-
1
-
-
0029004341
-
Cloning of a novel gene bearing missense mutations in early familial Alzheimer disease
-
Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a novel gene bearing missense mutations in early familial Alzheimer disease. Nature. 1995;375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
2
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lehad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 1995;269:973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lehad, E.1
Wasco, W.2
Poorkaj, P.3
-
3
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate AM, Chartier-Harlin MC, Mullan MC, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991;349:704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.M.1
Chartier-Harlin, M.C.2
Mullan, M.C.3
-
4
-
-
0027407565
-
Apolipoprotein E: High avidity binding to b-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schnechel D, et al. Apolipoprotein E: high avidity binding to b-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schnechel, D.3
-
5
-
-
0027327267
-
Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease
-
Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
-
(1993)
Neurology
, vol.43
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
-
6
-
-
0025262212
-
Transmission and age-at-onset patterns in familial Alzheimer's disease: Evidence for heterogeneity
-
Farrer LA, Myers RH, Cupples LA, et al. Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity. Neurology. 1990;38:395-403.
-
(1990)
Neurology
, vol.38
, pp. 395-403
-
-
Farrer, L.A.1
Myers, R.H.2
Cupples, L.A.3
-
7
-
-
0030893280
-
The role of heredity in late-onset Alzheimer disease and vascular dementia: A twin study
-
Bergem AL, Engedal K, Kringlen EL. The role of heredity in late-onset Alzheimer disease and vascular dementia: a twin study. Arch Gen Psychiatry. 1997;54:264-270.
-
(1997)
Arch Gen Psychiatry
, vol.54
, pp. 264-270
-
-
Bergem, A.L.1
Engedal, K.2
Kringlen, E.L.3
-
8
-
-
9044228404
-
Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?
-
Lautenschlager NT, Cupples LA, Rao VS, et al. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: what is in store for the oldest old? Neurology. 1996;46:641-650.
-
(1996)
Neurology
, vol.46
, pp. 641-650
-
-
Lautenschlager, N.T.1
Cupples, L.A.2
Rao, V.S.3
-
9
-
-
0023109592
-
Amyloid β protein gene: CDNA, mRNA distribution and genetic linkage near the Alzheimer locus
-
Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science. 1987;235:880-884.
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
-
10
-
-
0030174981
-
The gene defects responsible for familial Alzheimer's disease
-
Tanzi RE, Kovacs DM, Kim T-W, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 1996;3:159-168.
-
(1996)
Neurobiol Dis
, vol.3
, pp. 159-168
-
-
Tanzi, R.E.1
Kovacs, D.M.2
Kim, T.-W.3
Moir, R.D.4
Guenette, S.Y.5
Wasco, W.6
-
11
-
-
0029001744
-
Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease
-
Sorbi S, Nacmias B, Forleo P, Piancentini S, Latorraca S, Amaducci L. Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease. Ann Neurol. 1993;38:124-127.
-
(1993)
Ann Neurol
, vol.38
, pp. 124-127
-
-
Sorbi, S.1
Nacmias, B.2
Forleo, P.3
Piancentini, S.4
Latorraca, S.5
Amaducci, L.6
-
12
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
Schellenberg GD, Bird TD, Wijsman EM, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science. 1992;258:668-671.
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
-
13
-
-
0028350675
-
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease
-
Van Broeckhoven C, Backhovens H, Cruts M, et al. APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease. Neurosci Lett. 1994;169:179-180.
-
(1994)
Neurosci Lett
, vol.169
, pp. 179-180
-
-
Van Broeckhoven, C.1
Backhovens, H.2
Cruts, M.3
-
14
-
-
0030499031
-
Wide range in age of onset for chromosome 1-related familial Alzheimer's disease
-
Bird TD, Levy-Lahad E, Poorkaj P, et al. Wide range in age of onset for chromosome 1-related familial Alzheimer's disease. Ann Neurol. 1996;40:932-936.
-
(1996)
Ann Neurol
, vol.40
, pp. 932-936
-
-
Bird, T.D.1
Levy-Lahad, E.2
Poorkaj, P.3
-
15
-
-
8944241774
-
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
-
Sherrington R, Froelich S, Sorbi S, et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet. 1996;5:985-988.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 985-988
-
-
Sherrington, R.1
Froelich, S.2
Sorbi, S.3
-
16
-
-
0029073383
-
Genetic dissection of Alzheimer disease, a heterogeneous disorder
-
Schellenberg GD. Genetic dissection of Alzheimer disease, a heterogeneous disorder. Proc Natl Acad Sci U S A. 1995;92:8552-8559.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 8552-8559
-
-
Schellenberg, G.D.1
-
17
-
-
0028305380
-
Protective effect of apolipoprotein E type 2 allele for late-onset Alzheimer disease
-
Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late-onset Alzheimer disease. Nat Genet. 1994;7:180-184.
-
(1994)
Nat Genet
, vol.7
, pp. 180-184
-
-
Corder, E.H.1
Saunders, A.M.2
Risch, N.J.3
-
18
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
-
Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science. 1993;261:921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
19
-
-
0028843391
-
APOE and Alzheimer disease: Examination of allelic association and effect on age at onset in both early- And late-onset cases
-
Locke P, Conneally PM, Tanzi RE, et al. APOE and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genet Epidemiol. 1995;12:83-92.
-
(1995)
Genet Epidemiol
, vol.12
, pp. 83-92
-
-
Locke, P.1
Conneally, P.M.2
Tanzi, R.E.3
-
20
-
-
17744410836
-
APOE-4 and age-at-onset of Alzheimer's disease: The NIMH Genetics Initiative
-
Blacker D, Haines JL, Rodes L, et al. APOE-4 and age-at-onset of Alzheimer's disease: the NIMH Genetics Initiative. Neurology. 1997;48:139-147.
-
(1997)
Neurology
, vol.48
, pp. 139-147
-
-
Blacker, D.1
Haines, J.L.2
Rodes, L.3
-
21
-
-
0028889485
-
Statement on use of apolipoprotein E testing for Alzheimer's disease
-
American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer's Disease. Statement on use of apolipoprotein E testing for Alzheimer's disease. JAMA. 1995;274:1627-1629.
-
(1995)
JAMA
, vol.274
, pp. 1627-1629
-
-
-
22
-
-
0029944411
-
Apolipoprotein E genotyping in Alzheimer's disease
-
National Institute on Aging/Alzheimer's Association Working Group. Apolipoprotein E genotyping in Alzheimer's disease. Lancet 1996;347:1091-1095
-
(1996)
Lancet
, vol.347
, pp. 1091-1095
-
-
-
23
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995;373:523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
24
-
-
0029742199
-
Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science. 1996;274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
-
25
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996;2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
26
-
-
0028899724
-
Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with ApoE genotype and trisomy 21 (Down syndrome)
-
Hyman BT, West HL, Rebeck GW, et al. Quantitative analysis of senile plaques in Alzheimer's disease: observation of log-normal size distribution and molecular epidemiology of differences associated with ApoE genotype and trisomy 21 (Down syndrome). Proc Natl Acad Sci U S A. 1995;92:3586-3590.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 3586-3590
-
-
Hyman, B.T.1
West, H.L.2
Rebeck, G.W.3
-
27
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
-
Kim T-W, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 1997;277:373-376.
-
(1997)
Science
, vol.277
, pp. 373-376
-
-
Kim, T.-W.1
Pettingell, W.H.2
Jung, Y.K.3
Kovacs, D.M.4
Tanzi, R.E.5
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