Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.

Current topics in medicinal chemistry

Volumn 3, Issue 10, 2003, Pages 1075-1093

  Dinsmore, Christopher J ^a   Bell, Ian M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; GERANYLGERANYLTRANSFERASE TYPE I; GERANYLGERANYLTRANSFERASE TYPE-I; TRANSFERASE;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CLINICAL TRIAL; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; NEOPLASM; PROTEIN PROCESSING; REVIEW; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN ISOPRENYLATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037607008     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026033452113     Document Type: Review

References (70)