Substituted 3β-phenylethynyl derivatives of 3α-hydroxy-5α-pregnan- 20-one: Remarkably potent neuroactive steroid modulators of γ-aminobutyric acid(A) receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 198-207

  Hawkinson, Jon E ^a   Acosta Burruel, Manuel ^a   Yang, Kevin C ^a   Hogenkamp, Derk J ^a   Chen, Jie Sheng ^a   Lan, Nancy C ^a   Drewe, John A ^a   Whittemore, Edward R ^a   Woodward, Richard M ^a   Carter, Richard B ^a   Upasani, Ravindra B ^a  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA (4 ACETYLPHENYLETHYNYL) 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; FLUNITRAZEPAM; MUSCIMOL; NEUROSTEROID; PENTETRAZOLE; PROGESTERONE DERIVATIVE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; ELTANOLONE; FUSED HETEROCYCLIC RINGS; RECOMBINANT PROTEIN; TERT-BUTYLBICYCLOPHOSPHOROTHIONATE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; OOCYTE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SEIZURE; SUBCUTANEOUS DRUG ADMINISTRATION; XENOPUS LAEVIS; ANIMAL; DRUG EFFECT; METABOLISM; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; FLUNITRAZEPAM; GABA MODULATORS; HUMANS; MALE; MICE; MUSCIMOL; PREGNANOLONE; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 17944397975     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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