Didehydrofarnesyl diphosphate: An intrinsically fluorescent inhibitor of protein farnesyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2137-2140

  Liu, Xiao Hui ^a   Prestwich, Glenn D ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Farnesol; FTase; Geranylgeraniol; GGTase I; Inhibitor; Pentaene; Protein prenylation; Stereoselective Wittig

Indexed keywords

DIDEHYDROFARNESYL DIPHOSPHATE; FARNESYL DIPHOSPHATE; FUNGAL PROTEIN; PENTANE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE; INHIBITION KINETICS; REACTION ANALYSIS; STEREOCHEMISTRY; WITTIG REACTION; YEAST;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; FLUORESCENT DYES; POLYISOPRENYL PHOSPHATES;

EID: 1842791345     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.077     Document Type: Article

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