Wnt-1 but not epidermal growth factor induces β-catenin/t-cell factor-dependent transcription in esophageal cancer cells

Cancer Research

Volumn 62, Issue 1, 2002, Pages 277-282

  Mizushima, Takaaki ^a   Nakagawa, Hiroshi ^a   Kamberov, Yana G ^a   Wilder, Elizabeth L ^a   Klein, Peter S ^a   Rustgi, Anil K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DNA; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; WNT PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON POLYPOSIS; COMPLEX FORMATION; DNA BINDING; ENZYME INACTIVATION; ESOPHAGUS CANCER; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR UPREGULATION; REPORTER GENE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION INITIATION;

ANIMALS; BETA CATENIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOPLASM; CYTOSKELETAL PROTEINS; EPIDERMAL GROWTH FACTOR; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; WNT PROTEINS; WNT1 PROTEIN; XENOPUS LAEVIS; XENOPUS PROTEINS; ZEBRAFISH PROTEINS;

EID: 0036144406     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Recent advances in the diagnosis and surgical treatment of patients with carcinoma of the esophagus
2. Cytoplasmic β-catenin in esophageal cancers
3. Alteration of β-catenin expression in esophageal squamous-cell carcinoma
4. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
5. E-cadherin-catenin: More than a 'sticky' molecular complex
6. Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes
7. Functional interaction of β-catenin with the transcription factor LEF-1
8. β-catenin signaling and cancer
9. Linking colorectal cancer to Wnt signaling
10. Wnt signaling and cancer
11. Regulation of β-catenin signaling in the Wnt pathway
12. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
13. Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
14. Identification of c-MYC as a target of the APC pathway
15. PEA3 is upregulated in response to WNT1 and activates the expression of cyclooxygenase-2
16. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/β-catenin complex in early colorectal carcinogenesis
17. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
18. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
19. Novel expression and function of peroxisome proliferator-activated receptor γ (PPARγ) in human neuroblastoma cells
20. Human cyclin D1 oncogene and esophageal squamous cell carcinoma
21. Genetic steps in the development of squamous cell carcinoma of the esophagus
22. APC gene mutations in the mutation cluster region are rare in esophageal cancers
23. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
24. C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity
25. 2+ pathways
26. A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals
27. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
28. Transforming growth factor-α enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter
29. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
30. Activation of the Wnt signaling pathway: A molecular mechanism for lithium action
31. A CACCC box-like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a novel transcriptional factor in tissue-specific squamous epithelia
32. Differential regulation of glycogen synthase kinase 3β by insulin and wnt signaling
33. Insertional mutagenesis in mouse mammary tumorigenesis
34. Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1 (int-1) oncogene in reconstituted mammary gland
35. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
36. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
37. Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation
38. Wnt-1 signaling inhibits apoptosis by activating β-catenin/T cell factor-mediated transcription
39. Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos
40. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
41. Wnt-16a, a novel wnt-16 isoform, which shows differential expression in adult human tissues
42. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
43. Axin prevents Wnt-3a-induced accumulation of β-catenin
44. The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix
45. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
46. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium
47. Tumor suppressor genes