Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis

Arthritis and Rheumatism

Volumn 46, Issue 2, 2002, Pages 404-419

  Stokes, David G ^a   Liu, Gang ^a   Coimbra, Ibsen B ^a   Piera Velazquez, Sonsoles ^a   Crowl, Robert M ^b   Jiménez, Sergio A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; CADHERIN 11; CELL ADHESION MOLECULE; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; PLASTIC; POLYADENYLATED RNA; POLYMACON; RETINOID X RECEPTOR; SCLEROPROTEIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA MICROARRAY; EXPRESSED SEQUENCE TAG; FETUS; FIBROBLAST; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; MONOLAYER CULTURE; NORTHERN BLOTTING; OSTEOARTHRITIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; STEM CELL;

ADULT; ANIMALS; BLOTTING, NORTHERN; CARTILAGE; CATTLE; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN; COLLAGEN TYPE I; COLLAGEN TYPE II; DNA PRIMERS; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036166257     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10106     Document Type: Article

References (78)

1. Articular cartilage. Part I. Tissue design and chondrocyte-matrix interactions
2. Regulation of chondrocyte gene expression
3. Chondrocyte differentiation
4. Articular cartilage. Part II: Degeneration and osteoarthrosis, repair, regeneration, and transplantation
5. Autocrine regulation of articular cartilage
6. Collagen synthesis in normal and osteoarthritic human cartilage
7. Independent regulation of collagen types of chondrocytes during the loss of differentiated function in culture
8. Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage
9. Type X collagen synthesis in human osteoarthritic cartilage: Indication of chondrocyte hypertrophy
10. Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage
11. Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage
12. Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions
13. Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage
14. Subpopulations of chondrocytes from different zones of pig articular cartilage: Isolation, growth and proteoglycan synthesis in culture
15. Composition of proteoglycans synthesized in different layers of cultured anatomically intact articular cartilage
16. The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers
17. De-differentiated chondrocytes re-express the differentiated collagen phenotype when cultured in agarose gels
18. Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity
19. Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beads
20. Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture
21. The loss of phenotypic traits by differentiated cells in vitro: Differentiation of cartilage cells
22. Relationship between cell shape and type of collagen synthesized as chondrocytes lose their cartilage phenotype in culture
23. Synthesis of cartilage matrix by mammalian chondrocytes in vitro. II. Maintenance of collagen and proteoglycan phenotype
24. Chondroid expression of lapine articular chondrocytes in spinner culture following monolayer growth
25. Prolonged expression of differentiated phenotype by chondrocytes cultured at low density on a composite substrate of collagen and agarose that restricts cell spreading
26. Expression of the human chondrocyte phenotype in vitro
27. Expression of mRNAs for collagens and other matrix components in dedifferentiating and redifferentiating human chondrocytes in culture
28. Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads
29. Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes
30. Culture and growth characteristics of chondrocytes encapsulated in alginate beads
31. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads
32. Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation
33. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers
34. Cultivation of cell-polymer cartilage implants in bioreactors
35. Biodegradable polymer scaffolds for tissue engineering
36. Formation of nodular structures resembling mature articular cartilage in long-term primary cultures of human fetal epiphyseal chondrocytes on a hydrogel substrate
37. Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro
38. Collagen gene expression during limb cartilage differentiation
39. Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesis
40. Temporal and spatial transitions in collagen types during embryonic chick limb development
41. Human HtrA, an evolutionary conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
42. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
43. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
44. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
45. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor
46. 2 tension
47. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3
48. SOX9 is a potent activator of the chondrocyte-specific enhancer of the proα1(II) collagen gene
49. A new long form of Sox5 (L-SoxS), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
50. Sox9 is required for cartilage formation
51. Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors
52. Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis
53. Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes
54. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloproteinase genes independent of TGF-β
55. Transactivation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9
56. M-twist is an inhibitor of muscle differentiation
57. A TWIST in development
58. Cloning of the human twist gene: Its expression is retained in adult mesodermally-derived tissues
59. Id helix-loop-helix proteins in cell growth and differentiation
60. Expression of M-twist during postimplantation development of the mouse
61. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
62. Absolute requirement for aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
63. Evidence for a negative Pasteur effect in articular cartilage
64. IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis
65. Differential effects of insulin-like growth factors I and II on growth, differentiation and glucoregulation in differentiating chondrocyte cells in culture
66. Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro
67. BMP-6 is an autocrine stimulator of chondrocyte differentiation
68. Analysis of cartilage maturation using micromass cultures of primary chondrocytes
69. Immunolocalization of collagen types II and III in single fibrils of human articular cartilage
70. Presence and distribution of collagen II, collagen I, fibronectin, and tenascin in rabbit normal and osteoarthritic cartilage
71. Immunohistochemical analysis of interstitial collagens in cartilage of different stages of osteoarthrosis
72. Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies
73. Expression of type-X collagen in osteoarthritis
74. Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage
75. Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
76. Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues
77. Twist is required in head mesenchyme for cranial neural tube morphogenesis
78. TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage