New chemical synthesis of the promising cancer chemotherapeutic agent 12,13-desoxyepothilone B: Discovery of a surprising long-range effect on the diastereoselectivity of an aldol condensation

Journal of the American Chemical Society

Volumn 121, Issue 30, 1999, Pages 7050-7062

  Harris, Christina R ^a   Kuduk, Scott D ^a   Balog, Aaron ^a,c   Savin, Ken ^a,d   Glunz, Peter W ^a   Danishefsky, Samuel J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Havemeyer Hall ^*  (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12,13 DESOXYEPOTHILONE B; EPOTHILONE B; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHIRALITY; DIASTEREOISOMER; HYDROGENATION; MICROTUBULE ASSEMBLY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; SYNTHESIS;

EID: 0033523260     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja991189l     Document Type: Article

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