메뉴 건너뛰기




Volumn 71, Issue SUPPL. 1, 2003, Pages

Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's Disease;Pathomechanismen und hypothesengeleitete therapieoptionen bei der spätform der Alzheimer-Krankheit

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; GINKGO BILOBA EXTRACT; MEMANTINE;

EID: 0042156746     PISSN: 07204299     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (141)
  • 1
    • 0028834799 scopus 로고
    • Genetic susceptibility to Alzheimer disease
    • Pericak-Vance M, Haines JL. Genetic susceptibility to Alzheimer disease. Trends Genet 1995; 11: 504-508
    • (1995) Trends Genet , vol.11 , pp. 504-508
    • Pericak-Vance, M.1    Haines, J.L.2
  • 4
    • 0034254795 scopus 로고    scopus 로고
    • Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of type 2 diabetes mellitus
    • Holness MJ, Langdown ML, Sugden MC. Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of type 2 diabetes mellitus. Biochem J 2000; 349: 657-665
    • (2000) Biochem J , vol.349 , pp. 657-665
    • Holness, M.J.1    Langdown, M.L.2    Sugden, M.C.3
  • 5
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997; 20: 154-159
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 6
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotype, and treatment
    • Selkoe DJ. Alzheimer's disease: genotypes, phenotype, and treatment. Science 1997; 275: 630-631
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 8
    • 0029877684 scopus 로고    scopus 로고
    • Correlations between mental state and quantitative neuropathology in the Vienna prospective longitudinal study on dementia
    • Bancher C, Jellinger K, Lassmann H, Fischer P, Leblhuber F. Correlations between mental state and quantitative neuropathology in the Vienna Prospective Longitudinal Study on Dementia. Eur Arch Psychiatry Clin Neurosci 1996; 246: 137-146
    • (1996) Eur Arch Psychiatry Clin Neurosci , vol.246 , pp. 137-146
    • Bancher, C.1    Jellinger, K.2    Lassmann, H.3    Fischer, P.4    Leblhuber, F.5
  • 10
    • 0018826694 scopus 로고
    • Coenyzm A-acetylating enzymes in Alzheimer's disease: Possible cholinergic "compartment" of pyruvate dehydrogenase
    • Perry EK, Perry RH, Tomlinson BE, Blessed G, Gibson PH. Coenyzm A-acetylating enzymes in Alzheimer's disease: possible cholinergic "compartment" of pyruvate dehydrogenase. Neurosci Lett 1980; 18: 105-110
    • (1980) Neurosci Lett , vol.18 , pp. 105-110
    • Perry, E.K.1    Perry, R.H.2    Tomlinson, B.E.3    Blessed, G.4    Gibson, P.H.5
  • 12
    • 0032973711 scopus 로고    scopus 로고
    • Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
    • Michikawa M, Yanagisawa K. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J Neurochem 1999; 72: 2278-2285
    • (1999) J Neurochem , vol.72 , pp. 2278-2285
    • Michikawa, M.1    Yanagisawa, K.2
  • 14
    • 0033198566 scopus 로고    scopus 로고
    • Neuroactive steroids: Mechanism of action and neuropharmacological perspectives
    • Rupprecht R, Holsboer F. Neuroactive steroids: mechanism of action and neuropharmacological perspectives. Trends Neurosci 1999; 22: 410-416
    • (1999) Trends Neurosci , vol.22 , pp. 410-416
    • Rupprecht, R.1    Holsboer, F.2
  • 15
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy JM, Rürley SD. Cholesterol metabolism in the brain. Curr Op Lipidol 2001; 12: 106-112
    • (2001) Curr Op Lipidol , vol.12 , pp. 106-112
    • Dietschy, J.M.1    Rürley, S.D.2
  • 17
    • 0026625261 scopus 로고
    • Lowering the cholesterol content of MA 104 cells inhibits receptor-mediated transport by folate
    • Chang WJ, Rothberg GK, Kamen BA, Anderson RG. Lowering the cholesterol content of MA 104 cells inhibits receptor-mediated transport by folate. J Cell Biol 1992; 118: 63-69
    • (1992) J Cell Biol , vol.118 , pp. 63-69
    • Chang, W.J.1    Rothberg, G.K.2    Kamen, B.A.3    Anderson, R.G.4
  • 18
    • 0027997787 scopus 로고
    • Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis and capillary permeability of select macromolecules
    • Schnitzer JE, Oh P, Pinney E, Allard J. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis and capillary permeability of select macromolecules. J Cell Biol 1994; 127: 1217-1232
    • (1994) J Cell Biol , vol.127 , pp. 1217-1232
    • Schnitzer, J.E.1    Oh, P.2    Pinney, E.3    Allard, J.4
  • 19
    • 0032077150 scopus 로고    scopus 로고
    • Insulin-induced protein tyrosine phosphorylation cascade and signalling molecules are localized in a caveolin-enriched cell membrane domain
    • Smith RM, Harada S, Smith JA, Zhang S, Jarett L. Insulin-induced protein tyrosine phosphorylation cascade and signalling molecules are localized in a caveolin-enriched cell membrane domain. Cell Signal 1998; 10: 355-362
    • (1998) Cell Signal , vol.10 , pp. 355-362
    • Smith, R.M.1    Harada, S.2    Smith, J.A.3    Zhang, S.4    Jarett, L.5
  • 23
    • 0029086845 scopus 로고
    • Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia
    • Müller WE, Mutschler E, Riederer P. Noncompetitive NMDA Receptor Antagonists with Fast Open-Channel Blocking Kinetics and Strong Voltage-Dependency as Potential Therapeutic Agents for Alzheimer's Dementia. Pharmacopsychiat 1995; 28: 113-124
    • (1995) Pharmacopsychiat , vol.28 , pp. 113-124
    • Müller, W.E.1    Mutschler, E.2    Riederer, P.3
  • 24
    • 0029163166 scopus 로고
    • Desensitization of the neuronal insulin receptor: A new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?
    • Henneberg N, Hoyer S. Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)? Arch Gerontol Geriatr 1995; 21: 63-74
    • (1995) Arch Gerontol Geriatr , vol.21 , pp. 63-74
    • Henneberg, N.1    Hoyer, S.2
  • 25
    • 0036205701 scopus 로고    scopus 로고
    • The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: An update
    • Hoyer S. The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: An update. J Neural Transm 2002; 109: 341-360
    • (2002) J Neural Transm , vol.109 , pp. 341-360
    • Hoyer, S.1
  • 26
    • 0033605607 scopus 로고    scopus 로고
    • Insulin-degrading enzyme in the Alzheimer's disease brain: Prominent localization in neurons and senile plaques
    • Bernstein HG, Ansorge S, Riederer P, Reiser M, Frölich L, Bogerts B, Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques. Neurosci Letters 1999; 263: 161-164
    • (1999) Neurosci Letters , vol.263 , pp. 161-164
    • Bernstein, H.G.1    Ansorge, S.2    Riederer, P.3    Reiser, M.4    Frölich, L.5    Bogerts, B.6
  • 27
    • 0033197996 scopus 로고    scopus 로고
    • The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
    • Abbott MA, Wells DG, Fallon JR. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 1999; 19: 7300-7308
    • (1999) J Neurosci , vol.19 , pp. 7300-7308
    • Abbott, M.A.1    Wells, D.G.2    Fallon, J.R.3
  • 29
    • 0034012017 scopus 로고    scopus 로고
    • Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway
    • Solano DJ, Sironi M, Bonfini C, Solerte B, Govoni S, Racchi M. Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. FASEB J 2000; 14: 1015-1022
    • (2000) FASEB J , vol.14 , pp. 1015-1022
    • Solano, D.J.1    Sironi, M.2    Bonfini, C.3    Solerte, B.4    Govoni, S.5    Racchi, M.6
  • 30
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneural β-amyloid and requires mitogen-activated protein kinase signaling
    • Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneural β-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001; 21: 2561-2570
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6    Xu, H.7
  • 31
    • 0023030067 scopus 로고
    • Senile dementia and Alzheimer's disease: Brain blood flow and metabolism
    • Hoyer S. Senile dementia and Alzheimer's disease: brain blood flow and metabolism. Prog Neuropsychopharmacol Biol Psychiatry 1986; 10: 447-478
    • (1986) Prog Neuropsychopharmacol Biol Psychiatry , vol.10 , pp. 447-478
    • Hoyer, S.1
  • 32
    • 0029817301 scopus 로고    scopus 로고
    • Age-related changes in gene expression in the rat brain revealed by differential display
    • Salehi M, Hodgkins BJ, Merry BJ, Goyns MH. Age-related changes in gene expression in the rat brain revealed by differential display. Experientia 1996; 52: 888-891
    • (1996) Experientia , vol.52 , pp. 888-891
    • Salehi, M.1    Hodgkins, B.J.2    Merry, B.J.3    Goyns, M.H.4
  • 33
    • 0031067763 scopus 로고    scopus 로고
    • Identification of a rat brain gene associated with aging by PCR differential display method
    • Wu HC, Lee EHY. Identification of a rat brain gene associated with aging by PCR differential display method. J Mol Neurosci 1997; 8: 13-18
    • (1997) J Mol Neurosci , vol.8 , pp. 13-18
    • Wu, H.C.1    Lee, E.H.Y.2
  • 34
    • 0035852759 scopus 로고    scopus 로고
    • The effects of aging on gene expression in the hypothalamus and cortex of mice
    • Jiang CH, Tsien JZ, Schultz PG, Hu Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci USA 2001; 98: 1930-1934
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1930-1934
    • Jiang, C.H.1    Tsien, J.Z.2    Schultz, P.G.3    Hu, Y.4
  • 35
    • 0022183609 scopus 로고
    • The effect of age on glucose and energy metabolism in brain cortex of rats
    • Hoyer S. The effect of age on glucose and energy metabolism in brain cortex of rats. Arch Gerontol Geriatr 1985; 4: 193-203
    • (1985) Arch Gerontol Geriatr , vol.4 , pp. 193-203
    • Hoyer, S.1
  • 36
    • 0021308693 scopus 로고
    • Cellular aging: Selective vulnerability of cholinergic neurons in human brain
    • Bowen DM. Cellular aging: selective vulnerability of cholinergic neurons in human brain. Monogr Dev Biol 1984; 17: 42-59
    • (1984) Monogr Dev Biol , vol.17 , pp. 42-59
    • Bowen, D.M.1
  • 37
    • 0022884668 scopus 로고
    • Age-related increase in presynaptic noradrenergic markers of the rat cerebral cortex
    • Harik SI, McCracken KA. Age-related increase in presynaptic noradrenergic markers of the rat cerebral cortex. Brain Res 1986; 381: 125-130
    • (1986) Brain Res , vol.381 , pp. 125-130
    • Harik, S.I.1    McCracken, K.A.2
  • 38
    • 0027291876 scopus 로고
    • Aging prolongs the stress-induced release of noradrenaline in rat hypothalamus
    • Perego C, Vetrugno CC, De Simono MG, Algeri S. Aging prolongs the stress-induced release of noradrenaline in rat hypothalamus. Neurosci Lett 1993; 157: 127-130
    • (1993) Neurosci Lett , vol.157 , pp. 127-130
    • Perego, C.1    Vetrugno, C.C.2    De Simono, M.G.3    Algeri, S.4
  • 41
    • 0025913434 scopus 로고
    • Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease
    • Söderberg M, Edlund C, Kristensson K, Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 1991; 26: 412-425
    • (1991) Lipids , vol.26 , pp. 412-425
    • Söderberg, M.1    Edlund, C.2    Kristensson, K.3    Dallner, G.4
  • 42
    • 0029935694 scopus 로고    scopus 로고
    • Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice
    • Igbavboa U, Avdulov A, Schröder F, Wood WG. Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice. J Neurochem 1996; 66: 1717-1725
    • (1996) J Neurochem , vol.66 , pp. 1717-1725
    • Igbavboa, U.1    Avdulov, A.2    Schröder, F.3    Wood, W.G.4
  • 43
    • 0026502543 scopus 로고
    • Choline metabolism as a basis for the selective vulnerability of cholinergic neurons
    • Wurtman RJ. Choline metabolism as a basis for the selective vulnerability of cholinergic neurons. Trends Neurosci 1992; 15: 117-122
    • (1992) Trends Neurosci , vol.15 , pp. 117-122
    • Wurtman, R.J.1
  • 44
    • 0025334082 scopus 로고
    • Autopsy samples of Alzheimer's cortex show increased lipid perpidation in vitro
    • Subbarao KV, Richardson JS, Hug LC. Autopsy samples of Alzheimer's cortex show increased lipid perpidation in vitro. J Neurochem 1990; 55: 342-345
    • (1990) J Neurochem , vol.55 , pp. 342-345
    • Subbarao, K.V.1    Richardson, J.S.2    Hug, L.C.3
  • 45
    • 0033230623 scopus 로고    scopus 로고
    • Neuroplasticity failure in Alzheimer's disease, bridging the gap between plaques and tangles
    • Mesulam MM. Neuroplasticity failure in Alzheimer's disease, bridging the gap between plaques and tangles. Neuron 1999; 24: 521-529
    • (1999) Neuron , vol.24 , pp. 521-529
    • Mesulam, M.M.1
  • 46
  • 48
    • 0025856239 scopus 로고
    • Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross sectional comparison against advanced late-onset and incipient early-onset cases
    • Hoyer S, Nitsch R, Oesterreich K. Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross sectional comparison against advanced late-onset and incipient early-onset cases. J Neural Transm (P-D Sect) 1991; 3: 1-14
    • (1991) J Neural Transm (P-D Sect) , vol.3 , pp. 1-14
    • Hoyer, S.1    Nitsch, R.2    Oesterreich, K.3
  • 51
    • 0033653771 scopus 로고    scopus 로고
    • Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
    • Hoyer S. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Exp Gerontol 2000; 35: 1363-1372
    • (2000) Exp Gerontol , vol.35 , pp. 1363-1372
    • Hoyer, S.1
  • 52
    • 0031928535 scopus 로고
    • Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
    • Hoyer S. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J Neural Transm 1988; 105: 415-422
    • (1988) J Neural Transm , vol.105 , pp. 415-422
    • Hoyer, S.1
  • 53
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate τ phosphorylation in cultured human neurons
    • Hong M, Lee VMY. Insulin and insulin-like growth factor-1 regulate τ phosphorylation in cultured human neurons. J Biol Chem 1997; 272: 19547-19553
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.Y.2
  • 57
    • 0026781603 scopus 로고
    • Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases
    • Hoyer S. Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases. Mol Chem Neuropathol 1992; 16: 207-224
    • (1992) Mol Chem Neuropathol , vol.16 , pp. 207-224
    • Hoyer, S.1
  • 58
    • 0016741395 scopus 로고
    • Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces
    • Gibson GE, Jope R, Blass JP. Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces. Biochem J 1975; 148: 17-23
    • (1975) Biochem J , vol.148 , pp. 17-23
    • Gibson, G.E.1    Jope, R.2    Blass, J.P.3
  • 59
    • 0019731611 scopus 로고
    • 14C) glucose by tissue prisms from human neocortex
    • 14C) glucose by tissue prisms from human neocortex. Biochem J 1981; 196: 867-876
    • (1981) Biochem J , vol.196 , pp. 867-876
    • Sims, N.R.1    Bowen, D.M.2    Davison, A.N.3
  • 60
    • 0034468706 scopus 로고    scopus 로고
    • Crosslinking of α-synuclein by advanced glycation endproducts - An early pathophysiological step in Lewy body formation?
    • Münch G, Lüth HJ, Wong A, Arendt Th, Hirsch E, Ravid R, Riederer P. Crosslinking of α-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? J Chem Neuroanat 2000; 20: 253-257
    • (2000) J Chem Neuroanat , vol.20 , pp. 253-257
    • Münch, G.1    Lüth, H.J.2    Wong, A.3    Arendt, Th.4    Hirsch, E.5    Ravid, R.6    Riederer, P.7
  • 61
    • 0028802746 scopus 로고
    • A hierarchy of ATP-consuming processes in mammalian cells
    • Buttgereit F, Brand MD. A hierarchy of ATP-consuming processes in mammalian cells. Biochem J 1995; 312: 163-167
    • (1995) Biochem J , vol.312 , pp. 163-167
    • Buttgereit, F.1    Brand, M.D.2
  • 62
    • 0025719976 scopus 로고
    • Two novel kinases phosphorylate τ and the KSP site of heavy neurofilament subunits in high stoichiometric ratios
    • Röder HM, Ingram VM. Two novel kinases phosphorylate τ and the KSP site of heavy neurofilament subunits in high stoichiometric ratios. J Neurosci 1991; 11: 3325-3343
    • (1991) J Neurosci , vol.11 , pp. 3325-3343
    • Röder, H.M.1    Ingram, V.M.2
  • 63
    • 0028945978 scopus 로고
    • Activation of a neurofilament kinase, a τ kinase and a τ phosphatase by decreased ATP levels in nerve growth factor-differentiated PC 12 cells
    • Bush ML. Niyashiro JS, Ingram VM. Activation of a neurofilament kinase, a τ kinase and a τ phosphatase by decreased ATP levels in nerve growth factor-differentiated PC 12 cells. Proc Natl Acad Sci USA 1995; 92: 1962-1965
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1962-1965
    • Bush, M.L.1    Niyashiro, J.S.2    Ingram, V.M.3
  • 64
    • 0032800818 scopus 로고    scopus 로고
    • Intracellular APP processing and Aβ production in Alzheimer disease
    • Wilson CA, Doms RW, Lee VMY. Intracellular APP processing and Aβ production in Alzheimer disease. J Neuropathol Exp Neurol 1999; 58: 787-794
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 787-794
    • Wilson, C.A.1    Doms, R.W.2    Lee, V.M.Y.3
  • 71
    • 0033987298 scopus 로고    scopus 로고
    • Levels of α- and β-secretase cleared amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
    • Sennvik K, Fastbom J, Blomberg M, Wahlund LO, Winblad B, Benedikz E. Levels of α- and β-secretase cleared amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 2000; 278: 169-172
    • (2000) Neurosci Lett , vol.278 , pp. 169-172
    • Sennvik, K.1    Fastbom, J.2    Blomberg, M.3    Wahlund, L.O.4    Winblad, B.5    Benedikz, E.6
  • 72
    • 0035004604 scopus 로고    scopus 로고
    • Reduced expression of amyloid precursor protein, presenilin-1 and rab 3a in cortical brain regions in Alzeimer's disease
    • Davidsson P, Bogdanovic N, Lannfeldt L, Blennow K. Reduced expression of amyloid precursor protein, presenilin-1 and rab 3a in cortical brain regions in Alzeimer's disease. Dement Geriatr Cogn Dis 2001; 12: 243-250
    • (2001) Dement Geriatr Cogn Dis , vol.12 , pp. 243-250
    • Davidsson, P.1    Bogdanovic, N.2    Lannfeldt, L.3    Blennow, K.4
  • 73
    • 0024545260 scopus 로고
    • Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type
    • Hoyer S, Nitsch R. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type. J Neural Transm 1989; 75: 227-232
    • (1989) J Neural Transm , vol.75 , pp. 227-232
    • Hoyer, S.1    Nitsch, R.2
  • 74
    • 0025005188 scopus 로고
    • Ammonia is endogenously generated in the brain in the presence of presumed and verified dementia of Alzheimer type
    • Hoyer S, Nitsch R, Oesterreich K. Ammonia is endogenously generated in the brain in the presence of presumed and verified dementia of Alzheimer type. Neurosci Lett 1990; 117: 358-362
    • (1990) Neurosci Lett , vol.117 , pp. 358-362
    • Hoyer, S.1    Nitsch, R.2    Oesterreich, K.3
  • 76
    • 0030995428 scopus 로고    scopus 로고
    • On the voltage dependence of the mitochondrial permeability transition pore - A critical appraisal
    • Scorrano L, Petronilli V, Bernard P. On the voltage dependence of the mitochondrial permeability transition pore - a critical appraisal. J Biol Chem 1997; 272: 12295-12299
    • (1997) J Biol Chem , vol.272 , pp. 12295-12299
    • Scorrano, L.1    Petronilli, V.2    Bernard, P.3
  • 77
    • 0029657946 scopus 로고    scopus 로고
    • The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared
    • Gsell W, Strein I, Riederer P. The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared. J Neural Transm 1996; (Suppl) 47: 73-101
    • (1996) J Neural Transm , vol.47 , Issue.SUPPL. , pp. 73-101
    • Gsell, W.1    Strein, I.2    Riederer, P.3
  • 78
    • 0035160044 scopus 로고    scopus 로고
    • The Neuronal calcium sensor protein VILIP-1 Is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and Tau phosphorylation in vitro: A Link between calcium sensors and Alzheimer's disease?
    • Schnurra I, Bernstein HG, Riederer P, Braunewell KH. The Neuronal Calcium Sensor Protein VILIP-1 Is Associated with Amyloid Plaques and Extracellular Tangles in Alzheimer's Disease and Promotes Cell Death and Tau Phosphorylation in Vitro: A Link between Calcium Sensors and Alzheimer's Disease? Neurobiol Dis 2001; 8: 900-909
    • (2001) Neurobiol Dis , vol.8 , pp. 900-909
    • Schnurra, I.1    Bernstein, H.G.2    Riederer, P.3    Braunewell, K.H.4
  • 79
    • 0029925646 scopus 로고    scopus 로고
    • Neurotransmission and the ontogeny of human brain
    • Retz W, Kornhuber J, Riederer P. Neurotransmission and the ontogeny of human brain. J Neural Transm 1996; 103: 403-419
    • (1996) J Neural Transm , vol.103 , pp. 403-419
    • Retz, W.1    Kornhuber, J.2    Riederer, P.3
  • 82
    • 0027479538 scopus 로고
    • Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion
    • Sun FF, Fleming WE, Taylor BM. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochem Pharmacol 1993; 45: 1149-1155
    • (1993) Biochem Pharmacol , vol.45 , pp. 1149-1155
    • Sun, F.F.1    Fleming, W.E.2    Taylor, B.M.3
  • 84
    • 0035856407 scopus 로고    scopus 로고
    • On the turnover of brain cholesterol in patients with Alzheimer's disease. Hormonal induction of the cholesterol - Catabolic enzyme CYP 46 in glial cells
    • Bogdanovic N, Bretillon L, Lund EG, Diczfalusy U, Lannfelt L, Winblad B, Russell DW, Björkhem I. On the turnover of brain cholesterol in patients with Alzheimer's disease. Hormonal induction of the cholesterol - catabolic enzyme CYP 46 in glial cells. Neurosci Lett 2001; 314: 45-48
    • (2001) Neurosci Lett , vol.314 , pp. 45-48
    • Bogdanovic, N.1    Bretillon, L.2    Lund, E.G.3    Diczfalusy, U.4    Lannfelt, L.5    Winblad, B.6    Russell, D.W.7    Björkhem, I.8
  • 85
    • 0026524681 scopus 로고
    • Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol
    • Mason RP, Shoenmaker WJ, Shajenko L, Chambers T, Herbette LG. Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol. Neurobiol Aging 1992; 13: 413-419
    • (1992) Neurobiol Aging , vol.13 , pp. 413-419
    • Mason, R.P.1    Shoenmaker, W.J.2    Shajenko, L.3    Chambers, T.4    Herbette, L.G.5
  • 86
    • 0032405857 scopus 로고    scopus 로고
    • Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4
    • Mulder M, Ravid R, Swaab DF, de Kloet ER, Haasdijk ED, Julk J, Boom J, van der, Havekes LM. Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4. Alzheimer Dis Ass Disord 1998; 12: 198-203
    • (1998) Alzheimer Dis Ass Disord , vol.12 , pp. 198-203
    • Mulder, M.1    Ravid, R.2    Swaab, D.F.3    De Kloet, E.R.4    Haasdijk, E.D.5    Julk, J.6    Boom, J.7    Van der Havekes, L.M.8
  • 89
    • 0029973361 scopus 로고    scopus 로고
    • Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy
    • Wu Y, Sun FF, Tong DM. Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. Biophys J 1996; 71: 91-100
    • (1996) Biophys J , vol.71 , pp. 91-100
    • Wu, Y.1    Sun, F.F.2    Tong, D.M.3
  • 90
    • 0033791814 scopus 로고    scopus 로고
    • Membrane breakdown in acute and chronic neurodegeneration. Focus on choline-containing phospholipids
    • Klein J. Membrane breakdown in acute and chronic neurodegeneration. Focus on choline-containing phospholipids. J Neural Transm 2000; 107: 1027-1063
    • (2000) J Neural Transm , vol.107 , pp. 1027-1063
    • Klein, J.1
  • 91
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol microdomains in brain plasma membranes
    • Kirsch C, Eckert GP, Müller WE. Statin effects on cholesterol microdomains in brain plasma membranes. Biochem Pharmacol 2003; 65: 843-856
    • (2003) Biochem Pharmacol , vol.65 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Müller, W.E.3
  • 92
    • 0035142852 scopus 로고    scopus 로고
    • Cholesterol-dependent modulation of τ phosphorylation in cultured neurons
    • Fan QW, Yu W, Senda T, Yanagisawa K, Michikawa M. Cholesterol-dependent modulation of τ phosphorylation in cultured neurons. J Neurochem 2002; 76: 391-400
    • (2002) J Neurochem , vol.76 , pp. 391-400
    • Fan, Q.W.1    Yu, W.2    Senda, T.3    Yanagisawa, K.4    Michikawa, M.5
  • 93
    • 0037235059 scopus 로고    scopus 로고
    • Blockade of HMG-COA reductase activity causes changes in suppression of geranylgeranylpyrophosphate formation: Implications for Alzheimer's disease
    • Meske V, Albert F, Richter D, Schwarze J, Ohm TG. Blockade of HMG-COA reductase activity causes changes in suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease. Euro J Neurosci 2003; 17: 93-102
    • (2003) Euro J Neurosci , vol.17 , pp. 93-102
    • Meske, V.1    Albert, F.2    Richter, D.3    Schwarze, J.4    Ohm, T.G.5
  • 94
    • 0034870805 scopus 로고    scopus 로고
    • Membrane-disordering effects of β-amyloid peptides
    • Müller WE, Kirsch C, Eckert GP. Membrane-disordering effects of β-amyloid peptides. Biochem Soc Trans 2001; 29: 617-623
    • (2001) Biochem Soc Trans , vol.29 , pp. 617-623
    • Müller, W.E.1    Kirsch, C.2    Eckert, G.P.3
  • 96
    • 0033090880 scopus 로고    scopus 로고
    • Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain
    • Scheuer K, Rostock A, Bartsch R, Müller WE. Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry 1999; 32 (Suppl): 10-16
    • (1999) Pharmacopsychiatry , vol.32 , Issue.SUPPL. , pp. 10-16
    • Scheuer, K.1    Rostock, A.2    Bartsch, R.3    Müller, W.E.4
  • 97
    • 0342437559 scopus 로고    scopus 로고
    • Effects of piracetam on membrane fluidity in the aged mouse rat, and human brain
    • Müller WE, Koch S, Scheuer K, Rostock A, Bartsch R. Effects of piracetam on membrane fluidity in the aged mouse rat, and human brain. Biochem Pharmacol 1997; 53: 135-140
    • (1997) Biochem Pharmacol , vol.53 , pp. 135-140
    • Müller, W.E.1    Koch, S.2    Scheuer, K.3    Rostock, A.4    Bartsch, R.5
  • 98
    • 0033460182 scopus 로고    scopus 로고
    • Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761)
    • Hoyer S, Lannert H, Nöldner M, Chatterjee SS. Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761). J Neural Transm 1999; 106: 1171-1188
    • (1999) J Neural Transm , vol.106 , pp. 1171-1188
    • Hoyer, S.1    Lannert, H.2    Nöldner, M.3    Chatterjee, S.S.4
  • 99
    • 0030039729 scopus 로고    scopus 로고
    • Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse
    • Stoll S, Scheuer K, Pohl O, Müller WE. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 1996; 29: 144-149
    • (1996) Pharmacopsychiatry , vol.29 , pp. 144-149
    • Stoll, S.1    Scheuer, K.2    Pohl, O.3    Müller, W.E.4
  • 101
    • 0030458395 scopus 로고    scopus 로고
    • In vivo granulation of the peripheral-type benzodiazepine receptor and glucocorticoid syntheses by the Ginkgo biloba extract 761 and isolated gingkolides
    • Huri H, Ogwuegbu SO, Boujard N, Drieu D, Papedopulus V. In vivo granulation of the peripheral-type benzodiazepine receptor and glucocorticoid syntheses by the Ginkgo biloba extract 761 and isolated gingkolides. Endocrinology 1996; 137: 5707-5718
    • (1996) Endocrinology , vol.137 , pp. 5707-5718
    • Huri, H.1    Ogwuegbu, S.O.2    Boujard, N.3    Drieu, D.4    Papedopulus, V.5
  • 102
    • 0030759072 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia
    • Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. J Amer Med Ass 1997; 278: 1327-1332
    • (1997) J Amer Med Ass , vol.278 , pp. 1327-1332
    • Le Bars, P.L.1    Katz, M.M.2    Berman, N.3    Itil, T.M.4    Freedman, A.M.5    Schatzberg, A.F.6
  • 104
    • 0032574973 scopus 로고    scopus 로고
    • Acute stress facilitates long-lasting changes in cholinergic gene expression
    • Kaufer D, Friedman A, Seidman S, Soreq H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 1998; 393: 373-377
    • (1998) Nature , vol.393 , pp. 373-377
    • Kaufer, D.1    Friedman, A.2    Seidman, S.3    Soreq, H.4
  • 105
    • 0032574866 scopus 로고    scopus 로고
    • The stress of Gulf War syndrome
    • Sapolsky RM. The stress of Gulf War syndrome. Nature 1998; 393: 308-309
    • (1998) Nature , vol.393 , pp. 308-309
    • Sapolsky, R.M.1
  • 106
    • 0032486467 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors activate expression of the Egr gene family of transcription factors
    • Kammer H von der, Mayhaus M, Albrecht C, Enderich J, Wegner M, Nitsch RM. Muscarinic acetylcholine receptors activate expression of the Egr gene family of transcription factors. J Biol Chem 1998; 273: 14538-14544
    • (1998) J Biol Chem , vol.273 , pp. 14538-14544
    • Von der Kammer, H.1    Mayhaus, M.2    Albrecht, C.3    Enderich, J.4    Wegner, M.5    Nitsch, R.M.6
  • 107
    • 0035896466 scopus 로고    scopus 로고
    • Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease
    • Davidsson P, Blennow K, Andreasen N, Eriksson B, Minthon L, Hesse C. Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease. Neurosci Lett 2001; 300: 157-160
    • (2001) Neurosci Lett , vol.300 , pp. 157-160
    • Davidsson, P.1    Blennow, K.2    Andreasen, N.3    Eriksson, B.4    Minthon, L.5    Hesse, C.6
  • 108
    • 0035852773 scopus 로고    scopus 로고
    • Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
    • Woodruff-Pak DS, Vogel III RW, Wenk GL. Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc Natl Acad Sci USA 2001; 98: 2089-2094
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2089-2094
    • Woodruff-Pak, D.S.1    Vogel R.W. III2    Wenk, G.L.3
  • 109
    • 0034720172 scopus 로고    scopus 로고
    • Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy
    • Jeyrasasingam G, Yeluashvili M, Quik M. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. NeuroReport 2000; 11: 1173-1176
    • (2000) NeuroReport , vol.11 , pp. 1173-1176
    • Jeyrasasingam, G.1    Yeluashvili, M.2    Quik, M.3
  • 110
    • 0034489269 scopus 로고    scopus 로고
    • Cholinesterase inhibitors, β-amyloid precursor protein and amyloid β-peptides in Alzheimer's disease
    • Lahiri DK, Farlow MR, Hintz N, Utsuki T, Greig NH. Cholinesterase inhibitors, β-amyloid precursor protein and amyloid β-peptides in Alzheimer's disease. Acta Neurol Scand Suppl 2000; 176: 60-67
    • (2000) Acta Neurol Scand Suppl , vol.176 , pp. 60-67
    • Lahiri, D.K.1    Farlow, M.R.2    Hintz, N.3    Utsuki, T.4    Greig, N.H.5
  • 111
    • 0028170903 scopus 로고
    • Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties
    • Kornhuber J, Weller M, Schoppmeyer K, Riederer P. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Tansm 1994; 43 (Suppl): 91-104
    • (1994) J Neural Tansm , vol.43 , Issue.SUPPL. , pp. 91-104
    • Kornhuber, J.1    Weller, M.2    Schoppmeyer, K.3    Riederer, P.4
  • 112
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the M-Best study (Benefit and efficacy in severly demented patients during treatment with memantine)
    • Winblad B, Poritis N. Memantine in severe dementia: results of the M-Best study (Benefit and efficacy in severly demented patients during treatment with memantine). Int J Geriatr Psychiatry 1999; 14: 135-146
    • (1999) Int J Geriatr Psychiatry , vol.14 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 113
    • 0030945041 scopus 로고    scopus 로고
    • Pharmakotherapie bei Alzheimer-Demenz: Therapie kognitiver symptome - Neue studienresultate
    • Heidrich A, Rösler M, Riederer P. Pharmakotherapie bei Alzheimer-Demenz: Therapie kognitiver Symptome - neue Studienresultate. Fortschr Neurol Psychiat 1997; 65: 108-121
    • (1997) Fortschr Neurol Psychiat , vol.65 , pp. 108-121
    • Heidrich, A.1    Rösler, M.2    Riederer, P.3
  • 117
    • 0029774181 scopus 로고    scopus 로고
    • Pharmacology of selegiline
    • Gerlach M, Youdim MBH, Riederer P. Pharmacology of selegiline. Neurology 1996; 47 (Suppl 3): 2137-2145
    • (1996) Neurology , vol.47 , Issue.SUPPL. 3 , pp. 2137-2145
    • Gerlach, M.1    Youdim, M.B.H.2    Riederer, P.3
  • 118
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley R. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240: 622-630
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.1
  • 120
    • 0024810125 scopus 로고
    • Biochemical aspects of HMG CoA reductase inhibitors
    • Endo A, Hasumi K. Biochemical aspects of HMG CoA reductase inhibitors. Ad Enzyme Regul 1989; 28: 53-64
    • (1989) Ad Enzyme Regul , vol.28 , pp. 53-64
    • Endo, A.1    Hasumi, K.2
  • 122
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3 methyl-glutaryl Coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3 methyl-glutaryl Coenzyme A reductase inhibitors. Arch Neurol 2000; 57: 1439-1443
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 123
    • 0026565983 scopus 로고
    • Clinical heterogeneity of probable Alzheimer's disease
    • Blennow K, Wallin A. Clinical heterogeneity of probable Alzheimer's disease. J Geriatr Psychiatry Neurol 1992; 5: 106-113
    • (1992) J Geriatr Psychiatry Neurol , vol.5 , pp. 106-113
    • Blennow, K.1    Wallin, A.2
  • 125
    • 0035901715 scopus 로고    scopus 로고
    • Differential effects of lovostatin treatment on brain cholesterol levels in normal and ApoE-deficient mice
    • Eckert GP, Kirsch C, Müller WE. Differential effects of lovostatin treatment on brain cholesterol levels in normal and ApoE-deficient mice. NeuroReport 2001; 12: 883-887
    • (2001) NeuroReport , vol.12 , pp. 883-887
    • Eckert, G.P.1    Kirsch, C.2    Müller, W.E.3
  • 129
    • 0035816709 scopus 로고    scopus 로고
    • Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid
    • Kakio A, Nishimoto S, Yanagisawa K, Kozutsumi Y, Matsuzaki K. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid. J Biol Chem 2001; 276: 24985-24990
    • (2001) J Biol Chem , vol.276 , pp. 24985-24990
    • Kakio, A.1    Nishimoto, S.2    Yanagisawa, K.3    Kozutsumi, Y.4    Matsuzaki, K.5
  • 130
    • 0030860139 scopus 로고    scopus 로고
    • Estrogen and the treatment of Alzheimer's disease
    • Birge SJ, Mortel KF. Estrogen and the treatment of Alzheimer's disease. Am J Med 1997; 103: 36-45
    • (1997) Am J Med , vol.103 , pp. 36-45
    • Birge, S.J.1    Mortel, K.F.2
  • 131
    • 0031593920 scopus 로고    scopus 로고
    • Effects of estradiol (β-17) on learning, memory and cerebral energy metabolism in male rats after intracerebroventricular administration of streptozotocin
    • Lannert H, Wirtz P, Schuhmann V, Galmbacher R. Effects of estradiol (β-17) on learning, memory and cerebral energy metabolism in male rats after intracerebroventricular administration of streptozotocin. J Neural Transm 1998; 105: 1045-1063
    • (1998) J Neural Transm , vol.105 , pp. 1045-1063
    • Lannert, H.1    Wirtz, P.2    Schuhmann, V.3    Galmbacher, R.4
  • 132
    • 0033304886 scopus 로고    scopus 로고
    • The molecular and neuroanatomical basis for estrogen effects in the central nervous system
    • McEwen BS. The molecular and neuroanatomical basis for estrogen effects in the central nervous system. J Clin Endocrinol Metabol 1999; 84: 1790-1797
    • (1999) J Clin Endocrinol Metabol , vol.84 , pp. 1790-1797
    • McEwen, B.S.1
  • 134
    • 0035783908 scopus 로고    scopus 로고
    • Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus
    • Berchtold NC, Kesslak JP, Pike CJ, Adlard PA, Cotman CW. Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. Eur J Neurosci 2001; 14: 1992-2002
    • (2001) Eur J Neurosci , vol.14 , pp. 1992-2002
    • Berchtold, N.C.1    Kesslak, J.P.2    Pike, C.J.3    Adlard, P.A.4    Cotman, C.W.5
  • 136
    • 0027364185 scopus 로고
    • Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type
    • Manning CA, Ragazzino MC, Gold PE. Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type. Neurobiol Aging 1993; 14: 523-528
    • (1993) Neurobiol Aging , vol.14 , pp. 523-528
    • Manning, C.A.1    Ragazzino, M.C.2    Gold, P.E.3
  • 138
    • 0035668352 scopus 로고    scopus 로고
    • Effect of Ginkgo biloba extract (EGb 761) on glucose-metabolic-related markers in streptozotocin-damaged rat brain
    • Löffler T, Lee SK, Nöldner M, Chatterjee SS. Effect of Ginkgo biloba extract (EGb 761) on glucose-metabolic-related markers in streptozotocin-damaged rat brain. J Neural Transm 2001; 108: 457-1474
    • (2001) J Neural Transm , vol.108 , pp. 457-1474
    • Löffler, T.1    Lee, S.K.2    Nöldner, M.3    Chatterjee, S.S.4
  • 139
    • 0036209930 scopus 로고    scopus 로고
    • Alzheimer's vaccine: A cure worse than the disease?
    • Robinson SR, Münch G. Alzheimer's vaccine: a cure worse than the disease? J Neural Transm 2002; 109: 537-539
    • (2002) J Neural Transm , vol.109 , pp. 537-539
    • Robinson, S.R.1    Münch, G.2
  • 140
    • 0037203825 scopus 로고    scopus 로고
    • Nerve inflammation halts trial for Alzheimer's drug
    • Check E. Nerve inflammation halts trial for Alzheimer's drug. Nature 2002; 415: 462
    • (2002) Nature , vol.415 , pp. 462
    • Check, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.