Aβ42, presenilins, and Alzheimer's disease

Neurobiology of Aging

Volumn 19, Issue SUPPL. 1, 1998, Pages

  Iwatsubo, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

A 42; Alzheimer's disease; Amyloid protein; Presenilin

Indexed keywords

AMYLOID; AMYLOID A PROTEIN; AMYLOID BETA PROTEIN; PRESENILIN 1; PRESENILIN 2; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL CELL; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; ARTICLE; BRAIN; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; SENILE PLAQUE; TISSUE FIXATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; CELLS, CULTURED; HUMANS; MEMBRANE PROTEINS; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; SENILE PLAQUES; TISSUE FIXATION; TRANSFECTION;

EID: 0031626697     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(98)00027-X     Document Type: Conference Paper

References (13)

1. Cook D. G., Forman M., Sung J. C., Leight S., Kolson D. L., Iwatsubo T., Lee V. M.-Y., Doms R. W. Alzheimer Aβ(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Med. 3:1997;1021-1023.
2. Fukumoto H., Asami-Odaka A., Suzuki N., Shimada H., Ihara Y., Iwatsubo T. Amyloid β protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of Aβ42(43) and association of Aβ40 with cored plaques. Am. J. Pathol. 148:1996;259-265.
3. Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals evidence that an initially deposited species is Aβ42(43) . Neuron. 13:1994;45-53.
4. Iwatsubo T., Mann D. M. A., Odaka A., Suzuki N., Ihara Y. Amyloid β protein (Aβ) deposition. Aβ42(43) precedes Aβ40 in Down syndrome. Ann. Neurol. 37:1995;294-299.
5. Iwatsubo T., Saido T. C., Mann D. M. A., Lee V. M.-Y., Trojanowski J. Q. Full-length amyloid-β(1-42(43)) as well as amino-terminally modified and truncated amyloid-β42(43) deposit in diffuse plaques. Am. J. Pathol. 149:1996;1823-1830.
6. Jarrett J. T., Berger E. P., Lansbury P. T. Jr. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation implications for the pathogenesis of Alzheimer's disease . Biochemistry. 32:1993;4693-46971.
7. Kosaka T., Imagawa M., Seki K., Arai H., Sasaki H., Tsuji S., Asami-Odaka A., Fukushima T., Imai K., Iwatsubo T. The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid β protein ending at Aβ42(43). Neurology. 48:1997;741-745.
8. Mann D. M. A., Iwatsubo T., Cairns N. J., Lantos P. L., Nochlin D., Sumi S. M., Bird T. D., Poorkaj P., Hardy J., Hutton M., Prihar G., Crook R., Rossor M. N., Haltia M. Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease Predominance of Aβ42(43) . Ann. Neurol. 40:1996;149-156.
9. Mann D. M. A., Iwatsubo T., Nochlin D., Sumi M., Levy-Lahad E., Bird T. D. Amyloid (Aβ) deposition in chromosome 1-linked Alzheimer's disease. - The Volga German families. Ann. Neurol. 41:1997;52-57.
10. Maruyama K., Tomita T., Shinozaki K., Kume H., Asada H., Saido T. C., Ishiura S., Iwatsubo T., Obata K. Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of Aβ42(43). Biochem. Biophys. Res. Comm. 227:1996;730-735.
11. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2:1996;864-870.
12. Suzuki N., Cheung T. T., Cai X.-D., Odaka A., Otvos L. Jr, Eckman C., Golde T. E., Younkin S. G. An increased percentage of long amyloid β-protein is secreted by familial amyloid β-protein precursor (βAPP717) mutants. Science. 264:1994;1336-1340.
13. Tomita T., Maruyama K., Saido T. C., Kume H., Shinozaki K., Tokuhiro S., Capell A., Walter J., Grünberg J., Haass C., Iwatsubo T., Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc. Natl. Acad. Sci. USA. 94:1997;2025-2030.