-
2
-
-
0033624419
-
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
-
Albers D.S. & Beal M.F. (2000) Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural Transm. Suppl. 59, 133-154.
-
(2000)
J. Neural Transm. Suppl.
, vol.59
, pp. 133-154
-
-
Albers, D.S.1
Beal, M.F.2
-
3
-
-
1842867053
-
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The women's health Initiative randomized controlled trial
-
Anderson G.L., Limacher M., Assaf A.R. et al. (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the women's health Initiative randomized controlled trial. JAMA 291, 1701-1712.
-
(2004)
JAMA
, vol.291
, pp. 1701-1712
-
-
Anderson, G.L.1
Limacher, M.2
Assaf, A.R.3
-
4
-
-
0033214675
-
Presenilins: Molecular switches between proteolysis and signal transduction
-
Annaert W., De Strooper B. (1999) Presenilins: molecular switches between proteolysis and signal transduction. Trends Neurosci. 22, 439-443.
-
(1999)
Trends Neurosci.
, vol.22
, pp. 439-443
-
-
Annaert, W.1
De Strooper, B.2
-
5
-
-
0032557425
-
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis
-
Atwood C.S., Moir R.D., Huang X. et al. (1998) Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J. Biol. Chem. 273, 12817-12826.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12817-12826
-
-
Atwood, C.S.1
Moir, R.D.2
Huang, X.3
-
6
-
-
0033844944
-
Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid betal-42
-
Atwood C.S., Scarpa R.C., Huang X. et al. (2000) Characterization of copper interactions with Alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid betal-42. J. Neurochem. 75, 1219-1233.
-
(2000)
J. Neurochem.
, vol.75
, pp. 1219-1233
-
-
Atwood, C.S.1
Scarpa, R.C.2
Huang, X.3
-
7
-
-
0036593191
-
Oestrogen as a neuroprotective hormone
-
Behl C. (2002) Oestrogen as a neuroprotective hormone. Nat Rev. Neurosci. 3, 433-442.
-
(2002)
Nat Rev. Neurosci.
, vol.3
, pp. 433-442
-
-
Behl, C.1
-
8
-
-
0031918785
-
The genetics of Alzheimer disease: Current status and future prospects
-
Blacker D. & Tanzi R.E. (1998) The genetics of Alzheimer disease: current status and future prospects. Arch. Neurol. 55, 294-296.
-
(1998)
Arch. Neurol.
, vol.55
, pp. 294-296
-
-
Blacker, D.1
Tanzi, R.E.2
-
9
-
-
0027476024
-
A synaptic model of memory: Long-term potentiation in the hippocampus
-
Bliss T.V. & Collingridge G.L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
-
(1993)
Nature
, vol.361
, pp. 31-39
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
10
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X. & Sudhof T.C. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
11
-
-
2642582435
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
-
Cao X. & Sudhof T.C. (2004) Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279, 24601-24611.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
12
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny R.A., Atwood C.S., Xilinas M.E. et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665-676.
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
13
-
-
0033551782
-
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion
-
Cherny R.A., Legg J.T., McLean C.A. et al. (1999) Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J. Biol. Chem. 274, 23223-23228.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23223-23228
-
-
Cherny, R.A.1
Legg, J.T.2
McLean, C.A.3
-
14
-
-
0033954991
-
Oxidative stress and Alzheimer disease
-
Christen Y. (2000) Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71, 621S-629S.
-
(2000)
Am. J. Clin. Nutr.
, vol.71
-
-
Christen, Y.1
-
15
-
-
0842309491
-
Beta-secretase inhibition for the treatment of Alzheimer's disease - Promise and challenge
-
Citron M. (2004a) Beta-secretase inhibition for the treatment of Alzheimer's disease - promise and challenge. Trends Pharmacol. Sci. 25, 92-97.
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 92-97
-
-
Citron, M.1
-
16
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
Citron M. (2004b) Strategies for disease modification in Alzheimer's disease. Nat Rev. Neurosci. 5, 677-685.
-
(2004)
Nat Rev. Neurosci.
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
17
-
-
3042857903
-
Alzheimer's disease
-
Cummings J.L. (2004) Alzheimer's disease. N. Engl. J. Med. 351, 56-67.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
18
-
-
0033851022
-
Genetic epidemiology of Alzheimer's disease
-
Dartigues J.F. & Letenneur L. (2000) Genetic epidemiology of Alzheimer's disease. Curr. Opin. Neurol. 13, 385-389.
-
(2000)
Curr. Opin. Neurol.
, vol.13
, pp. 385-389
-
-
Dartigues, J.F.1
Letenneur, L.2
-
19
-
-
0033591017
-
Cholinergic markers in elderly patients with early signs of Alzheimer disease
-
Davis K.L., Mohs R.C., Marin D. et al. (1999) Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 281, 1401-1406.
-
(1999)
JAMA
, vol.281
, pp. 1401-1406
-
-
Davis, K.L.1
Mohs, R.C.2
Marin, D.3
-
20
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B., Saftig P., Craessaerts K. et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
-
21
-
-
0036156958
-
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
-
DeKosky S.T., Ikonomovic M.D., Styren S.D. et al. (2002) Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann. Neurol. 51, 145-155.
-
(2002)
Ann. Neurol.
, vol.51
, pp. 145-155
-
-
Dekosky, S.T.1
Ikonomovic, M.D.2
Styren, S.D.3
-
22
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., Haass C. (2003) Reconstitution of gamma-secretase activity. Nat Cell Biol. 5, 486-488.
-
(2003)
Nat Cell Biol.
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
23
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender K., Simons M., Bergmann C. et al. (2001) Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856-5861.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
-
24
-
-
0028535113
-
Anatomy and physiology of glutamate in the CNS
-
Greenamyre J.T. & Porter R.H. (1994) Anatomy and physiology of glutamate in the CNS. Neurology 44, S7-S13.
-
(1994)
Neurology
, vol.44
-
-
Greenamyre, J.T.1
Porter, R.H.2
-
25
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C. (2004) Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 23, 483-488.
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
26
-
-
0029031466
-
Age-specific incidence of Alzheimer's disease in a community population
-
Hebert L.E., Scherr P.A., Beckett L.A. et al. (1995) Age-specific incidence of Alzheimer's disease in a community population. JAMA 273, 1354-1359.
-
(1995)
JAMA
, vol.273
, pp. 1354-1359
-
-
Hebert, L.E.1
Scherr, P.A.2
Beckett, L.A.3
-
27
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C., Konietzko U., Streffer J.R. et al. (2003) Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
-
28
-
-
0036260892
-
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
-
Holsinger R.M., McLean C.A., Beyreuther K., Masters C.L., Evin G. (2002) Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann. Neurol. 51, 783-786.
-
(2002)
Ann. Neurol.
, vol.51
, pp. 783-786
-
-
Holsinger, R.M.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
29
-
-
0034473527
-
The role of proteolysis in Alzheimer's disease
-
Hooper N.M., Trew A.J., Parkin E.T., Turner A.J. (2000) The role of proteolysis in Alzheimer's disease. Adv. Exp. Med. Biol. 477, 379-390.
-
(2000)
Adv. Exp. Med. Biol.
, vol.477
, pp. 379-390
-
-
Hooper, N.M.1
Trew, A.J.2
Parkin, E.T.3
Turner, A.J.4
-
30
-
-
0042156746
-
Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease. Fortschr
-
Hoyer S, & Riederer P. (2003) Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease. Fortschr. Neurol. Psychiatr. 71 (Suppl. 1), S16-S26.
-
(2003)
Neurol. Psychiatr.
, vol.71
, Issue.SUPPL. 1
-
-
Hoyer, S.1
Riederer, P.2
-
31
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M., Lendon C.L., Rizzu P. et al. (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393, 702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
-
32
-
-
0035923502
-
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
-
Kitazume S., Tachida Y., Oka R., Shirotani K., Saido T.C., Hashimoto Y. (2001) Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc. Natl. Acad. Sci. USA 98, 13554-13559.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13554-13559
-
-
Kitazume, S.1
Tachida, Y.2
Oka, R.3
Shirotani, K.4
Saido, T.C.5
Hashimoto, Y.6
-
33
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo E.H. & Squazzo S.L. (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
34
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R. & Ilagan M.X. (2004) Gamma-secretase: proteasome of the membrane? Nat Rev. Mol Cell Biol. 5, 499-504.
-
(2004)
Nat Rev. Mol Cell Biol.
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
35
-
-
0141763668
-
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis
-
Lanctot K.L., Herrmann N., Yau K.K. et al. (2003) Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis. CMAJ 169, 557-564.
-
(2003)
CMAJ
, vol.169
, pp. 557-564
-
-
Lanctot, K.L.1
Herrmann, N.2
Yau, K.K.3
-
36
-
-
2942530300
-
Acetylcholinesterase and its inhibition in Alzheimer disease
-
Lane R.M., Kivipelto M., Greig N.H. (2004) Acetylcholinesterase and its inhibition in Alzheimer disease. Clin. Neuropharmacol. 27, 141-149.
-
(2004)
Clin. Neuropharmacol.
, vol.27
, pp. 141-149
-
-
Lane, R.M.1
Kivipelto, M.2
Greig, N.H.3
-
37
-
-
0842325530
-
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
-
Lichtenthaler S.F., DomingueZ D.I., Westmeyer G.G. et al. (2003) The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J. Biol. Chem. 278, 48713-48719.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48713-48719
-
-
Lichtenthaler, S.F.1
Dominguez, D.I.2
Westmeyer, G.G.3
-
38
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell M.A., Robertson J.D., Teesdale W.J., Campbell J.L., Markesbery W.R. (1998) Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 158, 47-52.
-
(1998)
J. Neurol. Sci.
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
39
-
-
0035180875
-
Invited review: Estrogens effects on the brain: Multiple sites and molecular mechanisms
-
McEwen B.S. (2001) Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J. Appl. Physiol. 91, 2785-2801.
-
(2001)
J. Appl. Physiol.
, vol.91
, pp. 2785-2801
-
-
McEwen, B.S.1
-
41
-
-
0242268945
-
Immunotherapeutic approaches to Alzheimer's disease
-
Monsonego A. & Weiner H.L. (2003) Immunotherapeutic approaches to Alzheimer's disease. Science 302, 834-838.
-
(2003)
Science
, vol.302
, pp. 834-838
-
-
Monsonego, A.1
Weiner, H.L.2
-
42
-
-
0036799799
-
Antioxidants as treatment for neurodegenerative disorders
-
Moosmann B. & Behl C. (2002) Antioxidants as treatment for neurodegenerative disorders. Expert Opin. Investig. Drugs 11, 1407-1435.
-
(2002)
Expert Opin. Investig. Drugs
, vol.11
, pp. 1407-1435
-
-
Moosmann, B.1
Behl, C.2
-
43
-
-
1642373224
-
Selenoprotein synthesis and side-effects of statins
-
Moosmann B. & Behl C. (2004) Selenoprotein synthesis and side-effects of statins. Lancet 363, 892-894.
-
(2004)
Lancet
, vol.363
, pp. 892-894
-
-
Moosmann, B.1
Behl, C.2
-
44
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., Weller R.O. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 9, 448-452.
-
(2003)
Nat. Med.
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
45
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A., Perry G., Aliev G. et al. (2001) Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759-767.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
-
46
-
-
0036846405
-
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
-
Pietrzik C.U., Busse T., Merriam D.E., Weggen S., Koo E.H. (2002) The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J. 21, 5691-5700.
-
(2002)
EMBO J.
, vol.21
, pp. 5691-5700
-
-
Pietrzik, C.U.1
Busse, T.2
Merriam, D.E.3
Weggen, S.4
Koo, E.H.5
-
47
-
-
2442498577
-
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
-
Pietrzik C.U., Yoon I.S., Jaeger S., Busse T., Weggen S., Koo E.H. (2004) FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J. Neurosci. 24, 4259-4265.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4259-4265
-
-
Pietrzik, C.U.1
Yoon, I.S.2
Jaeger, S.3
Busse, T.4
Weggen, S.5
Koo, E.H.6
-
48
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
Postina R., Schroeder A., Dewachter I. et al. (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113, 1456-1464.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
-
49
-
-
0033765735
-
Oxidative injury in diseases of the central nervous system: Focus on Alzheimer's disease
-
Pratico D. & Delanty N. (2000) Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am. J. Med. 109, 577-585.
-
(2000)
Am. J. Med.
, vol.109
, pp. 577-585
-
-
Pratico, D.1
Delanty, N.2
-
50
-
-
0037417238
-
Memantine in moderate-to-severe Alzheimer's disease
-
Reisberg B., Doody R., Stoffler A., Schmitt F., Ferris S., Mobius H.J. (2003) Memantine in moderate-to-severe Alzheimer's disease. N. Engl. J. Med. 348, 1333-1341.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
Schmitt, F.4
Ferris, S.5
Mobius, H.J.6
-
51
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie C.W., Bush A.I., Mackinnon A. et al. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 60, 1685-1691.
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
-
52
-
-
0036827161
-
Abeta as a bioflocculant: Implications for the amyloid hypothesis of Alzheimer's disease
-
Robinson S.R. & Bishop G.M. (2002) Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease. Neurobiol. Aging 23, 1051-1072.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 1051-1072
-
-
Robinson, S.R.1
Bishop, G.M.2
-
53
-
-
0026447529
-
Complement activation by beta-amyloid in Alzheimer disease
-
Rogers J., Cooper N.R., Webster S. et al. (1992) Complement activation by beta-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 89, 10016-10020.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Webster, S.3
-
54
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
Saura C.A., Choi S.Y., Beglopoulos V. et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42, 23-36.
-
(2004)
Neuron
, vol.42
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.Y.2
Beglopoulos, V.3
-
55
-
-
0042020173
-
Treatment of Alzheimer's disease: Current status and new perspectives
-
Scarpini E., Scheltens P., Feldman H. (2003) Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2, 539-547.
-
(2003)
Lancet Neurol.
, vol.2
, pp. 539-547
-
-
Scarpini, E.1
Scheltens, P.2
Feldman, H.3
-
56
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D., Barbour R., Dunn W. et al. (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
57
-
-
0033668050
-
Galantamine: A review of its use in Alzheimer's disease
-
Scott L.J. & Goa K.L. (2000) Galantamine: a review of its use in Alzheimer's disease. Drugs 60, 1095-1122.
-
(2000)
Drugs
, vol.60
, pp. 1095-1122
-
-
Scott, L.J.1
Goa, K.L.2
-
58
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe D.J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
59
-
-
0041355557
-
Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
-
Selkoe D. & Kopan R. (2003) Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 26, 565-597.
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
60
-
-
84985570313
-
Biochemistry of oxidative stress
-
Sies H. (1986) Biochemistry of oxidative stress. Angew. Chem. Int. Ed. Engl. 25, 1058-1071.
-
(1986)
Angew. Chem. Int. Ed. Engl.
, vol.25
, pp. 1058-1071
-
-
Sies, H.1
-
61
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M., Keller P., De Strooper B., Beyreuther K., Dotti G.G., Simons K. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA 95, 6460-6464.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dotti, G.G.5
Simons, K.6
-
62
-
-
0036714243
-
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
-
Simons M., Schwarzler F., Lutjohann D. et al. (2002) Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann. Neurol. 52, 346-350.
-
(2002)
Ann. Neurol.
, vol.52
, pp. 346-350
-
-
Simons, M.1
Schwarzler, F.2
Lutjohann, D.3
-
63
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use
-
Stewart W.F., Kawas C., Corrada M., Metter E.J. (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology 48, 626-632.
-
(1997)
Neurology
, vol.48
, pp. 626-632
-
-
Stewart, W.F.1
Kawas, C.2
Corrada, M.3
Metter, E.J.4
-
64
-
-
0030273584
-
NMDA receptors: From genes to channels
-
Sucher N.J., Awobuluyi M., Choi Y.B., Lipton S.A. (1996) NMDA receptors: from genes to channels. Trends Pharmacol. Sci. 17, 348-355.
-
(1996)
Trends Pharmacol. Sci.
, vol.17
, pp. 348-355
-
-
Sucher, N.J.1
Awobuluyi, M.2
Choi, Y.B.3
Lipton, S.A.4
-
65
-
-
3242803587
-
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: A systematic review
-
Szekely C.A., Thorne J.E., Zandi P.P. et al. (2004) Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 23, 159-169.
-
(2004)
Neuroepidemiology
, vol.23
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
-
66
-
-
13344293701
-
Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome
-
Teller J.K., Russo C., DeBusk L.M. et al. (1996) Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome. Nat. Med. 2, 93-95.
-
(1996)
Nat. Med.
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
Debusk, L.M.3
-
67
-
-
0029795197
-
The pathogenesis of Alzheimer disease: An alternative to the amyloid hypothesis
-
Terry R.D. (1996) The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis. J. Neuropathol. Exp. Neurol. 55, 1023-1025.
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 1023-1025
-
-
Terry, R.D.1
-
69
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S., Eriksen J.L., Das P. et al. (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414, 212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
-
70
-
-
0019410162
-
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
-
Whitehouse P.J., Price D.L., Clark A.W., Coyle J.T., DeLong M.R. (1981) Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10, 122-126.
-
(1981)
Ann. Neurol.
, vol.10
, pp. 122-126
-
-
Whitehouse, P.J.1
Price, D.L.2
Clark, A.W.3
Coyle, J.T.4
Delong, M.R.5
-
71
-
-
0031875257
-
Cholinergic strategies for Alzheimer's disease
-
Winkler J., Thal L.J., Gage F.H., Fisher L.J. (1998) Cholinergic strategies for Alzheimer's disease. J. Mol. Med. 76, 555-567.
-
(1998)
J. Mol. Med.
, vol.76
, pp. 555-567
-
-
Winkler, J.1
Thal, L.J.2
Gage, F.H.3
Fisher, L.J.4
-
72
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
73
-
-
0036670693
-
Cholesterol and Alzheimer's disease
-
Wolozin B. (2002) Cholesterol and Alzheimer's disease. Biochem. Soc. Trans. 30, 525-529.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 525-529
-
-
Wolozin, B.1
-
74
-
-
0346688728
-
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study
-
Zandi P.P., Anthony J.C., Khachaturian A.S. et al. (2004) Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch. Neurol. 61, 82-88.
-
(2004)
Arch. Neurol.
, vol.61
, pp. 82-88
-
-
Zandi, P.P.1
Anthony, J.C.2
Khachaturian, A.S.3
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