Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: Correlation of ring size with biological activity in the epothilone series

Journal of Organic Chemistry

Volumn 67, Issue 22, 2002, Pages 7737-7740

  Rivkin, Alexey ^a   Njardarson, Jon T ^a   Biswas, Kaustav ^a   Chou, Ting Chao ^a   Danishefsky, Samuel J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RING-CLOSING METATHESIS;

ASSAYS; CELLS; OLEFINS; SYNTHESIS (CHEMICAL); TUMORS;

AROMATIC COMPOUNDS;

10,11 DEHYDRO 12,13 DESOXYEPOTHILONE B; 10,11 DEHYDRO 13,14 [17]DESOXYEPOTHILONE B; 10,11 DEHYDRO 14,15 [18]DESOXYEPOTHILONE B; EPOTHILONE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CORRELATION ANALYSIS; DRUG POTENCY; DRUG SYNTHESIS; ESTERIFICATION; IN VITRO STUDY; STEREOCHEMISTRY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; EPOTHILONES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NEOPLASM METASTASIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036827835     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0204294     Document Type: Article

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