Combination of reduced oxygen tension and intermittent hydrostatic pressure: A useful tool in articular cartilage tissue engineering

Journal of Biomechanics

Volumn 34, Issue 7, 2001, Pages 941-949

  Hansen, Ute ^a   Schünke, Michael ^a   Domm, Christian ^a   Ioannidis, Niki ^a   Hassenpflug, Joachim ^b   Gehrke, Thorsten ^b   Kurz, Bodo ^a  

^a Kiel and Lungen Clinic Grosshansdorf   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Bovine articular chondrocytes; Collagen; Intermittent hydrostatic pressure; Oxygen; Phenotype; Proliferation; Tissue engineering

Indexed keywords

BIOASSAY; CARTILAGE; CELLS; COLLAGEN; HYDROSTATIC PRESSURE;

INHIBITING EFFECTS;

BIOMECHANICS;

COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 9;

ANIMAL CELL; ARTICULAR CARTILAGE; BIOENGINEERING; CARTILAGE CELL; CATTLE; CELL CULTURE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROSTATIC PRESSURE; IMMUNOCYTOCHEMISTRY; NONHUMAN; OXYGEN TENSION; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BIOMECHANICS; BIOMEDICAL ENGINEERING; CARTILAGE, ARTICULAR; CATTLE; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; COLLAGEN; HYDROSTATIC PRESSURE; IMMUNOHISTOCHEMISTRY; OXYGEN; PHENOTYPE; THYMIDINE;

EID: 0034982488     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9290(01)00050-1     Document Type: Conference Paper

References (29)

1. Influence of oxygen concentration and mechanical factors on differentiation of connective tissues in vitro
2. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
3. + exchange by hydrostatic pressure in isolated bovine articular chondrocytes
4. The effect of oxygen tension on proteoglycan synthesis and aggregation in mammalian growth plate chondrocytes
5. Expression of mRNAs for collagens and other matrix components in dedifferentiating and redifferentiating human chondrocytes in culture
6. Collagen type IX; evidence for covalent linkages to type II collagen in cartilage
7. Mechanical and physiochemical determinants of the chondrocyte biosynthetic response
8. Bovine articular chondrocyte function in vitro depends upon oxygen tension
9. The effects of hydrostatic pressure on matrix synthesis in articular cartilage
10. Effect of motion and load on articular cartilage in animal models
11. Contact pressure in the human hip joint measured in vivo
12. Cartilage response to mechanical force in high-density chondrocyte cultures
13. Improvement in the ethidium bromide method for direct fluorometric estimation of DNA and RNA in cell and tissue homogenates
14. Beta-adrenergic receptors and effects in cultured rat thymic epithelial cells
15. Expression of reduced amounts of structurally altererd aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure
16. Anaerobic and aerobic metabolism in articular cartilage
17. In vitro metabolic response of articular cartilage segments to low levels of hydrostatic pressure
18. Slowing down aging of cultured embryonal chick chondrocytes by maintenance under lowered oxygen tension
19. Joint motion in the absence of normal loading does not maintain normal articular cartilage
20. Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants
21. Adaptation of chondrocytes to low oxygen tension; relationship between hypoxia and cellular metabolism
22. Type IX collagen proteoglycan from cartilage is covalently cross-linked to type II collagen
23. Time-dependent effects of intermittent hydrostatic pressure on articular chondrocyte type II collagen and aggrecan mRNA expression
24. In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure
25. Intermittent sub-amient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism
26. Hydrostatic pressure influences mRNA expression of transforming growth factor-beta 1 and heat shock protein 70 in chondrocyte-like cell line
27. In vitro studies of the effect of intermittent compressive forces on cartilage cell proliferation
28. Responses of articular cartilage explant cultures to different oxygen tensions