Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes

Osteoarthritis and Cartilage

Volumn 12, Issue 4, 2004, Pages 336-345

  Coimbra, Ibsen B ^a,b   Jimenez, Sergio A ^a   Hawkins, David F ^a   Piera Velazquez, Sonsoles ^a   Stokes, David G ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Articular cartilage; Gene expression; Human chondrocytes; Hypoxia; Osteoarthritis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA;

ADAPTATION; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL ISOLATION; CELL SUSPENSION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FROZEN SECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; HYBRIDIZATION; HYPOXIA; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; OSTEOARTHRITIS; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RNA EXTRACTION; STEADY STATE; VASCULARIZATION;

EID: 1842788526     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2003.12.005     Document Type: Article

References (53)

1. Falchulk KH, Goetzl EJ, Kulka JP. Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med 1970;49:223-31.
2. Lund-Olesen L. Oxygen tension in synovial fluids. Arthritis Rheum 1970;13:769-76.
3. Treuhaft PS, McCarty DJ. Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum 1971;14:475-84.
4. Silver IA. Measurement of pH and ionic composition of pericellular sites. Phil Trans R Soc Lond B 1975; 271:261-72.
5. 2, pressure, pH, and lactate in human osteoarthritis of the hip. Clin Orthop 1988;229:149-55.
6. Shapiro IM, Tokuoka T, Silverton SF. Energy metabolism in cartilage. In: Hall BK, Newman S, Eds. Cartilage: Molecular Aspects. Boston: CRC Press 1991;97-130.
7. 2 and blood flow in the rabbit knee joint due to stimulation of the posterior articular nerve. J Physiol 1992; 449:607-17.
8. Lane JM, Brighton CT, Menkowitz BJ. Anaerobic and aerobic metabolism in articular cartilage. J Rheum 1977;4:334-42.
9. Lee RB, Urban JPG. Evidence for a negative Pasteur effect in articular cartilage. Biochem J 1997;321: 95-102.
10. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999;15:551-78.
11. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993;9:4304-8.
12. 2 tension. Proc Natl Acad Sci USA 1995;92:5510-4.
13. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95:7987-92.
14. Salceda S, Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997;272:22642-7.
15. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
16. Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513-8.
17. Semenza GL. Hypoxia-inducible factor-1: Oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001;7:345-50.
18. 2 homeostasis by hypoxia-inducible factor 1. Genes Dev 1998;12:149-62.
19. Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, et al. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 2001;21:3436-44.
20. Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Phar. 2002;64:993-8.
21. Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277:38205-11.
22. Figueroa YG, Chan AK, Ibrahim R, Tang Y, Burow ME, Alam J, et al. NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression. Exp Hematol 2002;30:1419-14127.
23. Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L. Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation. Biochem J 2003;370:1011-7.
24. Haddad JJ, Land SC. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett 2001;505:269-74.
25. Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM. Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism. J Cell Physiol 1996;168:424-32.
26. Grimshaw MJ, Mason RM. Modulation of bovine articular chondrocyte gene expression in vitro by oxygen tension. Osteoarthritis Cart 2001;9:357-64.
27. Hansen U, Schunke M, Domm C, Ioannidis N, Hassenpflug J, Gehrke T, et al. Combination of reduced oxygen tension and intermittent hydrostatic pressure: A useful tool in articular cartilage tissue engineering. J Biomech 2001;34:941-9.
28. Murphy CL, Sambanis A. Effect of oxygen tension and alginate encapsulation on restoration of the dedifferentiated phenotype of passaged chondrocytes. Tissue Eng 2001;7:791-803.
29. Domm C, Schunke M, Christesen K, Kurz B. Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cart 2002;10:13-22.
30. Stokes DG, Liu G, Coimbra IB, Piera-Velazquez S, Crowl RM, Jimenez SA. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum 2002;46:404-19.
31. Reginato AM, Iozzo RV, Jimenez SA. Formation of nodular structures resembling mature articular cartilage in long-term primary cultures of human fetal epiphyseal chondrocytes on a hydrogel substrate. Arthritis Rheum 1994;37:1338-49.
32. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292: 468-72.
33. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res 1983;11:1475-89.
34. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 2001;15:2865-76.
35. Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
36. Akeno N, Czyzyk-Krzeska MF, Gross TS, Clemens TL. Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2 alpha. Endocrinology 2001;142:959-62.
37. Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999;274:32631-7.
38. Minet E, Arnould T, Michel G, Roland I, Mottet D, Raes M, et al. ERK activation upon hypoxia: Involvment in HIF-1 activation. FEBS Lett 2000;468:53-8.
39. Muller JM, Krauss B, Kaltschmidt C, Baeuerle PA, Rupec RA. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway. J Biol Chem 1997;272:23435-9.
40. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 1998;17:5085-94.
41. Kim KW, Bae SK, Lee OH, Bae MH, Lee MJ, Park BC. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Res 1998;58:348-51.
42. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999;59:3915-8.
43. Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1 beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 2002;512:157-62.
44. Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates HIF-1 through a PI-3-kinase/TOR-dependent pathway. J Biol Chem 2002;277:27975-81.
45. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, et al. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci USA 1998;95:10188-93.
46. Loeser RF, Shanker G. Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro. Arthritis Rheum 2000;43:1552-9.
47. Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999;94:1561-7.
48. Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, Mochan E. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 2000;350:307-12.
49. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, et al. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 2001;89:47-54.
50. Hu C-J, Wang L-Y, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-74.
51. van der Kraan PM, van den Berg WB. Anabolic and destructive mediators in osteoarthritis. Curr Opin Clin Nutr Metab Care 2000;3:205-11.
52. Shikhman AR, Brinson DC, Valbracht J, Lotz MK. Cytokine regulation of facilitated glucose transport in articular chondrocytes. J Immunol 2001;167:7001-8.
53. Namiki A, Brogi E, Kearney M, Kim EA, Wu T, Couffinhal T, et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 1995;270:31189-95.