Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: A suggestive link between the chemistry and biology of epothilones

Angewandte Chemie - International Edition

Volumn 42, Issue 22, 2003, Pages 2518-2521

  Yoshimura, Fumihiko ^a,b   Rivkin, Alexey ^a,b   Gabarda, Ana E ^a,b   Chou, Ting Chao ^a   Dong, Huajin ^a   Sukenick, George ^a   Morel, Florence F ^c   Taylor, Richard E ^c   Danishefsky, Samuel J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Antitumor agents; Conformational analysis; Natural products; Structure activity relationships

Indexed keywords

CHEMICAL BONDS; CONFORMATIONS; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS; SYNTHESIS (CHEMICAL);

MOLECULAR MODELING;

KETONES;

9,10 DEHYDROEPOTHILONE B; ANTINEOPLASTIC AGENT; EPOTHILONE B; EPOTHILONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ANALYSIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; EPOTHILONES; INFUSIONS, INTRAVENOUS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; TIME FACTORS;

EID: 0038339582     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351407     Document Type: Article

References (36)

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