vol.58 , pp. 4957-4962
    • Lieubeau-Teillet, B.1    Rak, J.2    Jothy, S.3    Iliopoulos, O.4    Kaelin, W.5    Kerbel, R.S.6
  • 34
    • 3242725198 scopus 로고    scopus 로고
    • HIF activation by pH-dependent nucleolar sequestration of VHL
    • Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat Cell Biol 2004;6:642-7.
    • (2004) Nat Cell Biol , vol.6 , pp. 642-647
    • Mekhail, K.1    Gunaratnam, L.2    Bonicalzi, M.E.3    Lee, S.4
  • 35
    • 0032477788 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    • Pause A, Lee S, Lonergan KM, Klausner RD. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci U S A 1998;95:993-8.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 993-998
    • Pause, A.1    Lee, S.2    Lonergan, K.M.3    Klausner, R.D.4
  • 37
    • 17044452288 scopus 로고    scopus 로고
    • HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
    • Mandriota SJ, Turner KJ, Davies DR, et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002;1:459-68.
    • (2002) Cancer Cell , vol.1 , pp. 459-468
    • Mandriota, S.J.1    Turner, K.J.2    Davies, D.R.3
  • 38
    • 0030793576 scopus 로고    scopus 로고
    • Altered expression of transforming growth factor-α: An early event in renal cell carcinoma development
    • Everitt JI, Walker CL, Goldsworthy TW, Wolf DC. Altered expression of transforming growth factor-α: an early event in renal cell carcinoma development. Mol Carcinog 1997;19:213-9.
    • (1997) Mol Carcinog , vol.19 , pp. 213-219
    • Everitt, J.I.1    Walker, C.L.2    Goldsworthy, T.W.3    Wolf, D.C.4
  • 39
    • 0024851629 scopus 로고
    • Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β 1 in renal cell carcinoma
    • Gomella LG, Sargent ER, Wade TP, Anglard P, Linehan WM, Kasid A. Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β 1 in renal cell carcinoma. Cancer Res 1989;49:6972-5.
    • (1989) Cancer Res , vol.49 , pp. 6972-6975
    • Gomella, L.G.1    Sargent, E.R.2    Wade, T.P.3    Anglard, P.4    Linehan, W.M.5    Kasid, A.6
  • 40
    • 0031964099 scopus 로고    scopus 로고
    • Transforming growth factor α is a target for the von Hippel-Lindau tumor suppressor
    • Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor α is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998;58:226-31.
    • (1998) Cancer Res , vol.58 , pp. 226-231
    • Knebelmann, B.1    Ananth, S.2    Cohen, H.T.3    Sukhatme, V.P.4
  • 41
    • 0032795938 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells
    • Koochekpour S, Jeffers M, Wang PH, et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 1999;19:5902-12.
    • (1999) Mol Cell Biol , vol.19 , pp. 5902-5912
    • Koochekpour, S.1    Jeffers, M.2    Wang, P.H.3
  • 42
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000;157:411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 43
    • 0034533143 scopus 로고    scopus 로고
    • Targeting tumors through the HIF system
    • Ratcliffe PJ, Pugh CW, Maxwell PH. Targeting tumors through the HIF system. Nat Med 2000;6:1315-6.
    • (2000) Nat Med , vol.6 , pp. 1315-1316
    • Ratcliffe, P.J.1    Pugh, C.W.2    Maxwell, P.H.3
  • 44
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 46
    • 0037567558 scopus 로고    scopus 로고
    • Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice
    • Weber KL, Doucet M, Price JE, Baker C, Kim SJ, Fidler IJ. Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice. Cancer Res 2003;63:2940-7.
    • (2003) Cancer Res , vol.63 , pp. 2940-2947
    • Weber, K.L.1    Doucet, M.2    Price, J.E.3    Baker, C.4    Kim, S.J.5    Fidler, I.J.6
  • 47
    • 4143058243 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and epidermal growth factor receptor therapies in renal cell carcinoma: Do we need a better mouse trap?
    • Dancey JE. Epidermal growth factor receptor and epidermal growth factor receptor therapies in renal cell carcinoma: do we need a better mouse trap? J Clin Oncol 2004;22:2975-7.
    • (2004) J Clin Oncol , vol.22 , pp. 2975-2977
    • Dancey, J.E.1
  • 48
    • 0345714775 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
    • Drucker B, Bacik J, Ginsberg M, et al. Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 2003;21:341-5.
    • (2003) Invest New Drugs , vol.21 , pp. 341-345
    • Drucker, B.1    Bacik, J.2    Ginsberg, M.3


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